Clinical trials: Glucocorticoid-induced Adrenal Insufficiency
Rheumatoid Arthritis
Difference in GC-induced Adrenal Insufficiency in RA Related to Polymorphisms in the Glucocorticoid Receptor Gene
Development of glucocorticoid (GC)-induced adrenal insufficiency is a serious adverse effect of GC treatment. It is today not possible to predict this adverse effect.
- Trial name
- NCT01411046
- Testing
- Synacthen test
- Where
- Denmark
- Volunteers
- 106 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Adrenal Insufficiency, Polymyalgia Rheumatica
Effect of Supplemental Hydrocortisone During Stress in Prednisolone-induced Adrenal Insufficiency
In this double-blinded randomised placebo-controlled clinical trial, the aim is to determine the effect of supplemental hydrocortisone compared with placebo during mild to moderate physical or mental stress on health related…
- Conditions
- Adrenal Insufficiency, Polymyalgia Rheumatica, Giant Cell Arteritis
- Trial name
- RESCUE (NCT05435781)
- Testing
- Hydrocortisone
- Where
- 3 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- Marianne Christina Klose
Inflammatory Disorder, Autoimmune
Taper Or Abrupt Steroid Stop: TOASSTtrial
This study is an Investigator-initiated, placebo-controlled, multicenter noninferiority trial, comparing rapid termination of systemic glucocorticoid treatment with a tapering regime over 4 weeks.
- Trial name
- TOASST (NCT03153527)
- Testing
- Prednisone
- Where
- 16 sites in Germany, Switzerland
- Volunteers
- 530 people
- Sponsor
- University Hospital, Basel, Switzerland
Glucocorticoid-induced Adrenal Insufficiency
Post-corticosteroid Insufficiency: Search for a Threshold Value for Cortisol at 8 Hours, Prospective Study
Post-corticosteroid insufficiency is found in 40-60% of patients within 10 weeks following the cessation of prolonged corticosteroid therapy and in 20% of patients still after 1 year.
- Trial name
- SYNASTOPRO (NCT06208098)
- Testing
- Salivary cortisol dosage
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Adrenal; Insufficiency Gluccorticoid-Induced, Cushing; Syndrome or Disease, Glucocorticoid-Induced
The Risk of Adrenal Insufficiency and Cushing Syndrome Associated With Glucocorticoid Therapy in People With Chronic Inflammatory Diseases
Glucocorticoids are widely used for the treatment of chronic inflammatory diseases. Although glucocorticoids are effective in controlling disease symptoms, continuous use of the drugs can lead to suppression of adrenal hormones…
- Trial name
- NCT03575247
- Testing
- Glucocorticoids
- Volunteers
- 111,804 people
- Sponsor
- University of Leeds
Adrenal Insufficiency
Hydrocortisone Versus Methylprednisolone for the Treatment of Glucocorticoid-Induced Adrenal Insufficiency
This study aims to compare the use of methylprednisolone and hydrocortisone as replacement therapies in patients with glucocorticoid-induced adrenal insufficiency.
- Trial name
- NCT07703098
- Testing
- Patients will receive 3 mg of methylprednisolone once daily. The dose is administered in the morning (1 ½ tablets of 2 mg Medrol after breakfast)., Patients will receive 15 mg of hydrocortisone daily. The dose is split into 10 mg in the morning after breakfast and 5 mg after 6-7 hours.
- Where
- Slovenia
- Volunteers
- 66 people
- Sponsor
- University Medical Centre Ljubljana