Clinical trials: Gram-Negative Bacteria
Periodontitis, Periodontal Diseases
Epithelial Mesenchymal Transition and Periodontitis
Periodontitis is a chronic inflammatory disease results is destruction of the attachment apparatus of the teeth and ultimately tooth loss.
- Conditions
- Periodontitis, Periodontal Diseases, Epithelial-Mesenchymal Transition, Transcription Factors
- Trial name
- NCT05403164
- Testing
- Modified Widman flap, Gingivectomy
- Where
- Iraq
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Gram Negative Bacterial Infections
Efficacy and Mortality of a Loading Dose of Colistin in Critical Ill Patients
The study hypothesis is that the loading dose of intravenous colistin (6 million of international units) is associated with greater clinical and microbiological efficacy, and reduced mortality of critically ill patients infected…
- Trial name
- NCT02117986
- Testing
- colistin
- Where
- 2 sites in Chile
- Volunteers
- 200 people
- Sponsor
- Hospital Barros Luco Trudeau
Urinary Tract Infection(UTI)
E. Coli for Prevention of Catheter UTI in SCI Patients
The overall goal of this project is to develop a new approach for the prevention of urinary tract infection (UTI) in persons who rely on indwelling catheters for bladder drainage.
- Trial name
- NCT00458471
- Testing
- Insertion of a urinary catheter coated with benign E. coli
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Enterobacteriaceae Infections
Effect of Imipenem and Meropenem on the Digestive Microbiota and the Emergence and Carriage of Multidrug-resistant Bacteria
Among enterobacteria, ESBL production is the leading cause of multidrug resistance. The first cases of ESBL-producing Enterobacteriaceae (EBLSE) infections were described in the 1980s and subsequently spread worldwide.
- Trial name
- MERIMI (NCT05516433)
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Ventilator Associated Pneumonia
Efficacy Study of Colistimethate Sodium Inhalation in Patients With Ventilator-associated Pneumonia
There might be additional benefit on clinical outcomes from adjunctive colistimethate sodium inhalation as therapy for multidrug resistant Gram-negative ventilator-associated pneumonia.
- Trial name
- NCT01975350
- Where
- Taiwan
- Volunteers
- 49 people
- Sponsor
- National Taiwan University Hospital
Arthritis, Reactive, Reiter Disease
Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria
Reactive arthritis, also known as Reiter's syndrome, is a form of arthritis that occurs as a reaction to an infection elsewhere in the body. It is characterized by inflammation of the joints, tendons, urogenital tract, and eyes.
- Trial name
- NCT00351273
- Testing
- Doxycycline and Rifampin, Azithromycin and Rifampin
- Where
- 3 sites in United States, Canada
- Volunteers
- 42 people
- Sponsor
- University of South Florida
Fluoroquinolone Resistant Enteric Bacteria
Incidence of Fluoroquinolone Resistant Bacteria in Patients Undergoing Prostate Biopsy
In this study, the investigators aim to establish the incidence of enteric fluoroquinolone resistant bacteria in a contemporary clinical cohort.
- Trial name
- NCT02140502
- Where
- 2 sites in Finland
- Volunteers
- 200 people
- Sponsor
- Helsinki University Central Hospital
Respiratory Distress Syndrome, Adult, Multi-antibiotic Resistance
Multi-drug Resistant Gram-negative Bacteria and Veno-venous Extracorporeal Membrane Oxygenation (ECMO)
Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a life-support technique used in patients with most severe acute respiratory distress syndrome (ARDS).
- Trial name
- MDR-ECMO (NCT06199141)
- Where
- Italy
- Volunteers
- 279 people
- Sponsor
- University of Padova
Nosocomial Infection
In Vitro Activity of Ceftolozane-tazobactam Against Contemporary Nosocomial Gram "-" Pathogens Isolated in Russia
Infections caused by resistant gram-negative bacteria are becoming increasingly prevalent and now constitute a serious threat to public health worldwide because they are difficult to treat and are associated with high morbidity…
- Trial name
- NCT04679610
- Where
- Russia
- Volunteers
- 700 people
- Sponsor
- The Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy (IACMAC)
Gram-Positive Bacterial Infections, Escherichia Coli Infections
Study Evaluating Piperacillin-Tazobactam on Certain Bacteria in Hematology and Oncology Units
To determine the value of increasing use of piperacillin/tazobactam as empiric therapy and restricting extended-spectrum cephalosporins in reducing the cases of ESBL producing Escherichia coli and Klebsiella pneumoniae in…
- Conditions
- Gram-Positive Bacterial Infections, Escherichia Coli Infections, Klebsiella Infections
- Trial name
- NCT00167999
- Testing
- piperacillin-tazobactam
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Bacteremia Caused by Gram-Negative Bacteria, Bacterial Pneumonia
A Post-Marketing Study to Assess the Efficacy and Safety of Intravenous Polymyxin B and Colistin Methanesulfonate in Patients With Carbapenem-Resistant Gram-Negative Bacterial Infection
This is a retrospective, observational, post-marketing study to evaluate the clinical response, microbiological response, mortality, and safety of intravenous polymyxin B and colistin methanesulfonate in patients with…
- Trial name
- NCT06966284
- Where
- Taiwan
- Volunteers
- 480 people
- Sponsor
- TTY Biopharm
Bacteremia Sepsis
Nanomotion-based Resistell AST to Determine the Antibiotic Susceptibility of Gram-negative Bacteria Causing Bacteremia and/or Sepsis
Blood culture samples from bacteremia patients positive for Gram-negative bacteria will be tested for antibacterial susceptibility using Resistell Phenotech device.
