Clinical trials: Goal Directed Fluid Therapy
Perioperative/Postoperative Complications, Hypovolemia
Goal-directed Therapy in High-risk Surgery
There is growing evidence that the risk of postoperative complications can be decreased by optimizing the amount and type of infusion fluids given during surgery, steered by goal-directed therapy based on flow-related hemodynamic…
- Conditions
- Perioperative/Postoperative Complications, Hypovolemia, Hypoxia
- Trial name
- NCT01681238
- Testing
- Protocol group 2, Protocol group 1
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Guangzhou First People's Hospital
Surgery
The Effect of Intraoperative Goal Directed Restricted Fluid Therapy on Extravascular Lung Water
The aim of this study is to compare the use of Goal Directed fluid therapy guided by Stroke volume variation plus a restricted fluid management approach to standard fluid management in patients undergoing major abdominal…
- Trial name
- NCT02845310
- Testing
- Restricted fluid therapy group, Standard fluid management
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Cairo University
Thoracoscopic Lobectomy, Thoracic Anesthesia
Goal-Directed Fluid Therapy for Thoracoscopic Lobectomy
The investigators aimed to examine the effect of goal-directed fluid therapy (GDFT) compared to conventional fluid therapy in thoracoscopic lobectomy surgery with ERAS protocol on intraoperative pulmonary oxygenation and 30-day…
- Conditions
- Thoracoscopic Lobectomy, Thoracic Anesthesia, Enhanced Recovery After Anesthesia, Lung Cancer
- Trial name
- NCT07050979
- Testing
- Goal-Directed Fluid Therapy (GDFT), Conventional Fluid Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Cukurova University
Spine Disease
GDFT Based on PPV Compared With Standard Fluid Therapy in Patients Undergoing Complex Spine Surgery: RCT
The investigators will do the Goal directed fluid therapy by protocolized fluid management in the experimental group, using PPV to guide the fluid administration, compare with standard fluid management in patients undergoing…
- Trial name
- NCT03164811
- Testing
- goal directed fluid therapy, Controlled
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Major Abdominal Surgery
Implementation of Computer-Assisted Intraoperative Goal-Directed Fluid Therapy
The aim of this study is to compare the implementation of computer-assisted goal directed fluid therapy (GDFT) to standard of care fluid therapy in major abdominal surgery.
- Trial name
- NCT02978430
- Testing
- Computer-assisted GDFT, Standard of care
- Where
- Belgium
- Volunteers
- 260 people
- Sponsor
- Erasme University Hospital
General Anesthesia
Effect of Goal-directed Fluid Therapy Using Stroke Volume Variation in Patients Undergoing Free Flap Reconstruction After Head and Neck Cancer Resection
Investigators hypothesized that goal-directed fluid therapy using stroke volume variation will improve postoperative recovery in patients undergoing free flap reconstruction after head and neck cancer resection.
- Trial name
- NCT02003066
- Testing
- Standard fluid therapy, Conservative fluid therapy
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Yonsei University
Scoliosis
Blood and Fluid Management During Scoliosis Surgery
In the present retrospective study, it was hypothesized that application, in scoliosis surgery, of a protocol for blood and fluid management, based on goal directed fluid therapy, cell salvage and tranexamic acid, could lead to…
- Trial name
- NCT03814239
- Testing
- protocol
- Where
- Greece
- Volunteers
- 35 people
- Sponsor
- George Papanicolaou Hospital
Fluid Overload
Restrictive or Doppler-guided Fluid Treatment in Colorectal Surgery
This is a clinical randomised double blinded multicentre trial of two different fluid treatments during colorectal surgery in an enhanced recovery programme A restricted fluid regimen aiming at zero fluid balance and less than…
- Trial name
- NCT03677622
- Testing
- Voluven to near maximal stroke volume of the heart
- Volunteers
- 150 people
- Sponsor
- Holbaek Sygehus
Perioperative Care, Fluid Therapy
Paired Comparison of SVV and PVI Accuracy
This study will compare two operating-room monitors-stroke volume variation (SVV, from the arterial line) and the Pleth Variability Index (PVI, from the pulse oximeter)-to see which one more accurately predicts whether giving a…
- Conditions
- Perioperative Care, Fluid Therapy, Monitoring, Physiologic, Hemodynamics
- Trial name
- NCT07260890
- Testing
- Stroke Volume Variation (SVV) monitoring, Pleth Variability Index (PVI) monitoring
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Fluid Therapy
The Effect of Goal-directed Therapy Guided by Stroke Volume Variation and Cardiac Index in Non-severe Surgical Patients
To evaluate the application of fluid-infusion therapy with the combination of stroke volume variation (SVV) and cardiac index (CI) as the primary judgment in non-severe patients underwent resection of gastrointestinal tumor.
- Trial name
- NCT02841046
- Testing
- cardiac index, Stroke Volume Variation
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Intraoperative Hypotension, Pulmonary Complication
Perioperative Goal Directed Therapy (PGDT) in Spinal Surgery in the Prone Position
This study aims at evaluating if a specific protocol, that can be framed in the innovative concept of Perioperative Goal Directed Therapy (PGDT), based on the evaluation of the Stroke Volume Variation (SVV) - a parameter deriving…
- Conditions
- Intraoperative Hypotension, Pulmonary Complication, Cardiovascular Complication
- Trial name
- PGDT (NCT04025086)
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- University of Catania
Anemia in Patients Undergoing Gastric Cancer Surgery Under Goal-directed Fluid Therapy, Macro-microcirculation Uncoupling
Anemia on Sublingual Microcirculation in GDFT
The goal of this observational study is to learn about the effects of anemia on sublingual microcirculation in patients undergoing goal-directed fluid therapy (GDFT) during surgery.
- Trial name
- NCT07583927
- Testing
- No intervention
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Fudan University
Noradrenaline
Prophylactic Norepinephrine for Prevention of Acute Kidney Injury in Living-Donor Liver Transplantation
goal-directed fluid therapy has demonstrated benefits on postoperative organ function, vasopressor support with norepinephrine is commonly employed to maintain perfusion pressure, though its renal impact in this setting remains…
- Trial name
- NE AKI in LDLT (NCT07885657)
- Testing
- Norepinephrine started prophylactically immediately post induction of general anesthesia, Norepinephrine infusion will only initiated if mean arterial pressure <65 mmHg despite preload optimization (stroke volume variation <12%) or if systemic vascular resistance <800 dynes•s/cm⁵
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Mansoura University
Surgery Complications
Effects of GDHT (Goal Directed Hemodynamic Therapy) Using a Non-invasive Hemodynamic Monitoring in Elective Neurosurgery
This study aims to assess the safety and efficacy of GDHT using the non-invasive Starling™ SV System in elective neurosurgery. The tested group of patients (n=70) will be compared with a control group (n=70), where hemodynamic…
- Trial name
- NCHGDT (NCT07101991)
- Testing
- Standard monitoring, Goal-Directed Therapy
- Where
- Czechia
- Volunteers
- 140 people
- Sponsor
- Brno University Hospital
Fluid Therapy, Brain Edema
Effects of Intraoperative GDFT on the Postoperative Brain Edema
Whether a fluid protocol aiming for protecting vital organ perfusion or fluid restriction is favorable to post-craniotomy outcomes such as brain edema remains uncertain.
- Conditions
- Fluid Therapy, Brain Edema, Brain Tumor
- Trial name
- NCT03323580
- Testing
- GDFT, traditional fluid therapy
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Beijing Tiantan Hospital
Goal Directed Therapy, Fluid Therapy
Goal Directed Therapy Versus Standard Care in Lung Resection Surgery (GDT-thorax Study).
The primary aim of this study is to quantify and compare the hemodynamic control of cardiac index in patients who receive either goal-directed therapy or standard hemodynamic management in lung resection surgery
- Trial name
- GDT-thorax (NCT03245372)
- Testing
- Standard care, Goal directed therapy
- Where
- Spain
- Volunteers
- 31 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Vascular Hypotension, Hypovolemia
Impact of GDT in Robot-assisted Laparoscopic Urological Surgery for Low to Moderate Risk Patients
Robot assisted urological procedures are often long surgical cases that can potentially result in complicated postoperative hospital course.
- Conditions
- Vascular Hypotension, Hypovolemia, Hypervolemia
- Trial name
- NCT03213574
- Testing
- Control Group, Treatment Group
- Where
- United States
- Sponsor
- Loma Linda University
Hemodynamic Instability
Hemodynamic Response During Goal Directed Fluid Therapy in the OR
The purpose of this study is to retrospectively evaluate the hemodynamic response to goal directed fluid therapy fluid during open abdominal surgery where goal directed fluid therapy is a standard of care after establishing a…
- Trial name
- NCT02365688
- Testing
- Initial bolus pre-incision
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Medtronic - MITG
Fluid Therapy
Goal Directed and Liberal Fluid Therapy
The aim is to compare intraoperative goal directed fluid therapy (GDFT) versus liberal fluid therapy in patients undergoing elective colorectal surgery by using noninvasive electrical cardiometry.
- Trial name
- NCT05487222
- Testing
- ICON
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Ovarian Cancer
Restrictive or Individualized Goal-Directed Fluid Replacement Strategy in Ovarian Cancer Cytoreductive Surgery
This is a single center prospective randomized controlled study comparing the postoperative outcome after cytoreductive surgery in ovarian cancer patient after using restrictive or individualized goal-directed fluid replacement…
- Trial name
- RIGoROCS (NCT03519165)
- Testing
- EV1000(FloTrac System 4.0)
- Where
- India
- Volunteers
- 145 people
- Sponsor
- Tata Medical Center