Clinical trials: Glucose Regulation
Diabetes, Prediabetes
Meta-analyses of the Effect of Dietary Pulses on Acute Postprandial Metabolic Control
Dietary pulses (beans, peas, chickpeas, and lentils), more commonly known as "legumes", are generally recognized as healthy components of the diet.
- Conditions
- Diabetes, Prediabetes, Dysglycemia, Overweight
- Trial name
- NCT01605422
- Testing
- Dietary pulses
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Excessive Weight Gain During Pregnancy, Gestational Diabetes
Intervention to Promote Changes of Healthy Lifestyle (Physical Activity and Nutrition) During Gestation
The purpose of this study are: Assess the impact of an intervention to the adoption of healthy lifestyles among pregnant women at high risk of gestational diabetes mellitus on: weight gain in pregnancy the levels of maternal and…
- Trial name
- NCT01782105
- Testing
- Healthy lifestyle counseling, Control group
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Université de Sherbrooke
Obesity
Sugar-replacement Sweeteners, and Blood Sugar Control
Several sugar-replacement sweeteners are currently on the market, including saccharine (ex. Sweet'N Low), aspartame (ex. Equal), and sucralose (ex. Splenda).
- Trial name
- SIR (NCT01128829)
- Testing
- Water, Sucralose
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Diabetes, Type 2, Non-Insulin Dependent
Comparative Effectiveness of Prescribed Adapted Physical Activity (APA), Either Practiced Independently After Training, or Supervised by an APA Teacher, on Glycemic Regulation in People With Unbalanced Type 2 Diabetes.
Comparative effectiveness on glycemic balance of a non-pharmacological treatment, Adapted Physical Activity (APA), either supervised by a qualified APA instructor or unsupervised in autonomy, in individuals with inadequately…
- Conditions
- Diabetes, Type 2, Non-Insulin Dependent, Poorly Controlled Diabetes Mellitus
- Trial name
- ACTIDIAB (NCT06598865)
- Testing
- adapted physical activity
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Type 1 Diabetes
Technology-delivered Physical Activity Program for Adolescents With Type 1 Diabetes
This project is comprised of a two-arm randomized control trial (RCT) testing the feasibility, acceptability, and preliminary efficacy of a nationally scalable program, Activate, a 12-week, technology-delivered diabetes…
- Trial name
- Activate (NCT05319600)
- Testing
- Diabetes behavior change skills training, Physical activity promotion program
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Vermont
Gestational Diabetes Mellitus
Study of Pregnancy Regulation of Insulin and Glucose
It is unknown whether beta cell dysfunction and insulin resistance in Gestational Diabetes Mellitus (GDM) is representative of a chronic maternal defect, unmasked by pregnancy, or whether it is the result of an imbalance of a…
- Trial name
- SPRING (NCT02763267)
- Testing
- Oral glucose tolerance test
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Massachusetts General Hospital
Type2 Diabetes, Cardiovascular Diseases
Peanuts and Glycemic Control
A two-period randomized crossover study will be conducted to determine the effect of peanuts on glycemic control, and elucidate the role of the microbiome in glucose regulation, in individuals with impaired fasting glucose.
- Trial name
- NCT03654651
- Testing
- Peanut, High carbohydrate snack
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Penn State University
Diabete Type 2, Obesity
Effects of Plant Based Lipids on Glucose Regulation and Cognitive Variables
The overall goal is to increase the knowledge that can be used for the development of food products with anti-diabetic properties, with the purpose to facilitate healthier food choices for people.
- Trial name
- NCT05276128
- Testing
- lipids
- Where
- 2 sites in Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Lund University
Insulin Resistance Syndrome
Diagnostic Interest of the IRAP Protein (Insulin Regulated Amino Peptidase) in Insulin Resistance
There is currently no reliable, diagnostic tests of insulin resistance other than the hyperinsulinemic euglycemic clamp which, due to its constraints and cost, is reserved for research.
- Trial name
- IRAP-IR (NCT04028895)
- Testing
- Dosage of IRAP during OGTT
- Where
- 4 sites in France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Prediabetic State
Effects of Branch Chain Amino Acids on Glucose Tolerance in Obese Pre-Diabetic Subjects
Branching chain amino acids (BCAA) have both beneficial and detrimental effects of on metabolism have been established and therefore warrants further investigation.
