Clinical trials: Glucose Regulation
Insulin Resistance
Regulation of KATP Channels and Na+/K+ ATPase in Relation to Fatigue Development
To investigate the role of ATP sensitive K+ potassium channels and the Na+/K+ pump in the development of fatigue in healthy and in insulin resistant subjects.
- Trial name
- NCT03775902
- Testing
- Nicorandil
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Schizophrenia
Glucose Regulation During Risperidone and Olanzapine Treatment
The overall purpose of this research is to look at how two of the most commonly prescribed newer antipsychotic medications, risperidone and olanzapine, affect substances in the body such as glucose and insulin.
- Trial name
- NCT00006195
- Testing
- risperidone, olanzapine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Type 2 Diabetes, Atherosclerosis
The Copenhagen Insulin and Metformin Therapy Trial
Type 2 Diabetes Mellitus patients (T2DM) have an increased mortality rate due to macrovascular disease. The primary objective of the study is to evaluate the effect of an 18-month treatment with metformin versus placebo in…
- Conditions
- Type 2 Diabetes, Atherosclerosis, Arteriosclerosis
- Trial name
- CIMT (NCT00657943)
- Testing
- metformin, insulin detemir, insulin aspart + insulin aspart protamin
- Where
- 9 sites in Denmark
- Volunteers
- 415 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 2 Diabetes
Regulation of Tissue Lipolysis by Insulin in Type 2 Diabetes
Inadequate suppression of intramuscular and adipose tissue lipolysis, and consequent excessive delivery of fatty acids to ectopic tissues (e.g.
- Trial name
- NCT01680133
- Testing
- Hyperinsulinemic euglycemic clamp
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Glycemic Control, Diet, Food and Nutrition
Using CGM for Evaluating Effects of Food on Glucose Regulation in Healthy Humans
The specific goal of this pilot study is to evaluate if it is possible to detect a statistical difference in postprandial glycemia after meals served with and without a drink previously shown to reduce postprandial glycemia by…
- Trial name
- NCT04848233
- Where
- Sweden
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- DoubleGood AB
Diabetes
Regulation of Hepatic Insulin Extraction
This study is in the area of Type 2 diabetes and genetics Healthy Volunteers and those with mild type 2 diabetes may be eligible to participate This study is searching for genes that may affect the body's processing/digestion of…
- Trial name
- RHIE (NCT00811044)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Thrombosis, Type 2 Diabetes Mellitus
Fatty Acid Regulation of Platelet Function in Diabetes
This study investigates the potential protective effects of altering fatty acid in the platelet as a method for prevention of platelet activation and thrombosis in type 2 diabetes mellitus.
- Trial name
- NCT02373332
- Testing
- omega-3 and -6 fatty acids and their 12-LOX oxylipins
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Dyslipidaemia, Insulin Resistance
Regulation of Intestinal and Hepatic Lipoprotein Secretion by Resveratrol
Resveratrol, an ingredient of red wine and available in Canada in highly purified form as an over-the-counter health supplement, has been shown to have a number of health benefits.
- Trial name
- NCT01451918
- Testing
- Resveratrol
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Obesity
Sleep and Obesity in Teenagers
This study aims to investigate 1. whether sleep extension results in improvements of endocrine and metabolic markers of obesity and diabetes in obese teenagers, 2.
- Trial name
- NCT00841347
- Testing
- habitual sleep length period + extended sleep length period, extended sleep length period + habitual sleep length period
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Diabetes
Acute Regulation of Intestinal and Hepatic Lipoprotein Production by Glucagon
Insulin resistant states are characterized by hepatic lipoprotein (VLDL) particle overproduction. Numerous hormonal and nutritional factors are known to influence hepatic lipoprotein particle production, including insulin and…
- Trial name
- Glucagon (NCT01155206)
- Testing
- glucagon
- Where
- Canada
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Abdominal Obesity, Metabolic Syndrome
Acupuncture in the Regulation of Dai Meridian for the Metabolism of Visceral Adipose Tissue in Abdominal Obese Patients
To evaluate the effectiveness of acupuncture therapy combined with healthy education for patients with abdominal obesity.
