Clinical trials: Gonadal Steroid Hormones
Premenstrual Syndrome, Depression
Combined Hormone Replacement in Menstrually-Related Mood Disorders
This study investigates the effects on symptoms of combined treatment with estrogen and progesterone in women with severe premenstrual syndrome (PMDD).
- Trial name
- NCT00005011
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Institute of Mental Health (NIMH)
Emotion Regulation, Estradiol
Estradiol's Effect on Brain Volume and Connectivity
Ovarian hormones are not only modulators of cognitive function, emotion regulation and mental health, but also seem to affect brain plasticity and functional connectivity, During the menstrual cycle, women experience cyclic…
- Trial name
- NCT06312033
- Testing
- Estradiol Valerate
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- International Research Training Group 2804
Anovulation
Effect of Bright Light on Sex Hormones and Ovulation in Humans
The study investigated whether bright artificial light may influence menstrual cycle and ovulation conclusively, and what underlying hormonal changes for this effect are.
- Trial name
- NCT00327366
- Testing
- Light therapy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Russian Academy of Medical Sciences
Hypogonadism
Effects on the Brain of Lupron Induced Hypogonadotropic Hypogonadism With and Without Testosterone Replacement
There is evidence that suggests male sex hormones (androgens) play a significant role in brain (central nervous system) functioning.
- Trial name
- NCT00001412
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Ventricular Premature Complexes
Relativity Study Between Idiopathic Ventricular Arrhythmia and Sex Hormone Levels in Different Stages of Menstrual Cycle
The purpose of this study is to determine whether the occurrence of idiopathic right ventricular outflow tract(RVOT) arrhythmia is relative to sex hormone levels in different stages of female menstrual cycle
- Trial name
- NCT00606736
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Harbin Medical University
Varicocele, Infertility
Varicocelectomy: Can Sex-hormones Predict Improvements in Semen Quality?
The purpose of this study is to determine if the pre-operative levels of sex-hormones can be used to identify the varicocele patients who can expect improvements in their semen parameters following varicocelectomy.
- Conditions
- Varicocele, Infertility, Semen Quality
- Trial name
- NCT01296230
- Testing
- Hormone and semen measurements before varicocelectomy
- Where
- 2 sites in Denmark
- Volunteers
- 3 people
- Sponsor
- Copenhagen University Hospital at Herlev
HIV/AIDS, Gender
Transgender Youth and PrEP: PK, Safety, Uptake & Adherence - Intervention Development
To address the critical scientific gaps in PrEP safety for transgender youth and to plan for appropriate implementation of PrEP in transgender youth communities, the study will be conducted in 3 integrated phases.
- Conditions
- HIV/AIDS, Gender, Behavior and Behavior Mechanisms
- Trial name
- NCT04077138
- Where
- 3 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hektoen Institute for Medical Research
Nicotine Dependence, Contraception
Smoking, Sex Hormones, and Pregnancy
The investigators aim to (1) examine the association between levels of progesterone (Prog), allopregnanolone (Allo), and the estradiol/progesterone (E2/P) ratios with smoking-related symptomatology during ad libitum smoking and…
- Trial name
- NCT01811225
- Testing
- Low-dose Progesterone, High-dose Progesterone
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Premenstrual Syndrome
Evaluation of Safety/Efficacy of Diagnostic Skin Test Panel and Desensitization Hormone Kit for Treatment of Premenstrual Syndrome (PMS)
The EVE-PMS technology is intended for determination of intolerance or sensitivity to sex hormones, among women suffering from severe PreMenstrual Syndrome (PMS) and desensitizes them with the relevant sex hormones in order to…
- Trial name
- NCT00873262
- Testing
- Skin test panel and desensitization kit, Skin test panel and solvent
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- EVE Medical Systems Ltd.
HIV/AIDS, Gender
Transgender Youth and PrEP: PK, Safety, Uptake & Adherence - PK Study
To address the critical scientific gaps in PrEP safety for transgender youth and to plan for appropriate implementation of PrEP in transgender youth communities, the study will be conducted in 3 integrated phases.
- Conditions
- HIV/AIDS, Gender, Behavior and Behavior Mechanisms
- Trial name
- NCT03652623
- Testing
- TDF/FTC
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Hektoen Institute for Medical Research
Migraine
Puberty, Sex Hormones and Pain Sensitivity in Adolescents With Migraine
The purpose of this research study is to investigate the relationships between sex hormone levels and experimental pain sensitivity and migraine severity will be examined.
- Trial name
- IHS (NCT05738213)
- Testing
- Thermal stimuli, Pressure stimuli, Pain ratings
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Erectile Dysfunction
Retrospective Analysis of Erectile Dysfunction (ED) Patients Based on a Large-scale Clinical Database
The goal of this observational study is to analyze existing clinical data to characterize in male patients aged 18 and older diagnosed with Erectile Dysfunction (ED).
- Trial name
- NCT07913477
- Where
- China
- Volunteers
- 2,800 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Menstrual Cycle, Hormonal Contraception
Oxytocin and Reward Processing in Women
Oxytocin is a hypothalamic neuropeptide that is best known for its peripheral physiological effects in the female organism i.e., uterine contractions during birth.
- Trial name
- NCT06222749
- Testing
- Intranasal oxytocin administration
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- International Research Training Group 2804
Coronary Artery Disease, Myocardial Infarction
Barts Sex-CAD Database - Sex Hormones and Inflammatory Status in Coronary Artery Disease
There is a lack of understanding of how Coronary Artery Disease (CAD) - meaning the blocking or furring up of the arteries of the heart - starts and progresses in women.
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Acute Coronary Syndrome, Atherosclerosis
- Trial name
- NCT06327984
- Where
- United Kingdom
- Volunteers
- 6,000 people
- Sponsor
- Queen Mary University of London
Healthy Volunteers
Dose-Response of Gonadal Steroids and Bone Turnover in Older Men
The purpose of this study is to determine the levels of testosterone and/or estradiol at which changes in bone turnover, body composition, strength, sexual function etc. begin to occur in older men.
- Trial name
- NCT00114114
- Testing
- Testosterone, Goserelin acetate
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Rotator Cuff Tears
Sex Hormone Supplementation and Rotator Cuff Repair: A Preliminary Randomized Trial
Shoulder tendon tears are a common cause of shoulder pain and disability and after surgery the repaired tendon often does not heal.
- Trial name
- NCT04944836
- Testing
- Clomiphene Citrate, Rotator Cuff Repair
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Utah
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Transsexualism
Observational Study on Metabolism and Psychopathology in Transsexual Patients
Gender identity disorders (also known as transsexualism) is defined as a condition in which a person with apparently normal somatic sexual differentiation is convinced that he or she is actually a member of the other sex.
- Trial name
- NCT02185274
- Where
- 3 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Perimenopause, Perimenopause-Related Depression
Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY)
This observational study examines the safety and effects of injecting Muse cells (a type of naturally occurring stem like cells found in adult tissues such as fat or bone marrow) directly into the ovaries of women aged 28 to 70…
- Conditions
- Perimenopause, Perimenopause-Related Depression, Premature Ovarian Insufficiency, Premature Ovarian Failure (POF)
- Trial name
- MUSE-OVARY (NCT07511660)
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- Healing Hope International
Hormonal Contraception
Stress Reactivity and Hormonal Contraception
For almost 60 years, millions of women globally have relied on oral contraceptive (OC) pills for pregnancy prevention and addressing menstrual irregularities.
- Trial name
- NCT06223126
- Testing
- Combined oral contraception, Discontinuation of a combined oral contraception
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen