Clinical trials: Glucose Metabolism
Type 2 Diabetes Mellitus
A Study of Omarigliptin (MK-3102) in Participants With Type 2 Diabetes Mellitus With Chronic Kidney Disease or Kidney Failure on Dialysis (MK-3102-019)
The purpose of this study is to evaluate the efficacy and safety of omarigliptin in participants with type 2 diabetes mellitus and moderate or severe chronic renal insufficiency or end stage renal disease on dialysis with…
- Trial name
- NCT01698775
- Testing
- Omarigliptin, Glipizide, Insulin
- Volunteers
- 213 people
- Sponsor
- Merck Sharp & Dohme LLC
Obesity, Metabolic Syndrome
Effect of Resvida, a Comparison With Calorie Restriction Regimen
The purpose of this study is to compare the effects of the antioxidant "resveratrol" to a diet intervention (Calorie Restriction) to determine how each of them affects the following: gene expression profile, cholesterol (lipids)…
- Conditions
- Obesity, Metabolic Syndrome, Diabetes, Aging
- Trial name
- Resvida (NCT00823381)
- Testing
- resveratrol, Calorie Restriction
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Type 2 Diabetes
Dynamic in Vivo PET Imaging and ex Vivo Biopsies From Skeletal Muscle and Adipose Tissue to Investigate the Effects of Exercise on Insulin Resistance and Mitochondrial Energetics in Type 2 Diabetes
The overall aim of this pilot study is to investigate the effects of exercise training on skeletal muscle and adipose tissue insulin resistance in subjects with Type 2 Diabetes (T2D).
- Trial name
- EXPET (NCT04754581)
- Testing
- Maximal ATP Production (ATPmax), Exercise Testing (VO2max), Muscle Biopsy
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Type 2 Diabetes
Does the Natural Medicinal Plant St John's Wort Affect the Glucose Tolerance in Healthy Individuals
The goal of the study is to examine if healthy individuals that ingest St John's wort will have a significantly difference in glucose tolerance.
- Trial name
- NCT01921881
- Testing
- St John's wort
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Type 2 Diabetes, Postprandial Lipemia
Differential Effects of Protein Quality on Postprandial Lipemia in Response to a Fat-Rich Meal in Type 2 Diabetes: Comparison of Whey, Casein, Gluten, and Cod Protein
Enhanced and prolonged postprandial triglyceride responses involve increased cardiovascular risk in type 2 diabetes. It has been demonstrated that dietary fat and carbohydrates profoundly influence postprandial…
- Trial name
- NCT00817973
- Testing
- Casein, Whey, Cod
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Aarhus University Hospital
Diabetes Mellitus, Type 2
PMS of Trazenta on the Long-term Use as Add-on Therapy
Study to investigate the safety and efficacy of long-term daily use of Trazenta® Tablets as add-on therapy in patients with type 2 diabetes mellitus.
- Trial name
- NCT01904383
- Testing
- Trazenta
- Where
- Japan
- Volunteers
- 4,057 people
- Sponsor
- Boehringer Ingelheim
Diabetes Mellitus, Cigarette Smoking
The Effectiveness of Smoking Cessation in Prediabetic Smokers
Existing literature investigating the impact of smoking cessation on new-onset diabetes mellitus (DM) risk is conflicting. Combing the need for smoking cessation and body weight self-management to prevent the progression of…
- Conditions
- Diabetes Mellitus, Cigarette Smoking, Prediabetes
- Trial name
- NCT01926041
- Testing
- Varenicline for tobacco smoking cessation, Individualized counseling about both smoking cessation and weight control techniques
- Where
- Taiwan
- Volunteers
- 589 people
- Sponsor
- National Taiwan University Hospital
Dysautonomia in Children With Type 1 Diabetes, Healthy Volunteer
Dysautonomia in Children With Type 1 Diabetes
Some physiological factors, such as physical activity, or pathological factors, such as sepsis or diabetes, are known to modulate the overall autonomic activity and the individual's intrinsic capacity to regulate their…
- Trial name
- DYSDIAB (NCT07455994)
- Testing
- Neurocoach® and Sudoscan®
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Hypertension, Cardiovascular Disease
Socioeconomic Status, Psychosocial Factors, and CVD Risk in Mexican-American Women
Cardiovascular disease (CVD) is the leading cause of death in American women, claiming on average 40% of all female deaths each year.
- Conditions
- Hypertension, Cardiovascular Disease, Metabolic Disorders
- Trial name
- NCT00387166
- Where
- United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Atherosclerosis, Coronary, Diabetes Mellitus
Fat Around Heart Arteries as a Measure of Inflammation in Patients With Diabetes
In this prospective study, the objective is to investigate inflammation in the arteries of the heart. A heart CT scan (CCTA) will be used to measure inflammation by assessing the fat tissue surrounding the arteries of the heart.
- Conditions
- Atherosclerosis, Coronary, Diabetes Mellitus, Diabetes Mellitus Type 2, Inflammation
- Trial name
- PCAT-DM (NCT06644651)
- Where
- Denmark
- Volunteers
- 314 people
- Sponsor
- Odense University Hospital
Colorectal Disease
The Effect of the Preoperative Oral Carbohydrate Attenuating Immediate Postoperative Insulin Resistance on PI3K Dependent Signaling Pathway
The purpose of this study is to delineate the effects of preoperative oral carbohydrate on immediate postoperative insulin resistance (PIR) in patients undergoing elective open colorectal cancer resection, and to further clarify…
- Trial name
- NCT00755729
- Testing
- Preoperative Oral Carbohydrate
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Shanghai Changzheng Hospital
Hyperglycemia
Efficacy and Safety of Angelica Gigas N. Extract on Improvement of Hyperglycemia
This study was conducted to investigate the effects of daily supplementation of Angelica gigas N. extract on improvement of Hyperglycemia .
- Trial name
- NCT03258229
- Testing
- Angelica gigas N. extract
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Diabetes Type 2, Hematologic Malignancy
Effect of Smartphone App on Activity
A smartphone app will be installed on smartphones of patients with type 2 diabetes or hematologic malignancies that do not exercise. The app will send SMS messages to encourage exercise.
- Trial name
- NCT02612402
- Testing
- messages generated by learning algorithm, constant weekly message reminding patient to exercise
- Where
- Israel
- Volunteers
- 270 people
- Sponsor
- Rambam Health Care Campus
Diabetes Mellitus, Type 2, Frailty
Power Strength Training in Type 2 Diabetic Mellitus Older Adults
Diabetes is a disease with a high impact in the population older than 65 years old. Some indications suggest that diabetes in the old age aggravate the negative effects of ageing, as the loss of muscle mass and strength, bringing…
- Trial name
- DIAPOW (NCT04332302)
- Testing
- Power resistance training
- Where
- Spain
- Volunteers
- 41 people
- Sponsor
- Technical University of Madrid
Type 2 Diabetes Mellitus
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus on Background Insulin
The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron compared with placebo in adults with Type 2 Diabetes Mellitus (T2DM), treated with a background insulin and other background…
- Trial name
- Eluminate-3 (NCT07664553)
- Testing
- Elecoglipron
- Where
- 132 sites in United States, Australia and 11 more
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
Diabetes
Effect of Vildagliptin in Type 2 Diabetes Treated With Sulphonylurea and Metformin
Dual combination therapy with metformin and sulphonylurea is the most commonly used combination regimen to treat patients with type 2 diabetes.
- Trial name
- NCT01099137
- Testing
- Vildagliptin, Sulphonylurea dose-up
- Where
- South Korea
- Volunteers
- 344 people
- Sponsor
- Seoul National University Bundang Hospital
Diabetes Mellitus
Multiple Grain in Type 2 Diabetes
We aim to investigate the beneficial effect of adding grain fiber to daily rice meal in type 2 diabetic patients. We anticipate this intervention will improve glycemia and lipid profile in these patients.
- Trial name
- NCT00337337
- Testing
- Multiple grain, Ordinary Asian- rice
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Cheng-Kung University Hospital
Fatty Liver, Nonalcoholic
The Impact Of SGLT2 -I on Metabolic Dysfunction -Associated Steatotic Liver Disease In Patients With Type 2 Diabetes Mellitus
Study question 1:Could SGLT2-I improve hepatic fibrosis, steatosis, and inflammatory markers in type 2 diabetic patients with Metabolic associated steatotic liver disease Question 2:Which drug of SGLT2-I group is more effective…
- Trial name
- NCT06117137
- Testing
- SGLT2 inhibitor
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Sohag University
Diabetes Mellitus, Type 2
Treatment of GLP-1 for Diabetic Bariatric Patients
This study is for patients that are diabetic, and require insulin for glycemic control, and going through the bariatric surgery process.
- Trial name
- NOVO-GLP1 (NCT04624672)
- Testing
- Semaglutide (1 Mg Dose)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Geisinger Clinic
Pre Diabetes, Prediabetic State
Study to Assess the Effects of Non Digestible Carbohydrates on Long-Term Glucose Homeostasis in Untreated Prediabetic Subjects
This clinical study aims to prove that the efficacy of non digestible carbohydrates supplementation (daily dose of 20 grams consumed twice a day for 12 weeks) on the regulation of glucose homeostasis is superior than placebo in…
- Conditions
- Pre Diabetes, Prediabetic State, Dysglycemia, PreDiabetes
- Trial name
- FOS_GLUCOSE (NCT04767672)
- Testing
- Non digestible carbohydrates
- Where
- 3 sites in France
- Volunteers
- 66 people
- Sponsor
- Tereos
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