Clinical trials: Glomerular Filtration Rate
Kidney Function Test
Development of a Bayesian Estimator for Calculating Plasma Iohexol Clearance
In kidney transplantation, donor selection is based in part on the assessment of the functional capacity of the kidneys. For this purpose, it is recommended to measure the glomerular filtration rate (GFR) by a reference…
- Trial name
- CLIO (NCT05136963)
- Testing
- Iohexol, pharmacokinetics
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Kidney; Disease (Functional), Chronic Kidney Disease
Early Screening and Diagnosis of CKD
Chronic kidney disease (CKD) is a global public health problem. The prevalence of CKD in adults in China was 10.8%. Albuminuria measurement and estimating glomerular filtration rate (GFR) are the primary means of screening for…
- Trial name
- NCT02841371
- Testing
- 99mTc-DTPA
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Glomerular Filtration Rate
Evaluation of Protein Loading on Measurement of Renal Reserve
The goal of this clinical trial is to evaluate the effect of protein loading on the measurement of renal reserve using the MediBeacon Transdermal glomerular filtration rate (tGFR) system.
- Trial name
- NCT07335614
- Testing
- Lumitrace, MediBeacon Transdermal Glomerular Filtration Rate Measurement System (TGFR)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- MediBeacon
Healthy
Effect of Repeated Doses of BI 1060469 and BI 1021958 on Glomerular Filtration Rate (GFR) in Healthy Volunteers
Main objective is to investigate the measured glomerular filtration rate (mGFR) as assessed by iohexol clearance in healthy male normovolemic subjects after oral administration of single and repeated doses of BI 1060469, and BI…
- Trial name
- NCT02202512
- Testing
- Cimetidine, BI 1060469 high dose, BI 1060469 low dose
- Where
- Germany
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Chronic Kidney Disease
Association Between Urine Concentration Ability and the Progression of Chronic Kidney Disease
The study hypothesis is that urine concentrating ability can predict the rate of kidney function decline. Patients with kidney disease at the investigatorsclinic will be asked to give first morning urine sample and osmolarity…
- Trial name
- NCT01423045
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Benaya Rozen-Zvi
Short-term Graft Function, Metabolic Effects
Amino Acid Infusion in Kidney Transplant Recipients
The study addresses the impact of amino acid infusion in the early post-transplant period on graft function and the incidence of post-transplant complications.
- Conditions
- Short-term Graft Function, Metabolic Effects, Nutritional Effect, Immunological &Amp; Inflammatory Markers
- Trial name
- AID-KT (NCT06929637)
- Testing
- Infusion Therapy, Saline solution infusion
- Where
- Slovakia
- Volunteers
- 100 people
- Sponsor
- University Hospital, Martin
Disorder Related to Renal Transplantation
The Effects of Omega-3 Fatty Acids in Renal Transplantation
Omega-3 fatty acids are provided through dietary intake of fish and seafood. Several dietary supplements containing omega-3 fatty acids are also commercially available.
- Trial name
- ORENTRA (NCT01744067)
- Testing
- Omega-3 fatty acids
- Where
- 2 sites in Norway
- Volunteers
- 132 people
- Sponsor
- Oslo University Hospital
Chronic Kidney Disease
Effect of Dietary Fiber on Non-dialysis Patients With Chronic Kidney Disease
The main objective of this study was to investigate the effect of dietary fiber on anemia and glomerular filtration rate in non-dialysis patients with chronic kidney disease.
- Trial name
- NCT05835648
- Testing
- Nutrasumma
- Volunteers
- 56 people
- Sponsor
- Qianfoshan Hospital
Living Kidney Donation
The Living Kidney Donor Safety Study
The main goal of this study is to understand the long-term effects of kidney donation on blood pressure, kidney function, and patient-reported health-related quality of life.
- Trial name
- LKD (NCT00936078)
- Where
- 13 sites in Australia, Canada
- Volunteers
- 1,438 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Autosomal Dominant Polycystic Kidney Disease, Disease Progression
Efficacy Study of Water Drinking on PKD Progression.
This is a prospective 5-year study to compare the change in total kidney volume (TKV) before and after tolvaptan therapy, as the primary endpoint, in patients with ADPKD.
- Trial name
- ESWP (NCT01348035)
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Kyorin University
Chronic Kidney Disease, End-Stage Renal Disease
Establish the Caring Model of Children With Chronic Kidney Disease and End-stage Renal Disease: To Set up Childhood Glomerular Filtration Rate (GFR) Formula in Taiwan
Inulin's usefulness as a diagnostic agent is based on the method of its elimination from the body. Inulin is biologically inert, unbound by plasma proteins, freely filtered at the glomerulus, and is neither reabsorbed…
- Trial name
- NCT01250626
- Volunteers
- 80 people
- Sponsor
- China Medical University Hospital
Chronic Kidney Disease (CKD)
Urologic-nephrological Care of Chronic Kidney Disease in Saxony-Anhalt/Magdeburg.
