Clinical trials: Glaucoma, Low Tension
Normal Tension Glaucoma
IOP Lowering Effects of Topical Anesthetics Used Frequently in the Ophthalmology Clinic
The primary purpose of this study is to determine whether topical ophthalmic anesthetics lower the intraocular pressure in the eye.
- Trial name
- NCT01254149
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Normal Tension Glaucoma (NTG), Low-Tension Glaucoma, Bilateral
Study of an Investigational Product, QLS-111, Provided as an Eyedrop, for Treatment of Normal Tension Glaucoma (NTG)
Qlaris' Phase 2 clinical trial investigating the safety, tolerability, and ocular hypotensive efficacy of QLS-111 in normal tension glaucoma patients.
- Conditions
- Normal Tension Glaucoma (NTG), Low-Tension Glaucoma, Bilateral, Low-Tension Glaucoma, Unspecified Eye, Glaucoma
- Trial name
- Nightingale (NCT06030193)
- Testing
- QLS-111 ophthalmic solution (0.015%), Timolol Maleate PF 0.5% Ophthalmic Solution (Timolol)
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Qlaris Bio, Inc.
Open Angle Glaucoma, Normal Tension Glaucoma
Reproducibility of Blood Flowmetry in Human Retina Using the Nidek Laser Speckle Flowgraphy LSFG-NAVI System
In addition to intraocular pressure blood perfusion pressure in the optic nerve is an important factor determing the cause of glaucoma. Increasing evidence suggests that in glaucoma patients retinal blood may be decreased.
- Conditions
- Open Angle Glaucoma, Normal Tension Glaucoma, Healthy
- Trial name
- LSFG Repro (NCT04014933)
- Testing
- LASER SPECKLE FLOWGRAPHY
- Where
- Switzerland
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Corneal Ectasia, Corneal Disease
Computer-aided Diagnosis of Ocular Diseases Based on Corneal Biomechanics
The purpose of this study is the investigation of biomechanical properties of the cornea using computer-aided data analysis. Currently, it is known that keratoconus and glaucoma are ocular disease that are associated with…
- Conditions
- Corneal Ectasia, Corneal Disease, Corneal Astigmatism, Keratoconus
- Trial name
- EyeTwin (NCT04475900)
- Testing
- Corneal biomechanics (Corvis ST, Oculus, Wetzlar, Germany), Corneal topography and tomography (Pentacam, Oculus, Wetzlar, Germany), Optic nerve head measurement
- Where
- Germany
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Normal Tension Glaucoma
Magnetic Resonance Imaging of Patients With Normal Tension Glaucoma
The purpose of this study is to study the occurrence rate of masses such as brain tumors in patients with newly diagnosed Normal Tension Glaucoma.
- Trial name
- NCT00175786
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Glaucoma, Primary Open Angle
LSFG in Patients With Normal Tension Glaucoma Tension Glaucoma
Glaucoma is the second leading cause of blindness worldwide. Literature shows increasing evidence that dysfunction of ocular microcirculation in the optic nerve influences the progression of glaucoma.
- Trial name
- NCT03318510
- Testing
- Laser Speckle Flowgraphy
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Augenabteilung Allgemeines Krankenhaus Linz
Low Tension Glaucoma
Evaluation of Blood Flow Regulation With Laser Speckle Flowgraphy
The study includes Caucasian patients with diagnosis of normal tension glaucoma and age- and sex-matched healthy individuals. Measurements of optic nerve head blood flow will be performed with laser speckle flowgraphy (LSFG).
- Trial name
- NCT03391518
- Testing
- Water drinking test
- Where
- Austria
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Augenabteilung Allgemeines Krankenhaus Linz
Glaucoma; Drugs, Normal Tension Glaucoma
Peripapillary Blood Flow After Use of Anti-glaucoma Medications: An OCT Angiography Study
This study evaluates the possible acute changes in peripapillary blood flow after instillation of antiglaucoma medications in patients with primary open angle glaucoma (POAG), normal tension glaucoma (NTG), or ocular hypertension…
- Conditions
- Glaucoma; Drugs, Normal Tension Glaucoma, Primary Open-angle Glaucoma
- Trial name
- NCT03323164
- Testing
- Timolol Maleate, Brimonidine Tartrate
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Wills Eye
Glaucoma
COSOPT (Timolol/Dorzolamide Combination) Normal Tension Glaucoma Study (MK0507A-161)(COMPLETED)
A study to evaluate the effect of the 12-week treatment with timolol/dorzolamide combination eyedrops (COSOPT) on decrease in intraocular pressure (IOP) at 2 hours after the study drug administration
- Trial name
- NCT00832377
- Testing
- timolol/dorzolamide combination
- Volunteers
- 37 people
- Sponsor
- Merck Sharp & Dohme LLC
Glaucoma, Primary Open Angle Glaucoma
Transcorneal Electrical Stimulation for the Treatment of Visual Field Defects in Patients With Open-Angle Glaucoma
Glaucoma is a progressive optic neuropathy with retinal ganglion cell loss which leads to visual field loss. Open-angle glaucoma is the most common form of glaucoma.
- Conditions
- Glaucoma, Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma, Pigment Dispersion Glaucoma
- Trial name
- TES-GPS (NCT06682962)
- Testing
- Transcorneal electrical stimulation (TES) with the OkuStim 2 System
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Okuvision GmbH
Normal Tension Glaucoma, High Tension Glaucoma
Differences in Nerve Fiber Layer Between Patients With Normal- and High-Pressure-Glaucoma
The purpose of the study is to prove if there is any difference in the nerve fiber layer between patients with normal- and high-tension-glaucoma with similar structural optic nerve head parameters.
- Trial name
- NCT01488032
- Volunteers
- 44 people
- Sponsor
- Technische Universität Dresden
Glaucoma, GLAUCOMA 1, OPEN ANGLE, D (Disorder)
24-hour Wear Performance and Safety Study of Smartlens miLens Contact Lens for IOP Monitoring
The goal of this clinical trial is to learn if a new contact lens device can record patterns in eye pressure for 24 hours in adults with glaucoma and in healthy participants.
- Conditions
- Glaucoma, GLAUCOMA 1, OPEN ANGLE, D (Disorder), Ocular Hypertension, Ocular Hypertension (OH)
- Trial name
- NCT06689696
- Testing
- miLens system
- Where
- 3 sites in United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Smartlens, Inc.
Normal Tension Glaucoma
A New View of Normal Tension Glaucoma: Autoregulation and Systemic Blood Pressure
The objective of this study is to determine whether systemic blood pressure in the body is related to the development and progression of normal tension glaucoma in the eye.
- Trial name
- NCT00706056
- Where
- 2 sites in United States
- Volunteers
- 85 people
- Sponsor
- Weill Medical College of Cornell University
Normal Tension Glaucoma
R&D of Non-invasive Innovative Intracranial Waves Monitoring System for Diagnostics and Treatment Monitoring of Patients with Normal Tension Glaucoma
Assessment and monitoring of intracranial pressure (ICP) changes are important in the management of cerebral pathologies. In the eye, ICP increase and decrease both correlate with optic neuropathies, the former because of…
- Trial name
- NCT06443411
- Testing
- Monitoring of cerebral hemodynamics
- Where
- Lithuania
- Volunteers
- 156 people
- Sponsor
- Lithuanian University of Health Sciences
Primary Open Angle Glaucoma, Normal Tension Glaucoma
Correlation of Orbital Cerebrospinal Fluid Pressure and Retinal Venous Outflow in Primary Open-angle Glaucoma
A spontaneous venous pulsation over the optic disc is an ophthalmological sign that can potentially be found in up to 98% of healthy individuals.
- Trial name
- NCT01795014
- Where
- Belgium
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Glaucoma, Ocular Hypertension
EVALUATION of CATS TONOMETER PRISM in LASIK SUBJECTS
The CATS Tonometer prism clinical study is intended to determine repeatability of intraocular pressure measurement in human corneas which have undergone a LASIK procedure when compared to a standard Goldmann prism, validating the…
- Conditions
- Glaucoma, Ocular Hypertension, Normal Tension Glaucoma
- Trial name
- NCT06266351
- Testing
- This is observational IOP measurement
- Where
- 2 sites in United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Intuor Technologies, Inc.
Glaucoma, Glaucoma, Open Angle
Relationship Between Central Corneal Thickness and Intraocular Pressure Measures Instruments.
The purpose of this study is to evaluate the relationship between intraocular pressure and central corneal thickness using various instruments in ocular hypertension, normal-tension glaucoma, primary open angle glaucoma…
- Conditions
- Glaucoma, Glaucoma, Open Angle, Ocular Hypertension, Keratoconus
- Trial name
- NCT00347191
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Aston University
Macular Retinoschisis, Macular Detachment
Macular Retinoschisis and Detachment Associated With Glaucomatous Optic Neuropathy
Clinical features, optical coherence tomography findings and surgical outcome in eyes with macular retinoschisis and detachment with normal tension glaucoma but without optic disc pit or high myopia were evaluated.
- Conditions
- Macular Retinoschisis, Macular Detachment, Normal Tension Glaucoma
- Trial name
- NCT01862627
- Testing
- Optical coherence tomography
- Where
- Japan
- Volunteers
- 11 people
- Sponsor
- Kyorin University
Glaucoma, Open Angle
Study of Medical Treatment of Low-Pressure (Normal Tension) Glaucoma
Low-pressure (normal tension) glaucoma is a type of open-angle glaucoma resulting in damage to the optic nerve and abnormalities of the visual field.
- Trial name
- NCT00317577
- Testing
- brimonidine, timolol
- Where
- 12 sites in United States
- Volunteers
- 160 people
- Sponsor
- Chicago Center for Vision Research
Glaucoma
Alcon® Ex-PRESS® Glaucoma Filtration Device in Japanese Patients
The purpose of this study is to assess the efficacy and safety of the Alcon Ex-PRESS® Glaucoma Filtration Device (Ex-PRESS) in Japanese subjects with normal tension glaucoma.
- Trial name
- NCT02246777
- Testing
- Ex-PRESS® Glaucoma Filtration Device, Model P50PL
- Where
- Japan
- Volunteers
- 32 people
- Sponsor
- Alcon Research