Clinical trials: Gingiva Disorder
Gingivitis
Protocol Efficacy of Mouthwashes in Experimental Gingivitis
This research was performed to find out the clinical efficacy and the anti-plaque and anti-gingivitis properties of a new oral health product (mouthwash and oral gel; StellaLife) compared to chlorhexidine.
- Trial name
- NCT07270952
- Testing
- StellaLife, Chlorhexidine
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Periodontal Disease
Periodontal Disease and Circulatory Microbial Components
The goal of this project is to study the immune activity of certain proteins present in the blood of patients with severe periodontal disease. Periodontal disease (gum disease) is the major cause of tooth loss among adults.
- Trial name
- CirCo (NCT01154855)
- Testing
- Prophylaxis ; Gross debridement for diseased patients
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Periodontitis, Gingivitis
Evaluation of Salivary Biomarker Levels in Individuals With Different Periodontal Conditions
In order to determine the pathogenesis of chronic inflammatory diseases, the levels of various cytokines are examined in tissues and fluids taken from the body.
- Conditions
- Periodontitis, Gingivitis, Periodontal Health
- Trial name
- NCT06558136
- Testing
- Saliva obtaining
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Gingival Recession
CGF and PRF in the Gingival Recessions Treatment
This study hypothesized that CGFs' placement together with CAF may enhance the healing of soft tissues better than use of PRF together with CAF.
- Trial name
- NCT04261634
- Testing
- Concentrated Growth Factor Membrane, Platelet Rich Fibrin
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Periodontitis, Adult
GCF miRNA-223 , -214 Levels in Smokers and Nonsmokers Periodontitis Patients
Objective: Periodontitis is a multifactorial disease that affects a wide range of populations. However, its pathogenesis remains unclear. miRNAs are now considered potential diagnostic markers for many inflammatory diseases.
- Trial name
- NCT06064799
- Testing
- miRNA-223 & -214 detection
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Gingivitis, Periodontitis
Is Professional Tooth Cleaning Necessary for Managing Gingivitis (Gingival Inflammation) if Subjects Use Intelligent Toothbrushes?
Periodontitis is highly prevalent and develops from plaque-induced gingivitis. Managing gingivitis is key to preventing periodontitis and its complications.
- Trial name
- NCT07549347
- Testing
- Optimal oral care regimen, Periodontal Treatment
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Gingivitis
Efficacy of an Amine and Zinc Lactate - Containing Mouthrinse in the Home-based Treatment of Plaque-induced Gingivitis in Adolescents.
The goal of this clinical trial is to evaluate if the adjunctive use of an amine and zinc lactate - containing mouthrinse may give significant benefits in the home-based treatment of plaque-induced gingivitis in adolescents.
- Trial name
- SPA (NCT06671106)
- Testing
- toothbrushing, flossing, Toothpaste Product
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Università degli Studi di Ferrara
Abdominal Obesity
Single Strain Probiotic
Probiotics have been recognized as functional foods with beneficial effects against obesity and cardiometabolic diseases, such as dyslipidemia, type 2 diabetes and the reduction of visceral fat mass, body weight and waist…
- Trial name
- CHOICE (NCT05882149)
- Testing
- Single strain probiotic
- Where
- Spain
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Rosa Sola
Dental Plaque
Livionex Oral Microbiome and Dental Plaque Control in HSCT Recipients
Children undergoing chemotherapy, radiation treatment and Hematopoietic Stem Cell Transplantation (HSCT) have significant difficulties achieving good oral hygiene and dental plaque control.
- Trial name
- NCT02617407
- Testing
- Livionex® Dental Gel, PreviDent 5000 plus/Tom's of Maine Children's toothpaste, Kolibree Toothbrush
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, San Francisco
Gingival Diseases
Evaluate Clinical Research From Commerical Oral Care Products
The purpose of this study is to conduct a clinical study comparing anti-plaque efficacy of commercial oral care products.
- Trial name
- NCT00759187
- Testing
- Fluoride, Triclosan/Fluoride, Chlorhexidine Gluconate
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis; Chronic, Oxidative Stress
Efficacy of Green and White Tea Extract Mouthwashes in the Management of Plaque-induced Gingivitis: A Clinical and Biochemical Study
Background and objective: Tea is the second most consumed drink in the world after water. Gingivitis is among the most common infectious diseases.
- Conditions
- Gingivitis; Chronic, Oxidative Stress, Inflammation
- Trial name
- NCT05861206
- Testing
- GT-MW group (5% Green tea), WT-MW group (5% White tea),EO-MW group (Listerine mouthrinse), CHX-MW group (0.12% CHX, as a positive control group)
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Yağmur Saraç Gül
Dental Caries, Probiotics
Effect of Probiotics on Oral Homeostasis During Sugar Stress
The present study is a double-blinded randomized clinical trial with a duration of 28 days.
- Conditions
- Dental Caries, Probiotics, Gingivitis
- Trial name
- NCT05073393
- Testing
- Sugar stress
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Periodontal Disease, Gingival Inflammation and Bleeding
Efficacy of Oral Hygiene Regimens in Patients Undergoing Non-Surgical Periodontal Treatment
The objective of this clinical study is to evaluate the efficacy of multi-component oral hygiene regimens as adjunctive to non-surgical periodontal treatment in patients with stage II periodontitis.
- Trial name
- PEREG (NCT07803484)
- Testing
- Active Oral Hygiene Regimen
- Where
- 2 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- Colgate Palmolive
Gingival Recession
Platelet-Rich Fibrin Dressing in the Management of Free Gingival Graft
Evaluation of two dressing materials; a Platelet-Rich Fibrin (PRF) dressing and a non-eugenol-based (Coe-Pak™) dressing in the management of free gingival graft and donor site palatal wound.
- Trial name
- NCT03589235
- Testing
- A free gingival graft, A Platelet-Rich Fibrin dressing, A non-eugenol-based dressing
- Where
- Syria
- Volunteers
- 20 people
- Sponsor
- Damascus University
Pulpitis, Pulpitis - Irreversible
Comparison of Aquaporin -4, -5, -9 and IL-8 Levels in GCF, Dentin Fluid and Pulp Samples
This study aimed to compare the changes in AQP -4, -5, -9, and IL-8 levels in pulp tissue, GCF, and dentin fluid samples routinely obtained during the treatment of healthy and symptomatic teeth diagnosed with irreversible…
- Conditions
- Pulpitis, Pulpitis - Irreversible, Pulp Inflammation, Healthy Pulp
- Trial name
- NCT06938191
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Periodontal Diseases, Obesity, Morbid
Gingival Crevicular Fluid of Adiponectin and Resistin As Predictable Implement in Staging and Grading System of Periodontitis
The goal of this clinical trial is to evaluate the relationship between obesity and gingival crevicular fluid resistin and adiponectin in periodontitis patients as well as assess the effect of non-surgical periodontal therapy on…
- Trial name
- NCT06604013
- Testing
- non-surgical full-mouth periodontal therapy without using adjunct disinfectants, GCF level of adiponectin and resistin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Al-Azhar University
Gingivitis
Dietary Diversities: Exploring the Influence of Keto Diet and Intermittent Fasting on Oral Health and Salivary Inflammatory Biomarkers
This study aims to investigate the impact of short term, two distinct dietary interventions, namely the Keto diet and Intermittent Fasting on oral health by measuring the severity of: Periodontal diseases (Gingivitis).
- Trial name
- NCT06597708
- Testing
- keto diet, intermittent fasting with calorie restriction
- Where
- Iraq
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Al-Mustansiriyah University
Gingival Bleeding
Garlic With Lime Juice and Chlorhexidine Mouthwash
the study about herbal mouthwash. it is clinical trial .the investigator will compare between chlorhexidine mouthwash and garlic with lime juice mouthwash.and their effect on gingival bleeding and plaque and salivary bacteria.
- Trial name
- mouthwash (NCT03105960)
- Testing
- garlic with lime mouth wash, chlorhexidine
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Periodontitis, Aggressive Periodontitis
IL-34 Levels in Various Types of Periodontitis
The objective of this study is to 1) identification of the impact of IL-34 on the pathogenesis of periodontal disease and determine whether any relationship among the existing levels of Gingival crevicular fluid (GCF) Interleukin…
- Trial name
- NCT04223869
- Testing
- non-surgical periodontal treatment
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Periodontitis, Diabetes Mellitus
Effects of Gum Disease Treatment on Host Defense Factors
Human immune system produces many different factors, which will influence health-disease statuses. This partially explains why under similar conditions only some people become sick.
- Trial name
- PETREBED (NCT03146975)
- Testing
- Non-surgical periodontal treatment
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
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