Clinical trials: Global Surgery
Anesthesia Brain Monitoring, Ketamine
Effect of Ketamine on BIS Values
Aim of this trial is to define if Concentration at the effector site (Ce) of Ketamine, calculated with DOMINO model infusion pump are correlated with Bispectral Index BIS values during general anaesthesia for breast surgery.
- Trial name
- NCT05288764
- Testing
- Bispectral Index
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- University of Padova
Hip Fractures, COVID-19
Anesthesia Technique in COVID-19 Positive Hip Fracture Patients
Patients with COVID undergoing hip fracture repair have high mortality rates. If spinal anesthesia is associated with decreased rates of mortality, this study could provide hypothesis generating data for prospective studies.
- Conditions
- Hip Fractures, COVID-19, General Anesthesia, Spinal Anesthesia
- Trial name
- NCT05133648
- Testing
- Hip Fracture Surgery, COVID-19 infection
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Sleep Apnea
A Study of Danavorexton in People With Obstructive Sleep Apnea After General Anesthesia for Abdominal Surgery
The main aim is to see if danavorexton can help improve people's breathing in the recovery room after abdominal surgery.
- Trial name
- NCT05814016
- Testing
- Danavorexton
- Where
- 19 sites in United States
- Volunteers
- 41 people
- Sponsor
- Takeda
Asana Adjustment
Effects of Postural Adjustment on Hemodynamics in Patients Undergoing Prone Spine Surgery Under General Anesthesia
The prone position is a special position often used for spinal surgery. As a special position of general anesthesia, after induction of general anesthesia, severe hemodynamic fluctuations often occur when the supine position is…
- Trial name
- NCT05749978
- Testing
- Asana adjustment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhuan Zhang
Nasal Surgery
Performance of EEG During Emergence Agitation in Nasal Surgery.
The purpose of the study is to evaluate the relationship between perioperative electroencephalogram and emergence agitation in the nasal surgery.
- Trial name
- NCT05654311
- Testing
- Nasal surgery
- Where
- South Korea
- Volunteers
- 55 people
- Sponsor
- Gangnam Severance Hospital
Abdomen, Acute
The Hospital Volume Relationship in Emergency Laparotomy Outcomes
Introduction 'Emergency Laparotomy' is an umbrella term for a set of commonly performed procedures which are known to carry a significant risk of mortality and morbidity.
- Trial name
- NCT02047812
- Where
- United Kingdom
- Volunteers
- 40,000 people
- Sponsor
- University of Edinburgh
Hip Fractures
Combined Plexus Block for Hip Fracture Surgery.
Hip fracture surgery requires high risk anesthetic procedure for elderly patients (1). General anesthesia, continuous spinal anesthesia and peripheral nerve blocks are three anesthetic techniques possible.
- Trial name
- NCT03356704
- Testing
- no intervention
- Volunteers
- 593 people
- Sponsor
- University Hospital, Montpellier
Breast Cancer
Comparison of Paravertebral Block With General Anesthesia in Patients Undergoing Breast Cancer Surgery
The purpose of this project is to determine if there is a difference between paravertebral block and general anesthesia in terms of time to discharge from the Post-Anesthesia Care Unit and pain level in patients undergoing…
- Trial name
- NCT00645138
- Testing
- Paravertebral Block, General Anesthesia
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Weill Medical College of Cornell University
Third Molar Extraction
Analgesic Effect of Peripheral Dexmedetomidine
Dexmedetomidine is an alpha 2-adrenoreceptor agonist, which provides sedation, analgesia and anxiolysis in clinical practice (Cortinez et al., 2004,Hall et al., 2000).
- Trial name
- NCT00971178
- Testing
- local dexmedetomidine, Peripheral normal saline, IV dexmedetomidine
- Volunteers
- 105 people
- Sponsor
- The University of Hong Kong
Adverse Effect of Other General Anesthetics
Folic Acid Intervention During Recovery
Research purposes：Comparison of preoperative folic acid and placebo intervention on postoperative recovery of sputum in children undergoing general anesthesia for head and neck and maxillofacial surgery Test type：Randomized…
- Trial name
- NCT04135885
- Testing
- Folic Acid
- Volunteers
- 300 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Temperament, Trauma (Including Fractures)
How Personality Type Affects Pain and the Need for General Anesthesia in Patients Receiving an Arm Nerve Block for Wrist Fracture Surgery
This study looked at whether a person's emotional personality type affects how they experience pain and how well a regional anesthesia technique works during arm surgery.
- Trial name
- NCT07450768
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Postoperative Pain, Postoperative Sleep Quality
The Effect of Intraoperative Use of Dexmedetomidine During the Daytime Operation vs the Nighttime Operation on Postoperative Sleep Quality and Pain Under General Anesthesia
General anesthesia is a medically induced state of low reactivity consciousness which is similar to natural sleep. Some studies found that general anesthesia as an independent risk factor could result in a desynchronization of…
- Conditions
- Postoperative Pain, Postoperative Sleep Quality, Intraoperative Dexmedetomidine, General Anesthesia
- Trial name
- NCT03990987
- Testing
- time of receiving operation
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Shengjing Hospital
Anesthesia
High Flow Oxygen in Patients Undergoing Surgery Under General Anesthesia
Preoxygenation remains an important determinant of morbidity and mortality in anesthesia despite advances in mask ventilation and difficult intubation management. 1.
- Trial name
- OPTIFLOW (NCT03554863)
- Testing
- Nasal High Flow Oxygen, Facial Mask
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- CMC Ambroise Paré
Septic Shock, Multiple Organ Failure
Severe Sepsis/Septic Shock on Admission to the General Surgical ICU
Severe sepsis/septic shock are serious complications of infection with high morbidity and mortality. Recent information showed that early and aggressive resuscitation may help improving survival and outcome especially the…
- Conditions
- Septic Shock, Multiple Organ Failure, Fatal Outcome
- Trial name
- NCT01363635
- Where
- Thailand
- Volunteers
- 800 people
- Sponsor
- Mahidol University
General Anesthesia
Effect of Sevoflurane and Propofol on Hepato-splanchnic Pressure and Flow During Hepatobiliary Surgery
Blood loss in hepatobiliary surgery is correlated with an increase in postoperative complications (e.g. transfusion related lung injury and tumor recurrence) and reduced longterm survival.
- Trial name
- NCT03772106
- Testing
- Propofol Fresenius, sevorane
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- University Hospital, Ghent
Anesthesia
The Effect and Mechanism of Respiratory Stimulant Doxapram on Facilitating Emergence
The current study is designed to investigate the difference of plasma orexin A levels between doxapram group and controlled group at emergence time from sevoflurane-remifentanil anesthesia who will undergo elective lumbar surgery.
- Trial name
- NCT02820025
- Testing
- doxapram, saline
- Where
- China
- Volunteers
- 40 people
- Sponsor
- General Hospital of Ningxia Medical University
Myocardial Injury
Perioperative Endothelial Dysfunction
More than one in 100 otherwise healthy patients undergoing non-cardiac surgery will die within 30 days post-operatively, and of these patients 45% will die from vascular causes such as myocardial infarction.
- Trial name
- NCT02344771
- Testing
- Elective colon cancer surgery
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- Zealand University Hospital
Neurodevelopmental Disorder, Bilateral Inguinal Hernia
Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery in Infants
This is a prospective randomized controlled trial comparing dexmedetomidine sedation with caudal anaesthesia, and general sevoflurane anaesthesia with caudal anaesthesia for inguinal herniotomies in neonates and infants below 3…
- Trial name
- DEGA (NCT02559102)
- Testing
- Dexmedetomidine sedation, General sevoflurane anaesthesia, Caudal anaesthesia
- Where
- Singapore
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Anti-bacterial Agents, Pharmacokinetics
The Expected Advantage of Administering Prophylactic Antibiotics Using Target- Concentration Controlled Infusion
Preoperative antimicrobial prophylaxis is a key element for the prevention of surgical site infection, the most common type of nosocomial infection in surgical patients.
- Conditions
- Anti-bacterial Agents, Pharmacokinetics, General Surgery
- Trial name
- NCT05253339
- Testing
- target-controlled infusion (one of the administration methods), Standard administration method
- Where
- South Korea
- Volunteers
- 2,494 people
- Sponsor
- Asan Medical Center
Airway Complication of Anaesthesia
The Clinical Efficacy of Recently Developed Supraglottic Airway Device, I-gel™, in Neonates and Infants: Comparison With Classic-laryngeal Mask Airway (c-LMA)
Although the safety and efficacy of the Classic-laryngeal mask airway (c-LMA) in children has been shown in several large observational studies, findings suggest that the smaller-sized c-LMAs, in particular sizes 1 and 1½, are…
- Trial name
- NCT01437137
- Testing
- classic-laryngeal mask airway (c-LMA), i-gel™
- Where
- South Korea
- Volunteers
- 54 people
- Sponsor
- Yonsei University
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