Clinical trials: Gliosis
Morbid Obesity
Effects of Morbid Obesity and Bariatric Surgery on Brain Inflammation, and Activation of Central Reward System
Background: The investigators have found that obesity and insulin resistance result in significantly increased brain insulin-stimulated glucose uptake, whereas in every other tissue glucose uptake is lower in the obese compared…
- Trial name
- BARIBRAIN (NCT04343469)
- Testing
- Bariatric Surgery (RYGB or LSG)
- Where
- 2 sites in Finland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Obesity, Gliosis, Weight-Loss
A Cohort Study of Weight Loss and Gliosis
Patients and clinicians need better options to prevent the weight regain that almost universally follows a weight loss intervention. In lay terms, a new, higher "set point" seems to occur after people gain weight.
- Trial name
- NCT03578887
- Testing
- Behavioral Weight Loss Program, Roux-en-Y Gastric Bypass or Sleeve Gastrectomy
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Washington
Epilepsy, Focal Cortical Dysplasia
Use of a Tonometer to Identify Epileptogenic Lesions During Pediatric Epilepsy Surgery
Refractory epilepsy, meaning epilepsy that no longer responds to medication, is a common neurosurgical indication in children. In such cases, surgery is the treatment of choice.
- Conditions
- Epilepsy, Focal Cortical Dysplasia, Tuberous Sclerosis, Hemimegalencephaly
- Trial name
- NCT04344626
- Testing
- Intra-operative brain tonometry
- Where
- 2 sites in United States, Canada
- Sponsor
- University of California, Los Angeles
Epimacular Gliosis, Macular Hole
Observational Study - ILM Peeling
This observational study investigates the effects of epimacular membrane peeling on the structure and function of the retina.
- Trial name
- NCT01083056
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University Hospital Tuebingen
Genetics, Obesity
Inherited and Environmental Risks Acting on Body Weight
The goal of this research is to investigate genetic and environmental factors that contribute to obesity through brain inflammation.
- Trial name
- INTERACT (NCT07430852)
- Testing
- Diet modification
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Washington
Gliosis, Obesity
Does What You Eat Affect Your Brain
The purpose of this study is to use magnetic resonance imaging (MRI) to evaluate the human hypothalamus for signs of inflammation in response to specific diets.
- Conditions
- Gliosis, Obesity, Eating
- Trial name
- WYE (NCT05626907)
- Testing
- Diet modification #1, Diet modification #2, Diet modification #3
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Washington
Spinal Cord Injury (SCI)
Metformin in Preventing Secondary Gliosis Following Acute Thoraco-Lumbar Spinal Cord Injury
Background: Spinal cord injury (SCI) is a major global health problem, with thoraco-lumbar injuries often leading to paraplegia and incomplete neurological recovery.
- Trial name
- NCT07272967
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Badr University
Cerebral Gliosis, Positron Emission Tomography
[18F]BF3-BPA Injection for PET Imaging Study of Gliomas in the Brain
In this clinical study, we proposed to perform [18F]BF3-BPA PET imaging in subjects with gliomas, to observe the binding ability and non-specific binding of the tracer to glioma lesions in vivo, and at the same time to evaluate…
- Trial name
- NCT06148207
- Testing
- [18F]BF3-BPA Injection for PET Imaging
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Gliosis, Child Obesity
Building Research for Intervention Development in Gliosis and Eating Habits
The goal of this study is to 1) use magnetic resonance imaging (MRI) to evaluate the effect of nutritious foods on inflammation in the human hypothalamus of children and 2) assess the feasibility and acceptability of nutritious…
- Conditions
- Gliosis, Child Obesity, Eating
- Trial name
- BRIDGE (NCT06870578)
- Testing
- Diet modification
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Washington
Quality of Life, Phone Use, Cell
Evaluation of the Impact of a Connected Application on the Follow-up of Patients Treated for Glial Lesions Operated
This study is to evaluate the efficacy of a mobile app for monitoring the quality of life of patients but also on detection delay of side effects and/or complications linked to the therapeutic management.
- Conditions
- Quality of Life, Phone Use, Cell, Glial Scar
- Trial name
- TELEGLIO (NCT05067049)
- Testing
- Connected application arm, Unconnected arm
- Where
- France
- Volunteers
- 66 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Glaucoma
Photographic Imaging of the Retina and Optic Nerve Head of Glaucoma Patients and Normal Controls
Retinal structures are difficult to visualize because the retina is optically transparent. In glaucoma, the microglia in the retina becomes activated in eyes with glaucomatous damage.
- Trial name
- NCT00430274
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Selim Orguel
Astrogliosis, Postoperative Cognitive Dysfunction
Association Between Changes of GFAP After Surgery and Postoperative Delayed Cognitive Recovery
Assessment of serum level of glial fibrillary acidic protein (GFAP) before surgery (on the day of surgery), 24 hours after surgery and on 3 or 4 postoperative day.
- Conditions
- Astrogliosis, Postoperative Cognitive Dysfunction, Postoperative Delirium
- Trial name
- NCT03683537
- Testing
- Glial fibrillary acidic protein
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Moscow Clinical Scientific Center
Obesity, Childhood
Impact of Hypothalamic Gliosis on Appetite Regulation and Obesity Risk in Children
BEAM is a multi-site longitudinal cohort study of hypothalamic gliosis, central regulation of appetite and weight gain in children.
- Trial name
- NCT04260048
- Where
- 2 sites in United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Washington