Clinical trials: Goal-directed Fluid Therapy, open to volunteers
Intraoperative Hypotension
Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) for Perioperative Hemodynamic Optimization in Patients Under General Anesthesia
This study investigates if the Hypotension Prediction Index (HPI) combined with the Assisted Fluid Management (AFM) software can improve perioperative hemodynamic management in adult patients undergoing general anesthesia.
- Trial name
- NCT07301307
- Testing
- Acumen IQ sensor with Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) software, Conventional Intraoperative Hemodynamic management
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Circulatory Failure, Shock State
Fluid-responsiveness Assessment Simplified by Electric Cardiometry in Children
In this study of diagnostic accuracy, the investigators aim to validate a faster, simpler, and noninvasive test of fluid-responsiveness in critically ill children.
- Conditions
- Circulatory Failure, Shock State, Fluid Therapy
- Trial name
- FAST (NCT07522580)
- Testing
- validation a test of fluid-responsiveness in critically ill children
- Where
- 4 sites in France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Bordeaux
Postoperative Complications
GDFT on the Postoperative Outcome in Head and Neck Cancer Surgery
The goal of this clinical trial is to evaluate whether goal-directed fluid therapy (GDFT) can improve the postoperative recovery in patients undergoing head and neck cancer surgery.
- Trial name
- NCT06468852
- Testing
- Goal-Directed Fluid Therapy
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Beijing Tongren Hospital
Noradrenaline
Prophylactic Norepinephrine for Prevention of Acute Kidney Injury in Living-Donor Liver Transplantation
goal-directed fluid therapy has demonstrated benefits on postoperative organ function, vasopressor support with norepinephrine is commonly employed to maintain perfusion pressure, though its renal impact in this setting remains…
- Trial name
- NE AKI in LDLT (NCT07885657)
- Testing
- Norepinephrine started prophylactically immediately post induction of general anesthesia, Norepinephrine infusion will only initiated if mean arterial pressure <65 mmHg despite preload optimization (stroke volume variation <12%) or if systemic vascular resistance <800 dynes•s/cm⁵
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Mansoura University
Esophageal Cancer (EsC), Postoperative Pulmonary Complications (PPCs)
Effect of VExUS Score on Postoperative Pulmonary Complications in Elderly Patients
Brief Summary This clinical trial aims to evaluate whether perioperative goal-directed fluid therapy (GDFT) targeting a venous excess ultrasound (VExUS) score of 1 can reduce postoperative pulmonary complications (PPCs) in…
- Trial name
- NCT07691944
- Testing
- VExUS Score-Guided Intraoperative Goal-Directed Fluid Therapy
- Volunteers
- 126 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Hemodynamic
Three Different GHDT ( Goal Hemodynamic Directed Therapy) Strategies for Intraoperative Fluid Management Optimization During Major Abdominal Surgery: A Randomized Controlled Trial
Major oncological surgery is among the most complex procedures, involving patients with a combination of high-risk factors that can significantly influence immediate postoperative outcomes and quality of life.
- Trial name
- SMART FLUID (NCT06871150)
- Testing
- Flotrac sensor, HPI, HPI-AFM
- Where
- 3 sites in Italy
- Volunteers
- 150 people
- Sponsor
- ASST Sette Laghi
Cirrhosis, Liver, Cirrhotic Cardiomyopathy
Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis
Point-of-care echocardiography is used to guide septic shock resuscitation in patients with severe sepsis in the intensive care unit (ICU), but without systematic evidence for efficacy in critically patients with Cirrhosis and…
- Conditions
- Cirrhosis, Liver, Cirrhotic Cardiomyopathy, Septic Shock
- Trial name
- ECLIPSE-I (NCT07286643)
- Testing
- POCUS, Fixed Resuscitation Strategy based on Target MAP
- Where
- India
- Volunteers
- 140 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Sepsis, Intra-Abdominal Infections
Gelaspan vs Crystalloid Therapy in Sepsis
The goal of this randomized clinical trial is to evaluate whether balanced gelatin solution is more effective and safe than balanced crystalloid solution for perioperative fluid management in adults with sepsis undergoing…
- Trial name
- SPACES (NCT07172451)
- Testing
- Balanced Gelatin Solution, Acetate Ringer's Solution
- Where
- 9 sites in China
- Volunteers
- 318 people
- Sponsor
- Shanghai Zhongshan Hospital
Fluid Responsiveness, Laparoscopic Surgery
Fluid Responsiveness in Laparoscopic Surgery: End-Expiratory Occlusion Test Versus Mini-Fluid Challenge
Background Fluid management is central to perioperative care, but only about half of surgical patients increase their stroke volume after a fluid challenge.
