Clinical trials: Goals
Weight Loss, Weight, Body
Sleep Goal-focused Online Access to Lifestyle Support
The overall goal of the study is to develop a novel weight loss intervention for postpartum people by providing strategies to improve sleep, diet, and physical activity behaviors.
- Trial name
- SGOALS (NCT05942326)
- Testing
- Sleep GOALS, Education
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Orthopedic Disorder
Does Goal Elicitation Improve Patient Perceived Involvement
The purpose of this study is to determine if goal elicitation among orthopaedic patients improves their perceived involvement in care.
- Trial name
- NCT03645135
- Testing
- Goal elicitation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Stanford University
Breast Cancer
Incorporation of AlloMaxTM in Breast Reconstruction Ver8-15-12
The purpose of this study is to measure the level of AlloMax™ incorporation (cellular infiltration, collagen production, and neovascularization) in human breast reconstruction.
- Trial name
- NCT01679223
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Nevada, Las Vegas
Advance Care Planning, Goals of Care
Trial of Advance Care Planning (ACP) & Goals of Care Designations (GCD) Discussions
The Canadian population is aging and more people are living with advanced chronic diseases. At the end of life (EOL), the use of invasive medical treatments in hospitals is increasing and associated with worse outcomes.
- Trial name
- NCT02463162
- Testing
- Conversations Matter videos
- Where
- 15 sites in Canada
- Volunteers
- 240 people
- Sponsor
- University of Alberta
Breast Cancer
Study of Letrozole With or Without BYL719 or Buparlisib, for the Neoadjuvant Treatment of Postmenopausal Women
The purpose of the study was to determine whether treatment with a PI3K inhibitor plus letrozole led to an increase in pathologic clinical response and Objective Response Rate compared to treatment with placebo plus letrozole in…
- Trial name
- NCT01923168
- Testing
- alpelisib, buparlisib
- Where
- 86 sites in United States, Australia and 15 more
- Volunteers
- 340 people
- Sponsor
- Novartis Pharmaceuticals
Nerve Pain
Objective Assessment of Sensory Nerve Fiber Sensitivity
This pilot study utilizes a unique technology to determine nerve fiber sensitivity. This will allow us to determine whether this method and device can discern changes in pain intensity and type, which is predicated on differing…
- Trial name
- NCT03596489
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Julia Finkel
Hip Disease, Hypotension
Hypotension Probability Index in Anesthesia
The aim of the study is to investigate the value of the Hypotension Probability Index in reducing intraoperative hypotension in patients with primary hip replacement.
- Conditions
- Hip Disease, Hypotension, Surgery, Anesthesia
- Trial name
- NCT03663270
- Testing
- Hypotension probability index (HPI)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Giessen
Malignant Melanoma
Follow-up of a National Cohort of Melanoma Resectable Stage II, Stage III or IV Patients or Unresectable Primary
Prevention of melanoma can be efficient but mortality remains unchanged and 15 to 20% of patients still die from melanoma. Indeed metastatic melanoma is a heterogeneous highly and multiple mutations driven cancer.
- Trial name
- MelBase (NCT02828202)
- Testing
- Biological, Tissular, Quality of life
- Where
- 27 sites in France
- Volunteers
- 6,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Doula Support, Postpartum
The Goal is to Examine the Impact of Doula-delivered, Nurse-coordinated Postpartum Care Among Individuals With Preterm Births <34 Weeks' Gestation Requiring NICU Admission.
The primary objective of this research is to conduct a randomized clinical trial to examine the impact of nurse-coordinated, doula-delivered postpartum support (intervention arm) on postpartum health care utilization, health…
- Conditions
- Doula Support, Postpartum, Postpartum Depression (PPD), Postpartum Anemia
- Trial name
- NEST (NCT07787845)
- Testing
- Doula-delivered, Nurse-coordinated postpartum support
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of South Carolina
Fluid Loss, Enhanced Recovery
Role of Goal Directed Fluid Therapy in Enhanced Recovery After Surgery in Gastro-intestinal Oncosurgeries
Enhanced recovery after surgery (ERAS) protocols are multimodal perioperative care pathways designed to achieve early recovery and reducing postoperative morbidity after surgical procedures by maintaining preoperative organ…
- Trial name
- GDFT ERAS (NCT06026475)
- Testing
- Goal directed Fluid Therapy, Conventional Fluid Therapy
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
Immune Checkpoint Inhibitors, Anti-programmed Death-1 Antibody
PD-1 Antibody and Radiotherapy for Recurrent Cervical Cancer
This study is to investigate retrospectively the effects of combination of immune checkpoint inhibitors anti-programmed death-1 antibody (PD-1 antibody) and radiotherapy for recurrent, metastatic and persistent advanced cervical…
- Conditions
- Immune Checkpoint Inhibitors, Anti-programmed Death-1 Antibody, Radiotherapy, Recurrent Cervical Carcinoma
- Trial name
- NCT05310305
- Testing
- Radiotherapy for targeted lesions and PD-1 antibody
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Lei Li
End Stage Renal Disease
Goal Directed Fluid Administration for Kidney Transplantation
The goal of the proposed study is to evaluate the efficacy of a goal-directed fluid administration algorithm on early graft function in patients undergoing kidney transplantation.
- Trial name
- NCT02192086
- Testing
- goal directed fluid therapy, Control Group
- Volunteers
- 21 people
- Sponsor
- Medical University of South Carolina
Sleep Deprivation
Chronic Sleep Restriction and Driving
Young subjects and patients with nocturnal respiratory disorders are frequently involved in sleep-related accidents. This study assess the impact of chronic sleep restriction (4 hr of sleep during 5 days) or total sleep…
- Trial name
- PRIVASOM (NCT00560456)
- Testing
- Chronic sleep restriction and driving simulator
- Where
- 2 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Heart; Dysfunction Postoperative, Cardiac Surgery, C.Surgical Procedure; Cardiac
Goal Directed Therapy Aiming to Optimise Oxygen Central Venous Saturation in Children Undergoing Cardiac Surgery
The purpose of this study is evaluate goal-directed therapy with continuous central venous saturation compared to standard therapy in children undergoing cardiac surgery.
- Trial name
- NCT03469440
- Testing
- Continuous central venous oxygenation monitoring, Standard protocol
- Where
- Brazil
- Volunteers
- 65 people
- Sponsor
- Instituto do Coracao
Cardiac Arrest
Definition of Hemodynamic Thresholds in Out-of-Hospital Cardiac Arrest
This study seeks to evaluate, whether patients suffering from cardiac arrest, that can be successfully resuscitated, can be differentiated from those, that cannot be resuscitated, using arterial blood pressure values.
- Trial name
- HETOCA (NCT03172468)
- Where
- Austria
- Sponsor
- Medical University of Graz
Lung Ultrasound, Goal Directed Therapy
Lung Ultrasound-guided Hemodynamic Optimization
The formalized expert recommendation of the French Society of Anesthesia and Intensive Care recommends guiding vascular filling by measuring the stroke volume (SV) in surgical patients considered at high risk.
- Conditions
- Lung Ultrasound, Goal Directed Therapy, Non-cardiac Surgery
- Trial name
- POINTBAR (NCT05481723)
- Testing
- noradrenaline and vascular filling, pulmonary ultrasound after vascular filling
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Eligible for Day Case Surgery
Prediction of Pre-operative Anxiety by Heart Variability and Pupillometry
The purpose of this study is to determine whether heart rate variability levels and pupillometric measures are effective objective predictors of anxiety among patients before surgery.
- Trial name
- INNOVANX (NCT04154410)
- Testing
- Analgesia Nociception Index, algiscan
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brain Injuries, Traumatic
Application of Early Goal-directed Sedation in Patients With Severe Brain Injury
EGDS management strategy was implemented in ICU patients with severe brain injury, the depth of sedation and GCS score were monitored, and the protective effects of EGDS strategy and standard sedation strategy on the brain of…
- Trial name
- NCT04525482
- Testing
- Early goal-directed sedation programs
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Functionality, Strength
Objective Assessment of Physical Activity in Older Adults
The purpose of the present study is to evaluate the validity of 2 objective measures of physical activity among older adults. In addition, the investigators will examine the influence of functionality, walking aids, walking speed…
- Conditions
- Functionality, Strength, Validity During Daily Activities, Physical Activity
- Trial name
- NCT01621035
- Where
- Belgium
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Uveitis
Objective Choroidal Thickness Measurements in Uveitis
Optical Coherence Tomography (OCT) machines are non-contact instruments that can provide micrometer scale imaging of biological tissue.
- Trial name
- NCT03889860
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University