Clinical trials: Graft Function
Kidney Transplantation
Benefit of Early Protocol Biopsy and Treatment of Subclinical Rejection
This multicentre randomized, controlled trial (RCT) compared renal allograft histology and function in subjects treated with Tacrolimus + MMF + prednisone undergoing early protocol biopsies and treatment of subclinical rejection…
- Trial name
- NCT00885820
- Testing
- Tacrolimus, MMF, Corticosteroids (Prednisone)
- Where
- 12 sites in United States, Canada
- Volunteers
- 240 people
- Sponsor
- Astellas Pharma Inc
Poor Graft Function, Hematopoietic Stem Cell Transplantation Complications
Expanded Donor Stem Cells for Poor Graft Function After Stem Cell Transplantation in Children
Poor graft function (PGF) is a serious complication after allogeneic hematopoietic stem cell transplantation (HSCT) and may cause persistent low blood cell counts despite donor-cell engraftment.
- Trial name
- NCT07907172
- Testing
- Ex vivo HEB-001-expanded donor-derived CD34+ hematopoietic stem cells
- Volunteers
- 3 people
- Sponsor
- wang xiaodong
Anterior Urethral Stricture, Male
Anatomical and Functional Outcome of PSG Vs BMG for Urethral Substitution in Long Segment Anterior Urethral Strictures
This study aims to compare the penile skin graft and buccal mucosal graft for substitution of long anterior urethral strictures using one-sided dorsal perineal approach.
- Trial name
- NCT06056856
- Testing
- Penile skin graft substituttion urethroplasty, Buccal Mucosal Graft substitution urethroplasty
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Al-Azhar University
Low Back Pain
ED Physical Therapy for Chronic Low Back Pain
Emergency department (ED)-initiated physical therapy is a rapidly growing resource and represents a promising treatment approach to low back pain.
- Trial name
- NCT05206630
- Testing
- ED Physical Therapy
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Northwestern University
FAMM Flap Functional & Radiographic Review
Facial Artery Musculomucosal Flap and Bone Volume Gain in Alveolar Cleft Repair"
Research question: Is the usage of the facial artery musculomucosal flap (FAMM) technique effective on the bone volume in the repair of alveolar cleft? Aim of the study: To evaluate the application of the facial artery…
- Trial name
- NCT07512531
- Testing
- Application of FAMM flap on bone graft in alveolar cleft
- Volunteers
- 5 people
- Sponsor
- Cairo University
Delayed Graft Function
Correlation of Molecular Biomarkers With Biopsy Findings and Outcomes in Renal Transplant Recipients
This is a single-center, prospective, non-randomized, observational study to evaluate specific proteogenomic biomarker panels for acute rejection (AR) and chronic allograft nephropathy/interstitial fibrosis and tubular atrophy…
- Trial name
- NCT02463253
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Chronic Rejection of Cardiac Transplant
Everolimus and Low Dose CNI Compared With MMF and Full CNI Dose in Heart Transplanted Patients: One Year Follow up
The different mechanisms of action of Everolimus and cyclosporine suppress immune function in synergistic manner. Thus it is postulated that the use of Everolimus in combination with cyclosporine permits a significant…
- Trial name
- CRAD001AILO2 (NCT00596557)
- Testing
- everolimus
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Rabin Medical Center
Chronic Pancreatitis
Analysis of Graft Function Following Autologous Islet Transplantation
Analyze inflammatory markers and islet graft function through blood samples collected from subjects with chronic pancreatitis who undergo total pancreatectomy with auto islet transplantation.
- Trial name
- NCT03097185
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Baylor Research Institute
Brain Ischemia, Postoperative Confusion
Impact of Remote Ischemic Preconditioning Preceding Coronary Artery Bypass Grafting on Inducing nEuroprotection
Coronary artery disease (CAD) is the leading cause of death worldwide. Patients with severe CAD are often treated with coronary artery bypass grafting (CABG).
- Trial name
- RIPCAGE (NCT02177981)
- Testing
- Remote ischemic preconditioning, Control
- Where
- Croatia
- Volunteers
- 70 people
- Sponsor
- University of Zagreb
Fluid Responsiveness in Early Post-kidney Transplantation Period
Collapsibility Index of the Inferior Vena Cava and Kidney Transplantation
Delayed graft function following renal transplantation is common occurrence and is associated with an increased risk of acute rejection and chronic allograft nephropathy.
- Trial name
- CIVC-KT (NCT06799299)
- Testing
- No Intervention
- Where
- France
- Volunteers
- 150 people
- Sponsor
- CHU de Reims
Coronary Artery Disease
Home-Based Versus Center-Based Cardiac Rehabilitation After CABG Surgery
This randomized controlled trial was designed to compare the efficacy of a 12-week home-based telerehabilitation (HBTCR) program against traditional center-based cardiac rehabilitation (CBCR) and usual care in patients who have…
- Trial name
- NCT07243444
- Testing
- Structured Exercise Program, Standard Health Education
- Where
- China
- Volunteers
- 110 people
- Sponsor
- The First Hospital of Hebei Medical University
Peripheral Arterial Disease
Endothelial Function in Lower Extremity Bypass Grafts
This study will determine whether or not saphenous vein [arterial] bypass grafts in the leg relax in response to increases in blood flow.
- Trial name
- NCT00759707
- Testing
- L-N^G monomethyl arginine (L-NMMA)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Brigham and Women's Hospital
Coronary Artery Disease, Post Coronary Artery Bypass Grafting
Aerobic and Resistance Training in Post-CABG Patients
This study investigates the effect of combined aerobic and resistance training using resistance bands on diaphragmatic excursion and pulmonary function (FVC, FEV₁, PEF) in post-CABG patients undergoing phase II cardiac…
- Trial name
- NCT07034937
- Testing
- Combination of aerobic training (treadmill walking) and resistance training
- Volunteers
- 15 people
- Sponsor
- Universitas Padjadjaran
Cholecystitis, Acute, Cholecystitis, Chronic
BDD With UDCA Therapy After Laparoscopic Cholecystectomy
Prospective Study for the Effects of Biphenyl Dimethyl Dicarboxylate and Ursodeoxycolic Acid Therapy on Liver Function and Quality of Life After Laparoscopic Cholecystectomy Primary endpoint: peak level of postoperative AST…
- Trial name
- BULQ-LC (NCT03578055)
- Testing
- BDD with UDCA
- Where
- South Korea
- Volunteers
- 172 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Muscle Wasting
Effects of Functional Electrical Stimulation in Patients Undergoing Coronary Artery Bypass Grafting Surgery
Even with major advances in clinical therapy and percutaneous interventions, coronary artery bypass grafting (CABG) is the most common cardiac surgery performed worldwide and is an effective treatment in reducing symptoms and…
- Trial name
- NCT03560713
- Testing
- Functional Electrical Stimulation (FES)
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Universidade Federal de Santa Maria
Systemic Inflammatory Response Syndrome (SIRS), Leukocyte Disorders
Effects of Cardiopulmonary Bypass (CPB)-Leukocyte Filtration on Interleukins Serum Levels and Pulmonary Function
To test the hypothesis that leukocyte filtering during cardiopulmonary bypass (CPB) might reduce the inflammatory response and protect the lungs against the acute injury
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Leukocyte Disorders, Complications Due to Coronary Artery Bypass Graft
- Trial name
- PulmFunction (NCT01469676)
- Testing
- Filtering group LG-6, Pall Biomedical Products
- Volunteers
- 22 people
- Sponsor
- University of Sao Paulo
Gingival Recession
Patient and Operator Centered Outcomes Concerning Connective Tissue Graft Should Be Considered to Choose Adequately Which Protocol to Use
The goal of this clinical trial is to evaluate patient and operator centered outcomes after connective tissue graft harvesting with a fully digital workflow and compare this approach with a conventional one.
- Trial name
- RCT (NCT06604676)
- Testing
- guided soft tissue grafting, non-guided soft tissue grafting technique
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Coronary Artery Disease
Effectiveness of Early Cardiac Rehabilitation
The goal of this experimental study is to compare the effects of early (2nd week) cardiac rehabilitation applied in addition to usual care on functional capacity, quality of life, frailty and body composition in patients…
- Trial name
- NCT06116773
- Testing
- Training, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Function of Renal Transplant
Perioperative Aminophylline to Improve Early Kidney Function After a Kidney Transplant
The aim of this study is to evaluate whether peri-transplant administration of a drug named aminophylline to children undergoing a kidney transplant from deceased donors improves early graft function and also projects on long…
- Trial name
- RTphylline (NCT01759862)
- Testing
- Aminophylline, Theophylline drug levels
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Pediatric Liver Transplant
Prevalence of CYP3A5 Polymorphisms in the Donors and ABCB1 Polymorphisms in the Recipients Undergoing Pediatric Liver Transplant and Their Influence on Tacrolimus Levels and Graft Function.
It is known that Immunosuppression post-Liver transplant is central to achieving optimal outcomes in liver transplant recipients. It is required to maintain an adequate balance between reducing rejection and toxicities.
- Trial name
- NCT06361732
- Testing
- No intervention
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Institute of Liver and Biliary Sciences, India