Clinical trials: Gingival Condition
Tinnitus, Chronic Subjective Tinnitus
Acute Nicotine Gum and Auditory Brain Responses in Adults With Chronic Tinnitus
This study tests whether a single dose of nicotine gum changes brain responses to sounds and the ability to detect target sounds in non-smoking adults with chronic tinnitus.
- Trial name
- NCT07877701
- Testing
- Nicotine polacrilex gum 4 mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Xianhui Wang
Periodontis, Aggressive Periodontitis
Single-cell and Spatial Transcriptomic Profiling of Gingival Tissues in Aggressive and Chronic Periodontitis: Deciphering Cellular Heterogeneity and Inflammatory Microenvironment Features
The goal of this observational study is to investigate cellular heterogeneity and inflammatory microenvironment features in gingival tissues from patients with aggressive periodontitis compared to chronic periodontitis and…
- Trial name
- NCT07487272
- Where
- China
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Gingival Inflammation
Evaluation of Anti Bacterial Effect of Titanium Dioxide Nanoparticles on Baseplates of Twin Block
Background The objective of this study was to evaluate the antibacterial effect of Titanium dioxide nanoparticles incorporated into the acrylic baseplates of maxillary part of twin block appliances in orthodontic patients during…
- Trial name
- NCT06051487
- Testing
- titanium dioxide nanoparticles in test group
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Gingivitis
Probiotic Yoghurt Effect on Experimental Gingivitis
The aim of this study was to evaluate the effects of probiotic yoghurt on the development of gingival inflammation. Fifty-one periodontally healthy individuals were given standard oral hygiene instructions and randomly divided…
- Trial name
- NCT02546206
- Testing
- Probiotic Yoghurt, Natural Yoghurt
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Marmara University
Gynecologic Disease, Postoperative Ileus
Postoperative Chewing Gum and Gynecological Laparoscopic Surgery
The authors aimed to evaluate the effects of postoperative gum chewing on laparoscopic gynecological surgery, gastrointestinal function-intestinal mobility and early postoperative recovery.
- Conditions
- Gynecologic Disease, Postoperative Ileus, Paralytic Ileus
- Trial name
- NCT03884244
- Testing
- chewing gum
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Gingival Recession, Localized
Assessment of Gingival Health Following Rubber-Dam Isolation
The aim of this study is to evaluate the effect of retraction techniques on gingival health. Four different method (212 clamp (Hu-Friedy, USA); Brinker B4 clamp (Coltene Hygenic, USA); dental floss using the simple knot tie…
- Trial name
- NCT05850065
- Testing
- Hu-Friedy 212 clamp, dental floss using the simple knot tie method, Coltene B4 clamp
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marmara University
Idiopathic Thrombocytopenic Purpura
Study of a New Medication for Childhood Chronic Immune Thrombocytopenia (ITP), a Blood Disorder of Low Platelet Counts That Can Lead to Bruising Easily, Bleeding Gums, and/or Bleeding Inside the Body.
The purpose of this study is to investigate the efficacy, safety and tolerability of eltrombopag in children with previously treated chronic immune thrombocytopenia who are between 1 and 17 years of age. This is a 2 part study.
- Trial name
- PETIT2 (NCT01520909)
- Testing
- Eltrombopag
- Where
- 51 sites in United States, Argentina and 11 more
- Volunteers
- 92 people
- Sponsor
- GlaxoSmithKline
Gingival Enlargement
Gingival Hyperplasia Treatment With Surgical Scalpel vs Diode Laser in Orthodontic Patients.
Gingival enlargement is a common complication in orthodontic patients, often resulting from plaque accumulation and chronic inflammatory response during fixed appliance therapy.
- Trial name
- GINGILASCA (NCT07263763)
- Testing
- Scalpel Gingivectomy, Diode laser Gingivectomy
- Where
- Vietnam
- Volunteers
- 13 people
- Sponsor
- Nguyen Thu Thuy
Gingivitis, Dental Plaque Accumulation
Essential Oils Mouth Rinse and Dental Floss: Efficacy on Interproximal Gingivitis and Dental Plaque Accumulation
It is difficult to obtain patient's compliance with regular interproximal dental hygiene. Dental floss is recognized as an effective procedure to remove dental plaque and prevent gingivitis in the space between teeth, but it is…
- Trial name
- NCT01236963
- Testing
- Essential oils mouthrinse, Dental Floss
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Lisbon
Lumbar Spondylosis
Effect of Chewing Gum on Abdominal Distension in Patients After Lumbar Spine Surgery
According to chewing gum can promote the recovery of gastrointestinal function, it is used as an intervention measure for patients after lumbar surgery to evaluate the effect of chewing gum on improving abdominal distension of…
- Trial name
- NCT04970732
- Testing
- Gum chewing
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University Third Hospital
Periodontitis
Diode Laser Application With Non-Surgical Periodontal Treatment
Periodontitis is an infectious disease that causes destruction of periodontal tissues with complex etiology that develops due to local and systemic factors.
