Clinical trials: Global Surgery
Colorectal Neoplasms
DEXDES Trial: Dexmedetomidine-Desflurane Combination in Laparoscopic Colectomy
This randomized double-blind controlled clinical trial aims to evaluate the efficacy and safety of combining Dexmedetomidine with Desflurane in patients undergoing elective laparoscopic colectomy.
- Trial name
- NCT07239479
- Testing
- Dexmedetomidine + Desflurane, Desflurane + Normal Saline
- Where
- Vietnam
- Volunteers
- 40 people
- Sponsor
- Tam Anh Research Institute
Traumatic Brain Injury, Head Injury
Management and Outcomes Following Emergency Surgery for Traumatic Brain Injury
Primary aim: The primary aim of the study is to compare survival to discharge (or survival to 14 days post-operatively, whichever comes first) following emergency surgery for traumatic brain injury (TBI) across Human Development…
- Conditions
- Traumatic Brain Injury, Head Injury, Brain Injuries, Brain Trauma
- Trial name
- GNOS (NCT04212754)
- Testing
- Exposure: human development index of country
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- University of Cambridge
Anesthesia
Performance Assessment of the PMD-200 in Subjects Requiring Surgery Under General Anesthesia
The proposed study is designed to further demonstrate the performance of the Nociception Level (NoL) Index - in surgical patient under general anesthesia, by evaluating its response to controlled changes in the levels of noxious…
- Trial name
- NCT03466138
- Testing
- PMD-200
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Medasense Biometrics Ltd
Postoperative Neurocognitive Dysfunction, Postoperative Neurocognitive Disorder
The Role of Neuroinflammation on Neurocognitive Outcome in Cardiac Surgery
RATIONALE: Postoperative cognitive changes are common after cardiac surgery and can be categorised into three main types: postoperative delirium (POD), delayed neurocognitive recovery (DNCR) and postoperative neurocognitive…
- Conditions
- Postoperative Neurocognitive Dysfunction, Postoperative Neurocognitive Disorder, Cardiac Surgery, Major Surgery Under General Anesthesia
- Trial name
- INOCS (NCT07200726)
- Testing
- Observational study design - no intervention
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Ziekenhuis Oost-Limburg
Perioperative Cardiovascular Risk, Postoperative Complications (Cardiopulmonary)
AI-ECG for Preoperative Cardiovascular Risk Stratification Before General Surgery
This randomized controlled trial evaluates whether an artificial intelligence-enhanced electrocardiography (AI-ECG)-based strategy for preoperative cardiovascular risk stratification is noninferior to usual care in patients…
- Conditions
- Perioperative Cardiovascular Risk, Postoperative Complications (Cardiopulmonary), Preoperative Care
- Trial name
- NCT07774689
- Testing
- AI-ECG-based preoperative risk stratification (ECG Buddy)
- Where
- South Korea
- Volunteers
- 3,200 people
- Sponsor
- Seoul National University Bundang Hospital
Postoperative Nausea and Vomiting
Caffeine in the Prevention of Post-operative Nausea and Vomiting
The objective of this study is to determine if caffeine 500 mg intravenously is efficacious when added to standard anti-emetic prophylaxis in the prevention of post-operative nausea and vomiting (PONV) in patients undergoing…
- Trial name
- NCT00130026
- Testing
- Caffeine
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Beth Israel Deaconess Medical Center
Surgical Site Infection, Surgical Wound
Optimizing Closed Incision Negative Pressure Wound Therapy in Emergency Laparotomy
The purpose of this study is to find differences in rates of surgical site infections following emergency laparotomy with the use of two different incisional negative pressure wound therapy (iNPWT)devices.
- Conditions
- Surgical Site Infection, Surgical Wound, Surgical Wound Infection, Surgical Complication
- Trial name
- OPTIWOUND (NCT05716490)
- Testing
- Incisional negative pressure wound therapy, Control group - standard wound dressing
- Where
- Portugal
- Volunteers
- 114 people
- Sponsor
- Centro Hospitalar do Tâmega e Sousa
Surgery Complications, Surgery
SurgWeek-2: Identifying the Global Burden of Post Operative Complications: an International Prospective Cohort Study Protocol
This study aims to assess and improve the global outcomes following surgery. Every year approximately 313 million operations are performed, with 50 million people experiencing a complication and unfortunately 3.5 million people…
- Conditions
- Surgery Complications, Surgery, Global Surgery, Robotic
- Trial name
- SurgWeek-2 (NCT07785076)
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Vitrectomy Operation Under General Anesthesia
Comparison Between Propofol-remifentanil Total Intravenous Anesthesia and Desflurane-remifentanil Balanced Anesthesia With Regard to Post-anesthetic Functional Recovery Measured With QoR-40 in Vitrectomy
Total intravenous anesthesia (TIVA) and inhalation anesthesia are both widely and safely used, and there are many clinical trials comparing these on various aspects of anesthesia.
