Clinical trials: Gingival Condition
Gingivitis
Dose Finding Study to Assess Octenidine Mouthwash Concentrations in Comparison to Placebo
The objective of this clinical trial is to identify the most efficacious octenidine dihydrochloride concentration regarding bacterial count reduction in comparison to a placebo in the oral cavity.
- Trial name
- OML0113 (NCT02138552)
- Testing
- Octenidine dihydrochloride
- Where
- 2 sites in Germany
- Volunteers
- 90 people
- Sponsor
- Schülke & Mayr GmbH
Healthy
Effect of Xylitol-based Chewing Gums, Sugar-free and Sugared, on Salivary Flow and pH in Young Adults
This study was planned to evaluate the effects of xylitol-based chewing gums, sugar-free and sugared, on salivary flow and pH in young adults.
- Trial name
- NCT06370091
- Testing
- Gum of Xylitol, Gum of sugar free, Gum of sugar
- Where
- Ecuador
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad Católica de Cuenca
Wound Healing and Prevention, Oral Inflammation
Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva
The intervention in this study is to determine whether multiple applications of photobiostimulation with Nd-YAG laser improve wound healing following tooth extraction and alveolar ridge preservation.
- Conditions
- Wound Healing and Prevention, Oral Inflammation, Photobiomodulation, Post-operative Pain Management
- Trial name
- NCT07095556
- Testing
- Low-level laser therapy
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Dental Plaque, Gingivitis
The Clinical Investigation of a New Toothpaste Containing Stannous Fluoride as Compared to a Commercially Available Fluoride Toothpaste in Reducing Plaque and Gingivitis
The objective of this study is to evaluate the clinical efficacy of a new toothpaste containing stannous fluoride (SnF) as compared to Colgate Fluoride Toothpaste in reducing gingivitis and dental plaque.
- Trial name
- NCT03852056
- Testing
- MFP Fluoride toothpaste, Stannous fluoride toothpaste
- Where
- China
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingival Recession, Non-Carious Cervical Lesions (NCCLs)
Root Coverage Performance of Restorative Materials in Class V Cavities
This prospective randomized controlled clinical trial aims to evaluate the influence of different restorative materials placed in Class V cervical lesions on the clinical outcomes of root coverage surgery using a subepithelial…
- Trial name
- NCT07687654
- Testing
- No Restoration Control Group, Glass Ionomer Cement Group, Resin Composite Group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Zeliha Başak Çakır Erdil
Dental Caries
Effect of Xylitol-Containing Chewing Gum With/Without Bicarbonate Versus Paraffin Pellet on Salivary pH
36 eligible participants will be randomly divided into three groups (n=12) according to the tested chewing gum (A), where (A1) represents participants exposed to xylitol chewing gum, (A2) represents participants exposed to…
- Trial name
- NCT03061422
- Testing
- Xylitol, xylitol with bicarbonate, paraffin
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Diseases, Periodontitis
An Evaluation of the Effect of the Erchonia FX-405 Laser as an Adjunctive Treatment of Periodontitis
The purpose of this clinical study is to determine the effectiveness of the Erchonia® FX-405 (manufactured by Erchonia Corporation (the Company) in providing a noninvasive adjunctive treatment in combination with periodontal…
- Conditions
- Periodontal Diseases, Periodontitis, Gum Disease
- Trial name
- NCT06656325
- Testing
- Erchonia® FX405
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Erchonia Corporation
Diabete Mellitus, Dyslipidaemia
Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years
Overweight and obesity, as well as periodontitis, are common public health problems with increasing prevalence. Both conditions may be linked through shared mechanisms involving chronic low-grade systemic inflammation.
- Conditions
- Diabete Mellitus, Dyslipidaemia, Chronic Kidney Disease, Psychiatric Disorder
- Trial name
- NCT07880717
- Testing
- Periodontal Examination, Questionnaire interview, Anthropometric measurements
- Where
- Thailand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Periodontitis
Impact of Pycnogenol® on Gingival Inflammation
This randomized, double-blind, placebo-controlled 2-arm, parallel group clinical trial is designed to evaluate the impact of the regular consumption of a polyphenol-containing Maritime Pine (Pinus pinaster) bark extract…
- Trial name
- PINEGIN (NCT05786820)
- Testing
- Pycnogenol
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Wuerzburg University Hospital
Periodontitis, Gingivitis
Diagnostic Accuracy of Rapid Non-clinical Screening Tests for Early Detection of Periodontitis
Gum disease is the 6th most prevalent disease of mankind. It is a non-communicable non-resolving inflammation; if untreated it leads to tooth loss and inability to chew properly.
- Trial name
- NCT03928080
- Testing
- Bleeding on brushing
- Where
- China
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- The European Research Group on Periodontology (ERGOPerio)
Gingivitis
The Effects of Pistacia Mutica on De Novo Dental Plaque Formation, Gingival Inflammation and Oral Microorganisms
Dental plaque is a well known etiologic factor for gingivitis. Recently, herbal extracts are a matter of scientific interest to inhibit plaque accumulation on teeth.
