Clinical trials: Gram-negative Bacterial Infection
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Urinary Tract Infections
Selective Reporting of Antibiotic Susceptibility Test Results in Urinary Tract Infections in the Outpatient Setting
Antibiotic resistance is a serious and increasing worldwide threat to global public health. One of antibiotic stewardship programmes' objectives is to reduce inappropriate broad-spectrum antibiotics' prescription.
- Trial name
- NCT03612297
- Testing
- Selective reporting of Antibiotic Susceptibility Tests
- Volunteers
- 64,000 people
- Sponsor
- Central Hospital, Nancy, France
Typhoid
Non-inferiority Trial of Locally Manufactured Typhoid Conjugate Vaccine 'Typhocon' in Bangladesh
This is a double blinded, randomized-controlled, non-inferiority trial of a typhoid conjugate vaccine, Typhocon (Vi- polysaccharide conjugated to diphtheria toxoid, Vi-DT), manufactured by a local company, Incepta Vaccine…
- Trial name
- NCT05475379
- Testing
- Typhoid Vi polysaccharide-diphtheria toxoid conjugate vaccine (Vi-DT)
- Where
- Bangladesh
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Shigella Infection, Enterotoxigenic Escherichia Coli Infection
Shigella CVD 31000: Study of Responses With Shigella-ETEC Vaccine Strain CVD 1208S-122
The purpose of this study is to determine whether a live, oral, combined Shigella-ETEC vaccine candidate, known as strain CVD 1208S-122, is safe and immunogenic.
- Trial name
- NCT04634513
- Testing
- strain CVD 1208S-122
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Haemophilus Influenzae Type b (Hib) Infection
Immunogenicity and Safety of a Monovalent Glycoprotein-Conjugated (Diptheria Toxin -CRM197) Hib Vaccine in 13-59 Months Old Healthy Children
This study will evaluate the safety and immunogenicity of single dose of two commercially available vaccines used to prevent Haemophilus influenzae type b infections in children 13-59 months of age.
- Trial name
- NCT01125527
- Testing
- Monovalent glyco-conjugated vaccine against Haemophilus influenzae type b (Hib), Tetanus toxoid polysaccharide-conjugated vaccine against Haemophilus influenzae type b (Hib)
- Where
- China
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Gastroenteritis Escherichia Coli
Safety and Immunogenicity of Peru-15-pCTB in Healthy Adult Subjects
Enterotoxigenic Escherichia (E.) coli (ETEC) bacteria are the main cause of traveler's diarrhea and are significant pathogens affecting children and elderly individuals of developing countries.
- Trial name
- NCT00654108
- Testing
- Ciprofloxacin, Peru-15-pCTB, Sodium bicarbonate/Ascorbic Acid/Aspartame Buffer
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Gonorrhea
OptiGon - Optimising Laboratory Assays for Immune Responses to Gonococcus
This is an observational study. Blood from otherwise healthy patients presenting with confirmed N.gonorrhoea infection, prior to treatment, will be collected to (i) allow the optimisation of assays assessing the immune response…
- Trial name
- NCT05613725
- Testing
- Blood sample collection
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Oxford
Pertussis
Pertussis Vaccination in Pregnant Women
Brief Summary: The study compares four models of pertussis vaccination dispensation to pregnant women on the vaccine coverage obtained. In addition, the cost of the different models of vaccination will be evaluated.
- Trial name
- NCT03909126
- Testing
- Boostrix administered during gestational diabetes screening, Boostrix administered in high volume obstetric clinic
- Where
- 3 sites in Canada
- Volunteers
- 946 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Shigellosis
Tebipenem Trial in Children With Shigellosis
Background (brief): Shigellosis is the second leading cause of death due to diarrheal diseases worldwide (>200,000 deaths/year).
- Trial name
- NCT05121974
- Testing
- Tebipenem Pivoxil, Azithromycin, Ceftriaxon
- Where
- Bangladesh
- Volunteers
- 132 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Enterobacteriaceae Infections
Study on Reduced Antibiotic Treatment vs Broad Spectrum Betalactam in Patients With Bacteremia by Enterobacteriaceae
The continuous increase in the bacterial resistance rate and the slow arrival of new therapeutic options have turned into an antibiotic crisis.
