Clinical trials: Graft Function
Delayed Function of Renal Transplant
A Study on SANGUINATE™ for the Reduction of Delayed Graft Function in Kidney Transplant Patients
Safety and efficacy study of SANGUINATE on reduction of delayed graft function (DGF) in patients who will be recipients of a donation after brain death (DBD) donor kidney.
- Trial name
- NCT02658162
- Testing
- SANGUINATE, Normal Saline
- Sponsor
- Prolong Pharmaceuticals
Bronchiolitis Obliterans Syndrome (BOS)
Mechanisms and Targeted Therapy of Airway Basal Cell Dysfunction in Bronchiolitis Obliterans Syndrome
This experimental study aims to investigate the pathogenesis of bronchiolitis obliterans syndrome (BOS) and provide a basis for clinical diagnosis and treatment.
- Trial name
- NCT07018804
- Testing
- Bronchoscopic brushing, Single - cell cloning, Cell function identification
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Haikou Affiliated Hospital of Central South University Xiangya School of Medicine
ACL Reconstruction, Intraarticular Injection
Comparison of Functional Outcomes Following Arthroscopic ACL Reconstruction With Peroneus Longus Autograft With and Without Intra-articular Platelet-Rich Plasma Injection.
This prospective RCT investigates if a single 4 ml intra-articular PRP injection improves knee function after ACL reconstruction using peroneus longus autograft.
- Conditions
- ACL Reconstruction, Intraarticular Injection, PRP
- Trial name
- NCT07470359
- Testing
- PRP injection
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Lahore General Hospital
Ischemia Re-perfusion Injury
Omega 3 Lipid Emulsions and Liver Transplantation
The study Aims to investigate the possible beneficial impact of peri-operative or post-operative administration of Omega 3 enriched lipid emulsions on recipients for living donor liver transplantation.
- Trial name
- OTLT (NCT01957943)
- Testing
- SMOFLipid, equivalent volume of 10% glucose solution
- Where
- Egypt
- Volunteers
- 114 people
- Sponsor
- Mansoura University
Coronary Artery Bypass Graft, Chronic Kidney Disease
Evaluation of the Bone Mineral Density and Muscle Mass in Patients Post Coronary Artery Bypass Graft Surgery With Chronic Kidney Disease
The purposes of this study are: (1) to compare the body composition, physical activity, physical function, and quality of life between patients with and without CKD after CABG; and (2) to analyze the relationships among body…
- Trial name
- NCT01932008
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
Renal Transplant
Absence of Steroid in Renal Transplantation and Digital Fibrosis Observation
The main objective of this study is to demonstrate that the absence of post-transplantation corticosteroids does not induce a larger increase of renal graft fibrosis (by numerical reading) on biopsy at one year…
- Trial name
- Astronef (NCT01541176)
- Testing
- Absence of corticotherapy post-transplantation, Corticotherapy post-transplantation
- Where
- 8 sites in France
- Volunteers
- 193 people
- Sponsor
- Nantes University Hospital
Delayed Graft Function, Kidney Transplant
Early Conversion From CNI to Belatacept in Renal Transplant Recipients With Delayed and Slow Graft Function
The purpose of this study is to evaluate the safety and efficacy of conversion from a calcineurin inhibitor (tacrolimus or cyclosporine) immunosuppression therapy to Nulojix® (belatacept) immunosuppression therapy in patients…
- Trial name
- NCT01837043
- Testing
- Belatacept, Calcineurin Inhibitor
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Nair, Vinay, D.O.
Prostate Cancer, Erectile Dysfunction Following Radical Prostatectomy
Nerve Grafting Technique to Restore Erectile Function Post Radical Prostatectomy
A single arm prospective pilot trial evaluating the safety and the 1-year erectile recovery outcomes of patients undergoing a somatic to autonomic nerve grafting procedure for restoration of erectile function in patients who have…
- Trial name
- PRP-NR (NCT06458855)
- Testing
- Post radical prostatectomy nerve restoration procedure (PRP-NR)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Coronary Artery Bypass Grafting, Open Heart Surgery
Assessment of Platelet Function in Patients Undergoing Open Heart Surgery
The purpose of this external evaluation is to assess the system functionality and analytical performance of the Saturn Investigational Instrument (next generation VerifyNow instrument) and associated cartridge currently under…
- Conditions
- Coronary Artery Bypass Grafting, Open Heart Surgery, Aortic Surgery or Redo Surgery, On-pump Double or Triple Valve Procedures
- Trial name
- Saturn (NCT05441358)
- Testing
- Open Heart Surgery
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- LifeBridge Health
Cardiac Rehabilitation, Coronary Artery Bypass Surgery
Cardiac Rehabilitation After Coronary Artery Bypass Graft Surgery
This study aimed to evaluate the effects of cardiac rehabilitation program after CABG surgery on quality of life, sleep quality, anxiety, depression and cardiopulmonary functions.
- Trial name
- NCT06970938
- Testing
- Cardiac rehabilitation program
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Muhammed Onur Hanedan
Heart Disease, Ischemic Heart Disease
Stem Cell Injection to Treat Heart Damage During Open Heart Surgery
Background: Bone marrow stromal stem cells (also known as mesenchymal stem cells) have been isolated and are found to make large amounts of growth factors.
- Conditions
- Heart Disease, Ischemic Heart Disease, Coronary Artery Disease, Coronary Artery Disease (CAD)
- Trial name
- NCT01557543
- Testing
- Cell Therapy
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Kidney Transplant, Delayed Graft Function
Effect of Terlipressin for Intraoperative Blood Pressure Management in Kidney Transplantation
Prospective double blind randomized controlled trial. By randomizing patients undergoing kidney transplantation into a conventional catecholamine drug (dobutamine) blood pressure maintenance group and a terlipressin-complexed…
- Conditions
- Kidney Transplant, Delayed Graft Function, Intraoperative Hypotension
- Trial name
- NCT06855758
- Testing
- terlipressin
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing Friendship Hospital
Donor to Recipient Gender Mismatch in LDLT
Donor Gender Effect on Graft Function in Adult Egyptian Patients Undergoing Living Donor Liver Transplant
Liver transplantation (LT) represents the gold-standard therapy for the treatment in case of dreadful liver pathologies . It is thus a main concern to optimize the results in terms of post-LT survivals.
- Trial name
- NCT04068363
- Testing
- non interventional
- Where
- Egypt
- Volunteers
- 342 people
- Sponsor
- Ain Shams University
Myocardial Protection
Levosimendan and Myocardial Protection
The aim of this study is to investigate whether pharmacological pre-treatment with levosimendan reduces intensive care unit (ICU) length of stay in patients undergoing elective myocardial revascularization under cardiopulmonary…
- Trial name
- NCT00610350
- Testing
- levosimendan
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Coronary Artery Disease, Coronary Artery Bypass Grafting
Perioperative Intra-Aortic Balloon Pump (IABP) in Coronary Artery Bypass Grafting (CABG) Operations in Patients With Severely Depressed Left Ventricular Function
Since its first introduction in humans in 1962, Intra-Aortic Balloon Pump (IABP) is now the most commonly used therapeutic option to support failing heart in cardiac surgery.
- Trial name
- NCT00881192
- Testing
- IABP
- Where
- 2 sites in Italy
- Volunteers
- 160 people
- Sponsor
- IRCCS Policlinico S. Donato
Poor Graft Function, Stem Cell Transplantation
G-CSF Moblized Peripheral Harvest for Poor Engraftment After Stem Cell Transplantation
Poor graft function (PGF) is a common complication after allogeneic stem cell transplantation, which was associated with high mortality. The pathogenesis fo PGF was poorly understood.
- Conditions
- Poor Graft Function, Stem Cell Transplantation, Graft Versus Host Disease
- Trial name
- NCT01857336
- Testing
- infusion of G-CSF mobilized peripheral harvest
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University People's Hospital
Kidney Transplant, Kidney Transplant Failure
Dapagliflozin in Living-Donor Kidney Transplant Recipients
This randomized, open-label, single-center clinical trial aims to evaluate the effect of dapagliflozin on kidney allograft function in adult recipients of a first living-donor kidney transplant.
- Trial name
- DAPA-GRAFT (NCT07555106)
- Testing
- Dapagliflozin (10mg Tab), Standard of Care
- Where
- Mexico
- Volunteers
- 54 people
- Sponsor
- University of Guadalajara
Renal Transplantation
Study to Evaluate the Combination of Enteric-coated Mycophenolate Sodium (EC-MPS), Basiliximab, and C2-monitored Cyclosporine in de Novo Renal Transplant Recipients at Potential High Risk of Delayed Graft Function (DGF)
The aim of the study is to assess the short-term benefit of the combination of basiliximab, EC-MPS and cyclosporine microemulsion with C2 monitoring on the prophylaxis of acute rejection in a population of de novo renal…
- Trial name
- NCT00154232
- Testing
- Enteric-Coated Mycophenolate Sodium (EC-MPS)
- Volunteers
- 46 people
- Sponsor
- Novartis Pharmaceuticals
Open Heart Surgery
Comparison Between Levosimendan and Adrenaline in CABG Patients
The aim of this study is to compare between levosimendan and adrenaline in patients with pre-existing impaired systolic function (EF 30-40%), undergoing elective on-pump CABG, as regards hemodynamics and echocardiographic…
- Trial name
- NCT05222256
- Testing
- Levosimendan, Adrenaline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
End Stage Chronic Renal Failure, Chronic Kidney Disease (Stages 4 and 5)
Deceased Donor Kidney Storage at 10 Celsius Versus Conventional Storage
The goal of this clinical trial is to test how storage temperature of deceased donor kidneys affects kidney function after transplant in adult patients receiving a kidney transplant.
- Conditions
- End Stage Chronic Renal Failure, Chronic Kidney Disease (Stages 4 and 5), Kidney Transplantation Recipients
- Trial name
- NCT07385651
- Testing
- 10˚C deceased donor kidney storage using Traferox XPort
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University Medical Center