Clinical trials: Global Surgery
Rapid Sequence Induction
Classic and Modified Rapid Sequence Induction for Prevention of Gastric Content Regurgitation
Induction of anesthesia induces a loss of protective upper airway reflexes and is associated with gastric content regurgitation.
- Trial name
- NCT04312425
- Testing
- Modified rapid sequence induction, Classic rapid sequence induction
- Where
- China
- Volunteers
- 8,601 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Delirium
Delirium and Neuropsychological Recovery Among Emergency General Surgery Survivors
This study will evaluate the usefulness of the Urgent and Emergency Surgery (UES) Delirium Recovery Model. It is hypothesized that the cognitive, physical and psychological recovery of older UES delirium survivors will be…
- Trial name
- NCT05373017
- Testing
- DANE Recovery Program, Questionnaires
- Where
- 6 sites in United States
- Volunteers
- 528 people
- Sponsor
- University of Wisconsin, Madison
Periodontitis Chronic Generalized Severe, Hyperlipidemia
Effects of Non-surgical Periodontal Therapy on Severe Periodontitis and Hyperlipidemia
This study was a single-center, non-randomized, parallel-group design clinical trial, and each group was assigned a 1:1 ratio with or without hyperlipidemia.
- Conditions
- Periodontitis Chronic Generalized Severe, Hyperlipidemia, Gingival Crevicular Fluid, Serum
- Trial name
- NCT05548933
- Testing
- non-surgical periodontal therapy
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Anesthesia, General Anesthesia
Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery
The objective of this study is to determine if an opioid-free general anesthetic (OFA) technique utilizing lidocaine, ketamine, dexmedetomidine and magnesium reduce postoperative opioid consumption and speed return of bowel…
- Conditions
- Anesthesia, General Anesthesia, Analgesics, Opioid, Opioid Free Anesthesia
- Trial name
- RUMBLE (NCT04144933)
- Testing
- Acetaminophen, Gabapentin, Lidocaine 1% Injectable Solution, Dexmedetomidine, Ketamine, Dexamethasone, Ondansetron
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Saskatchewan
Anterior Cruciate Ligament Rupture, Femoral Nerve Block
FNB in ACL Recon Under GA
The investigators will compare the results of sono-guided femoral nerve block in arthroscopic surgery for anterior cruciate ligament reconstruction under general anesthesia.
- Trial name
- NCT06048848
- Testing
- Sono-guided injection, Ropivacaine injection, Saline injection
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Anesthesia
Psychological Assessment Before General Anesthesia (VeSPPA2018)
The level of preoperative anxiety can be related to the outcome of an operation and to the post operative patient management . The Dutch questionnaire APAIS (Amsterdam Preoperative Anxiety and Information Scale) is a useful tool…
- Trial name
- NCT03818464
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Parma
Oxygenation Index
Effects of Different Inhaled Oxygen Concentrations on Lung Function in Older Patients After Laparoscopic Gastrointestinal Surgery Under General Anesthesia
This was a multicenter, prospective, parallel-grouping, randomized controlled clinical study comparing low FiO2 (40%) and high FiO2 (80%) levels in older patients undergoing laparoscopic gastrointestinal surgery.
- Trial name
- NCT06359106
- Testing
- 80% Oxygen, 40% Oxygen
- Where
- 16 sites in China
- Volunteers
- 1,176 people
- Sponsor
- China Medical University, China
Regional Anesthesia, Heart Surgery
Nociception-directed Erector Muscle Spinae Plane Block in Open Heart Surgery
With the advent of ultrasound (US) guidance, use of regional anaesthesia (RA) is poised to grow and evolve. Recently, cardiac surgery has benefited from newer US guided interfascial techniques as they promise to fulfil all the…
- Trial name
- NESP (NCT04338984)
- Testing
- General anesthetic, Ropivacaine 0.5% Injectable Solution
- Where
- Romania
- Volunteers
- 86 people
- Sponsor
- Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu
Pathologic Stage I Gastric Cancer AJCC v8, Colorectal Cancer
Clinical Trial to Evaluate the Efficacy and Safety of a Thoracic and Abdominal Endoscopic Surgical System
Evaluation of the efficacy and safety of thoracic and abdominal endoscopic surgical systems manufactured by Shenzhen Cornerstone Robotics Technology Co., Ltd. for use in general, gynaecological and thoracic surgical procedures.
- Conditions
- Pathologic Stage I Gastric Cancer AJCC v8, Colorectal Cancer, Esophageal Cancer, Hepatectomy
- Trial name
- NCT06587152
- Testing
- Robot-assisted surgery
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Cornerstone Robotics
General Anesthetics Toxicity, Postoperative Cognitive Dysfunction
Tau/P-Tau and Neurocognitive Outcomes in Children
The proposed studies are aimed to measure Tau and P-Tau levels in pre- and postoperative blood, urine, feces and saliva, as well as to assess pre- and postoperative neurocognitive function in children (3 to 5 years old) who will…
- Conditions
- General Anesthetics Toxicity, Postoperative Cognitive Dysfunction, Child Development
- Trial name
- NCT03511729
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Intracerebral Hemorrhage
Rapid Evacuation and Access of Cerebral Hemorrhage Registry
The goal of this observational study is to quantify the real-world effect of minimally invasive surgery (MIS) in patients with acute spontaneous supratentorial intracerebral hemorrhage.
- Trial name
- REACH (NCT07651631)
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- Emory University
Emergent Surgery
Patients With Positive Urine Cocaine Metabolites Undergoing General Anesthesia
When it is safe to administer general anesthesia to the patient with cocaine positive urine drug screen has never been clearly determined.
- Trial name
- NCT01788202
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Rutgers, The State University of New Jersey
Surgical Site Infection
A Stratified, Multi-ARm, muLti-site Randomised Platform Trial Aiming to Reduce the INcidence of Post-operative SSI
MARLIN is a stratified, multi-arm, multi-stage factorial randomised platform trial aiming to reduce the incidence of post-operative surgical site infection (SSI).
- Trial name
- MARLIN (NCT06465901)
- Testing
- Chlorhexidine Gluconate 2.0% to 4.0% (e.g. Hibiscrub) preoperative shower, Intraoperative wound wash (e.g. Granudacyn), DACC surgical wound dressing (e.g. Leukomed Sorbact)
- Where
- 7 sites in Benin, Ghana and 5 more
- Volunteers
- 10,092 people
- Sponsor
- University of Birmingham
Deep Brain Stimulation Surgery, Electrophysiology
Analysis of Deep Brain Nuclei LFP and Cortical EEG Signals During the Recovery From General Anesthesia
The correlations of deep brain nuclei firing and cerebral cortex activity during recovery from general anesthesia is unclear. In this study, the local field potential (LFP) from the deep brain nuclei and the scalp…
- Conditions
- Deep Brain Stimulation Surgery, Electrophysiology, General Anesthesia, Consciousness, Loss of
- Trial name
- NCT06400901
- Testing
- No interventions
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Ruijin Hospital
Anesthesia, Regional
Comparison of an Interscalene Nerve Block With or Without Stellate Ganglion Block for Shoulder Surgery
This study describes the difference of analgesic effect of levobupivacaine 0.5% administered through an interscalene nerve block with or without a stellate ganglion block.
- Trial name
- NCT02879916
- Testing
- Levobupivacaine, NaCl 0.9%
- Volunteers
- 30 people
- Sponsor
- University Hospital, Antwerp
Ischemic Heart Disease
By Pass Surgery With Stem Cell Therapy in Chronic Ischemic Cardiopathy
Surgical revascularization has proven its efficacy in term of morbidity and mortality in patients with multivessel coronary disease and poor left ventricular function.
- Trial name
- NCT00690209
- Testing
- Autologous bone marrow derived stem cells myocardial transplantation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Clermont-Ferrand
Surgery, Fatigue, Mental
Comparing the Variation in Laparoscopic Skills Acquisition in Obstetrics & Gynaecology and General Surgical Trainees
The investigators postulate that there is a difference in the acquisition of Fundamental Laparoscopic Skills (FLS) between general surgical and Obstetrics \& Gynaecology (O\&G) trainees.
- Conditions
- Surgery, Fatigue, Mental, Fatigue, Training Group, Sensitivity
- Trial name
- LAGGS (NCT05116332)
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Lancaster University
Brain Neoplasms, Surgery
Small-dose Dexmedetomidine Effects on Recovery Profiles of Supratentorial Tumors Patients From General Anesthesia
An excellent recovery profile is critical for neurosurgical anesthesia. Rapid awakening, smooth blood pressure and heart rate (HR), a higher degree of coordination, painless or mild pain, as well as better tolerance to…
- Trial name
- NCT02007798
- Testing
- dexmedetomidine, normal saline
- Where
- China
- Volunteers
- 150 people
- Sponsor
- China Medical University, China
Quality of Recovery, Anesthesia Recovery Period
Comparing Quality of Recovery Between Desflurane & Isoflurane in Eye Surgery Patients at Dr George Mukhari Acad Hospital
Recovery after surgery and anaesthesia has traditionally been assessed with objective measures including time to awakening, time to regaining airway reflexes, duration of stay in the recovery room and/or hospital, and incidence…
- Trial name
- DIQoR (NCT04188314)
- Testing
- Desflurane, Isoflurane
- Where
- South Africa
- Volunteers
- 170 people
- Sponsor
- Sefako Makgatho Health Sciences University
Prostate Cancer Surgery
Spinal Anesthesia for Robotic Assisted Laparoscopic Prostatectomy
The investigators hypothesised that spinal anesthesia as an adjunct to general anesthesia would facilitate faster recovery and less pain in patients undergoing laparoscopic robotic prostatectomy.
- Trial name
- NCT06860893
- Testing
- Spinal Anesthesia with Bupivacaine
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- University Hospital of North Norway
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