Statement: Patients with Chronic kidney disease (CKD) with an estimated glomerular filtration rate (eGFR) under 60 ml/min using the MDRD-6 (Modification of Diet in Renal Disease) formula and/or CKD-EPI (Chronic Kidney Disease…
- Trial name
- UroCKDisS (NCT02229435)
- Where
- Germany
- Volunteers
- 1,031,336 people
- Sponsor
- University of Magdeburg
Chronic Kidney Disease
Assessment of Dialysis Initiation by a Fuzzy Mathematics Equation
The purpose of this study is to evaluate the impact of the optimal and late initiation of dialysis on the mortality and quality of life in end-stage renal disease (ESRD) patients by the Dialysis Initiation based on Fuzzy…
- Trial name
- ADIFE (NCT03385902)
- Testing
- optimal start time, late start time
- Where
- China
- Volunteers
- 388 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Transplantation, Kidney, Graft Occlusion, Vascular
GFR Measurement With Contrast-enhanced Dynamic MRI
The aim of the study is to optimize and validate this MR-based GFR measurement in patients with a renal transplant, compared with the reference method, the Cr51- EDTA method: to select the most accurate combination of…
- Trial name
- IREN (NCT00614081)
- Testing
- Contrast-enhanced dynamic MRI
- Where
- France
- Volunteers
- 71 people
- Sponsor
- University Hospital, Bordeaux
Renal Effects
Renal Effects of Erythropoietin in Humans
Erythropoietin (EPO) is a glycoprotein produced mainly in the kidney. After its release to the bloodstream EPO binds to its receptor predominantly located within the bone marrow where erythropoiesis is stimulated.
- Trial name
- EPO 2012 (NCT01584921)
- Testing
- Erythropoietin (Epoetin-beta, NeoRecormon®)
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Diabetes Mellitus Type 2
A Comparison of the Effects of Aleglitazar and Actos on Renal Function on Patients With Type 2 Diabetes.
This 2 arm study will compare the effects of aleglitazar and Actos, added to preexisting oral antihyperglycemic therapy and/or diet and exercise, on renal function in patients with type 2 diabetes, and normal or mildly impaired…
- Trial name
- NCT00461006
- Testing
- Actos, aleglitazar
- Where
- 52 sites in United States, Mexico and 3 more
- Volunteers
- 176 people
- Sponsor
- Hoffmann-La Roche
Hepatitis C, Renal Disease
eGFR Evolution in HCV Patients Receiving SOF-based or SOF-free DAAs
Data regarding the nephrotoxicity of sofosbuvir (SOF) remain controversial. The investigators compared the changes of estimated glomerular filtration rate (eGFR) in patients with chronic hepatitis C virus (HCV) infection…
- Conditions
- Hepatitis C, Renal Disease, Viral Hepatitis C
- Trial name
- NCT04047680
- Testing
- Sofosbuvir / Velpatasvir Oral Tablet, Sofosbuvir and Ledipasvir, Sofosbuvir Tablets
- Where
- 2 sites in Taiwan
- Volunteers
- 441 people
- Sponsor
- National Taiwan University Hospital
Chronic Kidney Disease
Pharmacokinetics and Safety of MB-102 (Relmapirazin) and the MediBeacon Transdermal GFR Measurement System in Evaluation of Kidney Function in Normal and Renal Compromised Subjects
The goal of this clinical trial was to compare transdermal glomerular filtration rate (tGFR) to plasma-derived indexed (to body surface area; BSA) GFR (nGFR) using MB-102 (relmapirazin) as the fluorescent compound.
- Trial name
- NCT05425719
- Testing
- MB-102, MediBeacon Transdermal Glomerular Filtration Rate Measurement System (TGFR)
- Where
- 8 sites in United States, China
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- MediBeacon
Renal Disease, Renal Insufficiency
Two-Point Measurement of Glomerular Filtration Rate by Iohexol Plasma Disappearance
The purpose of this study is to measure glomerular filtration rate (GFR) by iohexol plasma disappearance (gold standard) and measure serum Cystatin C levels (surrogate marker) in patients enrolled in our prospective study at…
- Trial name
- NCT01545531
- Testing
- Iohexol
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Washington
Renal Insufficiency Chronic
Effectiveness of a Structured Intervention to Reduce the Progression of Chronic Kidney (RENAP Study)
The propose of study is to study if an informative intervention and a structured follow-up carried out in health centres of primary care in patients with chronic kidney failure, stage 3, is more effective than the current…
- Trial name
- RENAP (NCT01872468)
- Testing
- Structured intervention
- Where
- Spain
- Volunteers
- 269 people
- Sponsor
- Gerencia de Atención Primaria, Madrid