- Trial name
- NCT04908098
- Testing
- diode laser, scaling - root planning
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Dental Caries
Comparing Mouth Rinses (and Chewing Gum) in Regard to Streptococcus Mutans Reduction
This study compared four mouth rinses/chews for their ability to reduce Streptococcus Mutans after usage. The four that were compared were chlorhexidine gluconate (0.12%), sodium fluoride (0.05%), paraffin wax chewing gum (sugar…
- Trial name
- NCT02598778
- Testing
- Chlorhexidine gluconate (0.12%), Sodium Fluoride (0.05%), Paraffin wax chewing gum (sugar-free)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Gingivitis
Philips AirFlosser Study
In the current study, Sonicare AirFloss (AF) will be used in combination with a Manual Toothbrush (MTB) in a population of manual toothbrush users who are irregular flossers and who exhibit signs of moderate gingivitis.
- Trial name
- NCT01700348
- Testing
- Airflosser, Manual Floss
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Tufts University
Gingivitis, Gingival Diseases
Effectiveness in Dental Plaque Reduction of Mouthwashes Containing Fatty Acids Compounds (F.A.G.) or Stannous Fluoride
Comparative study on the efficacy of two mouthwashes Containing Fatty Acids Compounds (F.A.G.) or Stannous Fluoride in the reduction of plaque score in individuals with spontaneous gengivitis
- Trial name
- NCT04977778
- Testing
- Fatty Acids Compounds (F.A.G.) Mouthwash, Stannous Fluoride (SF) Mouthwash
- Where
- Italy
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of L'Aquila
Dental Calculus
Testing if Tartarase Can Remove Dental Tartar
This study was designed to find our whether a novel toothpaste containing safe digestive enzymes (Tartarase) was able to remove pre-existing dental tartar when compared to a well-known toothpaste (Crest).
- Trial name
- NCT06139835
- Testing
- Tartarase
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Pontis Biologics, Inc.
Periodontitis, Gingivitis
Effect of a Liquid Toothpaste on Periodontal Disease
The aim of the present clinical study is to evaluate the efficacy and safety of the novel toothpaste in patients diagnosed with gingivitis and/or periodontitis.
- Trial name
- NCT03117153
- Testing
- DA-5502 liquid toothpaste
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Dong-A Pharmaceutical
Pregnancy
Matrix Metalloproteinases's in Oral Biofluids During Pregnancy and Postpartum
The aim of this study was to investigate salivary and gingival crevicular fluid (GCF) levels of MMP-8, MMP-9 and TIMP-1 during 2/3 trimester of pregnancy and after delivery
- Trial name
- NCT03516565
- Testing
- Saliva collection, GCF collection
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Bleeding, Pain
Colibricare Efficacy on Oral Surgical Procedures/Extraction Wound and Gingiva Retraction
In this randomized, three-arm trial, 120 patients undergoing wisdoms' extractions were assigned to control (gauze pressure application), commercial sponge, or Coli-sorb® groups.
- Trial name
- NCT07638930
- Testing
- wisdoms' surgical extractions
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Cairo University
Periodontal Diseases
Impact of SASP in the GCF on the Outcomes of Periodontal Regeneration
Objectives: To test the impact of clinical inflammation and molecular expression profile (senescence-associated secretory phenotype; SASP) in the gingival crevicular fluid (GCF) on the outcomes of minimally-invasive periodontal…
- Trial name
- NCT06354972
- Testing
- Minimally invasive surgical procedure
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Acne Vulgaris, Gingivitis and Periodontal Diseases
Retinoic Acid Therapy and Regulation of Salivary and Serum IL-1β, IL-8 and MCP-1 Levels
This prospective cohort study analysed the effects of systemic retinoic acid use on periodontal status, salivary flow rate (SFR), and salivary and serum levels of interleukin (IL)-1β, IL-8 and monocyte chemoattractant protein…
- Conditions
- Acne Vulgaris, Gingivitis and Periodontal Diseases, Saliva Collection, Inflammation Biomarkers
- Trial name
- NCT06879795
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medipol University
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