- Trial name
- NANO-RAST (NCT05002413)
- Testing
- Resistell AST
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- Resistell AG
Complications of Organ Transplant Stem Cells, Gram-Negative Bacterial Infections
Survey of Severe Infections by Gram Negative Bacteria in Patients Submitted to Stem Cell Transplant
All patients undergoing autologous or allogeneic stem cell transplant (SCT) for any underlying disease will be monitored for severe infections by gram negative bacteria (SIGNB) during the engraftment period.
- Trial name
- GITMO-SIGNB (NCT02088840)
- Where
- 54 sites in Italy
- Volunteers
- 2,769 people
- Sponsor
- Gruppo Italiano Trapianto di Midollo Osseo
Antibiotic Resistant Infection
Antibiotic Resistance in Global Pediatric Oncology Centers
Antibiotic resistance is one of the major health threats facing global as well as domestic populations, however it is not well characterized in pediatric patients.
- Trial name
- NCT03721562
- Where
- 5 sites in United States, El Salvador and 2 more
- Volunteers
- 560 people
- Sponsor
- St. Jude Children's Research Hospital
Dysentery, Bacillary
A Study to Evaluate Safety and Immunogenicity of 1 Booster Dose of 1790GAHB Vaccine in Healthy Adults Primed With 3 Doses of 1790GAHB Vaccine in Study H03_01TP Compared to 1 Vaccination of 1790GAHB in Either Subjects Who Received Placebo in the Same Study or naïve Subjects Not Part of H03_01TP Study
GVGH Shigella Sonnei 1970GAHB is a vaccine aimed at preventing the disease caused by Shigella sonnei. A post-hoc analysis of subjects who participated in the parent study showed significantly different responses in subjects with…
- Trial name
- NCT03089879
- Testing
- GVGH Shigella sonnei 1790GAHB vaccine
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Relationship of Carbapenem Use to Carbapenem Resistant Gram-negative Bacteria
Predictors of Rates of Resistant Gram-Negative Bacteria
Antibiotic resistance in gram-negative bacteria continues to increase in US hospitals. This comes at a time when there are few new drugs in development that are active for these resistant organisms.
- Trial name
- NCT01075009
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Virginia Commonwealth University
Infections
Effect of Antibiotic Rotation in the ICU on the Prevalence of Antibiotic Resistant Gram-negative Colonisation
The SATURN ICU-trial studies the effect of antibiotic rotation on the prevalence of antibiotic resistant Gram-negative colonisation.
- Trial name
- SATURN (NCT01293071)
- Testing
- Antibiotic rotation
- Where
- Netherlands
- Volunteers
- 10,000 people
- Sponsor
- UMC Utrecht
Oncology [See Also, Affected System], Hematological Disease
Assessing the Effect of Contact Isolation on Nosocomial Colonization With ESBL-EC in German Hematology/Oncology Wards
This study aims to evaluate the impact of contact isolation on the rate of hospital-acquired transmissions of ESBL-producing Escherichia coli (ESBL-EC) and the rate of colonization and infection.
- Conditions
- Oncology [See Also, Affected System], Hematological Disease, Infection Due to ESBL Escherichia Coli
- Trial name
- CONTAIN (NCT02456818)
- Volunteers
- 2,264 people
- Sponsor
- University of Cologne
Patients With Complicated Urinary Tract Infections Caused by P. Aeruginosa, Pseudomonas Aeruginosa
Safety and Efficacy Study of Ftortiazinon in the Treatment of Patients With Complicated Urinary Tract Infections Caused by P. Aeruginosa
This study is planned to evaluate the safety and efficacy of the drug Ftortiazinon in combination with the drug Maxipime® in comparison with placebo in combination with the drug Maxipime® in the treatment of hospitalized adult…
- Conditions
- Patients With Complicated Urinary Tract Infections Caused by P. Aeruginosa, Pseudomonas Aeruginosa, Pseudomonas Infections, Urinary Tract Infections
- Trial name
- NCT03638830
- Testing
- Ftortiazinon (tablets 300 mg) full dose + Maxipim
- Where
- 5 sites in Russia
- Volunteers
- 777 people
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
Atopic Dermatitis
Beginning Assessment of Cutaneous Treatment Efficacy of Roseomonas in Atopic Dermatitis
Background: Atopic dermatitis (AD) is a skin disease also called eczema. It is common in children and sometimes gets better on its own. However, chronic AD may cause asthma, food allergies, eye infections, and sleep problems.
- Trial name
- NCT03018275
- Testing
- Roseomonas mucosa
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)