Clinical trials: Gingival Crevicular Fluid
Periodontal Diseases
Hepcidin Levels in Periodontal Health and Disease
Periodontal disease refers to inflammatory disease of the periodontium caused by the host and/or pathogenic microorganisms. Anti-inflammatory and pro-inflammatory cytokines play a role in the periodontal inflammation process.
- Trial name
- NCT03789565
- Testing
- Biomarker test
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bulent Ecevit University
Behcet Syndrome, Periodontitis
Possible Association Between Behçet's Disease and Periodontal Diseases
Aim: This study explores the connection between Behçet's disease (BD), characterized by persistent oral and genital ulcers alongside iritis, and periodontal disease.
- Conditions
- Behcet Syndrome, Periodontitis, Gingival Diseases
- Trial name
- NCT07821528
- Testing
- Periodontal clinical indexes, saliva, gingival crevicular fluid sampling
- Volunteers
- 87 people
- Sponsor
- Gazi University
Periodontitis, Smoking
Interaction Between Smoking, GCF Periostin, IL17A, IL17E and Non-surgical Periodontal Therapy
It was aimed to evaluate the changes in the levels of Periostin, IL-17A and IL-17E cytokines in the gingival crevicular fluid (GCF) of periodontitis patients which non-surgical (Phase I) periodontal treatment applied to and their…
- Trial name
- NCT06326073
- Testing
- Non Surgical Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Periodontitis
Resolvin D1 Levels in Patients With Periodontitis
The purpose of the study was to determine the levels of Resolvin D1 (RVD1) in the gingival crevicular fluid (GCF) and saliva of the patients with periodontitis (P) and also to investigate the effects of non-surgical periodontal…
- Trial name
- NCT04496570
- Testing
- periodontal therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Ordu University
Chronic Periodontitis
Changes of GCF Levels of RANKL and Osteoprotegerin in Postmenopausal Osteoporosis
The investigators evaluated the effect of initial periodontal treatment on clinical findings and receptor activator of Nuclear Factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) in gingival crevicular fluid (GCF) of patients…
- Trial name
- NCT02808988
- Testing
- periodontal phase 1 therapy, gingival crevicular fluid collection, zoledronic acid
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Osteoporosis, Osteopenia
Periodontal Disease and Post-menopausal Osteoporosis
The aim of this study was to investigate the levels of RANKL and Osteoprotegerin, and their relationship in gingival crevicular fluid of post-menopausal women with osteoporosis/osteopenia and chronic periodontitis simultaneously…
- Conditions
- Osteoporosis, Osteopenia, Periodontal Disease
- Trial name
- NCT02184962
- Where
- Argentina
- Volunteers
- 81 people
- Sponsor
- Universidad Nacional de Córdoba
Periodontal Diseases
Evaluation of Biomarker Levels in Gingival Crevicular Fluid of Patients With Different Periodontal Diseases
Objectives: The aim of this study is; detection of peptidyl arginine deiminase4 (PAD4), galectin-3 and tumor necrosis factor alpha (TNF-α) levels in gingival crevicular fluid (GCF) samples of periodontally healthy, gingivitis and…
- Trial name
- NCT04777487
- Testing
- GCF obtaining
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Periodontitis, Hypertension
Effect of Non-surgical Periodontal Therapy in Hypertensive Patients With Assessment of Endocan and TNF-α Levels in GCF
There is a strong crossway relationship between periodontitis and hypertension. Hypertension is the most prevalent of cardiovascular diseases and its prevalence is increased by the presence of periodontitis.
- Conditions
- Periodontitis, Hypertension, TNF Alpha, Endocan
- Trial name
- NCT06627192
- Testing
- NSPT, clinical and biochemical assesment
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Periodontal Diseases
TNF-α/HIF-1α/VEGF Pathway in Periodontal Diseases
This study aimed to investigate gingival crevicular fluid (GCF) and salivary hypoxia inducible factor-1 alpha (HIF-1α), vascular endothelial growth factor (VEGF) and tumor necrosis factor-alpha (TNF-α) levels in different…
- Trial name
- NCT03558906
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Cardiovascular Diseases, Periodontal Diseases
Impact of Periodontal Treatment on Local miRNA Expression
To assess the impact of Fill Mouth Scaling and Root planing or Quadrant Scaling and Root planing gingival crevicular fluid (GCF) levels of miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 100-5p, miRNA 125-5p, miRNA 200b-3p and miRNA…
- Trial name
- NCT05275127
- Testing
- changes of gingival crevicular fluid miRNA
- Where
- Italy
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Catania
Chronic Peridontitis Patients, Chronic Gingivitis
Effect of Non-surgical Periodontal Therapy on Gingival Crevicular Fluid Interleukin-21 Levels
Human IL-21 is present in gingival crevicular fluid in periodontal health, gingivitis and chronic periodontitis. A significant increase in the concentration of IL-21 in gingival crevicular fluid is observed with an increase in…
- Conditions
- Chronic Peridontitis Patients, Chronic Gingivitis, Healthy
- Trial name
- NCT02861937
- Testing
- non surgical periodontal therapy
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Post COVID-19 Condition
Periodontal Health in Post COVID-19 Patients
The aim of this study is; To Assess the association between periodontal health and Matrix metalloproteinase-8 (MMP-8) level in Gingival Crevicular Fluid (GCF) in post COVID-19 patients.
