Clinical trials: Graft Function
Kidney Transplant, Delayed Graft Function
Tacrolimus to Sirolimus Conversion for Delayed Graft Function
The objective of this study is to evaluate the safety and efficacy of conversion from tacrolimus to sirolimus early after kidney transplantation in patients with delayed graft function (DGF)and slow graft function (SGF) in…
- Trial name
- RAPA (NCT00931255)
- Testing
- Tacrolimus, Sirolimus
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Maryland, Baltimore
Kidney Transplant Recipients
Risk Factors of Chinese Kidney Transplant Recipients DSA Based on MPA Immunosuppressive Regimen
THE INCIDENCE AND INFLUENTIAL FACTORS OF DSA IN CHINESE RENAL TRANSPLANT RECIPIENTS WITH MPA-BASED IMMUNOSUPPRESSIVE REGIMEN： A MULTI-CENTER CLINICAL STUDY (TIAIFOD STUDY) Study procedure Investigators at participating centers…
- Trial name
- NCT04444843
- Testing
- Mycophenolate Mofetil Capsules
- Where
- China
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Acute Coronary Syndrome
Timing of Coronary Artery Bypass Surgery Among Patients With Acute Coronary Syndromes Initially on Ticagrelor
Ticagrelor, a more potent P2Y12 inhibitor, has been shown to reduce major adverse cardiac events (MACE) in acute coronary syndromes (ACS). It is increasingly used as a first line therapy in ACS.
- Trial name
- RAPID CABG (NCT02668562)
- Testing
- Early CABG (Day 2-3 after ticagrelor discontinuation), Delayed CABG (Day 5-7 after ticagrelor discontinuation)
- Where
- 2 sites in Canada
- Volunteers
- 143 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Poor Graft Function
Decitabine and Umbilical Cord Blood for Poor Graft Function Post Allo-HSCT
This randomized trial aimed at validating the efficacy and safety of low-dose decitabine, together with umbilical cord blood in PGF post allo-HSCT patients.
- Trial name
- NCT05669079
- Testing
- decitabine, umbilical cord blood, Granulocyte-colony stimulating factor
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Coronary Artery Disease
FUNctional eFficacy of Hybrid coronAry REvascularization
The purpose of the study is to compare iFR-guided hybrid coronary revascularization (HCR) and traditional coronary artery bypass grafting (CABG) in terms of a functional efficacy of revascularization assessed by weighted average…
- Trial name
- FUNFARE (NCT04698460)
- Testing
- Hybrid coronary revascularization, Coronary artery bypass grafting
- Where
- Russia
- Volunteers
- 13 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Peripheral Artery Disease
Vorapaxar and Lower Extremity Bypass Grafts
There are no medical therapies indicated for reduction of limb ischemic events. Studies of dual-antiplatelet therapy with aspirin and clopidogrel versus aspirin alone (CASPAR) as well as studies of systemic anticoagulation (WAVE)…
- Trial name
- NCT02975583
- Testing
- Vorapaxar
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University
Ankle Fractures
Prospective Follow-up of the Results of Nail Arthrodesis of the Ankle
The goal of this prospective, single-center observational study is to describe the functional outcome of the surgical procedure in patient who undergone transplanted centromedullary nailing in the septic setting.
- Trial name
- PROCLOU (NCT06338566)
- Testing
- Follow-up
- Volunteers
- 20 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Erectile Dysfunction, Coronary Artery Disease
Erectile and Ejaculatory Function Following Coronary Revascularization
This observational, cross-sectional study aims to compare erectile and ejaculatory function between men with a history of coronary revascularization and men without known coronary artery disease.
- Conditions
- Erectile Dysfunction, Coronary Artery Disease, Ejaculation Disorders
- Trial name
- NCT07878260
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Coronary Artery Bypass Grafting, Myocardial Infarction
ARomatherapy for Cognitive Trajectory in Chinese After Coronary Artery Bypass Grafting
The ARCTIC-CABG (Aromatherapy for Cognitive Trajectory in Chinese after Coronary Artery Bypass Grafting) trial is a randomized, double-blind, 2-arm, parallel group, placebo-controlled study to evaluated the effects of…
- Trial name
- ARCTIC-CABG (NCT04102696)
- Testing
- Aromatherapy
- Volunteers
- 460 people
- Sponsor
- Beijing Anzhen Hospital
Liver Transplantation, Immune Tolerance
Immune Tolerance Induction After Liver Transplantation
This clinical trial is being conducted to help liver transplant recipients safely discontinue toxic immunosuppressive drugs years after surgery.
- Conditions
- Liver Transplantation, Immune Tolerance, Immune Tolerance/Drug Effects, Graft Survival
- Trial name
- iTILT (NCT07269041)
- Testing
- Donor Hematopoietic Stem and Progenitor Cell Infusion
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, Los Angeles
Acute Liver Failure, Fulminant Hepatic Failure
Safety and Efficacy of the ELAD System (ELAD) to Treat Acute Liver Failure (ALF)
This phase 2 study is developed to evaluate the effect of ELAD on overall survival (OS) in subjects with acute liver failure (ALF) compared to matched historical controls.
- Conditions
- Acute Liver Failure, Fulminant Hepatic Failure, Primary Graft Non-Function, Surgically-Induced Liver Failure
- Trial name
- NCT01875874
- Testing
- ELAD
- Where
- 18 sites in United States
- Volunteers
- 8 people
- Sponsor
- Vital Therapies, Inc.
Kidney Transplant Failure
Multidimensional System to Dynamically Predict Graft Survival After Kidney Transplantation
The incidence of end stage renal disease (ESRD) is rapidly increasing, now affecting an estimated 7.4 million people worldwide. Numerous parameters such as demographic, clinical and functional factors drive the deterioration of…
- Trial name
- DYNAKT (NCT04258891)
- Testing
- No intervention
- Where
- 18 sites in United States, Argentina and 5 more
- Volunteers
- 14,000 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Acidosis, Renal Insufficiency
Preserve-Transplant Study
The aim of this study is to test if alkali treatment will preserve kidney graft function and diminish the progression of chronic kidney disease in renal transplant patients.
- Conditions
- Acidosis, Renal Insufficiency, Kidney Transplantation
- Trial name
- NCT03102996
- Testing
- Nephrotrans
- Where
- 3 sites in Switzerland
- Volunteers
- 240 people
- Sponsor
- University of Zurich
COVID-19, SARS-CoV-2 Infection
Physical and Cognitive Impairments in People Suffering From Long COVID
Of the 1,900,000 Canadians who have been infected by COVID-19, 8 to 15% will continue to experience COVID-19 related symptoms well after 12 weeks. The persistence of such symptoms is now defined as "long COVID" syndrome.
- Conditions
- COVID-19, SARS-CoV-2 Infection, Corona Virus Infection, Physical Disability
- Trial name
- NCT05216536
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Laval University
Chronic Neck Pain
Virtual Reality Program for Managing Chronic Neck Pain
The goal of this clinical trial is to find out if a virtual reality-based rehabilitation program developed by our team can help people with chronic neck pain.
- Trial name
- NCT07189052
- Testing
- Virtual Reality Rehabilitation, Conventional Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Hacettepe University
Cardiopulmonary Bypass Graft
Assessment of Hemodynamic Response in Cardiopulmonary Bypass Graft After Cardiopulmonary Bypass Using Transesophegeal Echocardiography
This is a double blind randomization study, assessing hemodynamic response in patients who underwent a cardiopulmonary bypass graft (CABG) with cardiopulmonary bypass (CPB) using intraoperative trasnesophageal echocardiography…
- Trial name
- NCT01616069
- Testing
- epinephrine and levosimendan
- Where
- Brazil
- Volunteers
- 81 people
- Sponsor
- Federal University of Juiz de Fora
Graft Function
Intramuscular Injection of Mashed Parathyroid Tissue Into a Forearm During Thyroid Surgery to Prevent Permanent Postoperative Parathyroid Insufficiency (IMIPAT Study)
Parathyroid insufficiency is a common complication in thyroid surgery and occurs in 6.6 to 24%. Up to 4.4% suffer from permanent hypoparathyroidism requiring life-time substitution of calcium and vitamin D in order to maintain a…
- Trial name
- IMIPAT (NCT07516990)
- Testing
- Intramuscular injection of mashed parathyroid tissue into the brachioradial muscle during thyroid surgery
- Where
- 2 sites in Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Kidney Transplantation, Mannitol
Effects of Mannitol on Delayed Graft Function After Cadaveric Renal Transplantation
In this study we want to evaluate the effect of mannitol on postoperative renal biomarkers in patient receiving cadaveric renal transplantation.
- Trial name
- NCT02705573
- Testing
- Mannitol
- Where
- Austria
- Volunteers
- 34 people
- Sponsor
- Medical University of Vienna