Clinical trials: Glaucoma Open-Angle
Ocular Hypertension, Open-Angle Glaucoma
A Three Part Study of MGV354 in Ocular Hypertension or Glaucoma
The purpose of this study is to determine if the clinical profile of topical-ocular MGV354 merits further development for the indication of lowering intraocular pressure (IOP).
- Trial name
- NCT02743780
- Testing
- MGV354 ophthalmic suspension
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Alcon Research
To See the Safety and Efficacy of the Topical Latanoprost Compared With Topical Brimonidine in the Treatment of the Primary Open Angle Glaucoma Patients
The Effectiveness of Topical Latanoprost Compared With Topical Brimonidine in the Treatment of the Primary Open Angle Glaucoma
Outpatient department of cmch, ceitc,cimch POAG patients enrolled for the study.
- Trial name
- NCT04205201
- Testing
- Drugs, Investigational
- Where
- 2 sites in Bangladesh
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chittagong Medical College
Exfoliation Syndrome
Central Corneal Thickness in Glaucoma
The purpose of this study is to compare the central corneal thickness measurement in patients with exfoliation syndrome, exfoliative glaucoma, primary open-angle glaucoma, ocular hypertension and normal controls and to evaluate…
- Trial name
- NCT01023997
- Where
- Greece
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Glaucoma, Primary Open Angle
Glaucoma Assessment Via Reading Ability
To explore a quantitative glaucoma evaluation tool of glaucoma through the dynamic evaluation of reading ability based on logarithmic Chinese reading acuity chart (C-READ), and investigate its feasibility.
- Trial name
- NCT05673954
- Testing
- C-Read test
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University
Open Angle Glaucoma, Cataract
Swedish Microinvasive Glaucoma Surgery Study (SMIGS)
The purpose of the study is to investigate the efficacy of Cataract Surgery as stand-alone compared to Cataract Surgery in combination with Kahook Dual Blade Glide goniotomy (KDB) or iStent Inject W Trabecular Microbypass Stent…
- Conditions
- Open Angle Glaucoma, Cataract, Kahook Dual Blade Glide, Istent Inject W
- Trial name
- SMIGS (NCT05035394)
- Testing
- Cataract surgery, KDB, Istent
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Umeå University
OAG - Open-Angle Glaucoma, OHT - Ocular Hypertension
Effects of Netarsudil and Timolol on Retinal Blood Vessel Density and Visual Acuity
The purpose of this research study is to compare the effect of Netarsudil and Timolol on eye pressure and blood vessels of the back of the eye.
- Trial name
- NCT04064918
- Testing
- Netarsudil 0.02% QD, Timolol maleate 0.5% BID
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Diego
Primary Open Angle Glaucoma, Healthy Subjects
Efficacy of 24-hour Intraocular Pressure Fluctuation Recording With the SENSIMED Triggerfish Contact Lens Sensor
The objectives of this study are to assess the safety and effectiveness of the SENSIMED Triggerfish® (TF) device in continuous recording of relative fluctuation in intraocular pressure (IOP).
- Trial name
- NCT01390779
- Testing
- SENSIMED Triggerfish
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Sensimed AG
Primary Congenital Glaucoma
The Genetic Characteristics in South Korean Patients With Primary Congenital Glaucoma
Primary congenital glaucoma, which presents at birth or in infancy, if left untreated, may threaten vision. The incidence of congenital glaucoma varies among different geographic locations and ethnic groups.
- Trial name
- NCT01020721
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Ocular Hypertension, Primary Open Angle Glaucoma
Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AKB-9778 Ophthalmic Solution
The purpose of this Phase 1b study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of AKB-9778 ophthalmic solution (eye drops) administered for 7 days in adults.
- Trial name
- NCT04284514
- Testing
- AKB-9778 Ophthalmic Solution
- Where
- 2 sites in United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Aerpio Therapeutics
Primary Open Angle Glaucoma
The Antioxidant Effect of Routine Vascular Therapy for Normal Tension Glaucoma Patients
To quantify oxidative stress in circulating leukocytes of normal tension glaucoma patients, prior to and one month after routine vascular therapy.
- Trial name
- NCT00465348
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Open Angle Glaucoma, Ocular Hypertension
PSLT Compared to Prostaglandin Analogue Eye Drops
This study aims to compare the efficacy of PSLT and the topical use of prostaglandin-like hypotensive eye drops in the treatment of ocular hypertensive or glaucomatous patients in decreasing intraocular pressure and measuring…
- Trial name
- NCT05241938
- Testing
- PSLT, Prostaglandin analogue eye drops
- Where
- Brazil
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Glaucoma, Open-Angle, Ocular Hypertension
Intraocular Pressure With Loteprednol and Dexamethasone
The purpose of this study is to compare intraocular pressure (IOP) changes after pterygium surgery among patients using loteprednol and dexamethasone during the postoperative period.
- Trial name
- NCT00781300
- Testing
- Loteprednol Etabonate 0.5%, Dexamethasone 0.1%
- Where
- Brazil
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Open-Angle Glaucoma, Ocular Hypertension
A 12 Week Comparison of DuoTrav and Xalacom in Open-Angle Glaucoma
Hypothesis: H1: Efficacy of Duotrav will be superior to Xalacom at 24 hours post dosing when both medications are given in the morning H2: A significant proportion of patients will prefer dosing of once daily topical fixed…
- Trial name
- DVX (NCT00887029)
- Testing
- DuoTrav (travoprost-timolol ophthalmic drops), Xalacom (latanoprost-timolol ophthalmic drops)
- Where
- 2 sites in Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants Centres, Canada
Glaucoma, GLAUCOMA 1, OPEN ANGLE, D (Disorder)
Optical Coherence Tomography Findings Associated With the Glaucoma-periodontitis Stage
The aim of this observational study is to investigate the relationship between the stage of periodontal disease and retinal layer thicknesses in glaucoma patients using optical coherence tomography (OCT).
- Conditions
- Glaucoma, GLAUCOMA 1, OPEN ANGLE, D (Disorder), Periodontitis
- Trial name
- NCT07853469
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Primary Open Angle Glaucoma (POAG)
Purpose of This Study is to Evaluate the Safety and Efficacy of One, Two, or Three iStents for the Reduction of Intraocular Pressure in Open-angle Glaucoma Subjects
The purpose of this study is to evaluate the safety and efficacy of the iStent medical device that is implanted into the eye and designed to reduce eye pressure in patients with your condition.
- Trial name
- NCT01252849
- Testing
- iStent
- Where
- Armenia
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Glaukos Corporation
Glaucoma, Open-Angle, Healthy
Sensing Contact Lens-based Device for 24-hour Monitoring of Intraocular Pressure
Glaucoma is characterized by irreversible vision loss through the progressive death of optic nerve fibers unless timely diagnosis and adequate treatment are provided.
- Trial name
- NCT03689088
- Testing
- Goldfish, Tonometry
- Where
- Poland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Sensimed AG
Glaucoma
Safety of Topical Insulin Drops for Open-angle Glaucoma
Glaucoma, a leading cause of irreversible blindness worldwide, is characterized by a permanent loss of retinal ganglion cells (RGCs), a group of central nervous system (CNS) neurons that convey visual information from the retina…
- Trial name
- NCT04118920
- Testing
- Topical insulin (4 units), Topical insulin (20 units), Artificial tears
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Primary Open Angle Glaucoma, Normal Tension Glaucoma
Advanced Glycation End Products as a Biomarker for Accelerated Ageing
Globally primary open angle glaucoma (POAG) affects over 60 million people. The exact pathogenesis of POAG is poorly understood. A significant risk factor for glaucoma is advancing age.
- Conditions
- Primary Open Angle Glaucoma, Normal Tension Glaucoma, Ocular Hypertension
- Trial name
- NCT02863224
- Where
- United Kingdom
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma
Anti-inflammatory Therapy Following Selective Laser Trabeculoplasty
The type of anti-inflammatory medication used post selective laser trabeculoplasty (SLT) may have an impact on the intra-ocular pressure (IOP) lowering effect of SLT.
- Trial name
- NCT00485108
- Testing
- prednisolone 1%, ketorolac 0.5%, Artificial Tears (Methyl cellulose drops)
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Queen's University
Glaucoma, Open-Angle
Lamina Cribrosa Depth Change With Change in Eye Pressure
This is a study of the compliance of the lamina cribrosa with change in eye pressure.
- Trial name
- NCT03267849
- Testing
- wearing swimming goggles or having laser suturelysis
- Where
- United States
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University