Clinical trials: Global Surgery
Kidney Stones, Nephrolithiasis
Comparison of Different Ventilation Modes for Reducing Kidney Motion During Retrograde Intrarenal Surgery
This randomized clinical trial will compare four ventilation strategies during retrograde intrarenal surgery performed under general anesthesia.
- Trial name
- RIRS-VENT (NCT07705646)
- Testing
- Standard Ventilation, Hypoventilation, Intermittent Apnea Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Opioid-free Anesthesia, Cardiac Surgery
Evaluation of Non-opioid Balanced General Anesthesia in Cardiac Surgery With Extracorporeal Circulation: a Randomized, Controlled, Multicenter Superiority Trial
Opioid-free anesthesia (OFA) is a general anesthesia based on the use of hypnotics and non-opioid analgesics (lidocaine, ketamine, dexamethasone, esmolol).
- Trial name
- OFACAR (NCT04886453)
- Testing
- Balanced general anesthesia without morphine, Standard general anesthesia balanced with morphine, Data collection
- Where
- France
- Volunteers
- 321 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Gingival Recession, Localized, Gingival Recession, Generalized
Pain Management After Free Gingival Graft Surgery
Keratinized gingiva reduces the risk of gingival disease and infection by protecting the tissue around the teeth and is therefore very important for gingival health.
- Conditions
- Gingival Recession, Localized, Gingival Recession, Generalized, Gingival Recession, Mucogingival Surgery
- Trial name
- NCT06675734
- Testing
- diclofenac sodium solution
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul Aydın University
Postoperative Sore Throat
Comparison of Nebulized Ketamine With Nebulized Magnesium Sulfate for the Prevention of Postoperative Sore Throat
The aim of this study is to compare the efficacy of nebulized ketamine versus nebulized magnesium sulfate in reducing the incidence and severity of POST. Primary outcome To compare the incidence of POST method.
- Trial name
- NCT07381036
- Testing
- Ketamine nebulizer, Mg sulfate nebulizer
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sohag University
Recovery
Comparison of Recovery From General Anesthesia in Remimazolam With Flumazenil vs. Propofol
This prospective randomized trial aims to compare recovery time from discontinuation of remimazolam followed by flumazenil administration vs.
- Trial name
- NCT05435911
- Testing
- REMIMAZOLAM BESYLATE 2.5 Mg in 1 mL INTRAVENOUS INJECTION, POWDER, LYOPHILIZED, for SOLUTION [BYFAVO], Flumazenil, Propofol
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Seoul National University Hospital
Surgery
Ankle/Brachial Non-Invasive Blood Pressure Difference During General Anesthesia
Brachial non-invasive blood pressure (NIBP) monitoring is recommended as part of the American Society of Anesthesiology (ASA) basic monitoring package.
- Trial name
- NCT03547401
- Testing
- Ankle Non-invasive Blood pressure measurement, Arm Non-invasive Blood pressure measurement
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- Philippe VAN DER LINDEN
Coughing Response, Thyroid Surgery
Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General Anesthesia
Coughing is a common adverse reaction of thyroid surgery,which could result in postoperative bleeding.Postoperative bleeding is a serious and potentially life-threatening complication，which could result in acute upper airway…
- Conditions
- Coughing Response, Thyroid Surgery, General Anesthesia
- Trial name
- NCT02613806
- Testing
- Dexmeditomidine, normal saline
- Where
- China
- Volunteers
- 118 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
General Anaesthesia
Comparative Clinical Study of Efficacy and Safety of Remimazolam and Propofol in Patients Undergoing Elective Surgery Under General Anaesthesia
The purpose of this study was to perform comparative evaluation of clinical efficacy and safety of Remimazolam and Propofol for induction and maintenance of general anesthesia in patients undergoing elective surgery under general…
- Trial name
- NCT03669484
- Testing
- Remimazolam, Propofol, Fentanyl
- Where
- 6 sites in Russia
- Volunteers
- 150 people
- Sponsor
- R-Pharm
Biomarkers, Coronary Artery Bypass Surgery
Dynamics of microRNA Expression and Systemic Inflammatory Response in POCD After Cardiac Surgery
Postoperative cognitive decline (POCD) is one of the most common complications after cardiac surgery. It is characterized by impaired memory, attention, and executive functions and can have long-term consequences.
- Conditions
- Biomarkers, Coronary Artery Bypass Surgery, Interleukin-6, MicroRNAs
- Trial name
- NCT07231731
- Where
- Croatia
- Volunteers
- 48 people
- Sponsor
- Osijek University Hospital
Cesarean Section Rates
Cesarean Delivery in Uganda: A Mixed Methods Study
Recent data indicate that 1 in 5 women worldwide undergo Caesarean sections (CS) and in most regions CS rates are increasing. Sub-Saharan Africa has the lowest CS rate at 3.5%, compared to a global average of 19.1%.