- Trial name
- NCT02212340
- Testing
- fresofol and remifentanil, desflurane and remifentanil
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Yonsei University
Emergence Agitation, Remimazolam Besylate
Effect of Rematazolam Besylate, Propofol, and Sevoflurane Perioperative Sedation on Incidence of Emergence Agitation and Hemodynamics in Patients Undergoing Laparoscopic Abdominal Surgery
Emergence agitation (EA) is a transient, self-limited, non-fluctuating state of psychomotor excitement, which closely revolves around the emergence of general anesthesia.
- Conditions
- Emergence Agitation, Remimazolam Besylate, Perioperative Sedation, Laparoscopic Abdominal Surgery
- Trial name
- NCT05624424
- Testing
- Rematazolam Besylate, Propofol, Sevoflurane
- Where
- 6 sites in China
- Volunteers
- 1,317 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Urologic Diseases
ED50 of Cis-atracurium for Laryngeal Mask Incubation in General Anesthesia
1. The muscle relaxants can improve the conditions of laryngeal mask incubation and reduce the related complications (such as laryngeal spasm and postoperative throat pain) 2.
- Trial name
- NCT03668262
- Testing
- Cis-atracurium
- Where
- China
- Volunteers
- 35 people
- Sponsor
- China International Neuroscience Institution
Cholecystectomy
Global Evaluation of Cholecystectomy Knowledge and Outcomes, Indonesia
GECKO is a prospective, international, multicentre, observational cohort study delivered by GlobalSurg Collaborative. This will be on consecutive patients undergoing cholecystectomy, between 31st July 2023 to 19th November 2023…
- Trial name
- GECKO-ID (NCT06183346)
- Where
- 2 sites in Indonesia
- Volunteers
- 92 people
- Sponsor
- Udayana University
Ankle Fracture in Need of Surgical Fixation
The Effect of Nerve Blockades in Addition to General Anesthesia in Surgical Fixation of Ankle Fractures.
This clinical, randomized, and controlled study will provide valuable scientific evidence regarding the effect of adding peripheral nerve blockades to general anaesthesia during ankle surgery.
- Trial name
- NCT01923623
- Testing
- Ropivacaine block
- Sponsor
- Herlev Hospital
Postoperative Cognitive Deficit (POCD)
"Effects of Fluid Status and Regional Cerebral Oxygenation on Postoperative Cognitive Dysfunction in Patients Undergoing Lower Extremity Surgery Under General and Spinal Anesthesia."
We frequently encounter cognitive impairments in patients over 65 undergoing Lower extremity surgery, depending on comorbidities and the choice of anesthesia method.
- Trial name
- AECGSKD002 (NCT07302061)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Goztepe Training and Research Hospital
Global Surgery, Medical Missions
From Short-term Surgical Missions Towards Sustainable Partnerships
Introduction: Recently, the devastating consequences of neglected surgical care in global health became apparent with an estimated five billion people lacking access to safe surgical and anesthesia care.
- Trial name
- NCT04450823
- Testing
- no intervention
- Where
- Netherlands
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Global Surgery Amsterdam
Combination of General Anesthesia to Spinal and Epidural Techniques
Combination of Spinal-Epidural With General Anesthesia in Patients Undergoing Mega-Liposuction Surgery
The combination of general anesthesia to spinal and epidural techniques (CSEGA) proved to have a synergistic effect, thus, the use of sub-anesthetic doses can provide satisfactory anesthetic and analgesic results.
- Trial name
- NCT05301127
- Testing
- spinal-epidural device
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postoperative Cognitive Dysfunction
Correlation Between Markers of Neuronal Injury and Cognitive Dysfunction After Coronary Artery Bypass Surgery
This study aims to evaluate the possible Correlation Between Serum Levels of Markers of Neuronal Injury and Cognitive Dysfunction after Coronary Artery Bypass Surgery.
- Trial name
- NCT01550159
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- Maria José Carvalho Carmona
Elective Surgery, Coughing
Efficacy of Propofol vs Placebo in the Prevention of Coughing During Emergence of General Anesthesia Under Desflurane
Emergence of general anesthesia is a critical period, in the same way as the induction of anesthesia, during which several adverse events may occur.
- Trial name
- PROPOREV (NCT02932397)
- Testing
- Intravenous dose of 0.5 mg/kg of propofol, Intravenous dose of 0.05 mL/kg of saline solution
- Where
- Canada
- Volunteers
- 154 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Neurocognitive Disorder, General Anesthesia
EVALUATION OF POSTOPERATIVE NEUROCOGNITIVE IMPAIRMENT
In this prospective study, the effects of different anesthesia methods (total intravenous anesthesia and inhaled anesthesia) on neurocognitive function will be examined in patients undergoing breast-conserving surgery without…
- Conditions
- Neurocognitive Disorder, General Anesthesia, Total Intravenous Anesthesia, Sevoflurane Anaesthesia
- Trial name
- NCT06685770
- Testing
- Mini mental state assessment test, Mini-cog test
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Haseki Training and Research Hospital
Anesthesia
Assessment of Plasma Lactate in Non-cardiac Surgery Monitoring by Transthoracic Echocardiography
The study is a clinical trial, prospective and randomized of 60 patients of both genders, aged between 18 and 80 years, underwent major abdominal surgery.
- Trial name
- NCT03103373
- Testing
- Conventional monitor, Echocardiography
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Juiz de Fora
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