- Trial name
- NCT00972803
- Testing
- pistacia Mutica extract, Chlorhexidine
- Where
- Iran
- Volunteers
- 25 people
- Sponsor
- Tabriz University
Behavior, Gingivitis
Improving Dental Floss Adherence and Gingival Health With SMS and an Innovative Floss Holder
This study proposes to evaluate the effects of using a new floss holder (GumChuck) and the use of text messages during supportive periodontal therapy, on the psychological, behavioral and clinical parameters of patients with…
- Trial name
- NCT03120559
- Testing
- New Floss Holder - Gum Chucks, New Floss Holder - Gum Chucks/SMS
- Volunteers
- 144 people
- Sponsor
- University of Lisbon
Post Operative Pain, Acute, Periodontitis
The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration
Possible participants will be scheduled to have 2 gum flap surgeries done on 2 similar surgical sites in the mouth. The study looks at two different ways of giving dexamethasone, a medication used to reduce inflammation.
- Trial name
- NCT07832110
- Testing
- Dexamethasone IV injection, Dexamethasone Capsule
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Endodontic-Periodontal Lesions, Apical Periodontitis
The MTA Effect on Healing and Biomarkers in Endo-Perio Lesions
This project is a randomized controlled clinical study investigating the effect of Mineral Trioxide Aggregate (MTA) used as an apical plug in root canal obturation on periodontal healing and inflammatory biomarkers in teeth with…
- Conditions
- Endodontic-Periodontal Lesions, Apical Periodontitis, Periapical Disease
- Trial name
- NCT07653997
- Testing
- Root Canal Treatment with MTA Apical Plug, Root Canal Treatment with Resin-Based Sealer (AH Plus), Periodontal Therapy (Scaling and Root Planing)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Periodontitis, Peri-implant Mucositis
Biological Responses Affecting Early-stage Dental Implant Placement in Patients With History of Periodontitis
This prospective parallel, double-blind, four-arm randomised controlled clinical study is planned to assess the difference in the level of the inflammatory biomarkers expressed following the placement of the first dental implant…
- Conditions
- Periodontitis, Peri-implant Mucositis, Peri-Implantitis
- Trial name
- NCT05834946
- Testing
- Megagen implant placement, Biomate-Swiss implant
- Where
- Malaysia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Bleeding on Probing, Plaque
Efficacy and Safety Evaluation of Jet Floss EX After 8-week Application
This was a single center, comparison among treatments, 8-week study of the efficacy and safety of Jet Floss EX. Totally 72 eligible subjects were recruited in this study and randomly divided into 2 groups.
- Conditions
- Bleeding on Probing, Plaque, Gingival Index
- Trial name
- NCT06718959
- Testing
- the test product (Jet Floss EX), the control product (interdental brush)
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Guang Dong Bixdo Health Technology Co.,Ltd
Gingivitis, Orthodontic Treatment
Effect of Individually Trained Oral Prophylaxis (iTOP) on Gingival Health in Orthodontic Patients
This randomized controlled clinical trial aims to evaluate the effectiveness of individualized oral hygiene education using the Individually Trained Oral Prophylaxis (iTOP) method compared with conventional oral hygiene…
- Trial name
- NCT07468773
- Testing
- Individually Trained Oral Prophylaxis (iTOP) Oral Hygiene Training, Conventional Oral Hygiene Instruction
- Where
- United Arab Emirates
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Periodontitis
Photodynamic Therapy Plus Root Debridement in Gum Disease Treatment V2
Gum disease is a common disease, which affects 45% of the UK adult dentate population. It is caused by bacteria in dental plaque, which produces inflammation and a deepening of the natural crevice between the gum and the tooth…
- Trial name
- PDTV2 (NCT03270254)
- Testing
- light activated dye photodynamic therapy (PDT)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Periodontitis, Smoking Cessation
Effect of Nicotine Gingival Fibroblast Intoxication on the Response of Periodontal Treatment
Impact of nicotine gingival intoxication on the clinical outcomes after periodontitis non surgical treatment
- Conditions
- Periodontitis, Smoking Cessation, Tobacco Dependence
- Trial name
- ENIPT's (NCT07491627)
- Testing
- periodontal non-surgical treatment
- Where
- Belgium
- Volunteers
- 56 people
- Sponsor
- University of Liege
Gingivitis, Plaque, Dental
Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste
The 6-month clinical study was designed to investigate clinical efficacy on plaque and gingivitis for the stannous fluoride containing toothpaste (SNAP) compared to Colgate Cavity Protection Toothpaste after 3 and 6 months of…
- Trial name
- NCT06300866
- Testing
- Test, Control
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
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