Clinical trials: Glucotoxicity
Type 2 Diabetes Mellitus, Glucotoxicity
Comparative Study of Sitagliptin and Gliclazide With Metformin in Type 2 Diabetes Patients With Glucotoxicity
This study compares the efficacy and safety of sitagliptin phosphate combined with gliclazide sustained-release tablets versus metformin in treatment-naïve patients with type 2 diabetes mellitus (T2DM) and glucotoxicity.
- Trial name
- SG Metformin (NCT06613750)
- Testing
- Sitagliptin and Gliclazide, Metformin
- Where
- China
- Volunteers
- 129 people
- Sponsor
- Zhibin Xu
Type 2 Diabetes Mellitus, Pancreatic Beta Cell Function
Study To Evaluate Beta Cell Function and Glycemic Outcome by Intensive Insulin Therapy
This randomized controlled prospective study aims to evaluate the efficacy of intensive insulin therapy for long term glycemic control and improvement or preservation of beta cell function in newly diagnosed type 2 diabetes…
- Conditions
- Type 2 Diabetes Mellitus, Pancreatic Beta Cell Function, Glucotoxicity
- Trial name
- KIIT (NCT00474838)
- Testing
- intensive insulin group, Oral AntiDiabetic Drug (glimepiride and metformin)
- Where
- 8 sites in South Korea
- Volunteers
- 112 people
- Sponsor
- Kyunghee University Medical Center
Type 2 Diabetes
Treatment of Patients With Type 2 Diabetes With an Interleukin-1 Antagonist
Aim: To investigate the therapeutic potential of IL-1Ra in type 2 diabetes. Rationale: Since the major defect leading to a decrease in b-cell mass in type 2 diabetes is increased apoptosis, therapeutic approaches designed to…
- Trial name
- NCT00303394
- Testing
- IL-1Ra
- Where
- 2 sites in Denmark, Switzerland
- Volunteers
- 72 people
- Sponsor
- University of Zurich
Ketosis Prone Diabetes
Modeling Ketosis-Prone Diabetes Remission Via Diverse Mechanisms of Glucotoxicity
The goal of this study is to quantify day-to-day changes in blood glucose during treatment towards remission in ketosis-prone diabetes (KPDM) and describe them using a mathematical model of KPDM pathogenesis and remission.
- Trial name
- NCT06699810
- Testing
- Continuous Glucose Monitoring, Insulin
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Emory University
Type 1 Diabetes, Type 2 Diabetes
Glucotoxicity and Acute Exercise
Experimental hyperglycemia (5 hours) will be induced via a constant- or fluctuating-rate glucose infusion to establish different patterns of glycemia in healthy individuals.
- Trial name
- NCT01771614
- Testing
- Exercise, Hyperglycemia
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Type 2 Diabetes
The Impact of Glucotoxicity on Gastric Emptying in Chinese Patients With Newly Diagnosed Type 2 Diabetes
Gastric emptying is now recognized as a major determinant of the blood glucose response to carbohydrate in both health and type 2 diabetes (T2D).
- Trial name
- NCT05284344
- Testing
- Anti-Diabetics
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Adelaide