Clinical trials: Glaucoma, open to volunteers
Glaucoma
Efficacy and Safety of a Releasable Intraluminal Suture Technique to Reduce Hypotony Following Glaucoma Surgery Using the Preserflo Device
Glaucoma is a common and irreversible disease of the optic nerve. It is the second leading cause of blindness worldwide. Glaucoma can be treated with medication, laser therapy, or surgery; the latter is often necessary.
- Trial name
- PFLO (NCT07531199)
- Testing
- Classical surgery, Intraluminal suture
- Where
- France
- Volunteers
- 192 people
- Sponsor
- Hôpital Privé de la Baie
Glaucoma
Clinical Evaluation of Visual Field Change in Glaucoma: an Assessment of Different Models of Progression
The purpose of this observational study is to collect over time a series of data in patients with glaucoma in order to evaluate different approaches in defining the progression of this pathology.
- Trial name
- NCT05801471
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Centervue SpA
Refractory Glaucoma
PAUL® Glaucoma Implant Safety and Effectiveness Study
This prospective, multicenter clinical study is designed to evaluate the safety and effectiveness of the PAUL® Glaucoma Implant in adult patients with refractory glaucoma.
- Trial name
- NCT07907055
- Testing
- PAUL® Glaucoma Implant
- Volunteers
- 65 people
- Sponsor
- Clinical Research Consultants, Inc.
Glaucoma, Intraocular Pressure
Impact of Home Intraocular Pressure Telemonitoring on Intraocular Pressure Control and Glaucoma Progression
The goal of this clinical trial is to conduct a study randomizing glaucoma patients to home intra-ocular pressure (IOP) telemonitoring combined with Smart phone-based intervention (Management Paradigm I) or Smart phone-based…
- Conditions
- Glaucoma, Intraocular Pressure, Primary Open Angle Glaucoma
- Trial name
- NCT05940623
- Testing
- Home IOP telemonitoring with smart phone-based intervention, Standard care and smart phone-based intervention
- Where
- Hong Kong
- Volunteers
- 142 people
- Sponsor
- The University of Hong Kong
Primary Congenital Glaucoma, Goniotomy
Goniotomy in Primary Congenital Glaucoma
Brief Summary This is a multicenter cohort study designed to evaluate and compare the efficacy and safety of different surgical extents of goniotomy (GT) - specifically 120°, 240°, and 360° - in the treatment of Primary…
- Trial name
- NCT07550868
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sun Yat-sen University
Glaucoma, Glaucoma, Open-Angle
A Trial of Hydrus Microstent Versus Goniotomy
The goal of this clinical trial is to evaluate the comparative efficacy and safety of Hydrus Microstent, incisional goniotomy, and excisional goniotomy when combined with cataract surgery in patients with mild and moderate…
- Trial name
- NCT06289491
- Testing
- Hydrus Microstent, Incisional goniotomy, Excisional goniotomy
- Where
- United States
- Volunteers
- 243 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Glaucoma, Biofeedback Training
Efficacy of Biofeedback Training for Glaucoma
This randomized controlled clinical trial evaluates the efficacy of visual biofeedback training on visual function and quality of life in individuals with glaucoma.
- Trial name
- NCT07409077
- Testing
- Biofeedback Training
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto
Glaucoma Medication Adherence, Glaucoma Patients
Eye Patient Adherence and Compliance Study
This study looks at ways to help people with glaucoma take their eye drops regularly and attend their clinic appointments. Each participant will be asked about the main challenges they face, such as forgetfulness, difficulty…
- Trial name
- EYE-PACIP (NCT07793474)
- Testing
- Eye Droppers, Eye Educate, Eye Coordinate
- Where
- Canada
- Volunteers
- 189 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Pseudoexfoliation Glaucoma
The Safety and Efficacy of Direct SLT in Pseudoexfoliation Glaucoma
Prospective, multi-center, single arm, interventional study evaluating DSLT in patients with pseudoexfoliative glaucoma.
- Trial name
- NCT07401290
- Testing
- Direct selective laser trabeculoplasty
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Vance Thompson Vision
Exfoliation Glaucoma, Cataract
Comparison Of iStent to Laser in Exfoliation Glaucoma Helsinki Study Group
The purpose of the study is to investigate the efficacy of an iStent trabecular microbypass stent compared to selective laser trabeculoplasty in combination with cataract surgery in eyes with exfoliation glaucoma (EXF)
- Trial name
- COILEH (NCT04635020)
- Testing
- iStent, SLT-laser, Cataract surgery
- Where
- Finland
- Volunteers
- 285 people
- Sponsor
- Helsinki University Central Hospital
Glaucoma, Open-Angle, Normal Tension Glaucoma
Investigation of Neurovascular Coupling in Glaucoma Patients and Healthy Subjects
Glaucoma is characterized by a progressive loss of retinal ganglion cells (RGCs) leading to optic nerve head (ONH) damage and associated visual field defects.
- Conditions
- Glaucoma, Open-Angle, Normal Tension Glaucoma, Ocular Hypertension
- Trial name
- NCT03870230
- Testing
- Fourier Domain Doppler Optical Coherence Tomography (FDOCT), Dynamic Vessel Analyzer (DVA), Pattern Electroretinography (pERG)
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Glaucoma
INTEGRAL Study: A Longitudinal Study of Surgeries and Lasers in Glaucoma
The aim of this study is to create a large-scale register of all glaucoma patients diagnosed, followed and treated in a large tertiary centre specialising in glaucoma, in order to analyse whether specific factors influence the…
- Trial name
- NCT06227299
- Where
- Switzerland
- Volunteers
- 5,000 people
- Sponsor
- Swiss Glaucoma Research Foundation
Glaucoma
Modified Trabeculectomy After Failure of Combined Phaco With GATT
These procedures include deep non-penetrating sclerectomy, viscocanalostomy, and small incision trabeculectomy, avoiding Tenon's capsule.
- Trial name
- NCT07455786
- Testing
- Modified trabeculectomy
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Glaucoma
World Sight Foundation Field Machine (WSFFM) Pilot
The current situation outside of large cities in lower-income countries, as described above, is suboptimal for the diagnosis of glaucoma.
- Trial name
- WSFFM (NCT07674069)
- Testing
- World Sight Foundation Field Machine, Comparator
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Buckinghamshire Healthcare NHS Trust
Glaucoma
Change in IOP Fluctuation After DSLT
This is a prospective, single-center, single-arm, observational study designed to evaluate the change in diurnal intraocular pressure (IOP) fluctuation following Direct Selective Laser Trabeculoplasty (DSLT) in patients with…
- Trial name
- NCT07428668
- Testing
- Voyager DSLT
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ophthalmology Associates, Fort Worth
Cataract, Primary Angle-Closure Glaucoma
Anterior Segment Anatomy Assessed by Swept-Source OCT in Ocular Surgery Patients
This observational study aims to evaluate ocular anatomical parameters in patients undergoing anterior segment surgery using swept-source optical coherence tomography (SS-OCT).
- Trial name
- SS-OCT (NCT07903454)
- Testing
- Ocular anatomical parameters will be measured using a swept-source optical coherence tomography (SS-OCT) device (CASIA2; Tomey Corporation, Nagoya, Japan). The imaging examination will be used to asse
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Primary Open Angle Glaucoma (POAG), Juvenile Open Angle Glaucoma
Testing a Reading Module to Improve Reading Skills and Quality of Life in Glaucoma Patients
The goal of this interventional study is to test the effectiveness of reading rehabilitation module towards reading speed and error, and quality of life in glaucoma patients.The main questions it aims to answer are: 1.
- Conditions
- Primary Open Angle Glaucoma (POAG), Juvenile Open Angle Glaucoma, Normotensive Glaucoma, Primary Angle Closure Glaucoma
- Trial name
- NCT07741812
- Testing
- Reading Rehabilitation Module
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- Universiti Sains Malaysia
Neuro-Ophthalmology, Optic Neuropathies
Optic Nerve Head Evaluation Through Multimodal Blood Flow Analysis: a Prospective Observational, Multi-center Study
OCT-A and eco-colordoppler are technologies which enable optic nerve head (ONH) blood perfusion detection. The aim of the study is to assess ONH vascular and structural components in optic neuropathies with and without ONH edema…
- Conditions
- Neuro-Ophthalmology, Optic Neuropathies, Optic Atrophy, Hereditary, Leber, Optic Neuropathy, Anterior Ischemic
- Trial name
- FlowONH (NCT07075887)
- Volunteers
- 70 people
- Sponsor
- Barboni
Vision Impairment and Blindness, Glaucoma
Developing and Testing a Model to Identify Preventive Vision Loss Among Older Patients in General Practice
In this cohort study, the investigators will test vision screenings in Danish general practice for patients over 70 years of age with minimum one chronic condition.
- Conditions
- Vision Impairment and Blindness, Glaucoma, Age-Related Macular Degeneration, Cataract
- Trial name
- DETECT (NCT07015034)
- Testing
- focus on vision impairment in older patients in general practice
- Where
- 2 sites in Denmark
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Glaucoma Open-Angle Primary, Hypertension
The Acute Effect of Exercise Type And Timing on Ambulatory Blood Pressure and Intra-Ocular Pressure in Individuals With Glaucoma (The ACHIEVE-project).
ACHIEVE aims to determine whether exercise can be a safe and effective non-drug approach to improve blood pressure control in patients with primary open-angle glaucoma (POAG).
- Conditions
- Glaucoma Open-Angle Primary, Hypertension, Elevated Blood Pressure
- Trial name
- ACHIEVE (NCT07413614)
- Testing
- Exercise
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- KU Leuven