Clinical trials: Glucocorticoids
Obesity, Metabolic Syndrome X
Exercise Training and Hepatic Metabolism in Overweight/Obese Adolescent
The HEPAFIT Study aims to examine whether a 6-months physical education program has benefits on hepatic metabolism and cardiovascular health as well as on selected physical fitness and mental health outcomes among adolescent…
- Conditions
- Obesity, Metabolic Syndrome X, Lipid Metabolism Disorders, Body Composition, Beneficial
- Trial name
- HEPAFIT (NCT02753231)
- Testing
- Low physical activity program, High physical activity program, Low and High physical activity program
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidad Santo Tomas
Graves Disease, Graves Ophthalmopathy
Liver Function After Intravenous Methylprednisolone Administration
Graves' orbitopathy (GO) is a characterized by orbital soft tissue inflammation and oedema associated with glycosaminoglycan deposition and fibrosis. The most frequent cause is Graves' disease.
- Conditions
- Graves Disease, Graves Ophthalmopathy, Liver Diseases, Liver Failure
- Trial name
- NCT03667157
- Testing
- every week IVMP therapy, very high doses IVMP therapy
- Volunteers
- 68 people
- Sponsor
- Medical University of Warsaw
Steroid-induced Osteopor, Glucocorticoid-induced Ostepor
Efficacy and Safety of Denosumab Compared With Risedronate in Individuals Taking Glucocorticoids
This is a 2-year study to evaluate the effect of denosumab versus risedronate in adults with glucocorticoid-induced osteoporosis.
- Trial name
- GIOP (NCT01575873)
- Testing
- Denosumab, Risendronate
- Where
- 99 sites in United States, Argentina and 14 more
- Volunteers
- 795 people
- Sponsor
- Amgen
Adrenal; Insufficiency Gluccorticoid-Induced, Cushing; Syndrome or Disease, Glucocorticoid-Induced
The Risk of Adrenal Insufficiency and Cushing Syndrome Associated With Glucocorticoid Therapy in People With Chronic Inflammatory Diseases
Glucocorticoids are widely used for the treatment of chronic inflammatory diseases. Although glucocorticoids are effective in controlling disease symptoms, continuous use of the drugs can lead to suppression of adrenal hormones…
- Trial name
- NCT03575247
- Testing
- Glucocorticoids
- Volunteers
- 111,804 people
- Sponsor
- University of Leeds
Hyperandrogenism, Glucocorticoid Metabolism
Effect of Free Fatty Acids (FFA) on Androgen Precursors in Women
The purpose of this study is to determine whether free fatty acids modify the androgen levels in healthy young women.
- Trial name
- NCT00473603
- Testing
- lipid/heparin infusion
- Where
- Germany
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Gastrointestinal Cancer, Dietary Modification
Study of Parenteral Nutrition to Patients With Gastrointestinal Cancer
Clinical background: Weight loss is a common problem in patients suffering from gastrointestinal cancer. It is demonstrated that the prognosis for cancer patients with weight loss is worse than that for weight stable patients.
- Conditions
- Gastrointestinal Cancer, Dietary Modification, Cancer Cachexia, Quality of Life
- Trial name
- NCT02066363
- Testing
- Dietician advise, Parenteral nutrition
- Where
- Denmark
- Volunteers
- 47 people
- Sponsor
- Odense University Hospital
Body Composition, Beneficial, Oxidative Stress
Phase Angle and Body Composition, Inflammatory and Oxidative Stress Biomarkers.
The main purpose of the present study was to investigate the effects of 12 weeks of resistance training (RT) on phase angle (PhA), body composition, inflammatory and oxidative stress biomarkers, in older women and to evaluate…
- Conditions
- Body Composition, Beneficial, Oxidative Stress, Acute and Chronic Inflammation
- Trial name
- NCT02940145
- Testing
- Resistance Training
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Body Composition, Beneficial, Paresis
Meal Patterning on Weight Loss With Changes to Body Comp, Muscle and Metabolic Health
About two-thirds of adults in the United States are overweight or obese with likely adverse health consequences. A Moderate weight loss by dieting and exercise is recommended to improve health.
- Conditions
- Body Composition, Beneficial, Paresis, Impaired Glucose Tolerance
- Trial name
- S38 (NCT02066948)
- Testing
- wt loss, Meal Pattern, even
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Purdue University
Glucocorticoid-Associated Osteopenia and Osteoporosis
Alendronate Osteoporosis Study
This trial will test the hypothesis that among 20 children and adolescents from Children's Hospital, Boston with Crohn's disease, ulcerative colitis, systemic-onset juvenile rheumatoid arthritis, juvenile dermatomyositis…
- Trial name
- NCT00277251
- Testing
- Alendronate
- Volunteers
- 20 people
- Sponsor
- Boston Children's Hospital
Body Composition, Beneficial, Physical Fitness
Whole Body Vibration Training on Body Composition
The purpose of the study is to determine the effect of whole-body vibration (WBV) on body composition, physical fitness, and quality of life.
- Trial name
- NCT02571322
- Testing
- HyperVibe Whole Body Vibration training device, Aerobic Exercise
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Miami
Glucocorticoid-induced Hyperglycemia
Continuous Glucose Monitoring on Patients With Active Autoimmune Diseases Following High-dose Predisone Treatment
Glucocorticoid is widely used in clinical treatment. Recently, there was research about glucose fluctuations under low-dose and pulse steroid therapy in elderly patients with active autoimmune diseases.
- Trial name
- CGM (NCT03018600)
- Testing
- diet and exercise intervention
- Volunteers
- 25 people
- Sponsor
- Peking Union Medical College Hospital
Glucocorticoid
Serum FFA Desaturase Activity Index in Patients on High Dose Corticosteroids
Free fatty acid index will be measured in patients before and 1 month after high dose prednisone.
- Trial name
- FFA&steroids (NCT02872584)
- Testing
- Prednisone
- Volunteers
- 20 people
- Sponsor
- Rambam Health Care Campus
Glucocorticoids Deficiency
Ascorbic Acid Treatment in Congenital Glucocorticoids and Mineralocorticoids Deficiency Due to NNT Mutation
Nicotinamide nucleotide transhydrogenase (NNT) mutations cause glucocorticoid and mineralocorticoid deficiencies through decreased detoxification of reactive oxygen species (ROS) in adrenocortical cells.
- Trial name
- NCT02838472
- Testing
- Ascorbic Acid
- Where
- Israel
- Volunteers
- 3 people
- Sponsor
- Hadassah Medical Organization
Menopause, Insulin Resistance
Effects of Physical Training on Adipose Tissue Metabolism and Insulin Sensitivity in the Menopausal Transition Phase
The purpose of this study is to determine if physical exercise reduces the adverse changes in adipose tissue metabolism and insulin sensitivity that occurs in women during the menopausal transition.
- Conditions
- Menopause, Insulin Resistance, Body Composition, Beneficial
- Trial name
- NCT02076932
- Testing
- Spinning
- Where
- Denmark
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Patients With Glucocorticoid Treatment
Metformin to Prevent Metabolic Complications in Glucocorticoid Excess
The purpose of this study is to evaluate if a treatment with metformin compared to placebo reduces metabolic side-effects in patients with glucocorticoid treatment over three months time.
- Trial name
- NCT01187849
- Testing
- Metformin
- Where
- Switzerland
- Volunteers
- 29 people
- Sponsor
- University Hospital, Basel, Switzerland
Body Composition, Beneficial, Basal Metabolic Rate
Breakfast Meal Replacement
Purpose: To evaluate the effects of replacing breakfast with a high protein, high fat, high fiber meal replacement in overweight individuals, on body composition.
- Conditions
- Body Composition, Beneficial, Basal Metabolic Rate, Satiety, Overweight
- Trial name
- MRP (NCT02482545)
- Testing
- Meal replacement
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Whole Body Catabolisme Induced by Glucocorticoids
Glucocorticoid Induced Whole Body Catabolisme
The main purpose of the trial is to advance our knowledge on the possible mechanism underlying the catabolic effects of long-term treatment with glucocorticoid.
- Trial name
- NCT01762540
- Testing
- Glucocorticoids, Calcium Supplement
- Where
- Denmark
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Post-Transplant Glucocorticoid Induced Diabetes
Insulin Therapy for Post-transplant Glucocorticoid Induced Hyperglycemia
No consensus guidelines exist for management of post-transplant glucocorticoid induced hyperglycemia, but most published reviews recommend insulin as first line therapy.
- Trial name
- PTHG (NCT01648218)
- Testing
- Neutral protamine hagedorn (NPH) insulin, Regular human insulin or Insulin Aspart, Insulin glargine
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Vancouver General Hospital
Chronic Disease, Glucocorticoid Therapy, Response to
Efficacy Study of Recombinant Growth Hormone on Muscle Function in Children Long-term Treated With Glucocorticoid
Children suffering from chronic disease and receiving long-term glucocorticoid therapy suffer over years from severe growth retardation and profoundly altered body composition.
- Conditions
- Chronic Disease, Glucocorticoid Therapy, Response to, Growth Retardation
- Trial name
- NCT00813189
- Testing
- GH treatment
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Association REMEDE
Hyperglycemia
CrossFit Exercise to Improve Glucose Control for Overweight and Obese Adults
The purpose of this study was to examine the differences in glucose control, fitness, and body composition between a standard aerobic and resistance exercise training program and a shorter-duration, high-intensity CrossFit…
- Trial name
- NCT02185872
- Testing
- High-Intensity Functional Training, Aerobic and Resistance Training
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Kansas State University