- Trial name
- CRADLING (NCT06090695)
- Where
- 14 sites in Uganda
- Volunteers
- 11,760 people
- Sponsor
- Massachusetts General Hospital
Appendicitis Acute
Value of Ultrasound and Computed Tomography in the Diagnosis of Acute Appendicitis With Histopathology as Gold Standard.
This study is a retrospective evaluation of all patients treated surgically for appendicitis over a period of 3 years at the Sint- Andries Hospital, Tielt. Belgium.
- Trial name
- NCT05070000
- Testing
- Radiologic examination
- Volunteers
- 304 people
- Sponsor
- KU Leuven
Tongue Cancer
Effects of Different General Anesthesia Methods on Immune Responses in Patients Undergoing Surgery for Tongue Cancer
Surgical excision is the mainstay of treatment for tongue cancer. However, surgery-induced immunosuppression has been implicated in the development of post-operative septic complications and neoplasm metastasis.
- Trial name
- NCT01854021
- Testing
- intravenous anesthesia, combined intravenous-inhalational anesthesia, inhalational anesthesia
- Where
- China
- Volunteers
- 60 people
- Sponsor
- tiejun Zhang
Heart Defects, Congenital, Hypoplastic Left Heart Syndrome
Fluid Balance in Children Undergoing Fontan Surgery
This project will evaluate fluid balance and edema formation in children with congenital heart disease in need of a surgical procedure, The Fontan procedure.
- Trial name
- NCT02306057
- Testing
- Pre BCPC, Pre TCPC, BCPC surgery
- Where
- Norway
- Volunteers
- 39 people
- Sponsor
- Oslo University Hospital
Upper Extremity Surgery, Regional Anesthesia
Brachial Plexus Block vs General Anesthesia in Upper Extremity Surgery
This study compares two different anesthesia methods for upper arm and hand surgery: regional anesthesia (brachial plexus block) versus general anesthesia.
- Conditions
- Upper Extremity Surgery, Regional Anesthesia, General Anesthetic
- Trial name
- NCT07352839
- Testing
- Brachial Plexus Block, General Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Adana City Training and Research Hospital
Myocardial Bridge of Coronary Artery
Correlates of Left Ventricular Global Longitudinal Strain and Surgical Intervention on Myocardial Bridges
To examine the changes in left ventricular (LV) global longitudinal strain (GLS), using two-dimensional speckle tracking analysis, after left anterior descending (LAD) unroofing, in myocardial bridges (MBs) refractory to optimal…
- Trial name
- NCT04082546
- Testing
- Surgical unroofing of muscle-briged coronary artery
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Elderly, Epidural Anesthesia
Anesthesia-analgesia Methods and Postoperative Delirium
Postoperative delirium is a common complication in elderly patients after surgery. Its occurrence is associated with worse outcomes. The pathophysiology of delirium remains poorly understood.
- Conditions
- Elderly, Epidural Anesthesia, General Anesthesia, Major Surgery
- Trial name
- NCT01661907
- Testing
- Combined Epi-GA/PCEA, GA/PCIA
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- Peking University First Hospital
Anesthesia, General, Elective Gynecological Operation
Risk Factors for Post Operative Nausea and Vomiting(PONV) in Patients Underwent Gynecological Operation Under General Anesthesia
Risk factors for postoperative nausea and vomiting(PONV) such as past history of PONV and/or motion sickness, non-smoking status, female gender, planned opiate use for post-operative analgesia were identified in white people.
- Conditions
- Anesthesia, General, Elective Gynecological Operation, Chinese Female Patient, Adult
- Trial name
- NCT01020201
- Where
- China
- Volunteers
- 774 people
- Sponsor
- Huazhong University of Science and Technology
Postoperative Sore Throat, Endotracheal Intubation
Scheduled Endotracheal Tube Cuff Pressure Management and Postoperative Sore Throat
This randomized controlled trial evaluated whether scheduled measurement and adjustment of endotracheal tube cuff pressure using a handheld manometer could reduce postoperative sore throat in adults undergoing elective surgery…
- Trial name
- NCT07842081
- Testing
- Handheld Endotracheal Tube Cuff Manometer, Pilot-Balloon Palpation
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people
- Sponsor
- Hitit University
Antibiotic Prophylaxis
Efficacy of Post-operative Antibiotic Prophylaxis for Thoracic Surgery Requiring Tube Thoracostomy
The purpose of this study is to evaluate if post-operative antibiotic prophylaxis decreases infectious complications when compared to pre-operative antibiotics alone, in patients undergoing elective thoracic surgery requiring…
- Trial name
- NCT00818766
- Testing
- cefazolin or vancomycin
- Where
- United States
- Volunteers
- 251 people
- Sponsor
- Brigham and Women's Hospital
Emergency General Surgery
STRATA: Surgical Treatment Using Robotic Approach in The Acute Abdomen
Robotic surgery in the UK is now widely used in elective procedures based on evidence that it can improve outcomes, with improved vision and precision for the surgeon resulting in better results and greater rates of minimally…
- Trial name
- STRATA (NCT07850401)
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- Portsmouth Hospitals NHS Trust
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