Clinical trials: Glaucoma, Narrow Angle
Glaucoma, Angle-Closure, Astigmatism
Prevalence of Corneal Astigmatism Before Glaucoma Surgery in Chinese Patients With Primary Angle-closure Glaucoma
Clear-lens extraction has been considered as first-line therapy for primary angle closure glaucoma(PACG) and application of toric intraocular lens (IOLs) leads to better postoperative visual acuity, yet little is known about the…
- Trial name
- NCT03159780
- Where
- China
- Volunteers
- 808 people
- Sponsor
- Mingkai Lin
Glaucoma, Closed-Angle
Cataract Surgery Combined With Endoscopic Goniosynechialysis for Advanced Primary Angle Closure Glaucoma
In this prospective study, consecutive patients with advanced PACG and cataract who underwent Phaco-IOL-EGSL were invited to participate.
- Trial name
- NCT03686072
- Testing
- Cataract surgery with endoscopic goniosynechialysis
- Volunteers
- 19 people
- Sponsor
- Wenzhou Medical University
Glaucoma; Drugs
Efficacy of Tafluprost as an Adjunct to Medical Therapy for Residual Glaucoma After Trabeculectomy
A 6-month, parallel-group study of the safety and efficacy of tafluprostin for Chinese patients with posttrabeculectomy residual primary angle-closure glaucoma or posttrabeculectomy residual primary open angle glaucoma.
- Trial name
- NCT03595865
- Testing
- tafluprostin
- Volunteers
- 60 people
- Sponsor
- wangdabo
Glaucoma, Angle-Closure
Clinical Efficacy and Safety of Minimally Invasive Glaucoma Surgery on Primary Angle Closure Glaucoma
To evaluate the clinical efficacy (intraocular pressure reduction , success rate, the number of antiglaucoma medication) and safety of ab interno trabeculectomy (AIT) with Trabectome in Chinese PACG .
- Trial name
- NCT02964676
- Testing
- ab interno trabeculectomy with Trabectome, trabeculectomy
- Volunteers
- 246 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Glaucoma, Angle-Closure
Laser Peripheral Iridotomy Plus Laser Peripheral Iridoplasty for Primary Angle Closure
This is a 10-centre randomized controlled clinical trial to explore whether laser peripheral iridoplasty (LPIP) plus laser peripheral iridotomy (LPI) is more effective than single LPI to control the progression of primary angle…
- Trial name
- NCT02613013
- Testing
- neodymium:yttrium-aluminum- garnet laser, frequency-doubled Q-switched neodymium:yttrium-aluminum-garnet 532-nm laser, Pilocarpine
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Sun Yat-sen University
Cataract, Primary Angle-Closure Glaucoma
Anterior Segment Anatomy Assessed by Swept-Source OCT in Ocular Surgery Patients
This observational study aims to evaluate ocular anatomical parameters in patients undergoing anterior segment surgery using swept-source optical coherence tomography (SS-OCT).
- Trial name
- SS-OCT (NCT07903454)
- Testing
- Ocular anatomical parameters will be measured using a swept-source optical coherence tomography (SS-OCT) device (CASIA2; Tomey Corporation, Nagoya, Japan). The imaging examination will be used to asse
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Primary Open Angle Glaucoma (POAG), Juvenile Open Angle Glaucoma
Testing a Reading Module to Improve Reading Skills and Quality of Life in Glaucoma Patients
The goal of this interventional study is to test the effectiveness of reading rehabilitation module towards reading speed and error, and quality of life in glaucoma patients.The main questions it aims to answer are: 1.
- Conditions
- Primary Open Angle Glaucoma (POAG), Juvenile Open Angle Glaucoma, Normotensive Glaucoma, Primary Angle Closure Glaucoma
- Trial name
- NCT07741812
- Testing
- Reading Rehabilitation Module
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- Universiti Sains Malaysia
Primary Open Angle Glaucoma, Primary Angle Closure Glaucoma
Malay Glaucoma Eye Study II Navigation, Mobility and Reading Ability in Primary Glaucoma
With the improvement of health system, the life span of Asians has increased tremendously especially in Malaysia. As an early preparation to be an 'aging country' in 2023, Malaysia needs to prepare infrastructure and policy to…
- Trial name
- MaGESII (NCT04736264)
- Testing
- Visual rehabilitation module: navigation and mobility, Visual rehabilitation module: exercise, Visual rehabilitation module: reading
- Where
- Malaysia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Primary Angle-Closure Glaucoma
Predicting the Risk of Partial Ciliary Block After Cataract and Goniosynechialysis Surgery in Primary Angle-Closure Disease
Primary angle-closure disease (PACD) is a major cause of vision loss, often treated with a combined surgery that removes the eye's natural lens (cataract surgery) and physically opens the eye's drainage system…
- Trial name
- PCB-Risk (NCT07549438)
- Volunteers
- 1,150 people
- Sponsor
- Peking University People's Hospital
Glaucoma, Angle-Closure
Phacotrabeculectomy Versus Phacogoniotomy (PVP) in Advanced Primary Angle-closure Glaucoma
A multicenter, parallel, open, non-inferior randomized controlled trial was conducted to compare the effectiveness and safety of phacotrabeculectomy and phacogoniotomy in the treatment of advanced primary angle closure glaucoma…
- Trial name
- PVP (NCT04878458)
- Testing
- phacoemulsification with intraocular lens implantation combined with goniosynechialysis and goniotomy, phacoemulsification with intraocular lens implantation combined with trabeculectomy
- Where
- 2 sites in China
- Volunteers
- 124 people
- Sponsor
- Sun Yat-sen University
Intraocular Pressure
Azopt (Brinzolamide 1.0%) Plus Travatan (Travoprost 0.004%) in Treating Patients With Chronic Angle-Closure Glaucoma (CACG)
To evaluate the IOP (Intraocular Pressure) lowering efficacy and safety of Brinzolamide 1.0% (Azopt), dosed twice daily as adjunctive therapy in patients treated with Travoprost 0.004% (Travatan) once daily.
- Trial name
- NCT00758342
- Testing
- Travoprost 0.004% + Brinzolamide 1.0%, Travoprost 0.004% + Tears Natural
- Volunteers
- 37 people
- Sponsor
- Alcon Research
Primary Angle-Closure Glaucoma
The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis
Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can…
- Trial name
- NCT07539675
- Testing
- No Additional Experimental Intervention
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Zhongnan Hospital
Glaucoma, Acute Primary Angle-closure Glaucoma
Comparison of Anterior Chamber Paracentesis and Conventional Mannitol Infusion in Patients With Primary Acute Angle-closure Glaucoma
The investigators wanted to reported the results of immediate anterior chamber paracentesis (ACP), compared to Mannitol infusion, in patients with acute primary angle-closure glaucoma (PACG).
- Trial name
- NCT01266343
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Medical University WanFang Hospital
Glaucoma, Angle-Closure
Lens Extraction Combined With Goniosynechialysis Versus Trabeculectomy
To compare the effectiveness of lens extraction combined with goniosynechialysis and trabeculectomy in treating advanced angle-closure glaucoma.
- Trial name
- NCT04703712
- Testing
- Lens extraction combined with goniosynechialysis, Trabeculectomy surgery
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Primary Angle-closure Glaucoma
Kahook Dual Blade Goniotomy in Chronic Primary Angle-Closure Glaucoma
This prospective randomized controlled trial, conducted by the Ophthalmology Department of Peking University People's Hospital, aims to compare the intraocular pressure (IOP)-lowering efficacy and safety of two surgical…
- Trial name
- NCT07517302
- Testing
- Kahook Dual Blade (KDB) goniotomy, phacoemulsification with intraocular lens implantation combined with goniosynechialysis
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Peking University People's Hospital
Primary Angle Closure Glaucoma
Correlation Between Angle Closure Glaucoma Data and Lens Zonule Status
The goal of this observational study is to discuss the correlation between primary angle-closure glaucoma and the state of the suspended ligament of the lens and the pathogenesis of PACG by measuring the biological data of…
- Trial name
- NCT06184620
- Where
- China
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- Guangfu Dang
Optic Neuropathy, NAION - Non-Arteritic Ischemic Optic Neuropathy
Clinical Study of FB1001 in Patients
This study is designed for single-center, open-label, dose escalation phase I trial to evaluate the safety and tolerability of a single/multiple intravitreal injection of FB1001 in patients with APACG(Acute Primary Angle-Closure…
- Conditions
- Optic Neuropathy, NAION - Non-Arteritic Ischemic Optic Neuropathy, APAC - Acute Primary Angle Closure, Glaucoma, Angle-Closure
- Trial name
- NCT06506305
- Testing
- FB1001
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Glaucoma, Glaucoma, Open-Angle
Longitudinal Study on Glaucoma Surgery Using XEN® Gel Stent
To evaluate the safety and efficacy of the XEN® Gel Stent in mild to moderate glaucoma patients undergoing glaucoma surgery.
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma, Angle-Closure, Glaucoma, Primary Open Angle
- Trial name
- NCT03151577
- Testing
- XEN® Gel Stent implantation
- Volunteers
- 150 people
- Sponsor
- Swiss Vision Network
Primary Angle-Closure Glaucoma
Liwan Eye Study: the Fourth Follow-up
Primary angle-closure glaucoma (PACG) is one of the major causes of blindness affecting more than 20 million patients worldwide.
- Trial name
- NCT06333470
- Testing
- Primary angle closure diseases
- Volunteers
- 600 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Congenital Cataract, Aphakic Glaucoma
Prophylactic Peripheral Iridectomy Prevents Aphakic Angle-closure Glaucoma
This is a retrospective, nonrandomized comparative trial with historical control to investigate the safety and efficacy of a novel progressive grasping peripheral iridectomy (PGPI) surgical method in preventing aphakic…
- Trial name
- NCT03610295
- Testing
- PPI group, cataract extraction
- Where
- 2 sites in China
- Volunteers
- 87 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University