Clinical trials: Glaucoma, Open-Angle
Open Angle Glaucoma
Comparison of Efficacy Between Silicone Ahmed Glaucoma Valves and Second Trabeculectomy in Glaucoma Patients
In the management of open angle glaucoma, frequently more then one procedure is necessary to control the intra ocular pressure. There is still no consensus whether this second intervention should be a second trabeculectomy or a…
- Trial name
- NCT00665756
- Testing
- second Trabeculectomy, Ahmed Implant
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Open-Angle Glaucoma, Ocular Hypertension
A Phase II Study of AL-37807 to Treat Open-Angle Glaucoma or Ocular Hypertension
The purpose of this study is to determine whether AL-37807 is safe and effective in treating patients with open-angle glaucoma or ocular hypertension
- Trial name
- NCT00372931
- Testing
- AL-37807
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Alcon Research
Ocular Hypertension, Glaucoma, Open-Angle
Efficacy And Safety Of Xalatan Compared To Usual Care In Patients With Open Angle Glaucoma Or Ocular Hypertension.
The primary purpose is to compare the intraocular pressure reducing effect of Xalatan with that of usual care over 36 months. Safety and health care utilization will be evaluated.
- Trial name
- NCT00140062
- Testing
- latanoprost 0.005% (Xalatan)
- Where
- 27 sites in Finland, Sweden
- Volunteers
- 329 people
- Sponsor
- Pfizer
Glaucoma, Glaucoma, Open-Angle
Pigment Dispersion Syndrome With and Without Glaucoma
To compare patients having PDS without and with OH or GL by documenting and following the clinical features and course of their disease and evaluating the patient's performance on a variety of diagnostic tests.
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Ocular Hypertension
- Trial name
- NCT00001152
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- National Eye Institute (NEI)
Aniridia, Eye Abnormality
Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens
This study will investigate congenital or developmental eye abnormalities that affect the iris, cornea and lens, and are usually accompanied by elevated pressure within the eye.
- Conditions
- Aniridia, Eye Abnormality, Ocular Hypertension, Open Angle Glaucoma
- Trial name
- NCT00001161
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Eye Institute (NEI)
Open-Angle Glaucoma
Influence of Prostaglandins on Ocular Blood Flow in Glaucoma Patients
Vasoactivity of topical drugs may be of prognostic relevance in glaucoma. There is very little information for a major class, the prostaglandin analogues with regard to this aspect.
- Trial name
- NCT00308945
- Testing
- travoprost 0.004% (drug), latanoprost 0.005% (drug)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Basel, Switzerland
Glaucoma, Ocular Hypertension
Tolerability, Safety and Efficacy of RKI983 Eye Drops in Subjects With Primary Open Angle Glaucoma and Ocular Hypertension
This study will evaluate the tolerability and safety of RKI983 ophthalmic solution and explore the effect of the compound on intraocular pressure in subjects with ocular hypertension.
- Trial name
- NCT00515424
- Testing
- RKI983
- Where
- 5 sites in United States
- Volunteers
- 90 people
- Sponsor
- Novartis
Open-Angle Glaucoma, Ocular Hypertension
Latanoprost Versus Fotil
To compare the intraocular pressure effect and safety of latanoprost 0.005% given every evening versus PTFC given twice daily.
- Trial name
- NCT00304785
- Testing
- latanoprost 0.005%, Fotil
- Where
- 5 sites in Poland
- Volunteers
- 36 people
- Sponsor
- Pharmaceutical Research Network
Open-Angle Glaucoma
Diurnal Intraocular Pressure and Peripapillary Retinal Blood Flow in Medically Controlled Open-Angle Glaucoma
Diurnal fluctuations of intraocular pressure (IOP) and peripapillary retinal blood flow may have distinctive patterns in medically well-controlled open-angle glaucoma patients.
- Trial name
- IOPMG (NCT00481208)
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Yonsei University
Primary Open Angle Glaucoma, Ocular Hypertension
Effect of Epigallocatechin-Gallate on Inner Retinal Function in Ocular Hypertension and Early Glaucoma
The present study attempts to evaluate the potential beneficial effects of a flavonoid, the epigallocatechingallate, on retinal ganglion cell function, evaluated by pattern electroretinogram, in subjects with ocular hypertension…
- Trial name
- NCT00476138
- Testing
- Epigallocatechin-gallate
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Catholic University of the Sacred Heart
Glaucoma, Open-Angle
Titanium-Sapphire Laser Trabeculoplasty in Glaucoma: A Randomized Study Comparing Titanium-Sapphire With Argon Laser Trabeculoplasty in Open-Angle Glaucoma Patients
Titanium Sapphire laser trabeculoplasty is effective in lowering intraocular pressure in glaucoma patients, and is comparable to argon laser trabeculoplasty
- Trial name
- NCT00470964
- Testing
- Titanium Sapphire laser trabeculoplasty
- Where
- Israel
- Sponsor
- Goldschleger Eye Institute
Open Angle Glaucoma
Comparison of Efficacy of Two Groups of Glaucoma Drops (Xalatan vs.Cosopt) in Reducing Eye Pressure Following Laser (SLT)Treatment in the Management of Glaucoma.
WHAT IS THIS STUDY ABOUT? Glaucoma and ocular hypertension are chronic eye diseases that can damage the optic nerve and lead to vision loss or blindness. The optic nerve acts like an electric cable with over a million wires.
- Trial name
- NCT00440336
- Testing
- Cosopt, Xalatan
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Advanced Glaucoma Specialists
Open-Angle Glaucoma, Ocular Hypertension
Cosopt Versus Xalatan
To compare the 24-hour efficacy and safety, measured every three hours, of the dorzolamide/timolol fixed combination given twice daily versus latanoprost and placebo each given once daily.
- Trial name
- NCT00273429
- Testing
- timolol maleate 0.5%, dorzolamide/timolol maleate fixed combination, latanoprost 0.005%
- Where
- 2 sites in United States
- Sponsor
- Pharmaceutical Research Network
Primary Open Angle Glaucoma, Ocular Hypertension
The Efficacy of Selective Laser Trabeculoplasty
Selective laser trabeculoplasty (SLT) is a new method to reduce intraocular pressure in eyes with open angle glaucoma or ocular hypertension. SLT may also be effective for cases with previously failed ALT procedures.
- Conditions
- Primary Open Angle Glaucoma, Ocular Hypertension, Pseudo-Exfoliative Glaucoma, Pigment Dispersion Glaucoma
- Trial name
- NCT00347893
- Testing
- Selective laser trabeculoplasty
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Glaucoma Research & Education Group
Open-Angle Glaucoma
Glaucoma Laser Trial (GLT) Glaucoma Laser Trial Followup Study (GLTFS)
To compare the safety and long-term efficacy of argon laser treatment of the trabecular meshwork with standard medical treatment for primary open-angle glaucoma.
- Trial name
- NCT00000144
- Testing
- Argon Laser Treatment
- Sponsor
- National Eye Institute (NEI)
Primary Open Angle Glaucoma
Results of Ocular Compression and Suture Release in Trabeculectomy and Combined Surgery
The use of ocular compression and suture release have helped to improve the safety and decrease the risks of glaucoma filtering surgery.
- Trial name
- NCT00327405
- Where
- United States
- Sponsor
- University of Cincinnati
Glaucoma, Open Angle
Study of Medical Treatment of Low-Pressure (Normal Tension) Glaucoma
Low-pressure (normal tension) glaucoma is a type of open-angle glaucoma resulting in damage to the optic nerve and abnormalities of the visual field.
- Trial name
- NCT00317577
- Testing
- brimonidine, timolol
- Where
- 12 sites in United States
- Volunteers
- 160 people
- Sponsor
- Chicago Center for Vision Research
Open Angle Glaucoma, Ocular Hypertension
Additivity Study: Additive Effect on Eye Pressure of Azopt and Alphagan P to Travatan
The purpose of this study is to compare the additive effect on eye pressure of Azopt and Alphagan P to Travatan.
- Conditions
- Open Angle Glaucoma, Ocular Hypertension, Pseudoexfoliation Syndrome
- Trial name
- NCT00121147
- Testing
- Travatan, Azopt, Alphagan P
- Where
- 21 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hermann Eye Center
Open-Angle Glaucoma
Early Manifest Glaucoma Trial (EMGT)
The primary purpose is to compare the effect of immediate therapy to lower the intraocular pressure (IOP) versus late or no treatment on the progression of newly detected open-angle glaucoma, as measured by increasing visual…
- Trial name
- NCT00000132
- Testing
- Betaxolol, Argon Laser Trabeculoplasty
- Where
- 2 sites in Sweden
- Sponsor
- National Eye Institute (NEI)
Open-Angle Glaucoma
Collaborative Initial Glaucoma Treatment Study (CIGTS)
To compare the long-term effect of treating newly diagnosed open-angle glaucoma with standard medical treatment versus filtration surgery.
- Trial name
- NCT00000149
- Testing
- Beta Blocker, Trabeculectomy, Argon Laser Trabeculoplasty
- Sponsor
- National Eye Institute (NEI)