Clinical trials: Gingiva Disorder
Gingival Overgrowth
Evaluating Lip Repositioning for the Treatment of Excess Gingival Display With and Without Pretreatment With Botox
Since the introduction of the lip repositioning procedure by a number of modifications to the technique have been introduced. All these modifications were made to prevent the main complication of lip repositioning surgeries…
- Trial name
- NCT04030767
- Testing
- Botox Injectable Product
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Periodontal Inflammation
GCF Galectin-3 and Interleukin-1beta Levels in Periodontitis.
This study aims to evaluate gingival crevicular fluid Galectin-3 and Interleukin-1beta levels in different grades (B and C) of stage 3 periodontitis, concurrently, and also to investigate their discriminative efficiencies in…
- Trial name
- NCT05449093
- Testing
- Periodontal clinical measurements and gingival crevicular fluid sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Gingivitis
Dose-dependent Anti-inflammatory Effects of Vitamin D in a Human Gingivitis Model
The burden of chronic gingivitis and periodontitis in the US is disproportionately high among Non-Hispanic Blacks compared to Non-Hispanic Whites.
- Trial name
- NCT00779909
- Testing
- vitamin D3
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Boston University
Gingivitis, Dental Plaque
Antiplaque, Antigingivitis and Anti-inflammatory Effects of Myrrh Mouthwash
Myrrh-based mouthwash has the potential to be a suitable alternative to the gold standard chlorhexidine mouthwash for dental plaque and gingivitis reduction.
- Trial name
- NCT04723732
- Testing
- Myrrh mouthwash, Chlorhexidine mouthwash, Normal saline
- Where
- Saudi Arabia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Periodontitis
Periodontitis on Gingival Crevicular Fluid Metobolomics
This cross-sectional observational study will compare the gingival crevicular fluid metabolomic profile of 30 adults with periodontitis and 30 periodontally healthy adults.
- Trial name
- NCT07739732
- Testing
- Periodontal probing depth
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Catania
Bleeding Gum, Gingivitis
Clinical Investigation of Bleeding Reduction Efficacy on Toothpaste Containing 1.05% Chitosan
The purpose of this study is to assess the bleeding reduction efficacy of toothpaste containing 1.05% Chitosan compared to a regular fluoride toothpaste, and compared to a toothpaste containing 67% bicarbonate.
- Trial name
- NCT06955871
- Testing
- Toothpaste containing 1.05% Chitosan, Silica-based NaF Toothpaste, Toothpaste with 67% bicarbonate
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Colgate Palmolive
Abfraction
Treatment of NCCL Asociated With Gingival Recession With B.O.P.T. Technique
The purpose of this clinical trial is to evaluate the gingival margin changes resulting from the treatment with biologically oriented preparation technique (B.O.P.T.) of non-carious cervical lesions (NCCL).
- Trial name
- NCT05861193
- Testing
- Treatment of the abfraction with BOPT technique
- Where
- Spain
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Gingival Recession, Generalized
Adjunctive Use of Hyaluronic Acid in Multiple Coronally Advanced Flap
The primary aim of this study is to evaluate whether the effect of HA in combination with XCM for the treatment of MAGRs with a multiple coronally advanced flap technique (mCAF) achieves better results than the XCM with mCAF…
- Trial name
- NCT05370456
- Testing
- Local application of a HA gel for the treatment of MAGRs with mCAF technique and XCM, Treatment of MAGRs with mCAF technique and XCM
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Gingivitis, Periodontal Diseases
Gingival Health and Malocclusion Among Type 1 Diabetic Children and Adolescents
Introduction: This study aims to evaluate the gingivitis, periodontal profile and malocclusion in children and adolescents with diabetes.
- Conditions
- Gingivitis, Periodontal Diseases, Diabetes, Diabetes Mellitus, Type 1
- Trial name
- NCT06291129
- Testing
- Periodontal therapy
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Mouthwashes, Chlorhexidine
Effects of Two Daily CHX Mouthrinses on Plaque, Gingivitis and Staining
Τhe aim of this randomized clinical trial was to investigate the efficacy of two daily mouth rinses containing CHX and different combinations of H2O2 and CPC, when used adjunctive to mechanical oral hygiene, and compare them with…
- Conditions
- Mouthwashes, Chlorhexidine, Dental Plaque, Gingival and Periodontal Disease
- Trial name
- NCT07351370
- Testing
- chlorhexidine/ cetylpyridinium chloride/ hydrogen peroxide mouthwash, Chlorhexidine/ cetylpyridinium chloride
- Where
- Greece
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Dental School
Periodontitis, Dental Plaque
Antiplaque/Antigingivitis Effect of Lacer Oros Integral
Background; A new mouth rinse formulation ("Lacer Oros Acción Integral", Lacer SA, Barcelona, Spain) has been recently proposed, including O-Cymen-5-ol, potassium nitrate, zinc chloride, dipotassium glycyrrhizate, sodium…
- Conditions
- Periodontitis, Dental Plaque, Gingival Inflammation
- Trial name
- LacerINT (NCT04881357)
- Testing
- test mouth rinse (Lacer Oros Acción Integral - new formula, Barcelona, Spain)., control group
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Dental Plaque and Gingivitis
The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and Gingivitis
This is a six (6) month, double-blind, parallel, controlled clinical trial utilizing one hundred and sixty (160) adults to evaluate the reduction of dental plaque and gingivitis.
- Trial name
- NCT02243046
- Testing
- Control toothpaste, Experimental toothpaste, Active Comparator
- Where
- Dominican Republic
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingival Recession
Evaluation of Sticky Bone With or Without EDTA for Treatment of Gingival Recession
Gingival recession is a common clinical finding in periodontal disease which is frequently associated with esthetic concerns, root hypersensitivity, and root caries.
- Trial name
- NCT04980066
- Testing
- Sticky bone and EDTA, Sticky bone
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Alveolar Bone Loss, Alveolar Ridge Augmentation
Evaluation of Guided Tissue Regeneration With Autogenous Bone Chips and CGF During Implant Placement
CGF membranes will be prepared using a swing-lock centrifuge. A full-thickness mucoperiosteal flap will be elevated in a narrow alveolar ridge. Implants will be inserted.
- Conditions
- Alveolar Bone Loss, Alveolar Ridge Augmentation, Dental Implant
- Trial name
- CGF (NCT07521514)
- Testing
- concentrated growth factor (CGF) Membrane
- Where
- Egypt
- Volunteers
- 8 people
- Sponsor
- Cairo University
Gingival Recession
Evaluation of Root Coverage After the Use of Coronally Advanced Flap Either With Advanced Paltelet Rich Fibrin or Subepithilial Connective Tissue Graft in Treatment of Miller Class I and II Gingival Recession.
patients with Miller class I , II gingival recession will be divided into 2 groups (control, intervention).the control one will receive coronally advanced flap with subepithililal connective tissue graft harvested from the palate…
- Trial name
- NCT03695549
- Testing
- CAF + (A-PRF), CAF+SCTG
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis
GCF Levels of IL-1β and IL-6 in Gingivitis and Stage III-Grade C Periodontitis
Periodontal diseases are chronic diseases that occur as a result of a violation of the balance between microbial dental plaque and the host response.
- Trial name
- NCT04689438
- Testing
- gingival crevicular fluid
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Uşak University
Peri-Implantitis, Peri-implant Mucositis
Predictive Value of Reduced Keratinized Mucosa on the Secondary Prevention of Peri-implant Mucositis and Periimplantitis in Patients Attending Regular Supportive Peri-implant Care. A Longitudinal Analysis
Capture of the potential risk factor "lack of band of keratinised mucosa" over a period of up to 5 years. Recording of peri-implant inflammatory processes in study participants that are not recorded during normal tooth cleaning…
- Conditions
- Peri-Implantitis, Peri-implant Mucositis, Lack of Keratinized Gingiva
- Trial name
- NCT05804760
- Testing
- Measurement of implant parameters
- Where
- Germany
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Peri Implantitis
Comparison of Two Non-surgical Procedure to Manage Gum Disease Around Implants.
Research Question: Can a minimally invasive, non-surgical treatment approach (MINST) be more effective than the current standard non-surgical method in treating peri-implantitis, a common inflammatory condition affecting dental…
- Trial name
- NCT07365722
- Testing
- Non-Surgical Periodontal treatment (NSPT), Minimally-invasive non-surgical therapy of peri-implantitis
- Volunteers
- 80 people
- Sponsor
- King's College London
Periodontitis, Periodontal Diseases
Effect of Smoking and Periodontal Therapy on Salivary and Gingival Crevicular IL-17 and IL-35
Periodontal diseases are among the major causes of tooth loss. Smoking may play a role as a contributing factor in the development of periodontitis by reducing the immune response.
- Conditions
- Periodontitis, Periodontal Diseases, Smoking, Smoking, Tobacco
- Trial name
- NCT05281848
- Testing
- Non-surgical periodontal treatment
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Gazi University
Gingivitis
Controlled Clinical Trial of Traditional Chinese Medicine Mouthrinse
Traditional Chinese medicine (TCM) has been seen as the predominant way of treating disease in China over three thousand years. Certain TCM have scientifically proved to have anti-bacterial property.
- Trial name
- NCT01637948
- Testing
- Listerine mouthrinse, Chinese Medicine mouthrinse
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
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