Clinical trials: Gluten Sensitivity
Celiac Disease
Performance Evaluation of Capsule Endoscopy in the Diagnosis of Gluten Sensitive Enteropathy (MA-23)
The purpose of this study is to determine how well capsule endoscopy identifies changes in the small bowel mucosa of celiac disease patients.
- Trial name
- NCT00555737
- Testing
- Capsule Endoscopy
- Where
- 5 sites in United States, Finland and 1 more
- Volunteers
- 102 people
- Sponsor
- Medtronic - MITG
Irritable Bowel Syndrome, Gluten Sensitivity
Reduced Content of Gluten Diet on Patients With Irritable Bowel Syndrome (Pro.Ali.Fun.)
This study aim to manufacture bread and pasta with an reduced content of gluten and to assess the impact of reducing the daily intake of gluten by 50% in irritable bowel syndrome (IBS) patients.
- Trial name
- PROALIFUN (NCT03638544)
- Testing
- Reduced gluten bread and Pasta compared o normal gluten bread and Pasta
- Volunteers
- 20 people
- Sponsor
- University of Bari
Celiac Disease
Immune Response in Celiac Disease on In-vitro Gluten Challenge
The main purpose of this study is to see how cells taken from the lining of the intestine behave in the laboratory with exposure to gluten and other substances that act on the immune system.
- Trial name
- NCT01909050
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Beth Israel Deaconess Medical Center
Sjogren's Syndrome, Non-celiac Gluten Sensitivity
Wheat-free Diet in the Treatment of Sjogren's Syndrome
Recent data show that some foods can increase intestinal mucosa permeability and immune activation of subjects with gastrointestinal (GI) symptoms.
- Trial name
- NCT05644795
- Testing
- Wheat/milk free diet (W/MFD) group, Rice/turkey free diet (R/TFD) group
- Where
- 3 sites in Italy
- Volunteers
- 30 people
- Sponsor
- University of Palermo
Celiac Disease
Oral AGY for Celiac Disease
Celiac disease (CD) is an autoimmune disease of the small intestine caused by the consumption of gluten proteins from widely used food sources such as wheat, rye, and barley.
- Trial name
- NCT01765647
- Testing
- AGY
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Igy Inc.
Celiac Disease, Barrett Esophagus
Gluten Related Disorders in Barrett's Esophagus
In a small group of people gluten, a storage protein commonly in wheat and other grains, can cause gut inflammation and symptoms like diarrhea and abdominal pain.
- Conditions
- Celiac Disease, Barrett Esophagus, Gluten Sensitivity, GERD
- Trial name
- NCT03329534
- Testing
- Gluten free diet
- Volunteers
- 40 people
- Sponsor
- McMaster University
Not-celiac Gluten (Wheat) Sensitivity
Bioelectrical Impedance Analysis of Not-celiac Wheat Sensitivity Patients
Aim of the investigators' study is to evaluate one of the symptoms described by patients affected with the so-called "not-celiac wheat sensitivity" (NCWS).
- Trial name
- NCT01762566
- Testing
- wheat, xylose
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- University of Palermo
Diarrhea, Diarrhea Predominant Irritable Bowel Syndrome
Gluten Intolerance in Patients With Diarrhea Predominant Irritable Bowel Syndrome
The specific hypotheses are: Gluten supplementation for four weeks increases small intestinal permeability and accelerates colonic transit in patients with irritable bowel syndrome with diarrhea (IBS-D) or functional diarrhea…
- Trial name
- NCT01094041
- Testing
- Gluten free diet, Gluten rich diet
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Obesity, Celiac Disease
The Effect of Hazelnut Flour on Blood Glucose
One of the factors affecting human health is nutrition. The effects of foods on blood glucose are still under investigation. The Glycemic Index (GI), which is associated with many diseases today, is a value that measures the rate…
- Conditions
- Obesity, Celiac Disease, Blood Glucose, Flour Sensitivity
- Trial name
- Hazelnut (NCT06382506)
- Testing
- Consumption of Cornbread with Hazelnut Bread
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ege University
Non Coeliac Gluten Sensitivity
Bakery Products for Non-Coeliac Gluten Sensitive Consumers
The aim of the study is to produce a tolerable alternative to normal wheat bread which would be suitable for subjects with self-reported non-coeliac gluten sensitivity (NCGS).
- Trial name
- NCT02308397
- Testing
- Normal gluten containing bread, Bread with reduced gliadins content, Bread with reduced ATIs content
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Gluten Sensitivity, Wheat Sensitivity
Effects of a Probiotic Supplementation on Symptoms and Microbiome Characteristics in Patients With Non-celiac Gluten/Wheat Sensitivity.
The aim of this randomized, double-blind, placebo-controlled clinical trial is to investigate the effects of probiotics on symptoms and gut microbiota composition following gluten reintroduction.
- Trial name
- NCT06884241
- Testing
- Probiotic supplementation
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
Nonceliac Gluten Sensitivity
Dose-finding Gluten Challenge Trial in Nonceliac Gluten-sensitivity
An emerging problem in clinical practice is how to manage the growing number of patients who experience symptoms related to the ingestion of gluten-containing foods gluten and in whom celiac disease has been ruled out.
- Trial name
- RAPLAGE (NCT03188367)
- Where
- Italy
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- Antonio Di Sabatino
Celiac Disease, Wheat Hypersensitivity
Changes in Intestinal Permeability 4 Hours After Gluten Challenge
This study evaluates why people with celiac disease and non-celiac gluten/wheat sensitivity develop rapid onset symptoms within hours of gluten exposure. Half of subjects will be given gluten and half will not.
- Conditions
- Celiac Disease, Wheat Hypersensitivity, Gluten Sensitivity, Gluten Enteropathy
- Trial name
- NCT03288831
- Testing
- Gluten
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gluten Sensitivity
Gluten Free Diet in IBS
Patients with irritable bowel syndrome (IBS) often benefit from dietary changes. The effect of a gluten-free diet (GFD) on clinical symptom improvement and psychological well-being will be checked in patients with IBS.
- Trial name
- NCT04247737
- Testing
- gluten free diet
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Celiac Disease, Irritable Bowel Syndrome
Effect of FODMAP Restriction on Persistent GI-symptoms in Coeliac Patients
The first aim of the study is to investigate the prevalence of persistent gastrointestinal symptoms and compliance with gluten-free diet and the intake of FODMAP in adult celiac patients.
- Conditions
- Celiac Disease, Irritable Bowel Syndrome, Diet Modification, Gluten Sensitivity
- Trial name
- NCT03678935
- Testing
- Low FODMAP diet
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Gluten Sensitivity
Influence of the Immunosystem in Non-celiac Glutensensitivity
Patients with non-celiac gluten sensitivity (NCGS) complain about gastrointestinal and extraintestinal symptoms while consuming gluten-containing cereals.
- Trial name
- NCGS (NCT03268720)
- Testing
- FODMAP low diet, gluten-free diet
- Where
- Germany
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Non-coeliac Gluten Sensitivity
Effect of AN-PEP Enzyme on Gluten Digestion in Gluten Sensitive Individuals
In this trial, the effect of a low and a high dose AN-PEP will be investigated in gluten sensitive individuals. Volunteers receive a breakfast with background (0.5 g) gluten.
- Trial name
- AN-PEP-03 (NCT02060864)
- Testing
- AN-PEP
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- DSM Food Specialties
Celiac Disease, Non-celiac Gluten Sensitivity
Probiotic BL NCC 2705 and Gluten Sensitivity
The aim of the study is to confirm/prove safety of the probiotic and production of serpin in humans.
- Trial name
- NCT03775499
- Testing
- Intervention 1 : BL NCC 2705 + Maltodextrin, Intervention 1 : Maltodextrin, Intervention 2 : BL NCC 2705 + Maltodextrin
- Where
- Netherlands
- Volunteers
- 38 people
- Sponsor
- Société des Produits Nestlé (SPN)
Gluten Sensitivity
Effects of Ancient Grains-based Diet in a Closed Community
Recently it has been reported that a consistent percentage of the general population consider themselves to be suffering from problems caused by wheat and/or gluten ingestion, even though they do not have celiac disease or wheat…
- Trial name
- NCT03020511
- Testing
- Ancient wheat flours
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Palermo
Non-celiac Gluten Sensitivity, Non-celiac Wheat Sensitivity
Autoimmune Diseases and Serum Autoantibodies in NCWS and IBS Patients
In recent years, a new gluten- or wheat-related disease has emerged, a condition labelled "non-celiac gluten sensitivity" (NCGS) or "non-celiac wheat sensitivity" (NCWS).
- Trial name
- NCT04077840
- Where
- 2 sites in Italy
- Volunteers
- 58 people
- Sponsor
- University of Palermo