Clinical trials: Graft Survival
Survival, Prosthesis, Bone Loss
Osteotome-mediated Sinus Floor Elevation With or Without Grafting Material
Implant placement in the posterior part of the maxilla is frequently compromised or impossible due to atrophy of the alveolar process and pneumatisation of the maxillary sinus.
- Conditions
- Survival, Prosthesis, Bone Loss, Patient Satisfaction
- Trial name
- NCT04618900
- Testing
- Sinus floor elevation with a grafting material
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Liver Transplant; Complications
Outcome Analysis of Aspirin in Liver Transplantation
In the experimental setting inhibition of platelet activation was able to reduce immune-mediated necroinflammatory liver disease and consecutively hepatocellular carcinoma development.
- Trial name
- NCT04327427
- Testing
- Aspirin
- Where
- Switzerland
- Volunteers
- 3,000 people
- Sponsor
- University of Zurich
Liver Transplant Failure, Prognostic Biomarkers
Serum GLYcomics to Predict Graft Loss and Mortality After Liver Transplantation
The first 12 months after liver transplantation (LT) are decisive in posttransplant outcome, as almost half of deaths and two thirds of graft loss requiring retransplant occur in the first year after LT.
- Trial name
- GLYGALT (NCT05866796)
- Testing
- GlycoTransplantTest
- Where
- Belgium
- Volunteers
- 600 people
- Sponsor
- University Hospital, Ghent
Transplant; Failure, Heart
A Randomized Controlled Trial Comparing Non-ischemic to Ischemic Preservation in Adult Cardiac Transplantation
The overall aim of this proposal is to compare a new state-of-the-art ex-vivo organ preservation method with standard ischemic cold static storage of donor hearts in adult cardiac transplantation.
- Trial name
- NIHP (NCT03150147)
- Testing
- Non-ischemic preservation, Ischemic cold static storage
- Where
- Sweden
- Volunteers
- 47 people
- Sponsor
- Region Skane
Graft Vs Host Disease, Gastrointestinal Graft-Versus-Host Disease
Randomized Study of Oral Beclomethasone Dipropionate With Ten Days of Prednisone for Treatment of Gastrointestinal GVHD
Patients with gastrointestinal graft-vs.-host disease are randomized to oral beclomethasone dipropionate (BDP) 8 mg/day or identical placebo tablets for 50 days, along with a 10-day induction course of prednisone.
- Trial name
- NCT00233896
- Testing
- Oral beclomethasone dipropionate (drug)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Enteron Pharmaceuticals
Graft-Versus-Host Disease, Hematological Malignancies
Minitransplants With HLA-matched Donors : Comparison Between 2 GVHD Prophylaxis Regimens
The present project is a multicenter phase II trail aiming at comparing which of the two postgrafting immunosuppressive regimens proposed in this study will be best suited to prevent graft-versus-host disease (GVDH).
- Trial name
- NCT01428973
- Testing
- Mycophenolate mofetil, Sirolimus
- Where
- 13 sites in Belgium
- Volunteers
- 200 people
- Sponsor
- University of Liege
Graft Rejection
Efficacy and Safety of Everolimus in Recipients of Heart Transplants to Prevent Acute and Chronic Rejection
This trial was to examine the impact of everolimus and reduced dose of cyclosporine on efficacy and safety compared to mycophenolate mofetil and a standard dose of cyclosporine in heart transplant recipients.
- Trial name
- NCT00300274
- Testing
- everolimus, mycophenolate mofetil, cyclosporine
- Where
- 64 sites in United States, Argentina and 13 more
- Volunteers
- 721 people
- Sponsor
- Novartis Pharmaceuticals
Deceased Donor Kidney Transplantation, Living Donor Kidney Transplantation
Adequate Definition of Delayed Graft Function in Living and Deceased Donor Kidney Transplantation
It is required to establish an adequate definition of delayed graft function in deceased donor kidney transplantation. We attempt to compare various definitions of delayed graft function and find the definition that can predict…
- Trial name
- NCT02080117
- Testing
- kidney transplantation, living or deceased donor
- Where
- South Korea
- Volunteers
- 800 people
- Sponsor
- Samsung Medical Center
Type 1 Diabetes Mellitus
Strategies to Improve Islet Survival
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00464555
- Testing
- Islet transplant, Antithymocyte globulin, Basiliximab
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Liver Transplant
Controlled Donors After Circulatory Death and Brain Death: a Multicenter Study of Transfusion, One-year Graft Survival and Mortality. Cohort Study,
RBC requirement ein DBD and DCD liver transplants
- Trial name
- NCT04945135
- Where
- 2 sites in Spain
- Volunteers
- 591 people
- Sponsor
- Hospital Clinic of Barcelona
Infection
Postoperative Supplemental Oxygen in Liver Transplantation
The aim of this prospective randomized controlled trial is to evaluate the impact of high concentration supplemental postoperative oxygen therapy on short-term and long-term results of liver transplantation, particularly with…
- Trial name
- PSOLT (NCT02857855)
- Testing
- 80% fraction of inspired oxygen for 6 postoperative hours, 28% fraction of inspired oxygen for 6 postoperative hours
- Where
- Poland
- Volunteers
- 193 people
- Sponsor
- Medical University of Warsaw
Kidney Graft Dysfunction
Histology of Implantation Biopsies and Kidney Allograft Outcomes
The morphology of transplanted kidney is considered to be important for graft outcomes in early and late posttransplant period. Individual histological lesions at the time of kidney transplantation, such as sclerosis of…
- Trial name
- KALIMBO (NCT03155763)
- Testing
- Intraoperative kidney allograft preimplantation biopsy; Intraoperative kidney allograft postreperfusion biopsy
- Where
- Ukraine
- Volunteers
- 130 people
- Sponsor
- Andriy Trailin
Diabetes Mellitus, Type 1
Sirolimus vs Mycophenolate With Tacrolimus in Simultaneous Pancreas and Kidney Transplantation
This is prospective randomized open single center clinical study to compare effect of sirolimus vs mycophenolate tacrolimus based protocol on pancreas and kidney graft survival in simultaneous pancreas and kidney recipients.
- Trial name
- NCT03582878
- Testing
- Sirolimus Oral Product, Mycophenolate Mofetil
- Where
- Czechia
- Volunteers
- 238 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Heart Transplant Failure and Rejection
Allograft Dysfunction in Heart Transplant
The investigators will evaluate for early evidence of cardiac allograft dysfunction by cardiac MRI and single cell sequencing to determine underlying molecular and macroscopic causes.
- Trial name
- NCT03102125
- Testing
- Regadenoson
- Where
- United States
- Volunteers
- 376 people
- Sponsor
- Paul Kim
Dental Implant Survival Rate
Survival Rate of Dental Implants Placed in Sinus Lift Performed With Two Different Grafts
Previous in a randomized way, it will be performance 12 bilateral sinus lift with autologous bone in one side and the in other with xenograft material.
- Trial name
- NCT01836744
- Testing
- Survival rate dental implant (OsseoSpeed™)
- Where
- Portugal
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Grupo de Investigação: Cirurgia Oral, Peridontologia, Implantologia
Diabetes Mellitus
Post-operative Complications and Graft Survival With Conventional Versus Continuous Glucose Monitoring in Patients With Diabetes Mellitus Undergoing Renal Transplantation
This will be a prospective, randomized, single-blinded controlled trial in which the investigators evaluate post-operative serum glucose control using conventional point-of-care glucose monitoring in the morning and before meals…
- Trial name
- NCT04742023
- Testing
- Continuous Glucose Monitor Application, Finger Stick Glucose Measurement, Insulin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwell Health
Kidney Transplantation, Graft Survival
Longitudinal Dynamics of AT1R Antibodies in Kidney Transplant Recipients
This study aims to investigate the dynamics of Angiotensin II Type 1 Receptor Antibodies (AT1R-Ab) before and after kidney transplantation.
- Conditions
- Kidney Transplantation, Graft Survival, Angiotensin II Type 1 Receptor Antibody
- Trial name
- AT1R (NCT07374484)
- Where
- South Korea
- Volunteers
- 241 people
- Sponsor
- Seoul National University Hospital
Acute Myeloid Leukemia (AML)
Study to Improve OS in 18 to 60 Year-old Patients, Comparing Daunorubicin Versus High Dose Idarubicin Induction Regimens, High Dose Versus Intermediate Dose Cytarabine Consolidation Regimens, and Standard Versus MMF Prophylaxis of GvHD in Allografted Patients in First CR
This open label, multicenter phase II/III study with multiple randomization phases at differents stages of AML treatment (induction, consolidation and HSCT where applicable) is designed to improve OS in younger (18 to 60…
- Trial name
- BIG-1 (NCT02416388)
- Testing
- Idarubicin, Daunorubicin, HD Cytarabine
- Where
- 56 sites in France
- Volunteers
- 3,100 people
- Sponsor
- University Hospital, Angers
Coronary Artery Disease
Synergy Between PCI With TAXUS and Cardiac Surgery: SYNTAX Extended Survival
An investigator-driven, retrospective study to compare long-term survival-data (10-year follow-up) of patients with coronary artery disease (CAD), previously enrolled in the SYNTAX trial, who were randomized to percutaneous…
- Trial name
- SYNTAXES (NCT03417050)
- Testing
- No intervention will take place for this retrospective and observational study.
- Volunteers
- 2,636 people
- Sponsor
- Erasmus Medical Center
Breast Reconstruction, Lipofilling
Hyperbaric Oxygen Therapy to Improve Autologous Fat Graft Intake in Irradiated Breast
The goal of this clinical trial is to learn if hyperbaric oxygen therapy (HBOT) enhances fat graft survival in lipofilling procedures in irradiated breast cancer patients.
- Conditions
- Breast Reconstruction, Lipofilling, Hyperbaric Oxygen Therapy
- Trial name
- NCT07140198
- Testing
- Hyperbaric Oxygen Therapy, Control
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- University Hospital, Geneva