Clinical trials: Glutathione
Low Birth Weight
Synthesis of Glutathione From Low Birth Weight Newborn Babies
The aim of the study is to determine mechanisms leading to glutathione deficiency in low birth weight newborn babies. Compared to full term neonates, depletion in this population may be due to a decreased synthesis rate or to an…
- Trial name
- glutathione (NCT00607061)
- Testing
- Blood sample collection
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Nantes University Hospital
Detoxification Response
Guided Metabolic Detox Program
Adequate antioxidant supply is essential for maintaining metabolic homeostasis and reducing oxidative stress during detoxification.
- Trial name
- NCT06061289
- Testing
- SP Detox Program
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Standard Process Inc.
Cystic Fibrosis
Supplementation of Oral Reduced Glutathione in Pediatric Cystic Fibrosis Patients
Many individuals with cystic fibrosis experience growth failure. The reasons are not clear, but inflammation of the gut in these patients seems to be one important reason.
- Trial name
- NCT02029521
- Testing
- Oral reduced l-glutathione
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- Clark Bishop
Mantle Cell Lymphoma, B Cell Lymphoma
Study of Canfosfamide in Refractory or Relapsed Mantle Cell, Diffuse Large B Cell Lymphoma and Multiple Myeloma
This is a Phase 2 study to determine the efficacy and safety of canfosfamide treatment in relapsed or refractory mantle cell lymphoma, diffuse large B cell lymphoma and multiple myeloma.
- Conditions
- Mantle Cell Lymphoma, B Cell Lymphoma, Multiple Myeloma
- Trial name
- NCT01148108
- Testing
- Canfosfamide HCl for injection
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Telik
Healthy
Oral Liposomal Glutathione Supplementation in Healthy Subjects
This trial is designed to provide evidence of the efficacy of liposomal glutathione supplementation on healthy adults. The investigators anticipate that liposomal glutathione supplementation will enhance the levels of blood…
- Trial name
- NCT02278822
- Testing
- Low dose oral liposomal glutathione supplementation, High dose oral liposomal glutathione supplementation
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Parkinson's Disease
CNS Uptake of Intranasal Glutathione
Excessive free radical formation and depletion of the brain's primary antioxidant, glutathione, are established components of Parkinson's disease (PD) pathophysiology.
- Trial name
- NCT02324426
- Testing
- Reduced Glutathione
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Washington
Infertility, Anesthesia
The Effect of Music Therapy on Glutathione Peroxidase, Malondialdehyde and Pain in Oocyt Pick Up Patients.
It is used by music therapists to help the social, physical, emotional, psychological and psychological needs of patients. In a study, music has a positive effect on pain, anxiety, depression, shortness of breath, mood, facial…
- Conditions
- Infertility, Anesthesia, Oxidative Stress, Pain, Postoperative
- Trial name
- NCT04175873
- Testing
- music
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Multiple Sclerosis
Restoring Glutathione Synthesis With Tecfidera: An in Vivo H-MRS Single-Arm Study at 7T in Patients With RR MS
The primary objective is to directly estimate brain glutathione concentrations in vivo using H-MRS at 7T before and after initiation of Tecfidera in established multiple sclerosis (MS) patients considering switching therapy or…
- Trial name
- NCT02218879
- Testing
- Tecfidera
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Yale University
Alcohol Drinking
Effect of Glutathione on Blood Alcohol and Hangover Symptoms
Glutathione (a tripeptide of 3 amino acids - glutamic acid, cysteine and glycine) plays a great role in homeostasis, especially as a potent anti-oxidant.
- Trial name
- NCT00127309
- Testing
- Glutathione
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Piyavate Hospital
Post-polio Syndrome, Physical Activity
Glutathione and Health With Post-Polio Syndrome
In this study, people who have symptoms of post polio will take oral glutathione supplements for three months. Their levels of fatigue, physical activity and sleep efficiency will be assessed.
- Conditions
- Post-polio Syndrome, Physical Activity, Depression, Pain
- Trial name
- NCT01402570
- Testing
- Glutathione
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Glioblastoma Multiforme, Recurrent Glioma
Dietary Cysteine and Methionine Deprivation (CMD) in Glioma Patients
This pilot study looks at how certain diet changes affect the body in patients with recurrent brain tumors (glioma) who are planning to have standard treatment like radiation or surgery.
