Clinical trials: Gluten Sensitivity
Thyroid Fibrosis
Association of TTGA (Tissue Transglutaminase Antibody) and Histopathologic Findings in Thyroidectomy Patients
Gluten sensitivity is the most common auto-immune disease associated with auto-immune thyroiditis. This association is through elevated anti-Tissue transglutaminase (Anti-tTG) levels both in Celiac disease and thyroiditis.
- Trial name
- NCT04974255
- Testing
- Measuring of fibrosis in thyroid specimen and measuring of Anti-tTG in serum samples
- Where
- Turkey (Türkiye)
- Volunteers
- 198 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Non-Celiac Gluten Sensitivity
Efficacy of Probiotic ES1 for the Treatment of Non-Celiac Gluten Sensitivity
Study to demonstrate the efficacy of Probiotic ES1 in alleviating symptoms of gluten sensitivity in non-celiac gluten sensitive subjects exposed to a small, fixed amount of gluten.
- Trial name
- NCT02810301
- Testing
- Probiotic ES1
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Exzell Pharma Inc.
Inflammatory Back Pain
Inflammatory Back Pain and Gluten Free Diet
Articular involvement is the most frequent extra-intestinal manifestation of inflammatory bowel diseases (IBD). IBD-related spondyloarthropathy is mainly characterised by axial involvement (including inflammatory back pain…
- Trial name
- NCT03017716
- Testing
- Gluten free diet
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- University of Palermo
Celiac Disease, Gluten Sensitivity
Bovine Colostrum to Prevent Absorption of Gluten
To investigate the use of hyperimmune bovine colostrum to reduce gluten absorption. A double-blind, cross-over study will be performed in which persons who are following a strict gluten-free diet will be challenged with oral…
- Conditions
- Celiac Disease, Gluten Sensitivity, Non-celiac Gluten Sensitivity
- Trial name
- NCT05555446
- Testing
- Bovine colostrum
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Milky Way Life Sciences LLC
Celiac Disease in Children, Gluten Allergy
Mental Perfomance in Patients With Coeliac Disease
Coeliac disease (CD) is an immune-mediated systemic disorder triggered by gluten in genetically predisposed patients. The only available treatment is a strict life long gluten-free diet (GFD), which has been linked to a reduced…
- Trial name
- NCT06519916
- Testing
- Assessment of mental performance
- Where
- Switzerland
- Volunteers
- 444 people
- Sponsor
- University Children's Hospital Basel
The Objective is to Confirm the Role of Gluten in Triggering the Digestive and Extradigestive Symptoms of NCGS
GlutN : Randomized, Double-blind, Crossover Clinical Trial to Confirm the Role of Gluten in Non-celiac Gluten Sensitivity
For 25 years, non-celiac gluten sensitivity (NCGS) has been the subject of very prolific and confusing scientific literature. This clinical entity is defined by the appearance of digestive and extradigestive symptoms in the…
- Trial name
- GLUTN (NCT06347341)
- Testing
- Clinical study comparing a gluten-containing diet to a gluten-free diet
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Gluten Sensitivity
Assessment of the Effect of Gluten Free Toothpaste on the Ulcerative Events in Children With Celiac Disease
Celiac disease (CD) is the most common genetically based food intolerance in the world, with a prevalence among approximately 1% of the general population (Guandalini \& Assiri, 2014).
- Trial name
- NCT03771443
- Testing
- experimental gluten free toothpaste
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Celiac Disease
Inoculating Celiac Disease Patients With the Human Hookworm Necator Americanus: Evaluating Immunity and Gluten-sensitivity
The disappearance of intestinal parasites from humans in developed countries may be responsible for the upsurge in many diseases including Celiac Disease, Crohn's, ulcerative colitis, asthma and hay fever.
- Trial name
- NCT00671138
- Testing
- Necator americanus
- Where
- 3 sites in Australia
- Volunteers
- 20 people
- Sponsor
- Princess Alexandra Hospital, Brisbane, Australia
Celiac Disease
Impact of Gluten Contamination in Celiac Patients Clinically Responsive and Unresponsive to the Gluten-free Diet
The primary aim of the study is to detect the presence of gluten immunogenic peptides (GIP) in urine samples from celiac patients on a gluten-free diet clinically responsive and non-responsive to dietary treatment and from…
- Trial name
- GIP (NCT05066191)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Non-celiac Gluten Sensitivity
Tolerability of an Ancient Grain in Patients With Non-Celiac Wheat Sensitivity
Patients suffering from wheat-related troubles, in absence of celiac disease or wheat allergy diagnosis, can suffer from non-celiac wheat sensitivity (NCWS).
- Trial name
- NCT06191432
- Testing
- Administration of Triticum Monococcum flour, Administration of Triticum Aestivum flour
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- University of Palermo
Celiac Disease, Malabsorption Syndromes
Immune Responses to Gluten
This is a study of immune responses after eating gluten powder in people with celiac disease and healthy controls.
- Conditions
- Celiac Disease, Malabsorption Syndromes, Digestive System Disease, Intestinal Disease
- Trial name
- NCT05209568
- Testing
- Gluten Powder
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Non-celiac Gluten Sensitivity, Anemia
Anemia in Non-celiac Wheat Sensitivity
In recent years, a new gluten- or wheat-related disease has emerged, a condition labelled "non-celiac gluten sensitivity" (NCGS) or "non-celiac wheat sensitivity" (NCWS).
- Trial name
- NCT04377061
- Testing
- Evaluation of anemia
- Where
- 3 sites in Italy
- Volunteers
- 244 people
- Sponsor
- University of Palermo
Gluten Sensitivity
Gluten Sensitivity in Non-Celiac Patients
The idea is to evaluate if the so called "Gluten Sensitivity" is a real clinical entity. Gluten sensitive (GS) persons are defined as those patients, being neither celiac or allergic to weat, who develop symptoms following gluten…
- Trial name
- GS (NCT01485341)
- Testing
- gluten, rice starch
- Where
- 7 sites in United States, Italy
- Volunteers
- 108 people
- Sponsor
- University of Campania Luigi Vanvitelli
Non-celiac Gluten Sensitivity
Gluten and (Extra-)Intestinal Symptoms in NCGS
The goal of this randomized, double-blind, placebo-controlled study is to investigate the effect of expectancy related to gluten consumption versus actual gluten intake on overall GI symptoms in individuals with non-coeliac…
- Trial name
- WoW (NCT05779358)
- Testing
- Expectancy and gluten
- Where
- 3 sites in Netherlands, United Kingdom
- Volunteers
- 84 people
- Sponsor
- Maastricht University
Irritable Bowel Syndrome, Wheat Sensitivity
Effects of Wheat Breads on Symptoms of IBS, a Pilot Study
This is randomized pilot study comparing tolerability of yeast-baked wheat bread and sourdough wheat bread in irritable bowel syndrome.
- Trial name
- Wheat-IBS (NCT02572908)
- Testing
- Sourdough wheat bread, Regular yeast baked toast bread, Gluten-free diet
- Where
- Finland
- Volunteers
- 26 people
- Sponsor
- Oy Karl Fazer Ab
Not-celiac Wheat Sensitivity (NCWS), Familial Mediterranean Fever (FMF)
Gluten-related Disorders in Familial Mediterranean Fever Patients
It is known that the gluten-containing grains can be responsible for human diseases related to gluten exposure. These forms of gluten intolerance represent a heterogeneous set of conditions, including celiac disease (CD), wheat…
- Trial name
- NCT03563300
- Testing
- Wheat flour
- Where
- 2 sites in Italy
- Volunteers
- 8 people
- Sponsor
- University of Palermo
Celiac Disease, Cerebellar Ataxia
Gluten-Free Diet in Patients With Gluten Sensitivity and Cerebellar Ataxia
This study will screen patients with cerebellar ataxia to check for antibodies that indicate allergy to gluten (wheat protein) and will study the effect of a gluten-free diet in patients with these antibodies.
- Conditions
- Celiac Disease, Cerebellar Ataxia, Healthy
- Trial name
- NCT00006492
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Gastrointestinal Disorders
Change in Permeability of the Small Intestine After Treatment With Gluten
The overall hypothesis of this research study is that gluten intake alters intestinal barrier function in patients with Irritable Bowel Syndrome (IBS) diarrhea who also exhibit non-celiac gluten sensitivity (NCGS).
- Trial name
- NCT02098057
- Testing
- Gluten Healthy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Fibromyalgia
Impact of the Restriction of Sources of Gluten in Fibromyalgia Patients
The aim of this study is to evaluate the impact of gluten-free diets on symptoms and inflammatory markers in individuals with previous diagnosis of fibromyalgia (FM), as well as to identify the presence of non-celiac gluten…
- Trial name
- NCT03129906
- Testing
- Gluten, Rice protein
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- Federal University of Minas Gerais
NCGS, Gluten
Effect of Acute and Sub-acute Administration of Gluten on Extra-intestinal and Gastrointestinal Symptoms in Patients With Non-coeliac Gluten Sensitivity
The investigators will investigate the effects of acute and sub-acute administration of gluten on mood, intestinal permeability, gastrointestinal symptoms, gut microbiota and cortisol levels in NCGS patients.
- Trial name
- NCT03798249
- Testing
- Gluten
- Where
- 2 sites in Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven