Clinical trials: Glucose Homeostasis
Glucose Homeostasis
Postprandial Glucose Handing in Contraceptive and IUD Users
Goals: The long-term use of hormonal birth control has been shown to effect glucose handling, or blood sugar regulation, and potentially lead to insulin resistance which increases a person's risk for metabolic diseases such as…
- Trial name
- HCPG (NCT07169591)
- Testing
- Oral Glucose Tolerance test (75g 2-hour)
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- McMaster University
Prediabetes, Type 2 Diabetes
Effect of Totum-63, Active Ingredient of Valedia, on Glucose and Lipid Homeostasis on Subjects With Prediabetes
Given the data on the active ingredients of Totum-63, this research aims to evaluate the effect of its chronic consumption (24 weeks) on glucose and lipid homeostasis and especially on fasting plasma glucose in volunteers with…
- Conditions
- Prediabetes, Type 2 Diabetes, Hypertriglyceridemia, Obesity
- Trial name
- TOTUM-63 TWO (NCT02868177)
- Testing
- Totum-63
- Where
- 6 sites in France, Ireland and 2 more
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Insulin Sensitivity, 24-hour Glucose Control
Ultra-processed Food Consumption, Gut Microbiota, and Glucose Homeostasis
Advancing age is associated with gut dysbiosis, low-grade chronic inflammation, progressive insulin resistance, and increased risk of type 2 diabetes (T2D).
- Trial name
- NCT05358171
- Testing
- HIgh UPF controlled diet, No UPF controlled diet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Insulin Resistance, Deteriorated Glucose Homeostasis
Insulinotropic Effect of GIP and GLP-1 Before and After Reduced Glucose Tolerance
The incretin effect in patients with type two diabetes is reduced. The investigators have previously shown that it is possible to induce a defect in the incretin effect in healthy individuals.
- Conditions
- Insulin Resistance, Deteriorated Glucose Homeostasis, Inactivity
- Trial name
- NCT01173978
- Testing
- Steroid hormone, No intervention
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Obesity, Insulin Resistance
Synbiotic Therapy on Intestinal Microbiota and Insulin Resistance in Obesity
Background : There is a plausible relationship between microbial gut and insulin resistance. Intervention to prevent insulin resistance by modifying the microbial gut has been proposed but limited studies demonstrates the…
- Trial name
- NCT04642482
- Testing
- Synbiotic (Rillus)
- Where
- Indonesia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hasanuddin University
Glucose Tolerance
Pregnane X Receptor (PXR) Agonist Rifampicin Effects on Glucose, Lipid and Hormone Homeostasis
This clinical trial is designed to study the effects of rifampicin on the glucose, lipid and hormone homeostasis in healthy volunteers.
- Trial name
- NCT00985270
- Testing
- Rifampicin
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Oulu
Hereditary Fructose Intolerance
Fructose Supplementation in Carriers for Hereditary Fructose Intolerance
This study aimed to examine metabolic response to a short-term fructose enriched diet in carriers for hereditary fructose intolerance compared to controls.
- Trial name
- NCT03545581
- Testing
- Experimental diet Fru rich diet, Experimental low Fru diet
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Healthy
Orange Juice Consumption and Glucose Metabolism and Antioxidative Status
Aim of the study is to investigate the impact of orange juice consumption (with meals or between meals) as well as sugar sweetened beverage (SSB) consumption (between meals) on glucose homeostasis and antioxidative status.
- Trial name
- NCT02974478
- Testing
- Orange juice with meals, Orange juice between meals, Sugar sweetened beverage between meals
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Focus of Study: Oral Tolerance Test With Glucose, Lactose, Sucrose
Lactose, Sucrose & Corn Syrup Tolerance
Lactose, one of the key nutrients in human milk may be critically important to infants for more reasons than being a source of energy.
- Trial name
- NCT01789307
- Testing
- corn syrup solids, sucrose
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cardiovascular Risk, Hypercholerolemia
Study of the Effects of Yerba Mate on Cardiometabolic Health
The goal of this clinical trial is to learn if consuming a beverage prepared with yerba mate leaves helps to improve blood lipid levels in persons at high cardiovascular risk.
- Trial name
- INFU-SALUD (NCT06729905)
- Testing
- Yerba mate tea, Control drink
- Where
- Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Instituto de Ciencia y Tecnología de Alimentos y Nutrición
Physiology, Gastroenterology
GIP and GLP-1 on Gastric Emptying, Appetite and Insulin-glucose
Academic phase 1 study which investigates the effects of the two incretin hormones glucose-insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) on gastric emptying, appetite, insulin release and glucose disposal in…
- Conditions
- Physiology, Gastroenterology, Endocrinology
- Trial name
- GIP-GLP-gas (NCT01079624)
- Testing
- Glucose-insulinotropic peptide, Glucagon-like peptide-1
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Uppsala University
PreDiabetes, Impaired Glucose Tolerance
Glucose Homeostasis and Apple Polyphenols
The primary objective is to investigate the effect of apple polyphenol supplementation for 12 weeks on glucose homeostasis in prediabetic individuals.
- Conditions
- PreDiabetes, Impaired Glucose Tolerance, Glucose Metabolism Disorders
- Trial name
- NCT05951270
- Testing
- Apple Polyphenols, Control
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Glucose Tolerance, Lipid Homeostasis
Herbal Preparation and Glucose Homeostasis
Rationale: The incidence of obesity and type 2 diabetes (T2D) is increasing rapidly and accounts for a considerable part of health care costs.
- Conditions
- Glucose Tolerance, Lipid Homeostasis, Vascular Function, Inflammation
- Trial name
- Herbie (NCT02065271)
- Testing
- herbal supplement
- Where
- Netherlands
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Diabetes, Prediabetic
Sleep Effectiveness and Insulin and Glucose Homeostasis
The purpose of this study is to examine the influence of sleep effectiveness on glucose and insulin metabolism in health and disease (prediabetes and type two diabetes).
- Conditions
- Diabetes, Prediabetic, Prediabetes, Glucose Intolerance
- Trial name
- NCT01887691
- Testing
- eszopiclone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Type 2 Diabetes Mellitus
A Phase 1 Study to Investigate the Mechanism of Action of Ipragliflozin
In this study the effect of ipragliflozin on glucose homeostasis in healthy subjects and T2DM subjects, and the effect of exposure of ipragliflozin on urinary glucose excretion and plasma glucose in T2DM subjects will be…
- Trial name
- NCT01611363
- Testing
- ASP1941
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Europe B.V.
Diabetes Mellitus, Type 2
A Study to Determine Acute (After First Dose) and Chronic (After 28 Days) Effects of Empagliflozin (BI 10773) on Pre and Postprandial Glucose Homeostasis in Patients With Impaired Glucose Tolerance and Type 2 Diabetes Mellitus and Healthy Subjects
An open-label, phase II study to assess the acute and chronic effects of empagliflozin (BI 10773)on fasting and postprandial glucose homeostasis in patients with IGT and type 2 diabetes mellitus and assess the acute effects of…
- Trial name
- NCT01248364
- Testing
- BI 10773
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Health
Effects of Coffee Consumption on Health Among Adults
The purpose of this study is to research the changes of typical thermal processing food intervention on health outcome, metabolites, and gut microbiota, in order to explore the molecular mechanism of interaction between maillard…
- Trial name
- NCT03817944
- Testing
- Warm Water, Caffeinated Coffee, Decaffeinated Coffee
- Where
- China
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Prediabetic State, Substrate Oxidation
Effects of 2 Weeks Treatment With Dapagliflozin in Subjects With an Impaired Glucose Homeostasis on Nocturnal Substrate Oxidation
The purpose of this study is to investigate the effect of 2 weeks dapagliflozin treatment in individuals with a disrupted glucose homeostasis on the switch between carbohydrate and lipid oxidation during the night
- Trial name
- MaasFlex (NCT03721874)
- Testing
- Dapagliflozin 10mg
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Morbid Obesity, Metabolic Syndrome
FMT in Obesity: RYGB vs. LEAN vs. Autologous FMT
This double-blinded proof-of-concept study is proposed to explore the effects of fecal microbiota transfer (FMT) in human subjects.
- Conditions
- Morbid Obesity, Metabolic Syndrome, Diabetes, PreDiabetes
- Trial name
- DACH (NCT06268990)
- Testing
- Fecal microbiota transplantation
- Where
- Austria
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Wiebke Kristin Fenske
Healthy, Insulin Resistance
Effects of Hepatic Ultrasound on Metabolic Homeostasis
The purpose of this study is to define the effect of ultrasound exposure of the liver in the region of the porta hepatis on glucose homeostasis and insulin resistance in healthy subjects.
- Trial name
- NCT04622683
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Yale University