Clinical trials: Glucocorticoids
Glucocorticoids Toxicity, Rheumatoid Arthritis
Monıtorıng Glucocortıcoıd Treatment In Patıents Followed In Rheumatology Clınıc
Hypothesis 1: A reduction in side effects is achieved with monitoring glucocorticoid treatment by using the Glucocorticoid Toxicity Index (GTI) in patients using glucocorticoids.
- Conditions
- Glucocorticoids Toxicity, Rheumatoid Arthritis, Vasculitis, Systemic Lupus Erythematosus
- Trial name
- NCT05292456
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Hacettepe University
Healthy
Single Dose Study Of PF-04308515 And Prednisone On Carbohydrate
This study will investigate the effect of a single dose of PF-04308515 or prednisone on calculated measures of glucose tolerance and insulin resistance by using a modified oral glucose tolerance test.
- Trial name
- NCT01199029
- Testing
- PF-04308515, Prednisone
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
Infertility
Live Birth Rate After First Embryo Transfer With or Without Glucocorticoid Sensitivity Testing
This retrospective single-center observational cohort study evaluates live birth rates after the first embryo transfer following immune assessment in infertile women with documented uterine immune overactivation.
- Trial name
- GLUCO-IVF (NCT07449494)
- Where
- France
- Volunteers
- 148 people
- Sponsor
- Hopital Pierre Rouques - Les Bluets
Primary Immune Thrombocytopenia
Study on Glucocorticoid Combined With Gamma Globulin and Ropristine N01 in Treatment of Initial Severe ITP
The goal of this clinical trial is to learn if romiplostim N01 works to treat severe primary immune thrombocytopenia in adults. It will also learn about the safety of romiplostim N01.
- Trial name
- NCT06686927
- Testing
- corticosteroids combined with immunoglobulin and romiplostim
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Glucocorticoid-induced Osteoporosis
Romosozumab Versus Denosumab for Osteoporosis in Long-term Glucocorticoid Users
Glucocorticoid (GC) is the main stay of treatment of many rheumatic diseases but is also an important cause of secondary osteoporosis.
- Trial name
- NCT04091243
- Testing
- Romosozumab
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Tuen Mun Hospital
Safety and Efficacy
Vedolizumab, Anti-CD25 Antibody, Rapid Reduction of Glucocorticoids for SR-aGVHD With Gastrointestinal Involvement
Acute graft-versus-host disease (aGVHD) is the most common life-threatening complication of allogeneic hematopoietic stem cell transplantation.
- Trial name
- NCT06066840
- Testing
- Basiliximab, Vedolizumab
- Where
- China
- Volunteers
- 45 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Osteopenia, Osteoporosis
Network Osteoporosis Study
This study is evaluating the use of the drug alendronate in preventing or reversing bone loss in children and adolescents receiving steroid medications.
- Trial name
- NCT00209469
- Testing
- alendronate sodium
- Where
- 4 sites in United States
- Volunteers
- 90 people
- Sponsor
- Glaser Pediatric Research Network
Granulomatosis With Polyangiitis
The Assessment of Prednisone In Remission Trial - Centers of Excellence Approach
This study is a multi-center randomized controlled trial to evaluate the effects of using low-dose prednisone as compared to stopping prednisone treatment entirely.
- Trial name
- TAPIR (NCT01940094)
- Testing
- 5 mg Prednisone, 0 mg Prednisone
- Where
- 9 sites in United States, Canada
- Volunteers
- 159 people
- Sponsor
- University of Pennsylvania
Hyperandrogenism, Glucocorticoid Metabolism
Effect of Free Fatty Acids (FFA) on Androgen Precursors in Women
The purpose of this study is to determine whether free fatty acids modify the androgen levels in healthy young women.
- Trial name
- NCT00473603
- Testing
- lipid/heparin infusion
- Where
- Germany
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Osteoarthrosis
Effect of Methylprednisolone on Glucose Homeostasis in Patients Undergoing Total Hip- and Knee-arthroplasty
This study evaluates the pathophysiological effects of a single dose of Methylprednisolone administered prior to total hip- and knee-arthroplasty surgery. The investigators examine the effect on blood glucose homeostasis.
- Trial name
- NCT02332603
- Testing
- Methylprednisolone, Isotonic Sodium Chloride
- Where
- Denmark
- Volunteers
- 134 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Granulomatosis With Polyangitis
Evaluate the Remission MAINtenance Using Extended Administration of Prednisone in Systemic Anti-neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis.
Immunosuppressive therapy of granulomatosis with polyangiitis (GPA, Wegener's) and microscopic polyangiitis (MPA) has transformed the outcome from death to a strong likelihood of disease control and temporary remission.
- Trial name
- MAINEPSAN (NCT03290456)
- Testing
- Prednisone 5mg/day extended of 12 additional months
- Where
- 45 sites in France
- Volunteers
- 146 people
- Sponsor
- Hospices Civils de Lyon
Delirium - Postoperative, Stress, Physiological
Preoperative Single Glucocorticoid Hip Fracture Hip Fracture Surgery
The Study is a double-blinded, randomized, placebo-controlled trials. The Objective is to investigate the effect of single-high-dose glucocorticoid on surgical stress response and postoperative delirium among Elderly hip Fracture…
- Trial name
- NCT02317601
- Testing
- methylprednisolone sodium succinate
- Where
- Denmark
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Osteoporosis
HRT Versus Etidronate for Osteoporosis and Fractures in Asthmatics Receiving Glucocorticoids.
To determine and compare the effects of Hormone replacement therapy (HRT), etidronate, HRT plus etidronate and no treatment over 5 years in the prevention and treatment of glucocorticoid-induced osteoporosis and fractures in…
- Trial name
- NCT00376662
- Testing
- Hormone Replacement Therapy and Etidronate
- Where
- 2 sites in United Kingdom
- Volunteers
- 750 people
- Sponsor
- British Thoracic Society
Cushing Syndrome
Alterations of Muscle Secretome Associated With Muscle Atrophy Caused by Glucocorticoids
Several studies have shown that lean mass, in particular muscle mass, is an excellent predictive survival factor in many diseases.
- Trial name
- MYOSECRET (NCT03229395)
- Where
- Belgium
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Osteoporosis, Juvenile Rheumatoid Arthritis
Denosumab for Glucocorticoid-treated Children With Rheumatic Disorders
The purpose of this study is to evaluate denosumab as a novel treatment for bone loss in children treated with glucocorticoids for rheumatic disorders.
- Conditions
- Osteoporosis, Juvenile Rheumatoid Arthritis, Dermatomyositis, Polyarthritis
- Trial name
- NCT02418273
- Testing
- denosumab
- Where
- United States
- Sponsor
- Indiana University
Alcoholism
The Stress-Hormone System in Alcohol-Dependent Subjects
This study, conducted at the University of Texas Southwestern Medical Center and the Parkland Hospital in Dallas, will examine the stress hormone system of alcohol-dependent people.
- Trial name
- NCT00536146
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Disseminated Tuberculosis, HIV
Testing New Strategies for Patients Hospitalised With HIV-associated Disseminated Tuberculosis
The New Strat-TB trial is a superiority Phase III randomised control clinical trial with a 2X2 factorial design. The main aim of the study is to assess the efficacy and safety of high dose rifampicin and levofloxacin for 14 days…
- Trial name
- NEW-STRAT TB (NCT04951986)
- Testing
- Rifampin, Levofloxacin, Rifampicin, Pyrazinamide, Ethambutol and Isoniazid
- Where
- 2 sites in South Africa
- Volunteers
- 732 people
- Sponsor
- University of Cape Town
Hypercortisolism
A Study of the Efficacy and Safety of Relacorilant in Patients With Cortisol-Secreting Adrenal Adenomas
This is a Phase 3, randomized, double-blind, placebo-controlled study to assess the efficacy, and safety of relacorilant to treat hypercortisolism in patients with cortisol-secreting adrenal adenoma or hyperplasia associated with…
- Trial name
- GRADIENT (NCT04308590)
- Testing
- Relacorilant
- Where
- 45 sites in United States, Austria and 7 more
- Volunteers
- 137 people
- Sponsor
- Corcept Therapeutics
Full-frequency Sudden Hearing Loss
Sudden Hearing Loss Multi-center Clinical Trial
The incidence of sudden hearing loss is rising obviously resent year, Glucocorticoids have obtained obvious effect in the treatment of sudden deafness.
- Trial name
- NCT02026479
- Testing
- Dexamethasone Phosphate, Ginaton
- Volunteers
- 300 people
- Sponsor
- Peking University People's Hospital
Rheumatoid Arthritis
Intra-articular Glucocorticoid Treatment of the Elbow
BACKGROUND: Intra-articular glucocorticoid injections are frequently used to relieve symptoms of arthritis. Postinjection rest has been shown to improve the outcome of knee joint injections, but not for wrist injections.
- Trial name
- NCT00972530
- Testing
- immobilisation in a triangular sling
- Volunteers
- 90 people
- Sponsor
- Region Gävleborg