- Trial name
- NCT07553520
- Testing
- Normal diet, Cysteine/methionine deprivation (CMD) diet for 2 days, Cysteine/methionine deprivation (CMD) diet for 4 days
- Where
- United States
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Liver Cirrhosis, Liver Cancer
Vitamin B-6 and Glutathione on Inflammation, Homocysteine, Oxidative Stress and Antioxidant Capacities
This study is designed as a hospital-based cross-sectional and randomized placebo-controlled intervention trial. One hundred and fifty patients with either cirrhosis or cirrhosis combined with hepatocellular carcinoma (HCC) who…
- Trial name
- NCT02321579
- Testing
- vitamin B-6, Glutathione, Dextrins
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Taichung Veterans General Hospital
Lung Cancer
Impact of Lung Cancer Diagnosis on Relatives' Understanding of Genetic Risk and Receptivity to Quit Smoking
This study will explore beliefs and knowledge about genetics and smoking among smokers who have a first or second degree relative with advanced lung cancer, and whether their understanding of genetic risk influences their desire…
- Trial name
- NCT00341341
- Where
- United States
- Volunteers
- 757 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Malnutrition
Glutathione (GSH) Supplementation After Hospitalization
The purpose of this study is to see if oral liquid glutathione treatment, has any effect on improving health-related cellular protection, muscle size and strength, and fatigue, weakness, and quality of life in older adults with a…
- Trial name
- NCT03166371
- Testing
- Liposomal Glutathione (GSH)
- Sponsor
- Emory University
Periorbital Hypermelanosis
Treatment of Patients With Periorbital Hyperpigmentation
Periorbital hyperpigmentation (POH) is a common condition in dermatology practice. Periorbital hyperpigmentation is defined as bilateral, round, homogeneous pigmented macules.The etiology of POH is multifactorial including…
- Trial name
- NCT04389788
- Testing
- carboxy therapy, Dermapen with topical glutathione
- Where
- Egypt
- Volunteers
- 31 people
- Sponsor
- Sohag University
Oxidative Stress, Diabetes
Metabolic Analysis in Human Sulfur Amino Acid Deficiency
Varied food intake, disease, and genetic differences result in complex diet-health interactions. In principle, information-rich metabolic analyses combined with bioinformatic tools provide an approach to explore these…
- Conditions
- Oxidative Stress, Diabetes, Heart Diseases
- Trial name
- NCT00253760
- Testing
- dietary amino acids; cysteine and methionine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Late Life Depression
A Breathing-Based Meditation Intervention for Patients With Treatment Resistant Late Life Depression
Late-life depression affects 2-8% of seniors and causes high rates of caregiver distress and risk of suicide. To exacerbate the problem, antidepressants, the cornerstone of therapy, are resistant in 55-80% of this population.
- Trial name
- NCT03368560
- Testing
- Sudarshan Kriya Yoga
- Volunteers
- healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Amyotrophic Lateral Sclerosis
Safety of Urate Elevation in Amyotrophic Lateral Sclerosis (ALS)
This is a multi-center, 20-week study of inosine treatment. Study Objectives and Endpoints The primary objective of the study is to determine the safety and tolerability of oral administration of inosine (administered daily)…
- Trial name
- SURE-ALS2 (NCT03168711)
- Testing
- Inosine
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- Massachusetts General Hospital
Parkinson Disease
Effect of Aerobic Training on Oxidative Stress Markers in Patients With Parkinson's Disease
Parkinson's disease is a chronic, neurodegenerative disorder characterized with the loss of dopamine-producing neurons. This loss is likely to be related with several environmental and genetic factors.
- Trial name
- NCT05511402
- Testing
- Exercise training
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Saglik Bilimleri Universitesi
Busulfan Pharmacokinetic Analysis, GST Genetic Polymorphism
Busulfan Pharmacokinetic Analysis and GST Polymorphism in Adults Undergoing Hematological Stem Cell Transplantation
Between 100 up to 200 adults undergoing HSCT for their primary disease will be included in this pharmacokinetic/pharmacogenetic study. In the preparative protocol Busulfan (BU)will be included as indicated in a known protocol.
- Trial name
- NCT01071486
- Testing
- Hematological Stem Cell Transplantation
- Where
- Israel
- Sponsor
- Rambam Health Care Campus