- Trial name
- BCAA (NCT02684565)
- Testing
- BCAA High Protein supplement, BCAA Low Protein supplement
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, Los Angeles
Postprandial Glucose Regulation
Health Effects of Oats and Oat Bioactive in Human
Aim of the study is to investigate health effects of oats and oat derived components, in human intervention studies, with the purpose to build new knowledge for development of cardiometabolic protective foods.
- Trial name
- NCT03830736
- Testing
- Oat Beverage 1, Oat Beverage 2, Oat Beverage 3
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Lund University
Insulin Resistance
The Effect of Vasopressin on Glucose Regulation
Data from experimental animals and human epidemiological studies have suggested that hypohydration and/or low water intake is linked to poor glucose regulation and diabetes.
- Trial name
- HYPERGlu (NCT02761434)
- Testing
- Hypertonic Saline (3% NaCl), Isotonic Saline (0.9% NaCl)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Arkansas, Fayetteville
Appetitive Behavior
Active Video-game Playing and Food Intake in Children
The purpose of this experiment is to investigate the effect of active video game playing for 30 minutes on food intake and subjective appetite.
- Trial name
- NCT03722251
- Testing
- Glucose beverage, control beverage, glucose beverage and active video game playing, control beverage and active video game playing
- Where
- Canada
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Obesity, Type II Diabetes Mellitus
Yellow Pea Fractions and Short-term Food Intake, Subjective Appetite and Glycemic Response
It is hypothesized that yellow pea protein and fiber will reduce short-term food intake, subjective appetite and glycemic response.
- Conditions
- Obesity, Type II Diabetes Mellitus, Metabolic Syndrome
- Trial name
- NCT01242059
- Testing
- yellow pea protein, yellow pea fiber, Control
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetes Mellitus, Type 2
Evaluation of the Efficacy and Safety of DBL-4pen Mobile Application in Patients With Type 2 Diabetes
This study conducted in 40 adults living with type 2 diabetes is an interventional single-arm open-label before/after multicentric national study conducted as a clinical investigation according to the law EU 2017/745 art. 62.
- Trial name
- SERENIT2 (NCT05733962)
- Testing
- Use of the device DBL-4pen
- Where
- 4 sites in France
- Volunteers
- 40 people
- Sponsor
- Diabeloop
Polycystic Ovary Syndrome
Cortisol Regulation in Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine if insulin resistance (how well the body uses insulin and clears sugar) can affect cortisol levels in normal healthy women and women with polycystic ovary syndrome of all body weights.
- Trial name
- NCT00694759
- Testing
- pioglitazone, metformin
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Disorder of Glucose Regulation
The Glycaemic Effects of Glucerna® in Critically Ill Patients.
To investigate whether the administration of Glucerna achieves less glycaemic variability, defined as the mean absolute glucose (MAG) change, and better glycaemic control compared to a standard high-carbohydrate enteral formula.
- Trial name
- GluCip (NCT02594865)
- Testing
- Glucerna, Fresubin
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- PHJ van der Voort
Focus of Study: Oral Tolerance Test With Glucose, Lactose, Sucrose
Lactose, Sucrose & Corn Syrup Tolerance
Lactose, one of the key nutrients in human milk may be critically important to infants for more reasons than being a source of energy.
- Trial name
- NCT01789307
- Testing
- corn syrup solids, sucrose
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Hypertension
High-Dose Quinapril Versus Low-Dose Quinapril Plus Amlodipine in the Treatment of High-Risk Hypertensive Patients
The purpose of this study is to compare the impact of two blood pressure lowering treatments (high dose quinapril versus low dose quinapril plus amlodipine) on variations in heart rate over 24 hours.
- Trial name
- NCT00313547
- Testing
- Quinapril 40 mg, Quinapril 10 mg and amlodipine 5 mg
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Montreal Heart Institute
Obesity, Appetite Regulation
Tailoring Obesity Treatment Trial
The two main aims of this clinical study is; 1. To investigate if the results from a series of physiological tests and questionnaires prior to treatment, can be used to predict the treatment response to obesity medication 2.
- Conditions
- Obesity, Appetite Regulation, PreDiabetes
- Trial name
- TOTT (NCT06619015)
- Testing
- Pramlintide Acetate 1 MG/ML, Semaglutide Pen Injector, Sodium Chloride 0.9% Inj
- Where
- Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark