Clinical trials: Glial Tumors
Brain and Central Nervous System Tumors, Neuroblastoma
Radiolabeled MAB Therapy in Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal Cancer
The purpose of this study is to test the feasibility and toxicity of administering intrathecal immunotherapy for patients with central nervous system/leptomeningeal (CNS/LM) malignancies.
- Conditions
- Brain and Central Nervous System Tumors, Neuroblastoma, Sarcoma
- Trial name
- NCT00089245
- Testing
- Iodine I 131 MOAB 8H9
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- Y-mAbs Therapeutics
WHO Grade 3 Glioma, WHO Grade 4 Glioma
An Investigational Scan (Ga-68 PSMA-11 PET/CT) for Detection of Disease Recurrence or Progression in Patients With Glioma
This clinical trial evaluates whether gallium-68 (Ga-68) prostate specific membrane antigen (PSMA)-11 positron emission tomography (PET)/computed tomography (CT) imaging is useful in differentiating between disease that has come…
- Trial name
- NCT06444412
- Testing
- Computed Tomography, Electronic Health Record Review, Ga 68 PSMA-11
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic
Brain Stem Neoplasms, Primary, Neoplasms, Brain Stem
Thalomid and Carboplatin for the Treatment of Pediatric Brain Stem Glioma
Treatment on this study combines two drugs: Thalomid™ (thalidomide) and carboplatin. Thalidomide has been available for many years and has been used to treat many different illnesses.
- Trial name
- NCT00179881
- Testing
- Carboplatin, Thalomid, External Beam Radiation Therapy
- Where
- 6 sites in United States
- Volunteers
- 47 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Glioblastoma, Brain Cancer
Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma
The purpose of this research is to test the safety and effectiveness of the investigational drug ruxolitinib when it is combined with standard of care treatment (radiation therapy and temozolomide) for the treatment of newly…
- Conditions
- Glioblastoma, Brain Cancer, Glioblastoma Multiforme, Glioblastoma Multiforme of Brain
- Trial name
- NCT06991101
- Testing
- Ruxolitinib, Temozolomide, Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 190 people
- Sponsor
- Baptist Health South Florida
Glioblastoma
Impact of iMRI on the Extent of Resection in Patients With Newly Diagnosed Glioblastomas
Standard treatment of glioblastomas (GBMs) consists of microsurgical resection followed by concomitant chemoradiation. The extent of resection is one of the most important prognostic factors with significant influence on the…
- Trial name
- NCT02379572
- Testing
- iMRI-guided surgery, 5-ALA-guided surgery
- Where
- 15 sites in Germany
- Volunteers
- 315 people
- Sponsor
- University Hospital Tuebingen
Glioblastoma
Pegylated Liposomal Doxorubicine and Prolonged Temozolomide in Addition to Radiotherapy in Newly Diagnosed Glioblastoma
Glioblastomas represent 40% of all tumors of the central nervous system (CNS) and are among the most lethal tumors. Temozolomide (TMZ) combined with radiotherapy was the first substance to significantly improve the overall…
- Trial name
- NCT00944801
- Testing
- Pegylated Liposomal Doxorubicine
- Where
- Germany
- Volunteers
- 63 people
- Sponsor
- University of Regensburg
Glioma
Vascular Signature Mapping of Brain Tumor Genotypes
A glioma is a primary brain tumor in adults that is characterized by a highly variable, but overall poor survival. The optimal timing of treatment is in part determined by the expected biological behavior of the tumor.
- Trial name
- VASIM (NCT05274919)
- Testing
- Philips Achieva 7T MRI, X-ray (optional), Additional contrast injection
- Where
- 2 sites in Netherlands
- Volunteers
- 180 people
- Sponsor
- Leiden University Medical Center
Low-grade Glioma, IDH2 Gene Mutation
Niraparib In Recurrent IDH 1/2 Gliomas
This is a randomized, two-arm, open-label, phase 0 trial to assess intratumoral pharmacokinetics and pharmacodynamics of niraparib in subjects with progressive IDH1 or IDH2 mutant glioma.
- Conditions
- Low-grade Glioma, IDH2 Gene Mutation, Recurrent Glioma, IDH1 Mutation
- Trial name
- NCT05406700
- Testing
- Niraparib, Resection/Treatment with Niraparib
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Massachusetts General Hospital
Spinal Tumor
Clinical Research of H3F3AK27M in Spinal Glioma and Its Impact on TMZ Chemoradiotherapy
H3F3AK27M may be a feature of primary spinal cord glioma and affect the outcome and prognosis of TMZ chemoradiotherapy.
- Trial name
- NCT03668522
- Testing
- Genetic testing
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Southern Medical University, China
Glioma
PERMA-Based Intervention on Negative Emotions, Adherence, and Complications in Postoperative Glioma Patients
The goal of this clinical trial is to evaluate whether a PERMA-based integrated psychological intervention can reduce negative emotions, enhance treatment adherence, and decrease the risk of complications in postoperative glioma…
- Trial name
- Glioma (NCT06713395)
- Testing
- The control group received standard postoperative care, PERMA
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Yang Huang
Glioma of Brain
Noninvasively Predicting Gene Status of Glioma
Malignant gliomas are the most common and deadly primary brain tumors in adults. The clinical outcome of patients with glioblastoma depends on key molecular genetic alteration.
- Trial name
- NPGSOG (NCT03102112)
- Testing
- MRI examination
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Tang-Du Hospital
Glioblastoma, Adult, EGFR Amplification
GC1118 in Recurrent Glioblastoma Patients With High EGFR Amplification
This study is a phase 2 trial of GC1118, an EGFR monoclonal antibody, for recurrent glioblastoma patients who were treated with standard concurrent chemoradiation.
- Trial name
- NCT03618667
- Testing
- GC1118
- Where
- South Korea
- Volunteers
- 13 people
- Sponsor
- Samsung Medical Center
Newly Diagnosed Glioblastoma, Recurrent Glioblastoma
BRiTE - Bispecific T Cell Engager for Patients With Glioblastoma
This Phase 1 study will assess the safety of a novel brain Bispecific T cell engager (BRiTE) in patients with newly diagnosed or recurrent World Health Organization (WHO) Grade 4 glioblastoma (GBM).
- Trial name
- BRiTE (NCT04903795)
- Testing
- hEGFRvIII-CD3 (BRiTE)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mustafa Khasraw, MBChB, MD, FRCP, FRACP
High Grade Gliomas
Short Course of Radiation for Gliomas in Elderly Patients
Patients with high grade brain tumors will be treated to test shortened course of radiation therapy with the use of precise, focused radiation with cyberknife.
- Trial name
- NCT00386919
- Testing
- CyberKnife
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Beth Israel Deaconess Medical Center
Glioblastoma Multiforme, Astrocytoma
A Continuation Protocol for Patients Previously Enrolled in a Study of Toca 511
This is a multicenter, open-label, continuation study to allow subjects who have previously received Toca 511 to continue to receive Toca FC and to allow for extended safety observations.
- Conditions
- Glioblastoma Multiforme, Astrocytoma, Gliomas, Malignant
- Trial name
- NCT04327011
- Testing
- Toca 511 vector, Toca FC • Flucytosine • 5-FC • 5-Fluorocytosine
- Where
- 11 sites in United States
- Volunteers
- 65 people
- Sponsor
- Tocagen Inc.
Giant Cell Glioblastoma, Recurrent Glioblastoma
Vaccine Therapy in Treating Patients With Recurrent Glioblastoma
This pilot early phase I trial studies the side effects of vaccine therapy in treating patients with glioblastoma that has come back.
- Conditions
- Giant Cell Glioblastoma, Recurrent Glioblastoma, Recurrent Gliosarcoma
- Trial name
- NCT03360708
- Testing
- Laboratory Biomarker Analysis, Malignant Glioma Tumor Lysate-Pulsed Autologous Dendritic Cell Vaccine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Glioma
Quality of Life and Neurocognitive Functioning
Studying QoL in patients DLGG receiving TMZ is complex because of the multiples interactions between tumor characteristics, neurocognitive functioning, treatments, environment and psychopathological context in which these…
- Trial name
- TEMOIN (NCT03257618)
- Testing
- Temozolomide, QoL, neurocognitive and psycholpathological assessment
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Solid Tumor, Unspecified, Child, Relapsed Solid Neoplasm
A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling
This is a Phase 1/2, multicenter, open-label trial of avapritinib in participants 2 to < 18 years of age with advanced relapsed/refractory (R/R) solid tumors, including central nervous system (CNS) tumors, that harbor a PDGFRA…
- Conditions
- Solid Tumor, Unspecified, Child, Relapsed Solid Neoplasm, CNS Tumor
- Trial name
- NCT04773782
- Testing
- avapritinib
- Where
- 26 sites in United States, Australia and 7 more
- Volunteers
- 29 people
- Sponsor
- Blueprint Medicines Corporation
Malignant Glioma
D2C7-IT With Atezolizumab for Recurrent Gliomas
This is a phase 1 study of atezolizumab in combination with D2C7-IT, a dual-specific monoclonal antibody (mAB) with a high affinity for both EGFRwt- and EGFRvIII-expressing cells, in patients with recurrent World Health…
- Trial name
- NCT04160494
- Testing
- D2C7-IT (6920 ng/mL via convection-enhanced delivery), Atezolizumab (1200 mg every three weeks), D2C7-IT (4613.2 ng/mL via convection-enhanced delivery)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Darell Bigner
Glioblastoma, Glioblastoma, IDH-wildtype
Biomolecular Analysis for Predicting Response to Regorafenib
The study envisages NGS analysis on tumor tissue from patients treated with regorafenib for recurrent glioblastoma as per standard care, with the aim to identify predictive biomarkers for response.
- Trial name
- RegoRec (NCT05759195)
- Testing
- Biomolecular tumor analysis
- Where
- Italy
- Volunteers
- 53 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
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