Clinical trials: Glucose Variability, open to volunteers
Peripheral Neuropathy With Type 2 Diabetes
A Physiologic Comparison of Two Approaches to Treating Peripheral Neuropathy
Diabetic peripheral neuropathy is one of the most common and costly microvascular complications of diabetes impacting more than 50% of patients and costing more than 10.1 billion dollars annually.
- Trial name
- NCT05577390
- Testing
- Intraneural Facilitation Therapy Treatment, Standard Physical Therapy Treatment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Loma Linda University
Diabetes Mellitus Type 2
Medium-term Effects of a Polyphenol-rich Beverage Based on Red Grape Pomace Extract on Non-alcoholic Fatty Liver Disease, Cardiometabolic Risk Profile and Gut Microbiota in Subjects with Type 2 Diabetes
Nonalcoholic fatty liver disease (NAFLD) is a liver disease characterized by an abnormal accumulation of fat not due to alcohol or drug consumption that can evolve into steatohepatitis (NASH), fibrosis and cirrhosis.
- Trial name
- PoLiFat (NCT06895018)
- Testing
- Supplementation with Polyphenol Rich Drink
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Federico II University
Hypertension, Insulin Resistance Syndrome
Cf-PWV and TyG Index Study
This study aims to investigate how metabolic health is related to arterial stiffness and daily blood pressure patterns. High blood pressure is one of the leading causes of heart disease worldwide, but cardiovascular risk is not…
- Conditions
- Hypertension, Insulin Resistance Syndrome, Arterial Stiffness, Cardiovascular Risk
- Trial name
- RIGID-TyG (NCT07589374)
- Where
- Brazil
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Hospital de Base
Insulin Resistance
Impact of Starch Digestibility on Glycemic Variability and Control, Cardiometabolic and Inflammatory Profiles, Microbiota and Intestinal Health in Subjects With Insulin Resistance
To study the potential impact of a diet rich in both Slowly Digestible Starch (SDS) and Resistant Starch (RS), we propose a 2-month nutritional intervention study in which we will study the evolution of carbohydrate variability…
- Trial name
- GLYMICARE (NCT07408479)
- Testing
- Balanced diet high in Slowly Digestible Starch and Resistant Starch, Balanced diet low in Slowly Digestible Starch and Resistant Starch
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.
Type 1 Diabetes
Artificial Pancreas Technology to Reduce Glycemic Variability and Improve Cardiovascular Health in Type 1 Diabetes
This study will examine the potential cardiovascular effect(s) of artificial pancreas (AP) technology in patients with type 1 diabetes.
- Trial name
- WBH002 (NCT05653518)
- Testing
- Tandem t:slim X2 with Control-IQ Technology, Sensor augmented pump (SAP) therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Prediabetes
Effects of a Mediterranean Diet With Sequential Cycling and Rowing Exercise on Blood Sugar in Women With Prediabetes or Prediabetes Remission
The goal of this clinical trial is to learn how a Mediterranean-style diet, with and without added exercise, affects blood sugar control in women with prediabetes.
- Trial name
- NCT07326891
- Testing
- Mediterranean Diet, Supervised Sequential Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Begüm Yücesoy Güneysu
Prediabetes
Effects of Autonomic Nervous System Modulation by Heart Rate Variability Biofeedback Training With Resonant Frequency Breathing on Glucose Metabolism in Individuals With Prediabetes
Approximately 20% of adults have prediabetes in Germany. Prediabetes is defined as a condition with glucose levels outside the normal range but not yet meeting the criteria for type 2 diabetes.
- Trial name
- RwHRVBFinPD (NCT06739993)
- Testing
- Resonance frequency breathing with heart rate variability biofeedback training, Anti-Stress program
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Johannes Gutenberg University Mainz
Glycemic Variability in Coronary Patients
Effect of Glucose Variability on Morbidity and Mortality in Diabetic Patients Admitted in Coronary Care Unit
The study is to assess the effect of glycemic variability on morbidity and mortality in diabetic patient during admission in Coronary care unit in sohag university.
- Trial name
- NCT07506824
- Volunteers
- 120 people
- Sponsor
- Sohag University
Cardiac Surgery, Insulin Resistance
Impact of Preoperative Oral Carbohydrate Loading on Insulin Resistance in Pediatric Cardiac Surgery Patients
Surgical stress and preoperative fasting can induce insulin resistance, characterized by impaired cellular response to insulin and resulting hyperglycemia.
- Conditions
- Cardiac Surgery, Insulin Resistance, Pediatric Cardiac Surgery
- Trial name
- NCT07729280
- Testing
- Carbohydrate
- Where
- Indonesia
- Volunteers
- 44 people
- Sponsor
- Rifdhani Fakhrudin Nur
PreDiabetes, Heart Rate Variability (HRV)
Effects of Walking in Greenspace and the Built Environment in Adults With Prediabetes: A Randomized Crossover Trial
The goal of this randomized crossover trial is to compare the differences in psychological and physiological effects of walking in two different outdoor environments (urban/suburban commercial environments vs.
- Conditions
- PreDiabetes, Heart Rate Variability (HRV), Stress and Anxiety, Stress Biomarkers
- Trial name
- NCT06365723
- Testing
- Nature-based Walking, Built-environment/Commercial Walking
- Where
- 3 sites in United States
- Volunteers
- 216 people
- Sponsor
- University of Minnesota
Type 2 Diabetes (T2DM), Hyperglycemia
CGM-Based Glycemic Analysis After ESI
The goal of this clinical study is to learn how blood glucose levels change after an epidural steroid injection (ESI) with dexamethasone in adults.
- Conditions
- Type 2 Diabetes (T2DM), Hyperglycemia, Radicular Pain, Spinal Stenosis
- Trial name
- CGMSteroid (NCT07280780)
- Testing
- Epidural Steroid Injection, Continuous Glucose Monitoring
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Korea University Anam Hospital
T1DM, Sleep Disorders, Circadian Rhythm
Influence of Circadian Clock on Hormonal, Metabolic, Neurocognitive Markers in Adolescents With and Without Diabetes
Type 1 diabetes mellitus (T1DM), makes its appearance during childhood and youth, but management implications last till late adulthood.
- Conditions
- T1DM, Sleep Disorders, Circadian Rhythm, ADHD, Memory Impairment
- Trial name
- NCT04054934
- Testing
- Reversed Circadian Rhythm, Normal Circadian Rhythm
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Type 1 Diabetes
Do "sugar Swings" Impact the Brain Function and the Eating Behaviors of People with Type 1 Diabetes
In type 1 diabetes, it is common to choose the food we eat according to the blood sugar level and the insulin dose and vice versa.
- Trial name
- NCT05487534
- Testing
- Observational
- Where
- 2 sites in Canada
- Volunteers
- 150 people
- Sponsor
- Laval University
Type 2 Diabetes, Glucose Metabolism Disorders
The CGM-OGTT Glycemic Homeostasis Study
This is a prospective, exploratory, observational study aimed at investigating the mechanisms of glycemic homeostasis by comparing continuous glucose monitoring (CGM) data with results from the oral glucose tolerance test (OGTT).
- Trial name
- NCT07288372
- Volunteers
- 225 people
- Sponsor
- Shanghai 6th People's Hospital
Acute Coronary Syndrome, Continuous Glucose Measurement
Predictive Value of Glycemic Parameters Measured With the FSL Pro iQ During ACS
Disorders of glycemic regulation are common in patients hospitalized for acute coronary syndrome (ACS). Abnormal glycaemia is observed in 50% of cases, in 30-40% diabetes, and in 25-35% fasting hyperglycaemia or glucose…
- Conditions
- Acute Coronary Syndrome, Continuous Glucose Measurement, Glycemic Variability, Cardiovascular Event
- Trial name
- FREESCA (NCT06014112)
- Testing
- Freestyle Libre Pro iQ
- Where
- 9 sites in France
- Volunteers
- 850 people
- Sponsor
- University Hospital, Montpellier
Type 1 Diabetes (T1D), Type 2 Diabetes (T2DM)
"Sexual Activity and Hypoglycemia Risk in Adults With Type 1 or Type 2 Diabetes Using Insulin Therapy and Continuous Glucose Monitoring"
This observational study examines whether sexual activity influences the risk of hypoglycemia in adults with type 1 or type 2 diabetes treated with insulin therapy and using continuous glucose monitoring (CGM).
- Conditions
- Type 1 Diabetes (T1D), Type 2 Diabetes (T2DM), Hypoglycemia
- Trial name
- SEX-HYPO-CGM (NCT07286500)
- Testing
- No intervention
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Overweight , Obesity
Two-Week Stair-Climbing Exercise Snacks and Metabolic Health in Adults With Overweight or Obesity: A Pilot Study
This pilot study will evaluate whether brief bouts of stair climbing performed throughout the day for two weeks can improve metabolic health, cardiovascular fitness, and other health-related outcomes in adults with overweight or…
- Trial name
- NCT07849439
- Testing
- Stair-Climbing Exercise Snacks
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Duchenne Muscular Dystrophy
Wearable Technology to Evaluate Hyperglycemia and HRV in DMD
Duchenne muscular dystrophy (DMD) is an X-linked disorder that causes muscle wasting, cardiopulmonary failure, and premature death.
- Trial name
- NCT06124196
- Testing
- wearable technology
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Autonomic Function
Understanding Individual Variability in Neuronal Signal Transmission to Target Organs in Health and Disease
The goal of this clinical trial is to evaluate the influence of parasympathetic transmission from the brain to different metabolic organs. This transmission can be blocked with the muscarinic antagonist atropine.
- Trial name
- CPB_Atropine (NCT06912048)
- Testing
- Oral glucose tolerance test with double-tracer dilution and atropine infusion
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Breast Cancer Female, Cardiometabolic Syndrome
Metabolic Flexibility and Autonomic Control After Muscle Power vs Metabolic Power Training in Postmenopausal Oncological Women: the POWER Health Study
POWER Health is a randomized clinical trial with a two-arm parallel design whose objectives are 1) to study metabolic flexibility and autonomic function (both capacities that describe cardiovascular health) in a sample of…
- Conditions
- Breast Cancer Female, Cardiometabolic Syndrome, Metabolism Disorder, Lipid, Autonomic Dysfunction
- Trial name
- POWER Health (NCT06336070)
- Testing
- HIIT program (8 weeks), MPI program (8 weeks)
- Where
- Spain
- Volunteers
- 56 people
- Sponsor
- University of Valencia