- Trial name
- SIMPLIFY (NCT02795949)
- Testing
- Antipseudomonal beta-lactam antibiotic, De-escalation(short-spectrum antibiotic)
- Where
- 21 sites in Spain
- Volunteers
- 344 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Chlamydia
Chlamydia Trachomatis Immunology and Vaccinology Study
The primary objective is to prospectively follow 200 women with or at risk of cervicitis to determine the chlamydia-specific cellular responses that correlate with protection against incident infection.
- Trial name
- NCT01150747
- Testing
- ceftriaxone, Azithromycin
- Where
- 4 sites in United States
- Volunteers
- 347 people
- Sponsor
- Harold Wiesenfeld
Meningococcal Disease
Safety Surveillance of MenACWY-CRM Vaccine in Children
The purpose of this study is to summarize the occurrence of incident serious medically attended events and events of interest up to 1 year following MenACWY-CRM vaccination administered as part of routine clinical care.
- Trial name
- NCT01452438
- Testing
- MenACWY-CRM
- Where
- United States
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Lyme Disease, Tick-Borne Disease
Evaluation and Follow-up of People With Tick-borne Diseases
Background: Lyme disease is the most common tick-borne disease in the United States, but other diseases transmitted by ticks have also been on the rise in recent years.
- Trial name
- NCT04318925
- Where
- United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Urinary Tract Infections
Comparative Study of the Genomic Characteristics of Uropathogenic Escherichia Coli According to the Severity of Community-Acquired Urinary Tract Infections in Guadeloupe (COLIGENURI)
The aim is to identify genomic determinants (genes or gene clusters) associated with the severity of community-acquired E. coli urinary tract infections in Guadeloupe through a comparative approach integrating clinical…
- Trial name
- COLIGENURI (NCT07905638)
- Testing
- Whole-genome sequencing (WGS) of E. coli isolates (applies to all 3 groups)
- Volunteers
- 210 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
General Paresis
Clinical Findings in General Paresis
This is a study of the clinical and neuroimaging of general paresis. The investigators studied six patients with general paresis.
- Trial name
- NCT00921648
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Xijing Hospital
Retina, Regional Blood Flow
Effect of Antioxidants on Ocular Blood Flow, Endothelial Function, and Cytokine Levels in LPS Induced Inflammatory Model in Humans.
Oxidative stress, which refers to cellular damage caused by reactive oxygen intermediates, has been implicated in many disease processes, especially age-related disorders.
- Conditions
- Retina, Regional Blood Flow, Endotoxin, Escherichia Coli
- Trial name
- NCT00431691
- Testing
- vitamin and mineral supplement, Escherichia coli Endotoxin (LPS), 100% O2
- Where
- Austria
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Infections, Meningococcal
Safety of 4CMenB Exposure During Pregnancy
4CMenB was approved by the Food and Drug Administration (FDA) in the United States in January 2015 for people aged 10 through 25 years of age.
- Trial name
- NCT02640677
- Testing
- 4CMenB
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- GlaxoSmithKline
Trachoma
Safety and Immunogenicity of a Chlamydia Vaccine CTH522
CHLM-02 was a phase I, double-blind, randomized, placebo-controlled trial of the chlamydia vaccine CTH522. 65 trial participants were randomized into 12 groups and six cohorts (A1 to F2).
- Trial name
- CHLM-02 (NCT03926728)
- Testing
- CTH522-CAF01 IM, CTH522-CAF09b IM, CTH522 ID
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Statens Serum Institut
Insulin Resistance, NAFLD
Reversal of Lipid-Induced Insulin Resistance
The purpose of this study is to examine whether weight reduction decreases intramyocellular (IMCL) and hepatic lipid content, and improves insulin sensitivity of muscle and fat tissue in people who are insulin resistant and have…
- Trial name
- NCT02193295
- Testing
- Caloric Restriction
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Yale University
Pertussis/Whooping Cough, Bordetella Pertussis, Whooping Cough
Pertussis Challenge Study in Adults Vaccinated With BPZE1
This is a randomised, double-blinded, placebo-controlled trial of BPZE1 that includes virulent B. pertussis challenge followed by a safety follow-up.
- Trial name
- CHAMPION-1 (NCT05461131)
- Testing
- BPZE1, Azithromycin, Bordetella Pertussis Challenge Strain
- Where
- 2 sites in United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- ILiAD Biotechnologies
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