- Conditions
- Fluid Responsiveness, Laparoscopic Surgery, Hemodynamic Monitoring
- Trial name
- FLUID-LAP (NCT07911059)
- Volunteers
- 104 people
- Sponsor
- University Of Perugia
Surgery Complications
Effects of GDHT (Goal Directed Hemodynamic Therapy) Using a Non-invasive Hemodynamic Monitoring in Elective Neurosurgery
This study aims to assess the safety and efficacy of GDHT using the non-invasive Starling™ SV System in elective neurosurgery. The tested group of patients (n=70) will be compared with a control group (n=70), where hemodynamic…
- Trial name
- NCHGDT (NCT07101991)
- Testing
- Standard monitoring, Goal-Directed Therapy
- Where
- Czechia
- Volunteers
- 140 people
- Sponsor
- Brno University Hospital
Circulatory Failure / Shock State, Fluid Therapy
Metabolic Fluid Responsiveness in Children
The investigators aim to validate markers of metabolic fluid-responsiveness in children with acute circulatory failure following cardiac surgery.
- Trial name
- METAFRIC (NCT07255469)
- Where
- 8 sites in France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Bordeaux
Postoperative Complications, Pulmonary Complication
Low-Dose Norepinephrine With Conservative Fluid Therapy in Hepatobiliary Surgery
This prospective randomized controlled study aims to compare the effect of low-dose norepinephrine combined with conservative goal-directed fluid therapy versus conventional fluid therapy on postoperative pulmonary complications…
- Trial name
- NCT07892586
- Testing
- Conventional Fluid Therapy, Low-Dose Norepinephrine, Conservative Goal-Directed Fluid Therapy
- Volunteers
- 100 people
- Sponsor
- Assiut University
High-risk Lung Resection Surgery
Advanced Goal-Directed Impedancemetry Strategy for Lung Resection Surgery
High-risk patients scheduled for lung resection surgery are increasing and theoretically eligible to perioperative individualized goal-directed fluid therapy (GDFT).
- Trial name
- AEGIS (NCT06156943)
- Testing
- individualized goal-directed fluid therapy by Starling device, group managed by standard of care
- Where
- 10 sites in France
- Volunteers
- 722 people
- Sponsor
- Hospices Civils de Lyon
Anemia in Patients Undergoing Gastric Cancer Surgery Under Goal-directed Fluid Therapy, Macro-microcirculation Uncoupling
Anemia on Sublingual Microcirculation in GDFT
The goal of this observational study is to learn about the effects of anemia on sublingual microcirculation in patients undergoing goal-directed fluid therapy (GDFT) during surgery.
- Trial name
- NCT07583927
- Testing
- No intervention
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Fudan University
Bone Tumor, Acute Normovolemic Hemodilution
A Substudy of the Effect of Acute Normovolemic Hemodilution in Bone Tumor Surgery
The prevention of perioperative anemia has the potential to reduce complications, hospital stays, and long-term prognosis in patients undergoing bone tumor surgery.
- Conditions
- Bone Tumor, Acute Normovolemic Hemodilution, Goal-Directed Fluid Therapy
- Trial name
- NCT06881498
- Testing
- acute normovolemic hemodilution
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Elective Major Abdominal Surgery
Effectiveness of Goal-Directed Fluid Therapy Guided by Cardiac Index Versus Central Venous Pressure in Major Abdominal Surgery Patients in the ICU.
This study aims to compare two different methods for guiding intravenous (IV) fluid therapy in patients during their first 6 hours in the ICU after major abdominal surgery.
- Trial name
- NCT07303855
- Testing
- Goal-Directed Fluid Therapy (GDFT)
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Indonesia
Acute Normovolemic Hemodilution, Bone Tumor
The Effect of Acute Normovolemic Hemodilution in Bone Tumor Surgery
The prevention of intraoperative allogenetic blood transfusion has the potential to reduce complications, hospital stays, and long-term prognosis in patients undergoing bone cancer surgery.
- Conditions
- Acute Normovolemic Hemodilution, Bone Tumor, Goal-Directed Fluid Therapy, Transfusion
- Trial name
- NCT06459141
- Testing
- acute normovolemic hemodilution
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine