Clinical trials: Gingival Hyperpigmentation
Gingival Pigmentation, Gingival Hyperpigmentaion
Clinical Evaluation of Microneedling Technique With Topical Application of Silymarin on Gingival Hyperpigmentation in Comparison With Diode Laser and Scalpel Methods.
The present study will be carried to evaluate the efficacy of MN technique with topical Silymarin application in treating gingival hyperpigmentation in comparison with Laser and scalpel methods.
- Trial name
- Depigmentation (NCT07410156)
- Testing
- Gingival Depigmentation with Conventional Method, Gingival Depigmentation with Diode Laser, Gingival Depigmentation with Microneedling and Silymarin Application
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Gingival Pigmentation
Microneedling With Vitamin C Versus Injectable Vitamin C for Depigmentation in Gingival Melanin Hyperpigmentation
The study is a randomized controlled clinical trial comparing the use of microneedling with vitamin C against injecting vitamin C for depigmentation in physiological gingival melanin hyperpigmentation in a group of patients…
- Trial name
- NCT05786885
- Testing
- Microneedling will be done with application of topical vitamin C paste for depigmentation, Vitamin C injection
- Volunteers
- 22 people
- Sponsor
- Cairo University
Gingival Hyperpigmentation
Clinical Effectiveness Of Polishing Brush Compared To Ceramic Soft Tissue Trimming Bur In Gingival Depigmentation
Gingival hyperpigmentation, particularly of melanin origin, can pose significant aesthetic concerns, especially among patients with a high smile line.
- Trial name
- NCT07402720
- Testing
- Gingival Depigmentation using polishing brush, Depigmentation using ceramic soft tissue trimming bur
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Gingival Hyperpigmentation, Oral Pigmentation
Comparison of Er-YAG Laser, Air Polishing, and Surgical Excision for Gingival Hyperpigmentation
This randomized controlled clinical trial aimed to compare the effectiveness of different treatment approaches for physiologic gingival hyperpigmentation.
- Trial name
- APGH (NCT07672587)
- Testing
- Er:YAG Laser Therapy, Air Polishing with Erythritol Powder, Air Polishing with Sodium Bicarbonate Powder
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Physiological Gingival Hyperpigmentation
Evaluation of the Efficacy of Blue Laser in the Management of Gingival Hyperpigmentation Using Contact vs. Non-contact Mode
The goal of this clinical trial is to compare clinical and digital color parameter results of gingival depigmentation using blue laser in both contact and non- contact modes in patients with physiological gingival…
- Trial name
- NCT07836894
- Testing
- Gingival depigmentation using blue laser in non-contact mode, Gingival depigmentation using blue laser in contact mode
- Where
- Lebanon
- Volunteers
- 20 people
- Sponsor
- Beirut Arab University
Hyperpigmentation, Gingival Hyperpigmentaion
Effectiveness of Omega-3 Poly Unsaturated Fatty Acids on The Treatment of Gingival Hyperpigmentation
This new study compares the effectiveness of scalpel surgery and omega-3 poly unsaturated fatty acid (PUF) injections in treating gingival hyperpigmentation.
- Trial name
- Omega-3 (NCT07067515)
- Testing
- non surgical with PUFA injection, surgical treatment
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Suez Canal University
Gingival Pigmentation, Depigmentation
Gingival Hyperpigmentation Treatment
It is a clinical study conducted to evaluate the effect of vitamin C and Glucathonine injection of pigmented gingival tissue versus surgical removal by scalpel
- Conditions
- Gingival Pigmentation, Depigmentation, Vitamin C, Glutathione
- Trial name
- NCT07595705
- Testing
- Vitamin c and glutathione, Surgical depigmentation
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingival Hyperpigmentation
Gingival Depigmentation With Diode and Er,Cr:YSGG Laser: A Split-mouth Trial
Gingival hyperpigmentation is a common physiological condition caused by excessive melanin deposition in oral mucosa, negatively affecting smile esthetics.
- Trial name
- Laser (NCT07520266)
- Testing
- Er,Cr:YSGG laser, Diode laser
- Where
- 2 sites in Vietnam
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
Gingival Hyperpigmentation, Oral Health-Related Quality of Life
MEBO Bio-Dressing on Patient-Reported Outcomes and Tissue Healing Following Rotary Gingival Depigmentation
The purpose of this randomized, single-blind, parallel-group clinical trial is to evaluate the clinical efficacy of Moist Exposed Burn Ointment (MEBO) as a biological topical dressing compared to open secondary healing (no…
- Conditions
- Gingival Hyperpigmentation, Oral Health-Related Quality of Life, Wound Healing
- Trial name
- NCT07876921
- Testing
- MEBO Ointment
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Cairo University
Melanin Hyperpigmentation
Vitamin C Depigmenattion Versus Conventional Technique
Although physiologic gingival hyperpigmentation is not a pathologic condition, it is considered one of the main esthetic problems in dentistry.
- Trial name
- NCT03719274
- Testing
- vitamin c depigementation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingiival Hyperpigmentation
Comparison of Gingival Depigmentation Using Microneedling and Microneedling With Glutathione Gel - A Split Mouth Clinical Trial
The colour of gingiva is important determinant of smile esthetics.Owing to increasing awareness and demand for cosmetic procedures over the past decade, gingival depigmentation has gained popularity among periodontal plastic…
- Trial name
- NCT07748507
- Testing
- Microneedling using Dermapen device, Microneedling with 0.5 % Glutathione gel
- Where
- India
- Volunteers
- 15 people
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Gingival Pigmentation, Gingiival Hyperpigmentation
Evaluation of the Efficacy of Topical Application of Liquid Nitrogen and Ascorbic Acid in Treatment of Gingival Pigmentation
Aim of study The present study will be designed to evaluate the clinical and histomorphometric outcomes of using topical liquid nitrogen and topical ascorbic acid in gingival depigmentation.
- Trial name
- NCT07810101
- Testing
- Topical application of ascorbic acid for treatment of gingival pigmentation, Topical application of liquid nitrogen for treatment of gingival pigmentation, Treatment of gingival pigmentation by surgical technique
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Al-Azhar University
Gingival Hyperpigmentation
Licorice Extract Gel Versus Diode Laser for Physiologic Gingival Pigmentation
This randomized controlled clinical trial aims to compare the effectiveness of topical licorice extract gel and diode laser (445 nm) in the treatment of physiologic gingival pigmentation.
- Trial name
- NCT07325825
- Testing
- Diode Laser 445 nm, Licorice Extract Gel
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Alexandria University
Melanin Hyperpigmentation
Melanin Recurrence in Scalpel and LASER Gingival Depigmentation in Thin and Thick Phenotypes.
This study aimed to compare melanin pigmentation recurrence, pain perception and wound healing between laser and scalpel surgeries in thin and thick gingival phenotypes.Thirty patients (60 sites) were included in this study.
- Trial name
- NCT06886100
- Testing
- Diode laser, Scalpel No 15
- Where
- Yemen
- Volunteers
- 30 people
- Sponsor
- Thamar University
Gingival Pigmentation, Melanosis
Comparative Evaluation of Microsurgery vs Conventional Surgical Technique of Gingival Depigmentation
Gingiva being the most frequently pigmented tissue of the oral cavity challenges a lot of people with an esthetic concern. Increased production of melanin, a pigment produced by the melanocytes present in the basal and suprabasal…
- Trial name
- NCT05930392
- Testing
- Gingival depigmentation using microsurgery, Conventional surgical depigmentation
- Where
- India
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Hyperpigmentation; Melanin, Laser-Induced Hyperpigmentation
Laser-Assisted Gingival Depigmentation
This randomized clinical trial evaluated the recurrence rates of physiological gingival pigments during 24 months follow-up and the patient perceptions after the ablative depigmentation using two laser wavelengths; Diode 940 nm…
- Trial name
- NCT04680806
- Testing
- Er,Cr:YSGG laser 2780 nm, Diode laser 940 nm
- Where
- Qatar
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Academy of Laser Dentistry - Gulf Laser Chapter
Gingival Hyperpigmentation, Laser Depigmentation
Effect of Topical Argan Oil on Healing After Laser Depigmentation.
Effect of Argan oil vs placebo on healing after laser depigmentation
- Conditions
- Gingival Hyperpigmentation, Laser Depigmentation, Topical Argan Oil, Postoperative Gingival Healing
- Trial name
- NCT07357883
- Testing
- Laser Depigmentation
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ghada Adayil
Gingival Hyperpigmentation, Gingival Melanin Pigmentation
Vitamin C for Gingival Depigmentation
The purpose of this study is to evaluate the clinical and histopathological efficacy of topical vitamin C applications using three modalities (topical gel, microneedling , and mesotherapy) in gingival depigmentation.
- Trial name
- VitC-DePg (NCT07513727)
- Testing
- Topical Vitamin C ( control Arm), Vitamin C mesotherapy, Microneedling technique
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Al-Azhar University
Gingival Hyperpigmentaion
Ascorbic Acid Versus Diode Laser in the Treatment of Gingival Hyperpigmentation
Vitamin C affect the melanocytes function not the number while diode laser cause melanocytes destruction. Although diode laser and vitamin C have proved their effectiveness in depigmentation in previous studies, there are no…
- Trial name
- NCT03252418
- Testing
- Ascorbic Acid 500 MG, diode laser
- Volunteers
- 10 people
- Sponsor
- Ain Shams University
Gingival Pigmentation, Melanosis
Comparative Evaluation of Microsurgery vs Diode Laser Technique of Gingival Depigmentation
Gingiva being the most frequently pigmented tissue of the oral cavity challenges a lot of people with an esthetic concern. Increased production of melanin, a pigment produced by the melanocytes present in the basal and suprabasal…
- Trial name
- NCT05930366
- Testing
- Gingival depigmentation using microsurgery, Gingival Depigmentation using Diode Laser
- Where
- India
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak