Clinical trials: Gram-negative Bacterial Infection
Infection Due to Escherichia Coli, Acute Pyelonephritis
Sitafloxacin and Ertapenem Treatment for Acute Pyelonephritis Caused by Escherichia Coli
The aim of the investigators' study was to evaluate oral and non carbapenem antimicrobial agents which can be used in outpatient for the treatment of non-bacteremic acute pyelonephritis caused by Extended Spectrum Beta Lactamase…
- Trial name
- SETAP (NCT02537847)
- Testing
- Sitafloxacin, Ertapenem
- Where
- Thailand
- Volunteers
- 96 people
- Sponsor
- Mahidol University
Typhoid Fever
Salmonella Typhi Vi O-Acetyl Pectin-rEPA Conjugate Vaccine
This study will evaluate a new (conjugate) vaccine for typhoid fever, which remains a serious disease especially difficult to treat in developing countries.
- Trial name
- NCT00277147
- Testing
- BB IND 6989
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Secretory Diarrhea
Efficacy of iOWH032 in Dehydrating Cholera
The primary hypothesis is that administration of iOWH032 to adult and pediatric males and females with acute cholera due to V. cholerae O1 reduces stool output in the first 24 hours significantly more than does the current…
- Trial name
- POC (NCT02111304)
- Testing
- iOWH032
- Where
- Bangladesh
- Sponsor
- PATH
Clostridium Difficile Infection, VRE Infection
Antibiotic Stewardship and Infection Control in Patients at High Risk of Developing Infection by Clostridium Difficile, Vancomycin-Resistant Enterococci or Multi-Resistant Gram-Negatives
Throughout project, the investigators design, evaluate and disseminate infection control and antibiotic stewardship (ABS) measures aimed at reducing the incidence of Clostridium difficile infection (CDI).
- Conditions
- Clostridium Difficile Infection, VRE Infection, Nosocomial Infection, MRGN Bacteria
- Trial name
- ABSOLUTE (NCT03250104)
- Testing
- Infection Control, Antibiotic Stewardship
- Where
- Germany
- Volunteers
- 80,000 people
- Sponsor
- University Hospital of Cologne
Meningitis, Meningococcal Infection
Dose Comparison Study of Menactra® in US Children
To explore the potential benefit of the administration of Menactra vaccine as a two-dose regimen to children. Primary Objective: To assess, by age group, the immune response to Menactra vaccine after each vaccine injection.
- Conditions
- Meningitis, Meningococcal Infection, Neisseria Meningitidis
- Trial name
- NCT00700635
- Testing
- Menactra®: Meningococcal Polysaccharide Diphtheria Conjugate
- Where
- 15 sites in United States
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Drug Clearance After Severe Burn Injury
Pharmacokinetic Analysis of Cefiderocol in Patients With Acute Burn Injuries
Cefiderocol is a powerful, broad spectrum antibiotic approved to treat hospital-acquired or ventilator associated pneumonia and urinary tract infections.
- Trial name
- NCT07465432
- Testing
- Cefiderocol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Tennessee
Lyme Disease, Erythema Migrans
Erythema Migrans in Elderly
The investigators will focus on elderly patients with early Lyme borreliosis with the aim of assessing clinical course, serological response and treatment outcome of the disease as compared to younger adults.
- Conditions
- Lyme Disease, Erythema Migrans, Elderly Infection
- Trial name
- NCT03371563
- Testing
- Antibiotics, no intervention
- Volunteers
- 1,220 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Detection Accuracy, Patient Compliance
Reliability, Safety and Usability of the Transplantation Sensor System Combined With Myfortic® in Adult Kidney Transplant Patients
The main purpose of this exploratory trial is to evaluate the reliability, safety and usability of the Transplantation Sensor System when the Ingestible Event Marker (IEM) is given in combination with ECMPS 360 mg tablets in…
- Trial name
- NCT01320358
- Testing
- ECMPS-IEM
- Where
- 5 sites in Switzerland
- Volunteers
- 30 people
- Sponsor
- Novartis Pharmaceuticals
Diphtheria, Tetanus
Randomized Controlled Trial of the Impact of Mobile Phone Delivered Reminders and Travel Subsidies to Improve Childhood Immunization Coverage Rates and Timeliness in Western Kenya
The project goal is to conduct a randomized controlled trial (RCT) to test whether mobile phone short message system (SMS) reminders, either with or without mobile-phone based travel subsidies will improve timeliness, coverage…
- Conditions
- Diphtheria, Tetanus, Pertussis, Hepatitis B
- Trial name
- m-SIMU (NCT01878435)
- Testing
- SMS reminder, Travel subsidy, Travel subsidy 2
- Where
- Kenya
- Volunteers
- 2,018 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Hepatitis B, Poliomyelitis
Comparison of Immunogenicity and Reactogenicity of INFANRIX™ HEXA and HEXAVAC™ Vaccines as a Primary Vaccination Course
The study will compare the immunogenicity and the reactogenicity of INFANRIX™ HEXA and HEXAVAC™ vaccines in a 3, 5 and 11 - 12 month vaccination schedule.
- Conditions
- Hepatitis B, Poliomyelitis, Diphtheria, Acellular Pertussis
- Trial name
- NCT01457547
- Testing
- DTPa-HBV-IPV/Hib Vaccine (INFANRIX™ HEXA), DTPa-HBV-IPV-Hib vaccine (HEXAVAC™)
- Where
- 9 sites in Finland, Italy and 1 more
- Volunteers
- 494 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tetanus, Poliomyelitis
Safety and Immunogenicity of New Formulations of GlaxoSmithKline Biologicals' DTPa-HBV-IPV/Hib Vaccine (GSK217744)
This study is designed to evaluate the safety and immunogenicity of new formulations of GSK Biologicals' DTPa-HBV-IPV/Hib vaccine (GSK217744) when administered as a primary vaccination course to healthy infants at 2, 3 and 4…
- Conditions
- Tetanus, Poliomyelitis, Hepatitis B, Haemophilus Influenzae Type b
- Trial name
- NCT01248884
- Testing
- Infanrix hexa™, Prevenar 13®, GSK217744
- Where
- 16 sites in Dominican Republic, Finland
- Volunteers
- 721 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV Infections
Surveillance and Medical Help for HIV-infected Intravenous Drug Users in and Out of Prison
It is difficult to detect the intestinal protozoal infections among the HIV-infected persons or travelers diarrhea by using the traditional microscopy or staining methods.
- Trial name
- NCT00739258
- Where
- Taiwan
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Pertussis/Whooping Cough
The Optimal Timing of Vaccination in Pregnancy
The central aim of this study is to investigate the optimal timing of vaccination in pregnant women. Therefore, pregnant women will be vaccinated against pertussis at different timepoints and blood and breast milk samples will be…
- Trial name
- MATIMMUNE (NCT06466629)
- Testing
- Triaxis, Sanofi Pasteur
- Where
- Belgium
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Elke Leuridan, MD, PhD
Leptospirosis, Jarisch Herxheimer Reaction
Study of the Incidence of Jarisch-Herxheimer Reaction in Leptospirosis Patients in New Caledonia
The objective of the study is to estimate the incidence of Jarisch-Herxheimer Reactions (JHR) during antibiotic treatment of human leptospirosis cases in New Caledonia.
- Trial name
- LEPJARNC (NCT04882046)
- Testing
- Blood collection, Data collection
- Where
- 5 sites in New Caledonia
- Volunteers
- 900 people
- Sponsor
- Institut Pasteur
Lyme Disease
Feasibility of Teleyoga for Treatment of Lyme Disease
Primary Aims: Modify an existing teleyoga intervention to use with Lyme disease (LD) patients and address the technical challenges of at-home teleyoga
- Trial name
- NCT04867473
- Testing
- Teleyoga
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stanford University
HIV, Chlamydia
Implementation of a Sexual Health Intervention for Young Men Who Have Sex With Men (MSM) in Two Vietnamese Cities
This study seeks to implement a sexual health promotion intervention for male sex workers in Hanoi and Ho Chi Minh City, Vietnam.
- Conditions
- HIV, Chlamydia, Gonorrhea, Syphilis
- Trial name
- NCT02122094
- Testing
- Sexual Health Promotion Intervention
- Where
- 2 sites in Vietnam
- Volunteers
- 1,166 people, healthy volunteers welcome
- Sponsor
- National Development and Research Institutes, Inc.
Shigellosis
A Study to Determine If a New Shigella Vaccine is Safe, Induces Immunity and The Best Dose Among Kenyan Infants
In this study, the tetravalent bioconjugate candidate vaccine Shigella4V will be tested to obtain first-in-human data on its safety and immunogenicity in infants and to identify the preferred dose of Shigella4V in 9 month old…
- Trial name
- NCT04056117
- Testing
- Shigella 4V, MenACWY, Rabies
- Where
- 2 sites in Kenya
- Volunteers
- 597 people, healthy volunteers welcome
- Sponsor
- LimmaTech Biologics AG
Infections, Meningococcal
Study to Evaluate Meningococcal Serogroups A,C,W-135,Y Conjugate Vaccine When Given as 1 Dose to Healthy Subjects Aged 18-25 Years
The purpose of this study is to evaluate the safety, reactogenicity, immunogenicity and persistence up to three years after administration of one dose of the MenACWY conjugate vaccine when given to young adults aged 18-25 years.
- Trial name
- NCT00196950
- Testing
- Meningococcal (vaccine)
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Carbapenem-Resistant Enterobacteriaceae Infection, Pneumonia - Bacterial
Different Methods of Aerosolized Polymyxin B Inhalation for Treating Carbapenem-Resistant Gram-Negative Bacterial Pneumonia.
Study Design: A randomized, open-label, parallel-group clinical trial comparing the efficacy and safety of jet nebulization versus vibrating mesh nebulization of sulfate polymyxin B in mechanically ventilated patients with…
- Trial name
- NCT07086391
- Testing
- Polymyxin B Sulfate 25mg Jet Nebulization / Vibrating Mesh Nebulization
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Fujian Medical University Union Hospital
Erythema Migrans, Erythema Chronicum Migrans
Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice
Tick borne diseases are increasing in Norway. Lyme borreliosis is the most common infection. Erythema migrans is mainly diagnosed and treated in general practice.
- Conditions
- Erythema Migrans, Erythema Chronicum Migrans, Borreliosis, Lyme Disease
- Trial name
- NorTick_EM (NCT01368341)
- Testing
- Doxycycline, Phenoxymethylpenicillin, Amoxicillin
- Where
- Norway
- Volunteers
- 225 people
- Sponsor
- Morten Lindbaek
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