- Trial name
- NCT05950230
- Testing
- Assess Periodontal Health Status, Collecte GCF samples by paperstrip
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Chronic Periodontitis, Preterm Labor
Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients With Chronic Periodontitis
This case control-study measures the levels of Interleukin-17 in gingival crevicular fluid and placental tissue samples of pregnant females as a possible marker in determining whether or not an association exists between chronic…
- Trial name
- NCT03171675
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periodontal Pocket
Gingival Crevicular Fluid Bone Morphogenetic Protein - 2 Release Profile Following the Use of Perforated Membrane
One of the most important elements suggested to be provided through membrane perforations to augment regeneration are cell released growth factors from the overlying periosteal and gingival cells.
- Trial name
- MPM (NCT01860495)
- Testing
- perforated membrane, G2
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Periodontitis (Stage 3), Gremlin-1
Comparative Analysis of Gremlin-1, Syndecan-4 and IL-1 Beta Levels in Gingival Crevicular Fluid Among İndividuals With Periodontal Health and Stage III Periodontitis, Considering Both Smokers and Non-Smokers, Before and After Non-Surgical Periodontal Therapy
eriodontitis is a complex disease characterized by the inflammation and destruction of the tissues supporting the teeth, and smoking can adversely affect the pathophysiological changes in this process.
- Conditions
- Periodontitis (Stage 3), Gremlin-1, Syndecan 4, Interleukin 1-beta
- Trial name
- NCT06687005
- Testing
- non-surgical periodontal therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tugba Aydin
Periodontal Treatment, Cytokines
Non-surgical Periodontal Treatment and Periostin Levels
Two different studies were planned from the recruited samples. The aim of these studies was to investigate the effect of non-surgical periodontal treatment on the inflammatory markers levels in serum and gingival crevicular fluid…
- Trial name
- NCT05535049
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Pharmacological Action
Dental Restorations Effect on Oxidative Status of the Gingival Crevicular Fluid
The goal of the study was to ascertain the influence of dental caries and teeth position as well as the type and amount of the applied dental materials (DMs) on the oxidative stress (OS) status in gingival crevicular fluid (GCF).
- Trial name
- NCT03522532
- Testing
- Amalgam placement, Tetric EvoCeram placement, Beautifil placement
- Where
- Serbia
- Volunteers
- 88 people
- Sponsor
- Ervin Taso
Periodontal Disease
Efficacy of Laser Therapy for Periodontitis
The aim of this study is to evaluate the efficacy of diode laser in addition to periodontal treatment in periodontitis patients and to investigate their effects on gingival crevicular fluid (GCF) cytokine levels before and after…
- Trial name
- NCT07013162
- Testing
- High power diode laser + SRT, Low diode diode laser + SRT, Curettage (SRT) only
- Where
- 2 sites in Yemen
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Science and Technology, Yemen
Chronic Periodontitis, Aggressive Periodontitis
Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System
In the present clinical study including chronic, aggressive periodontitis and healthy individuals, the investigators aimed to determine the RANKL, osteoprotegrin (OPG), Interleukin-1 (IL-1β), IL-10, IL-1β levels in gingival…
- Conditions
- Chronic Periodontitis, Aggressive Periodontitis, RANKL/OPG Ratio, Gingival Crevicular Fluid
- Trial name
- NCT02190773
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Vascular Endothelial Growth Factor Overexpression, Membrane Alteration
Perforated Barrier Membranes Maintain Physiologic Gingival Crevicular Fluid Growth Factor Levels
Membrane modifecation: Guided tissue membrane perforations may serve as a more biologic scaffold that could allow for the free passage of biologic mediators from the periosteum and overlying gingival connective tissue into the…
- Trial name
- NCT02168322
- Testing
- collagen membrane
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University