Clinical trials: Glucose Homeostasis
Postprandial Glucose Homeostasis
The Effect of an Acute Increase in Plasma IL-6 on Glucose Tolerance When a Meal is Administered Intraduodenally
The aim of the study is to investigate and clarify whether the effect of IL-6 on glucose tolerance and insulin secretion are secondary to the changes in gastric emptying.
- Trial name
- DUIL-6 (NCT03660332)
- Testing
- Infusion of a liquid meal intraduodenally
- Where
- Denmark
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Glucose Homeostasis
Effects of Oral GLP-1 on Glucose Homeostasis and Appetite Profile in Healthy Male Subjects
The investigators aimed to investigate the pharmacokinetic and pharmacodynamic effects of a single dose (2 mg) of oral GLP-1 administered prior to an oral glucose tolerance test (oGTT) in 16 healthy males
- Trial name
- NCT00822003
- Testing
- Oral GLP-1
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Gestational Diabetes
Trimester Sequential Estimation of Serum Zonulin as a Predictor of Gestational Diabetes Mellitus
Gestational diabetes mellitus (GDM) is the development of glucose intolerance (GI) during pregnancy in a previously normoglycemic (NG) woman and associated with insulin resistance (IR).
- Trial name
- NCT06336512
- Testing
- ELISA
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Benha University
SDB, T2DM
Sleep Disordered Breathing and Impaired Glucose Homeostasis in Obese Children
SDB has been identified as an important risk factor for insulin resistance and the metabolic syndrome. In a recent study in patients with SDB and T2DM it was shown that CPAP therapy can lead to improvements in postprandial…
- Conditions
- SDB, T2DM, Obesity
- Trial name
- NCT02037100
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Glucose Intolerance, Insulin Resistance
Iron and Insulin Resistance in Overweight and Obese Humans
Determine the effects of reducing whole-body iron stores in overweight/obese subjects (via one-time blood donation) on adipose tissue iron content, factors regulating iron homeostasis and lipolytic rate in adipose tissue, as well…
- Conditions
- Glucose Intolerance, Insulin Resistance, Iron Metabolism
- Trial name
- Fe (NCT03348020)
- Testing
- Blood Donation
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Insulin Sensitivity, Oxidative Stress
Racial Differences in Vagal Control of Glucose Homeostasis, Chronic Study
Investigators will test the hypothesis that chronic restoration of vagal nerve activity with a central acetylcholinesterase inhibitor improves insulin sensitivity and reduces adipose tissue oxidation in obese African American…
- Trial name
- RDVCGH (NCT03014323)
- Testing
- Galantamine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Healthy, Metabolic Syndrome
Study of Metabolic Homeostasis in Chinese
In this open-label, acute intervention study, we will recruit 120 sex-matched participants aged 20-70 years (100 normal or overweight/obese subjects and 20 Mets subjects).
- Trial name
- NCT04173728
- Testing
- Standard mixed macronutrients tolerance test
- Where
- China
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Metabolic Syndrome X
Soy Protein Intake and the Metabolic Syndrome
Soy protein has a high biological value, and contains several potential health-related nutritional factors, i.e. its amino acids pattern, biological active peptides and non-protein compounds such as isoflavones.
- Trial name
- SOY (NCT01694056)
- Testing
- Soy protein diet, Control diet
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Healthy
Human Beta-2 Adrenergic Stimulation and Muscle Glucose Uptake
The purpose of this study is to investigate the effect of two weeks clenbuterol/placebo supplementation on skeletal muscle glucose disposal in healthy male volunteers.
- Trial name
- NCT03800290
- Testing
- Clenbuterol Hydrochloride
- Where
- Netherlands
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Healthy
Postprandial Effects of Mixed Herbs and Spices on Pathways Associated With Glucose Homeostasis and Inflammation on PBMCs of Healthy Subjects
This study aims to investigate the effect of mixed of herbs and spices on gene expression of pathways associated with glucose homeostasis, oxidative stress, inflammation and its interrelation with circulating miRNA, in the…
- Trial name
- NCT02931643
- Testing
- High fat challenge breakfast, High fat challenge breakfast with mixed-spices
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Lund University
Atherosclerosis, Type 2 Diabetes (T2D)
Arsenic, Disordered Glucose Homeostasis and Atherosclerosis
Investigators will recruit 250 subjects; Group A will consist of 100 prediabetic patients with an A1c of 5.7%-6.4%. Group B will consist of 100 patients with uncontrolled T2D defined as either a) an A1c of 6.5%-7.9% without…
- Trial name
- EMERALD-D (NCT02759289)
- Where
- United States
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
T2D
The Role of Traditional or Western Diet in the TBC1D4 Gene on Glucose Homeostasis in Greenland Inuits
Studies of Greenland Inuit before the 1980s found a low prevalence of type 2 diabetes (T2D) compared to Western populations. However, recent population studies in Greenland found a notably high prevalence of diabetes (9%) and…
- Trial name
- NCT04011904
- Testing
- Cross-over study
- Where
- Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Insulin Resistance, Type 2 Diabetes Mellitus with Features of Insulin Resistance
NUTRITIONAL INTERVENTION STUDY to EVALUATE the EFFECT of ACHETA DOMESTICUS POWDER CONSUMPTION on GLUCOSE HOMEOSTASIS and INTESTINAL DYSBIOSIS in HEALTHY and PREDIABETIC POPULATION.
A nutritional intervention study is proposed to evaluate the association between the consumption of A. domesticus (insect protein) powder and the effect on insulin resistance and the microbiome, in order to generate personalized…
- Trial name
- DIBAN (NCT06622616)
- Testing
- EVALUATE THE EFFECT OF ACHETA DOMESTICUS POWDER CONSUMPTION ON GLUCOSE HOMEOSTASIS AND INTESTINAL DYSBIOSIS
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- María Isabel Espinosa
Glucose Homeostasis
Dipeptidyl Peptidase-4 Inhibition on Glucagon-like Peptide-1 (GLP-1)
This research is being done to evaluate the effect of glucagon-like peptide-1 (GLP-1, a naturally occurring hormone) on insulin release and to examine whether there is extra insulin release when GLP-1 is not allowed to be rapidly…
- Trial name
- NCT00947011
- Testing
- Januvia
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Appetite and General Nutritional Disorders
The Effects of Whey, Rice and Potato pRotein isOlates on appeTite rEgulatIoN in Healthy Men
INTRODUCTION: Global protein consumption has been increasing for decades due to changes in socio-economic demographics and consumer trends towards higher protein intake, which may be related to their health benefits in…
- Trial name
- PROTEIN (NCT04876495)
- Testing
- Whey protein isolate, Potato protein isolate, Rice protein isolate
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Westminster
MODY-2 Diabetes
The Effect of ß-cell Specific Glucokinase Mutation on Glucose Homeostasis and Insulin Secretion in a MODY-2 Family
Type 2 diabetes mellitus patients exhibit many glucose homeostasis abnormalities in different tissues and organs. Among the more important defects are disturbed hepatic glucose metabolism and defective pancreatic β-cell function.
- Trial name
- NCT01960231
- Testing
- OGTT
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Insulin Resistance
Effects of Intranasal Insulin Administration on Tissue Specific Insulin Sensitivity
Recent research has suggested that intranasally administered insulin can reach the brain quickly without passing through circulation and evoke increased insulin sensitivity and tissue glucose consumption during insulin…
- Trial name
- NASO-PET (NCT02933645)
- Testing
- Actrapid, [18F]-FDG PET-CT, Hyperinsulinemic euglycemic clamp
- Where
- Finland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Overweight
Effects of a Food Preservative on Glucose Homeostasis
The investigators propose to examine the effects of the common food preservative sodium benzoate on blood glucose and related hormones and metabolites.
- Trial name
- NCT01179945
- Testing
- benzoate containing test drinks, non sodium benzoate containing test drinks
- Where
- 2 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Obesity, Metabolic Disease
The Role of Secretin on the Energy Homeostasis
As of last year, new insight into the function of secretin was brought about as rodent studies showed secretin to possess potential body weight-regulating effects.
- Conditions
- Obesity, Metabolic Disease, Diabetes, Adiposity
- Trial name
- THE-ROSE (NCT04613700)
- Testing
- Secretin
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Type 2 Diabetes
Effect of Bile Acid Sequestration on Postprandial GLP-1 Secretion, Glucose Homeostasis and Gut Microbiota
Accumulating evidence suggests that bile acids and bacteria in our intestines may constitute essential components in the complex mechanisms regulating gut hormone secretion and glucose homeostasis.
- Trial name
- NCT02061124
- Testing
- Sevelamer 1600 mg TID for 7 days
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen