Clinical trials: Glucose
Prediabetic State
RCT of a Polyherbal Dietary Supplement for Prediabetes
The primary purpose of this study is to evaluate the impact of a polyherbal dietary supplement (Designs for Health - GlucoSupreme™ Herbal) on markers of glycemic control and other structure/function outcomes among a sample of…
- Trial name
- NCT03388762
- Testing
- GlucoSupreme™ Herbal
- Where
- 4 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Hyperlipidemia
The Effect of Intranasal Insulin on Hepatic and Intestinal Triglyceride-rich Lipoprotein Production
This study compares the effect of insulin given as a nasal spray with a placebo. Insulin is a chemical messenger (hormone) in the body that controls fat (triglyceride) levels in the blood by controlling the amount of fat made by…
- Trial name
- LPNI (NCT03141827)
- Testing
- Insulin
- Where
- Canada
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Pancreatic Neoplasms, Type 3c Diabetes
Glucose Control Through a Bihormonal Artificial Pancreas in Patients After Total Pancreatectomy
In recent years total pancreatectomy is increasingly performed in selected patients due to the increasing use of preoperative chemotherapy, making more patients operable.
- Conditions
- Pancreatic Neoplasms, Type 3c Diabetes, Total Pancreatectomy
- Trial name
- PANORAMA (NCT06346366)
- Testing
- Bihormonal artificial pancreas (BIHAP) / closed loop
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Healthy
Rapid Effects of Hydrocortisone on Glucose-induced Insulin Secretion in Healthy Humans
The purpose of this study is to investigate the effect of hydrocortisone on glucose-induced insulin secretion and sensitivity, by means of an intravenous glucose tolerance test with frequent sampling (FSIGT) followed by minimal…
- Trial name
- NCT00709839
- Testing
- Hydrocortisone, Glucose 33%
- Where
- Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Glucose Metabolism Disorders
Acute Metabolic Effects of Melatonin Treatment
Modern living is associated with an epidemic of type 2 diabetes mellitus (T2DM). Sleep disturbances are strong independent risk factors for incident diabetes.
- Trial name
- NCT03204877
- Testing
- Melatonin
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity, Diabetes
Family Weight Management Study
The purpose of this study is to address the Healthy People 2010 obesity prevention objective. This study will test the effects of a comprehensive family weight management program on the BMI z-score of 7-12 year-old children with…
- Trial name
- NCT00851201
- Testing
- Intensive lifestyle, Standard intervention
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cystic Fibrosis
Study of Hepatic Glucose Production and De Novo Lipogenesis in Patients With Cystic Fibrosis
OBJECTIVES: I. Determine the amount of hepatic glucose production derived from gluconeogenesis and glycogenolysis in the post-absorptive state in patients with cystic fibrosis. II.
- Trial name
- NCT00014781
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Utah
Obesity
Females, Aging, Metabolism, and Exercise
This study is designed to determine whether a reduction in hormones (such as occurs during menopause) causes a decrease in calories burned during physical activity.
- Trial name
- FAME (NCT01712230)
- Testing
- GnRH agonist, Supervised cardiovascular exercise
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Female Reproductive System Disorder
Effect of Modifications of Nutritional Intake Upon Reproductive Hormones in Normal Women
Undernutrition has a known and well recognized negative impact on reproductive hormones, and ultimately fertility. In contrast, much less is known regarding the potential effects of overnutrition on the same hormones.
- Trial name
- Polynut (NCT02233283)
- Testing
- Clamp, Hypercaloric diet, Basal
- Where
- Switzerland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Diabetes
Validation of the Diabetes Deep Neural Network Score for Diabetes Mellitus Screening
The Validation of the Diabetes Deep Neural Network Score (DNN score) for Screening for Type 2 Diabetes Mellitus (diabetes) is a single center, unblinded, observational study to clinically validating a previously developed remote…
- Trial name
- NCT05303051
- Testing
- Application Validation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy Participants
Glycemic/Insulinemic Effects of Fresh Mango as a Sugar Substitute in Realistic Breakfasts.
Large blood sugar and insulin increases after meals high in table sugar are related to risk for diabetes and heart disease. Additionally, large increases in blood sugar may also negatively impact vascular health.
- Trial name
- NCT07045051
- Testing
- Low-Glycemic Breakfast Containing Oats and Mango, High-Glycemic Breakfast Containing Cereal and Mango, Low-Glycemic Breakfast Containing Oats and Table Sugar
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ball State University
Non-alcoholic Fatty Liver Disease, Diabetes
De Novo Lipogenesis, Lipid and Carbohydrate Metabolism in Non-alcoholic Fatty Liver Disease
The worldwide epidemic of obesity is paralleled with increased cases of non-alcoholic liver disease (liver fat accumulation) and diabetes.
- Trial name
- LINC (NCT00714129)
- Testing
- Dietary intervention (calorie restricted diet)
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Obesity, Childhood, Diabetes Mellitus, Type 2
The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort
The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort study is a unique and comprehensive longitudinal study of 630 Caucasian children and their parents that was designed to investigate the natural history and…
- Conditions
- Obesity, Childhood, Diabetes Mellitus, Type 2, Cardiovascular Risk Factor, Pediatric ALL
- Trial name
- QUALITY (NCT03356262)
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Diabetes Mellitus, Type 2
The Role of Gut Hormones and Hepcidin in Type 2 Diabetes Mellitus
This study aims to investigate the potential of the gut hormones GLP-1, PP, PYY and the iron regulatory hormone hepcidin as biomarkers for progression to complications in diabetes mellitus.
- Trial name
- NCT02413762
- Testing
- No intervention
- Where
- United Arab Emirates
- Volunteers
- 1,512 people, healthy volunteers welcome
- Sponsor
- Imperial College London Diabetes Centre
Prediabetic State, Diabetes Mellitus, Type 2
Noninvasive Skin Spectroscopy for Diabetes Screening
The objective of this study is to assess the performance of a noninvasive device for the early screening of Diabetes Mellitus.
- Trial name
- NCT00358254
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- InLight Solutions
Type 2 Diabetes and Exercise
Influence of Moderate Exercise on Blood Glucose in Type 2 Diabetics and Healthy Controls
Project description Research project title: Influence of moderate exercise on blood glucose in type 2 diabetics and healthy controls.
- Trial name
- DIEGO (NCT01765894)
- Testing
- 45 minutes of moderate exercise at the fasted state. Before test day 2: 3 days of carbohydrate loading.
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Type 2 Diabetes Mellitus
Study on Drug Interaction of HRS-1780 Tablets, Henagliflozin Tablets, Metformin Tablets and HRS-7535 Tablets in Healthy Human
This study was designed as a single-center, single-arm, open, fixed-sequence, self-controlled trial in healthy subjects.
- Trial name
- NCT06495931
- Testing
- HRS-1780 tablets, HR20033 tablets, HRS-7535 tablets
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Alcohol Consumption, Insulin Resistance
Identification of Biomarkers for Acute Intake of Beer and Alcohol and Acute Effects on Plasma and Insulin Response
The objective of the study is to identify biomarkers for acute intake of beer and alcohol in individuals with a high or low habitual intake.
- Trial name
- METABEER (NCT02449577)
- Testing
- Beverage sequence ABCD, Beverage sequence CADB, Beverage sequence DACB
- Where
- Denmark
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Gestational Diabetes Mellitus
Prevention of Diabetes Mellitus Type 2 in Women Post Gestational Diabetes Mellitus Diagnosis
Diabetes Mellitus (DM) is a chronic metabolic disorder with increasing incidence and long term complications. Its incidence differs in various ethnic populations.Gestational DM (GDM) is diagnosed when impaired glucose tolerance…
- Trial name
- GDM (NCT01480895)
- Testing
- Lifestyle instruction for Jews and Bedouin GDM women.
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Post Prandial Blood Glucose
The Effects of Salvia Hispanica-Enriched Foods on Glycemic and Insulinemic Responses and Subjective Satiety
Salvia hispanic (Salba) is postulated to increase satiety. This study determines the optimal amount of Salba as well as whether liquid or solid enriched products will produce maximum satiety.
- Trial name
- NCT00728065
- Testing
- White Bread, White bread with added 7.32g Salvia hispanica, White bread with added 15.58g Salvia hispanica
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
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