- Trial name
- NCT02427347
- Testing
- Acupuncture, Healthy education
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Dongfang Hospital Beijing University of Chinese Medicine
Spinal Cord Injuries, Type 2 Diabetes
Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord Injury and Type 2 Diabetes
It is not known whether a new diabetes drug, semaglutide, is an effective treatment for type 2 diabetes for persons with spinal cord injury (SCI), a population at higher risk for this condition.
- Trial name
- NCT06706284
- Testing
- Semaglutide Injectable Product
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Marzieh Salehi
The Focus of the Study is Healthy Volunteers
Appetite Regulation by a Breakfast Soft Bread
The aim of this study is to evaluate the appetite rating of a soft bread with a high content of fibre and protein (Puravita Breakfast®) as well as its capacity to modulate postprandial levels of glucose, insulin and…
- Trial name
- NCT02090049
- Testing
- Puravita Breakfast, Control
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Puratos
Type 1 Diabetes Mellitus, Sleep
Sleep and Glucose Regulation in Youth With Type 1 Diabetes Mellitus
The purpose of this project is to look at how sleep affects glucose values in children with Type 1 Diabetes Mellitus. It will also evaluate if glucose is affected by times of day due to the body's own internal rhythm also known…
- Trial name
- NCT00848822
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Arizona
Obesity, Diabetes Mellitus
Activating Brown Adipose Tissue Through Exercise
The energy burning capacity of brown adipose tissue makes it an attractive target for anti-obesity therapies. Sympathetic nervous system (SNS) is the classical regulator of brown adipose tissue; however, recent findings show a…
- Conditions
- Obesity, Diabetes Mellitus, Metabolic Syndrome X
- Trial name
- ACTIBATE (NCT02365129)
- Testing
- Exercise training based on recommendations for adults (WHO)
- Where
- Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Type 2 Diabetes, Systolic Hypertension
Blood Pressure Outcomes With Liraglutide Therapy
Purpose: The purpose of this study is to further study the mechanism by which liraglutide, a relatively new anti-hyperglycemic medication, might lower blood pressure in patients with Type 2 diabetes and high blood pressure.
- Trial name
- BOLT (NCT01755572)
- Testing
- Liraglutide
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Mount Sinai Hospital, Canada
Hypoglycemia, Type 1 Diabetes
Effect of C-peptide on Hypoglycemic Counterregulation
Iatrogenic hypoglycemia is the most prominent barrier to the safe, effective management of blood sugar in people with type 1 diabetes due to periodic over-insulinization.
- Trial name
- NCT06470295
- Testing
- Saline, C-peptide
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Hyperglycemia, Obesity Prevention
The Impact of Low Glycemic Index Nutritional Shake on Glucose Regulation in Overweight and Obese Adults
Low glycemic index nutritional shakes have clinically shown to improve post-prandial glycemic responses in acute laboratory control studies.
- Trial name
- SHAKE (NCT06856460)
- Testing
- powder shake with very low glycemic index, Ceral Breakfast
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Hyperlipidemia
Regulation of Intestinal and Hepatic Lipoprotein Production by Glucose and Fructose
Increased postprandial plasma triglycerides are associated with increased cardiovascular risk. Chronic consumption of carbohydrates is associated with increased levels of triglycerides.
- Trial name
- glucose (NCT01694446)
- Testing
- Intraduodenal glucose or fructose
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Schizophrenia
A Clinical Study That Will Assess the Effect of SEP-363856 and Prior Antipsychotic (PA) Standard of Care on Glucose and Regulation of Insulin in Patients With Schizophrenia
A Clinical Study that will look at an investigational medication, SEP-363856 (called "study medication") in patients with schizophrenia and assess whether it changes: how the body processes (uses) glucose (blood sugar) how much…
- Trial name
- NCT05463770
- Testing
- SEP-363856
- Where
- 8 sites in United States
- Volunteers
- 15 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.