Clinical trials: GnRH Antagonist
PCOS GnRH Antagonist and GnRH Agonist IVF/ICSI Cycles, IVF Outcomes
Effect of Estradiol Pretreatment on Follicular Synchronization and IVF Outcomes in Women With Polycystic Ovary Syndrome Undergoing ICSI Using GnRH Antagonist Protocol
This randomized clinical trial included 60 infertile women diagnosed with PCOS undergoing ICSI cycles using a GnRH antagonist protocol.
- Trial name
- NCT07727863
- Testing
- GnRH Antagonist Protocol, Estradiol Valerate 4mg
- Where
- Egypt
- Volunteers
- 61 people
- Sponsor
- Cairo University
GnRH Antagonist IVF Protocol, Fresh Embryo Transfer
GnRH for Luteal Support - Mechanism of Action
This prospective observational study will include women undergoing IVF treatment with a GnRH antagonist protocol and fresh embryo transfer at the IVF unit of Shaare Zedek Medical Center.
- Conditions
- GnRH Antagonist IVF Protocol, Fresh Embryo Transfer, Administration of Hormonal Luteal Support
- Trial name
- NCT07620067
- Testing
- GnRH agonist, Progesterone
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Heli Alexandroni
Advanced Prostate Cancer, GnRH Antagonist
A Study Investigating the Pharmacokinetics, Pharmacodynamics, Efficacy and Safety of Teverelix DP, a Gonadotropin-releasing Hormone (GnRH) Antagonist, in Patients With Advanced Prostate Cancer
The purpose of this clinical trial is to test the effectiveness of a dosing regimen of Teverelix DP castration rate defined as the cumulative probability of testosterone suppression to < 0.5 ng/mL with the lower bound of the 95%…
- Trial name
- NCT07457164
- Testing
- Teverelix DP 180 mg
- Volunteers
- 40 people
- Sponsor
- Antev Ltd.
Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation
Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Women With PCOS Undergoing PGT-A
This randomized trial aims to compare the euploid rate of blastocysts between PPOS (progestin-primed ovarian stimulation) and GnRH (gonadotrophin releasing hormone) antagonist protocols in patients with PCOS (polycystic ovary…
- Conditions
- Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation, Polycystic Ovarian Syndrome, GnRH Antagonist
- Trial name
- NCT05326087
- Testing
- GnRH antagonist, MPA
- Volunteers
- 204 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation
Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Patients Undergoing PGT-A
This randomized trial aims to compare the euploid rate of blastocysts between PPOS and GnRH antagonist protocols in patients undergoing PGT-A.
- Conditions
- Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation, Euploid Rate, GnRH Antagonist
- Trial name
- NCT04414748
- Testing
- GnRH antagonist, oral Duphaston
- Where
- China
- Volunteers
- 400 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
PPOS, GnRH Antagonist
PPOS Protocol Versus GnRH Anatagonist for Expected Normal Responder Patients Undergoing ART : a Randomized Clinical Trial
The aim of this study is to compare the efficacy and safety of Progestin-Primed Ovarian Stimulation (PPOS) protocol versus the fixed GnRH antagonist protocol in expected normal responder patients undergoing intracytoplasmic sperm…
- Conditions
- PPOS, GnRH Antagonist, Assisted Reproductive Techniques
- Trial name
- PPOS vs GnRH (NCT06868576)
- Testing
- Dydrogesterone Oral Tablet, Cetrorelix (Cetrotide)
- Where
- Egypt
- Volunteers
- 328 people
- Sponsor
- Kasr El Aini Hospital
IVF, GnRH Antagonist
Live Birth Rate Between PPOS and GnRH Antagonist Protocol in Patients With Anticipated High Ovarian Response
Progestin can inhibit the pituitary LH surge during ovarian stimulation and various studies show progestin-primed ovarian stimulation (PPOS) is effective in blocking the LH surge in IVF.
- Conditions
- IVF, GnRH Antagonist, PPOS
- Trial name
- NCT04414761
- Testing
- Progesterone, GnRH Antagonist
- Where
- China
- Volunteers
- 784 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Ovarian Hyperstimulation Syndrome, GnRH Antagonist
Preventive Application of GnRH Antagonist on Early OHSS
Ovarian hyperstimulation syndrome is an iatrogenic complication of controlled ovarian stimulation. Ovarian hyperstimulation syndrome prevention is a multistage process and more important than treatment.Preventive administration…
- Conditions
- Ovarian Hyperstimulation Syndrome, GnRH Antagonist, Aspirin, Vascular Endothelial Growth Factor
- Trial name
- NCT03188471
- Testing
- GnRH antagonist, aspirin
- Where
- China
- Volunteers
- 175 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Administration of Increased Dose of GnRH Antagonist for Coasting for Decreasing the Risk for Ovarian Hyperstimulation Syndrome( OHSS)
Administration of Increased Dose of GnRH Antagonist for Coasting for Decreasing the Risk for Ovarian Hyperstimulation Syndrome( OHSS)
Coasting is one of the means to reduce the risk of OHSS for patients at risk for severe OHSS. During coasting gonadotrophin administration is withheld until serum E2 levels drop to a range considered safe.
- Trial name
- NCT01109888
- Testing
- Cetrotide
- Sponsor
- Wolfson Medical Center
Poor Responders, IVF
Clomiphene Citrate Plus Gonadotropins and GnRH Antagonist Versus Flexible GnRH Antagonist Protocol Versus Microdose GnRH Agonist Protocol in Poor Responders Undergoing IVF
Poor ovarian response to stimulation in IVF cycles is a challenging and frustrating condition, due to its poor prognosis in terms of chances of pregnancy and live births.
- Conditions
- Poor Responders, IVF, Clomiphene Citrate, GnRH Agonist
- Trial name
- NCT02201914
- Testing
- Clomiphene citrate, Daily FSH and LH plus Cetrorelix, Triptorelin plus daily FSH anh LH
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Bioroma
Compare Pregnancy Rates Between FSH Stimulation and FSH and, GnRH Antagonist
Single Injection of Ganirelix in Gonadotropin Intrauterine Insemination (IUI) Cycles
Ovulation induction (OI) using gonadotropins is one of the most widely prescribed treatments of infertility. One common problem encountered while attempting OI using gonadotropins is premature ovulation.
- Trial name
- NCT01286051
- Testing
- Follistim administration, Follistim plus Ganirelix
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Houston Fertility Institute
PCOS GnRH Antagonist and GnRH Agonist IVF/ICSI Cycles
In Vitro Fertilization Outcomes of Two Treatment Protocols in Women With Polycystic Ovary Syndrome
Outcomes of IVF/ICSI cycles of women with PCOS undergoing Gonadotropin Releasing Hormone (GnRH) agonist and GnRH Antagonist fixed protocol.
- Trial name
- PCOS and ivf (NCT01354275)
- Testing
- To compare the IVF/ICSI outcomes of GnRH Antagonist cycle versus GnRH agonist cycle, GnRH Antagonist
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Bulent Haydardedeoglu