Clinical trials: Glucose Metabolism
Postprandial Glycemia, Postprandial Insulinemia
A Human Clinical Trial Evaluating the Effect of MealShape™ on Blood Glucose Level Following Consumption of Standard Meal
The purpose of the study is to evaluate the effect of MealShape, a Ceylon cinnamon extract (Cinnamomum zeylanicum) on blood glucose and insulin response after consumption of a standard meal composed of white bread, in healthy…
- Trial name
- NCT02074423
- Testing
- MealShape cinnamon extract
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Dialpha
Diabetes Mellitus, Healthy Volunteers
Impaired Wound Healing in Diabetic Foot Ulceration
An observational study to gather information about people who may have certain abnormalities in skin microcirculation and muscle metabolism and to determine whether these abnormalities affect wound healing.
- Trial name
- EPC (NCT00739323)
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Pre-diabetes, Diabetes
Gender Differences in Prevalence of Undiagnosed Diabetes in ACS
The primary goal of this study is to measure the prevalence of undiagnosed pre-diabetes/diabetes among women hospitalized with acute coronary syndromes (ACS) compared to men.
- Trial name
- NCT00589459
- Where
- 2 sites in United States
- Volunteers
- 103 people
- Sponsor
- Yale University
Hypoglycaemia
Recurrent Hypoglycaemia in Type 1 Diabetes
Patients with type 1 diabetes are at risk of very low blood sugar levels (hypoglycaemia) as a severe side effect to insulin therapy, in particular subjects who have lost warning of hypoglycaemia.
- Trial name
- HypoNeuro (NCT01337362)
- Testing
- Insulin clamp
- Where
- Denmark
- Volunteers
- 23 people
- Sponsor
- Hillerod Hospital, Denmark
Diabetes Mellitus
Headspace Mindfulness App Trial
The study is a prospective, randomized, non-blinded comparative group clinical trial comparing participants who receive access to a mindfulness software app, Headspace, to those who receive standard care (i.e., a list of…
- Trial name
- NCT03274362
- Testing
- Headspace Mindfulness App
- Volunteers
- 80 people
- Sponsor
- BCDiabetes.Ca
Obesity
Secretin Activates Human Brown Fat and Induces Satiation.
15 healthy males will be studied with PET/CT, using FDG to investigate glucose metabolism, and radiowater to investigate perfusion.
- Trial name
- GUTBAT (NCT03290846)
- Testing
- Secretin Human, Saline Solution, Cold exposure
- Where
- Finland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Type 1 Diabetes, Type 1 Diabetes Mellitus
Alleviating Carbohydrate Counting for Patients With Type 1 Diabetes Using a Novel Insulin-plus-pramlintide Artificial Pancreas
One of the main challenges in maintaining tight glucose control in a closed-loop system occurs at meal times. Amylin is a gluco-regulatory beta-cell hormone that is co-secreted with insulin in response to nutrient stimuli, and is…
- Conditions
- Type 1 Diabetes, Type 1 Diabetes Mellitus, Hyperglycemia, Postprandial
- Trial name
- NCT04163874
- Testing
- Fiasp, Pramlintide Acetate, Artificial Pancreas
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- McGill University
Prostate Cancer
Prospective Study of Insulin Resistance and Cardiovascular Disease Risk During Androgen Deprivation Therapy for Prostate Cancer
The purpose of this study is to find out if androgen deprivation therapy affects insulin, cardiac risk factors such as cholesterol level, and body fat and muscle.
- Trial name
- NCT00455624
- Testing
- Androgen deprivation therapy
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Type 2 Diabetes
The Impact of Free Fatty Acid (FFA-) Suppression on Myocardial Lipids and Function in Patients With Type 2 Diabetes
There is evidence that inhibition of FFA-release by acipimox is associated with a significant decrease in myocardial lipid content (MYCL) as well as the ejection fraction (as a marker of systolic left ventricular function) in…
- Trial name
- HYPOTESIS (NCT01980524)
- Testing
- acipimox
- Where
- Austria
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Alzheimer s Disease, Alzheimer Blood Biomarkers
Effect of Physiologic Insulin Administration on Insulin Sensitivity and Cognition
The goal of this clinical trial is to determine if a weekly delivery of insulin at short intervals lasting up to 2 hours can improve insulin sensitivity and cognition in adults with Alzheimer's Disease.
- Conditions
- Alzheimer s Disease, Alzheimer Blood Biomarkers, Insulin Sensitivity
- Trial name
- MIND-IT (NCT07265323)
- Testing
- Physiological Insulin Intervention
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Pennington Biomedical Research Center
Obesity
The Therapeutic Effects of Topiramate and Metformin on Second Generation Antipsychotics-induced Obesity
The primary aim of the study is to investigate the efficacy of metformin and topiramate on second-generation antipsychotic-induced obesity. The secondary domain we look at is the adverse effects of both drugs.
- Trial name
- NCT01384279
- Testing
- metformin, topiramate
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Beitou Armed Forces Hospital, Taipei, Taiwan
Obesity, Diabetes
Effects of High-Dose Resveratrol in Non-Diabetic Obese Males
The primary aim of our study was to examine the effects of two weeks of oral resveratrol on resting energy expenditure and insulin sensitivity in non-diabetic obese male subjects.
- Trial name
- NCT02247596
- Testing
- Resveratrol
- Where
- Singapore
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Khoo Teck Puat Hospital
Painful Diabetic Neuropathy, Diabetic Neuropathy
Study of Clonidine Hydrochloride Topical Gel, 0.1% in the Treatment of Pain Associated With Diabetic Neuropathy
The purpose of the study is to determine whether clonidine gel is an effective treatment for reducing the pain associated with painful diabetic neuropathy.
- Conditions
- Painful Diabetic Neuropathy, Diabetic Neuropathy, Neuropathy
- Trial name
- NCT02068027
- Testing
- Clonidine Gel 0.1%
- Where
- 23 sites in United States
- Volunteers
- 260 people
- Sponsor
- BioDelivery Sciences International
NAFLD, Pre-diabetes
Effect of Metadoxine on Oxidative Stress in Non-alcoholic Hepatic Steatosis
Oxidative stress is produced by imbalance between reactive oxygen species and antioxidant systems. This state is frequently associated with chronic diseases like obesity, insulin resistance, metabolic syndrome and hepatic…
- Trial name
- NCT02051842
- Testing
- Metadoxine
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Diabetes Mellitus, Non-Insulin-Dependent
A Research Study to Determine the Safety and Efficacy of Glucovance Compared to Metformin and Glyburide in Children and Adolescents With Type 2 Diabetes.
The purpose of this clinical research study is to see if Glucovance, a medication currently approved for use in adults with type 2 diabetes, can control type 2 diabetes safely and effectively in children 9 to 16 years of age.
- Trial name
- NCT00035542
- Testing
- Glucovance (metformin HCl/glyburide), metformin HCl, glyburide
- Where
- 50 sites in United States
- Sponsor
- Bristol-Myers Squibb
Type 2 Diabetes
Clinical Trail of Tang-min-Ling Pills in Type 2 Diabetes Mellitus
This is a randomized, doubled blind, dose-paralleled control, multi-centre clinical trail,to evaluate the efficacy of Tang-min-ling pills in the treatment of type 2 diabetes mellitus.
- Trial name
- NCT01087242
- Testing
- Tang-min Lin pill
- Where
- 4 sites in China
- Volunteers
- 480 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Diabetes type2, Obesity
The RESET System Pivotal Clinical Trial (Protocol Revision K)
A Randomized, Multi-Center, Pivotal Efficacy and Safety Study Evaluating the RESET System for Glycemic Improvement in Patients with Inadequately Controlled Type 2 Diabetes and Obesity, the STEP-1 Study.
- Trial name
- STEP-1 (NCT04101669)
- Testing
- RESET Liner
- Where
- 27 sites in United States
- Volunteers
- 264 people
- Sponsor
- Morphic Medical Inc.
Diabetes Mellitus, Type 1
Flexible, Intensive Insulin Therapy in Patients With Type 1 Diabetes
To prospectively evaluate the long term metabolic and psychological effects of flexible intensive insulin therapy (FIT) courses in an unselected population of type 1 diabetic patients at the University of Basel Hospital.
- Trial name
- NCT00595569
- Testing
- Flexible insulin therapy (FIT)
- Where
- Switzerland
- Volunteers
- 45 people
- Sponsor
- University of Lausanne Hospitals
Type 2 Diabetes Mellitus
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-06882961 in Japanese Adults With Type 2 Diabetes Mellitus
This is a Phase 1, randomized, double blind (sponsor open), parallel, placebo controlled, twice daily oral dosing study of PF 06882961 in adult Japanese participants with T2DM inadequately controlled on diet and exercise alone.
- Trial name
- NCT04552470
- Testing
- PF-06882961
- Where
- Japan
- Volunteers
- 37 people
- Sponsor
- Pfizer
Metabolic Syndrome X, Inflammation
Effect of Dietary Flavonoids on Intestinal Microbiota, Intestinal Inflammation and Metabolic Syndrome
The investigators have hypothesized that dietary flavonoids reduce insulin resistance and subclinical inflammation secondary to reductions in intestinal inflammation and permeability and that these events are mediated through…
- Trial name
- NCT02728570
- Testing
- High Dietary Flavonoids, Low Dietary Flavonoids
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Utah State University
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