Clinical trials: Glucocorticoids
Glucocorticoid Effect
Counteracting Deleterious Metabolic Glucocorticoid Effects With Metformin
Supraphysiological doses of glucocorticoids (GCs) are widely prescribed as immunosuppressants and metabolic side effects such as obesity and diabetes are extremely common.
- Trial name
- Gluco-Met (NCT04659915)
- Testing
- Metformin 500 mg Oral Tablets + Prednisone 20mg Tablets
- Where
- Switzerland
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Rheumatoid Arthritis, Adrenal Insufficiency
Rheumatoid Arthritis Adrenal Recovery Study
Cortisol is a naturally occurring stress hormone, made by the adrenal glands in response to hormones produced by the pituitary and hypothalamus.
- Trial name
- RAAR (NCT03294876)
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- University of Edinburgh
Bronchopulmonary Dysplasia, Respiratory Distress Syndrome in Premature Infant
Intratracheal Budesonide With Surfactant to Prevent Bronchopulmmonary Dysplasia.
This study is designed to determine whether intratracheal administration of budesonide combined with surfactant, as compared to surfactant alone, will modify ecographic (lung ultrasound score) and biological markers (IL-6…
- Conditions
- Bronchopulmonary Dysplasia, Respiratory Distress Syndrome in Premature Infant, Prematurity
- Trial name
- BuS (NCT04862377)
- Testing
- Poractant Alfa Intratracheal Suspension [Curosurf], Budesonide 0.5 MG/ML
- Volunteers
- 50 people
- Sponsor
- Hospital Clinic of Barcelona
Giant Cell Arteritis (GCA)
Bosentan in the Treatment of Giant Cell Arteritis
The purpose of this study is to determine whether a treatment with 3 months of bosentan associated to standard therapy might be superior to glucocorticoids alone in term of failure free survival at 12 months
- Trial name
- BOSICART (NCT06957002)
- Testing
- Bosentan, Glucocorticoids
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome
Glucocorticoid Therapy for Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a clinical syndrome of inflammatory lung injury characterized by increased pulmonary vascular permeability, loss of aerated lung tissue, severe hypoxemia and impaired compliance.
- Trial name
- NCT05401812
- Testing
- Intravenous glucocorticoid therapy
- Sponsor
- National Taiwan University Hospital
Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma
11C-YJH08 PET Imaging for Detection of Glucocorticoid Receptor Expression
This phase I trial studies if positron emission tomography (PET) imaging using 11C-YJH08 can be useful for detecting certain cell receptor expression in tumor cells in patients with cancer that has spread to other parts of the…
- Conditions
- Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma, Stage IV Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8
- Trial name
- NCT04927663
- Testing
- Computed Tomography, Magnetic Resonance Imaging, Positron Emission Tomography
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Rahul Aggarwal
Rheumatoid Arthritis
To Compare the Efficacy and Safety of Low-dose Glucocorticoids and Tofacitinib in Alleviating Moderate to High Disease Activity Rheumatoid Arthritis for 24 Weeks
Glucocorticoids are effective in the treatment of rheumatoid arthritis, but long-term use of glucocorticoids has many side effects. Tofacitinib is a new small-molecule drug targeting JAK, which has been found to act quickly.
- Trial name
- NCT05606107
- Testing
- Tofacitinib, Glucocorticoid
- Where
- 5 sites in China
- Volunteers
- 230 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Polymyalgia Rheumatica
Safety and Efficacy of tocilizuMAb Versus Placebo in Polymyalgia rHeumatica With glucocORticoid dEpendence SEMAPHORE
Patients are treated with infusions of Tocilizumab (TCZ) or placebo for 5 months. Clinical evaluation is performed using PMR-AS.
- Trial name
- NCT02908217
- Testing
- Tocilizumab
- Where
- 17 sites in France
- Volunteers
- 113 people
- Sponsor
- University Hospital, Brest
IgG4-related Disease
Short-term Glucocorticoid Combined with MMF for IgG4-RD
Comparison of short-term glucocorticoid monotherapy and short-term glucocorticoid combined with MMF in the treatment of IgG4 Related Disease
- Trial name
- NCT06663618
- Testing
- prednison, Mycophenolate mofetil
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Wen Zhang
Body Composition, Beneficial, Basal Metabolic Rate
Breakfast Meal Replacement
Purpose: To evaluate the effects of replacing breakfast with a high protein, high fat, high fiber meal replacement in overweight individuals, on body composition.
- Conditions
- Body Composition, Beneficial, Basal Metabolic Rate, Satiety, Overweight
- Trial name
- MRP (NCT02482545)
- Testing
- Meal replacement
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Post-traumatic Stress Disorder
Short Course Glucocorticoid Treatment for PTSD
The purpose of this study is to investigate if a 2-wk course of 20mg/day of oral prednisone in addition to standard care will result in reduced PTSD symptoms or symptom severity compared to placebo
- Trial name
- NCT00204737
- Testing
- prednisone
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Wisconsin, Madison
Refractory Migraine
Localized Injection of Lidocaine and Glucocorticoid for Headache Treatment Phase 1
The goal of this clinical trial is to test whether injecting lidocaine and steroids into two blood vessels of the brain can help treat chronic headaches (migraines).
- Trial name
- LIGHT 1 (NCT06462781)
- Testing
- Lidocaine hydrochloride, Methylprednisolone sodium succinate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The Cooper Health System
IgG4-related Disease With Eosinophilia
Baricitinib Plus Glucocorticoid for Eosinophilia in IgG4-RD
Evaluation of efficacy and safety of Baricitinib combined with glucocorticoid in patients of IgG4-related disease with eosinophilia.
- Trial name
- NCT05781516
- Testing
- Prednisolone, Baricitinib
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Wen Zhang
Rheumatoid Arthritis
Study to Compare the Efficacy of Tocilizumab With or Without Glucocorticoid Discontinuation in Rheumatoid Arthritis Participants
This Phase IIIb/IV, two-arm, randomized, double-blind, placebo-controlled, parallel-group, international, multicenter trial compares the change in disease activity (as assessed by Disease Activity Score in 28 joints [DAS28]…
- Trial name
- NCT02573012
- Testing
- Prednisone, Tocilizumab
- Where
- 39 sites in France, Germany and 4 more
- Volunteers
- 314 people
- Sponsor
- Hoffmann-La Roche
Long QT Syndrome
Study of LQT-1213 on QTc-induced Prolongation in Healthy Adult Subjects (Part1) and on Congenital Long QT in Patients Diagnosed With Type 2 or 3 Long QT Syndrome (Part 2).
Part 1: This is a Phase 1b, randomized, double-blind, crossover, dose escalation, placebo-controlled study to evaluate the effect of oral LQT-1213 on dofetilide-induced QTc prolongation in healthy adult subjects.
- Trial name
- NCT05906732
- Testing
- LQT-1213, Dofetilide 250 μg Cap
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Thryv Therapeutics, Inc.
Cancer
Methotrexate and Glucocorticoids in Treating Patients With Newly Diagnosed Acute Graft-Versus-Host Disease After Donor Stem Cell Transplant
RATIONALE: Methotrexate and glucocorticoid therapy, such as prednisone or methylprednisolone, may be an effective treatment for acute graft-versus-host disease caused by a donor stem cell transplant.
- Trial name
- NCT00357084
- Testing
- methotrexate, methylprednisolone, prednisone
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Fred Hutchinson Cancer Center
Osteoporosis
1 Year Open-label Extension to CZOL446H2337 Safety and Efficacy Trial of Zoledronic Acid Twice Yearly in Osteoporotic Children Treated With Glucocorticoids
This 1-year open-label extension to CZOL446H2337 is designed to evaluate the safety and efficacy of zoledronic acid twice yearly in osteoporotic children treated with glucocorticoids.
- Trial name
- NCT01197300
- Testing
- Zoledronic acid
- Where
- 10 sites in Australia, Canada and 4 more
- Volunteers
- 25 people
- Sponsor
- Novartis Pharmaceuticals
Acute Urticaria
Glucocorticoids With Antihistamines Versus Antihistamines in Acute Urticaria in Emergency
Acute urticaria is common and affected 12% of population. 400 patients come in department emergency of Toulouse each year and there aren't many studies in literature which evaluate the glucocorticoids treatment.
- Trial name
- CAHISU (NCT02565680)
- Testing
- prednisone
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse
Cortico Atrophy
Physiopathological Study and Pharmacological Modulation of Cutaneous Atrophy's Markers Induced by Glucocorticoids
Methodology :Phase III study, single centre, double blind, versus excipient, randomised, controlateral design. Selection of the patients :Number of subjects required 60 : 30 patients needing an oral corticotherapy 30 patients…
- Trial name
- NCT00709579
- Testing
- RV3391A
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Pierre Fabre Dermo Cosmetique
Idiopathic Membranous Nephropathy
Prognostic Model of GC/CTX in the Treatment of MN
The goal of this observational study is to explore the factors that can predict the prognosis difference in patients with idiopathic membranous nephropathy (IMN) under the treatment of glucocorticoid + cytoxan.
- Trial name
- NCT05667883
- Testing
- glucocorticoid + cytoxan
- Volunteers
- 50 people
- Sponsor
- Qianfoshan Hospital