Clinical trials: Glaucoma Open-Angle, open to volunteers
Glaucoma, Open Angle
SCTSC Versus Trabeculectomy in Medically Uncontrolled Open-Angle Glaucoma in Pseudophakic Patients
cyclodiode versus trabeculectomy with MMC in pseudophakic patients.
- Trial name
- NCT07152132
- Testing
- Trabeculectomy, Slow coagulation trans-scleral cyclophotocoagulation
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Minia University
Primary Open Angle Glaucoma (POAG), Ocular Hypertension (OHT)
REGN22530 for Adults With Primary Open Angle Glaucoma or Ocular Hypertension
This study will test an experimental drug called REGN22530 ("study drug") to see if it can help treat people with primary open angle glaucoma or ocular hypertension.
- Trial name
- BAHAMA (NCT07675824)
- Testing
- REGN22530
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- Regeneron Pharmaceuticals
Glaucoma, Open-Angle
Feasibility Clinical Evaluation of the Calibreye System
To evaluate the safety and feasibility of the Calibreye System in patients with open angle glaucoma.
- Trial name
- NCT05885022
- Testing
- Calibreye System
- Where
- 4 sites in India, Mexico and 1 more
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Myra Vision Inc.
Glaucoma, Ocular Hypertension
Evaluation of the Safety, Efficacy, Dose Response of the Bimatoprost Drug Ring System (BIM-DRS) in Pseudophakic Patients Diagnosed With Open Angle Glaucoma or Ocular Hypertension
The goal of this clinical trial is to learn if two different doses of the SpyGlass Bimatoprost-Drug Ring System (BIM-DRS) work to treat adult pseudophakic patients with either glaucoma or ocular hypertension.
- Trial name
- NCT07641296
- Testing
- BIM-DRS Low Dose, BIM-DRS High Dose, SpyGlass IOL with silicone pads (no drug)
- Volunteers
- 24 people
- Sponsor
- SpyGlass Pharma, Inc.
Primary Open Angle Glaucoma
Multicenter Glaucoma Study Investigating Standalone Canaloplasty
A multicenter, randomized, clinical trial to evaluate the efficacy of canaloplasty performed as a standalone procedure using the iTrack™ Advance canaloplasty device (Nova Eye, Inc.) as compared to the OMNI® Surgical System (Sight…
- Trial name
- MAGIC (NCT05786196)
- Testing
- Ab-interno canaloplasty utilizing the iTrack Advance device, Ab-interno canaloplasty utilizing the OMNI Surgical System
- Where
- 5 sites in Germany, Spain and 1 more
- Volunteers
- 86 people
- Sponsor
- Nova Eye, Inc.
Open Angle Glaucoma, Ocular Hypertension
24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular Hypertension Patients
The purpose of this study is to evaluate the effect on 24-hour IOP reduction of netarsudil-latanoprost fixed combination in one eye compared to latanoprost alone in the contralateral eye, dosed daily, 1 drop at night (QD, PM) in…
- Trial name
- NCT07325240
- Testing
- Netarsudil 0.02%/latanoprost 0.005% fixed dose combination ophthalmic solution, Latanoprost 0.005% Ophthalmic Solution
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Glaucoma Open-Angle Primary, Ocular Hypertension
[KJ-TFC-005] Phase 3 Study, Evaluate the Efficacy and Safety of TFC-003 in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension
[KJ-TFC-005] Phase 3 Study, Evaluate the Efficacy and Safety of TFC-003 in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension
- Trial name
- NCT07662759
- Testing
- TFC-003, TFC-003-R1, TFC-003-R2+TFC-003-R3
- Where
- South Korea
- Volunteers
- 188 people
- Sponsor
- Kukje Pharma
Glaucoma
Phase 2 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant
Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant
- Trial name
- NCT07075718
- Testing
- Gen 2 Travoprost Intracameral Implant, Timolol eye drops 0.5%
- Where
- 3 sites in United States
- Volunteers
- 110 people
- Sponsor
- Glaukos Corporation
GLAUCOMA 1, OPEN ANGLE, D (Disorder)
Preserflo MicroShunt Versus Trabeculectomy
The goal of this randomized controlled clinical trial is to learn whether two minimally invasive bleb-forming glaucoma implants can effectively treat adult patients with open-angle glaucoma who require surgical lowering of…
- Trial name
- PMSvT (NCT07496957)
- Testing
- Preserflo MicroShunt Implantation, Trabeculectomy with MMC
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Bialystok
OAG - Open-Angle Glaucoma
Clinical Trial to Evaluate the Safety and Effectiveness of a Canaloplasty Device in Subjects With Open-Angle Glaucoma
Clinical Trial to Evaluate the Safety and Effectiveness of a Canaloplasty Device in Subjects with Open-Angle Glaucoma
- Trial name
- NCT05696561
- Testing
- Canaloplasty Device
- Where
- 3 sites in Chile, Costa Rica and 1 more
- Volunteers
- 70 people
- Sponsor
- New World Medical, Inc.
Open-angle Glaucoma (OAG)
5-Year Postoperative Outcomes of Patients Who Completed the CREST Study
This study is designed to collect clinical data at 3, 4, and 5 years postoperatively for participants who completed the CREST Study without having secondary IOP-lowering surgery in the study eye(s).
- Trial name
- CREST-XT (NCT07480343)
- Testing
- CycloPen Micro-Interventional Cyclodialysis System, CycloPen Micro-Interventional Cyclodialysis System Post Cataract
- Where
- 10 sites in United States
- Volunteers
- 250 people
- Sponsor
- Iantrek, Inc.
Congenital Glaucoma
Study Aim to Compare the Effect of Different Technique of Airway Managment During Anaesthesia on the Haemodynamics and Intraocular Pressure. Patients Were Divided Into Three Groups of 25 Patients Each. (Group A); Patients Who Were Subjected to LMA Insertion (Group B ).
this study aim to compare the effect of different technique of airway managment during anaesthesia on the haemodynamics and intraocular pressure in pediatric patient undergoing congenital glaucoma surgery.
- Trial name
- Airway and IOP (NCT07504315)
- Testing
- laryngeal mask insertion, I gel mask insertion, Endotracheal tube insertion
- Volunteers
- 75 people
- Sponsor
- Sohag University
Juvenile Open Angle Glaucoma, Dry Eye Disease (DED)
Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye
The goal of this clinical trial is to evaluate the effects of stingless bee honey (Kelulut honey) in juvenile open-angle glaucoma patients.
- Conditions
- Juvenile Open Angle Glaucoma, Dry Eye Disease (DED), Interleukin 6, Retinal Nerve Fiber Layer Thickness
- Trial name
- HONEY-JOAG (NCT07396441)
- Testing
- Stingless bee honey (Kelulut)
- Where
- 4 sites in Malaysia
- Volunteers
- 60 people
- Sponsor
- Universiti Sains Malaysia
Glaucoma, Primary Open Angle Glaucoma (POAG)
Evaluation of BRUDYGLAUCO (DHA + Citicoline) in Patients With Glaucoma
This study aims to evaluate the effects of BrudyGlauco, a nutritional supplement containing DHA (docosahexaenoic acid) and citicoline, on visual function in people with glaucoma.
- Conditions
- Glaucoma, Primary Open Angle Glaucoma (POAG), Neuroprotection
- Trial name
- BRUDYGLAUCO (NCT07322965)
- Testing
- BrudyGlauco
- Where
- 2 sites in Spain
- Volunteers
- 108 people
- Sponsor
- Institut Catala de Retina
Glaucoma Open-Angle Primary, Ocular Hypertension
GLAUcoma Diagnostic and Imaging Analysis (GLAUDIA) Study
This observational study aims to identify early diagnostic markers of glaucomatous damage by combining functional and structural assessments.
- Trial name
- GLAUDIA (NCT07210216)
- Volunteers
- 60 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma
Uddevalla Skövde Transscleral Micropulse Study
Micro pulse transscleral laser treatment (MP-TLT) is a relatively new method to reduce the intraocular pressure (IOP) in glaucoma.
- Trial name
- USTMS (NCT05557721)
- Testing
- Topical lidocaine, MP-TLT
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Primary Open - Angle Glaucoma (POAG), Ocular Hypertension (OHT)
A Phase 2a Study Comparing the Efficacy, Safety and Tolerability of Pregabalin Eye Drops Comparing With Timolol Eye Drops in Adults With Glaucoma or High Eye Pressure.
This study is evaluating a new eye drop containing pregabalin (TB0001) as a potential treatment for people with primary open-angle glaucoma or ocular hypertension.
- Trial name
- NCT07913074
- Testing
- Arm 1: TB0001 ophthalmic solution 0.9%, Arm 2: TB0001 ophthalmic solution 1.2%, TB0001 ophthalmic solution 1.5%
- Where
- 3 sites in United States
- Volunteers
- 96 people
- Sponsor
- Tavo Biotherapeutics
Glaucoma, Primary Open Angle Glaucoma
Transcorneal Electrical Stimulation for the Treatment of Visual Field Defects in Patients With Open-Angle Glaucoma
Glaucoma is a progressive optic neuropathy with retinal ganglion cell loss which leads to visual field loss. Open-angle glaucoma is the most common form of glaucoma.
- Conditions
- Glaucoma, Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma, Pigment Dispersion Glaucoma
- Trial name
- TES-GPS (NCT06682962)
- Testing
- Transcorneal electrical stimulation (TES) with the OkuStim 2 System
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Okuvision GmbH
Glaucoma, Cataract
Evaluation of Microinvasive Glaucoma Surgery: MINIject® Versus Hydrus® Microstent in Combination With Cataract Surgery
The study aims to investigate postoperative outcomes after two different MIGS implants (MINIject or Hydrus) in combination with cataract surgery for patients with glaucoma.
- Trial name
- MINHY (NCT06844292)
- Testing
- MINIject with Cataract Surgery, Hydrus Microstent with Cataract Surgery
- Where
- Austria
- Volunteers
- 152 people
- Sponsor
- Medical University of Graz
Glaucoma
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma
There is increasing evidence that there are genetic risk factors for several forms of glaucoma, such as glaucoma caused by pseudoexfoliation syndrome (PXF) ,primary angle closure glaucoma (PACG) and primary open-angle glaucoma…
- Trial name
- NCT03423758
- Testing
- Blood sample
- Where
- Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna