Clinical trials: Graft-vs-host Disease
Chronic Kidney Disease stage3
Effect of Intradialytic Exercises in Chronic Kidney Disease Patients
the purpose of this study is to compare between intradialytic aerobic versus resistive exercises on immunity response in patients with chronic kidney disease.
- Trial name
- NCT06293092
- Testing
- leg pedaling cycling device, sand bags, hemodialysis sessions
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Ocular Graft-versus-host Disease
Allogeneic Platelet Lysate Eye Drops for the Treatment of Severe Chronic Ocular Graft-versus-host Disease
The study evaluates the efficacy and safety of allogeneic platelet lysate eye drops in patients with severe ocular graft versus host disease refractory to conventional systemic and local treatments.
- Trial name
- NCT05311514
- Testing
- Allogeneic platelet lysate eye drops
- Where
- Russia
- Volunteers
- 38 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Graft Rejection, Kidney Transplantation
TRAnscriptional Profile of Peripheral Blood Cells in Patient With Chronic Kidney and Lung Rejection: Correlation With Response to Extracorporeal Photo-aphereSiS
With this project, the research team aims to identify the molecular pathways associated with the response to extracorporeal photonchemioapheresis (ECP) in kidney or lung transplant patients suffering from chronic rejection, by…
- Conditions
- Graft Rejection, Kidney Transplantation, Lung Transplantation, Antibody-Mediated Rejection
- Trial name
- TRACKLESS (NCT07316829)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS)
Phase II Study of 5-azacytidine Maintenance After Transplant for AML or MDS
Despite improvements in outcomes after Hematopoietic Cell Transplantation (HCT) for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS), the risk of relapse remains high and is the most common cause of mortality after…
- Trial name
- UPCI 13-165 (NCT02204020)
- Testing
- 5-azacytidine (5-aza) maintenance therapy after transplant
- Where
- United States
- Sponsor
- University of Pittsburgh
Hematopoietic Stem Cells
Vedolizumab in the Prophylaxis of Intestinal Acute Graft Versus Host Disease (aGVHD) in Participants Undergoing Allogeneic Hematopoietic Stem Cell (Allo-HSCT) Transplantation
The purpose of this study is to evaluate the efficacy of vedolizumab when added to background aGvHD prophylaxis regimen compared to placebo and background aGvHD prophylaxis regimen on intestinal aGvHD-free survival by Day +180 in…
- Trial name
- NCT03657160
- Testing
- Vedolizumab
- Where
- 139 sites in United States, Argentina and 25 more
- Volunteers
- 343 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Migraine
Migraine--Investigational Treatment of Migraine With Noninvasive Brain Stimulation. (tDCS- Migraine)
The purpose of this study is to determine whether a painless and noninvasive procedure called Transcranial Direct Current Stimulation (tDCS) can be an effective therapy for the treatment of migraine and migraine-associated pain.
- Trial name
- NCT00521196
- Testing
- DC Stimulator (Transcranial Direct Current Stimulator)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Beth Israel Deaconess Medical Center
Hematologic Diseases
Intra Bone Marrow Injection Of Unrelated Cord Blood Cells
Compared to other stemcell sources cord blood (CB) is easier and safer to procure, has no donor attrition, a limitless supply, reduced viral transmission, less acute \& chronic GVHD, is rich in hematopoietic progenitor cells, and…
- Trial name
- CB01 (NCT00696046)
- Testing
- Intrabone Marrow Injection
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Acute Graft-versus-Host Disease
Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Acute Graft Versus-Host Disease
The purpose of this study is to compare the safety and efficacy of ECP treatment combined with high dose corticosteroids versus high dose corticosteroids alone, in the treatment of patients with newly diagnosed acute GvHD (Grades…
- Trial name
- NCT00282503
- Testing
- Methoxsalen+ECP, Methylprednisolone, Ecp
- Where
- 35 sites in United States, Australia and 9 more
- Volunteers
- 19 people
- Sponsor
- Mallinckrodt
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
Adding Itacitinib to Cyclophosphamide and Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Hematopoietic Stem Cell Transplants
This clinical trial evaluates the safety and effectiveness of adding itacitinib to cyclophosphamide and tacrolimus for the prevention of graft versus host disease (GVHD) in patients undergoing hematopoietic stem cell transplant.
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia, Myelodysplastic Syndrome
- Trial name
- NCT05364762
- Testing
- Cyclophosphamide, Itacitinib, Peripheral Blood Stem Cell Transplantation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center
Graft -Versus-host-disease, aGVHD
BPC2001 for the Prevention of Acute Graft-Versus-Host Disease Following Haploidentical Stem Cell Transplantation
A Phase IIb open label study evaluates the safety and efficacy of repeat doses of BPC2001 in combination with standard of care treatment for the prevention of acute graft-vs-host-disease (aGvHD) in subjects following…
- Conditions
- Graft -Versus-host-disease, aGVHD, Haploidentical Stem Cell Transplantation, cGVHD
- Trial name
- NCT07246031
- Testing
- BPC-2001
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- BioPhoenix Co., Ltd.
Uremia, Uremia; Chronic
Dynamic Breath VOC Profiling as a Non-invasive Tool to Assess Hemodialysis Adequacy
What is this study about? This is an observational study. The goal is to find out whether tiny chemicals in breath, called volatile organic compounds (VOCs), can help show if a hemodialysis session works well enough ("dialysis…
- Conditions
- Uremia, Uremia; Chronic, Hemodialysis
- Trial name
- NCT07189741
- Testing
- hemodialysis
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Second People's Hospital, Shanghai
Mycoses
Prophylaxis Trial in High Risk Allogenic Stem Cell Transplant Recipients With Graft vs. Host Disease
This trial is in high risk patients to determine the safety, tolerance and efficacy of posaconazole (POZ) vs. fluconazole in the prophylaxis against development of invasive fungal infections (IFI).
- Trial name
- NCT00034645
- Testing
- Posaconazole oral suspension
- Volunteers
- 600 people
- Sponsor
- Merck Sharp & Dohme LLC
Graft-versus-host Disease (GVHD)
The Application of Novel Identified CD8 Regulatory Precursors in Inducing Immune Tolerance After Allo-HSCT
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the most effective treatment for acute leukaemia. The reconstitution of the recipient's immune system with donor-derived HSCT cells and the development of immune…
- Trial name
- NCT06864598
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Hematopoietic and Lymphatic System Neoplasm
Axatilimab Plus Standard of Care Therapy for the Prevention of Graft Versus Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Hematologic Cancer, ABRAXAS Trial
This phase II trial studies how well adding axatilimab to standard of care (SOC) therapy works in preventing graft versus host disease (GVHD) following allogeneic hematopoietic stem cell transplantation (HCT) in patients with…
- Trial name
- NCT07349771
- Testing
- Allogeneic Hematopoietic Stem Cell Transplantation, Axatilimab, Biospecimen Collection
- Where
- 3 sites in United States
- Sponsor
- Mayo Clinic
Acute Graft-versus-Host Disease, Hematopoietic Stem Cell Transplantation
Tissue-resident Immune Cell Subsets in aGVHD
This is a prospective study investigating the role of tissue-resident immune cell subsets in the occurrence and progression of graft-versus-host disease following hematopoietic stem cell transplantation.
- Trial name
- NCT06708507
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Allogeneic Stem Cell Transplant, Graft Versus Host Disease
Nutrition and Outcomes of Hematopoietic Cell Transplantation (HCT)
Retrospective case-note review to determine if nutrition via the enteral compared to the parenteral route results in better outcomes after haematopoietic cell transplantation.
- Conditions
- Allogeneic Stem Cell Transplant, Graft Versus Host Disease, Hematologic Malignancy, Stem Cell Transplant Complications
- Trial name
- NCT03419078
- Volunteers
- 484 people
- Sponsor
- Imperial College Healthcare NHS Trust
Atopic Dermatitis
Study to Evaluate the Safety and Efficacy of Alefacept (Amevive) in Subjects With Moderate to Severe Atopic Dermatitis
This study will assess the safety, tolerability, and efficacy of Alefacept in patient with moderate to severe atopic dermatitis who could not be adequately controlled with topical therapies.
- Trial name
- NCT00832585
- Testing
- Alefacept
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Rush University Medical Center
Chronic Graft vs Host Disease
Donor Regulatory T-cells for Steroid-Refractory Chronic Graft-versus-host-Disease
A Phase I Trial of Donor Regulatory T-cells for Steroid-Refractory Chronic Graft-versus-Host-Disease in patients who do not obtain complete remission with ruxolitinib
- Trial name
- GVHD-TReG (NCT03683498)
- Testing
- Regulatory T-cell enriched infusion
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Graft vs Host Disease
Atorvastatin for the Prophylaxis of Acute GVHD in Patients Undergoing Matched Sibling Allogeneic Transplantation
Atorvastatin for prevention of acute GVHD
- Trial name
- NCT01175148
- Testing
- Atorvastatin calcium (Lipitor)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- West Virginia University
Graft-Versus-Host Disease
Mesenchymal Stromal Cells as Treatment of Chronic Graft-versus-host Disease
The aim of the study is to evaluate the safety and efficacy of mesenchymal stromal cells as treatment for steroid-refractory chronic graft-versus-host disease.
- Trial name
- NCT01522716
- Testing
- Mesenchymal stromal cells
- Where
- Sweden
- Volunteers
- 11 people
- Sponsor
- Karolinska Institutet
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