Clinical trials: Gram-positive Bacterial Infections
Clostridium Difficile Infection
Phase I Trial to Determine the Safety and Pharmacokinetics of CRS3123.
This is a Phase I, single center, randomized, placebo-controlled, double-blind, multiple ascending dose study to evaluate the safety and tolerability of CRS3123, a methionyl-tRNA synthetase inhibitor.
- Trial name
- NCT02106338
- Testing
- CRS3123
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis Infection, Tuberculosis Prevention
Qualitative Understanding of Community TB Services Pre and Post the CHIP-TB Trial
This qualitative study is designed to elicit the perspectives of relevant stakeholders to adapt a community-based TB/HIV intervention aimed on providing home-based TB prevention treatment (TPT) initiation for child TB contacts…
- Trial name
- NCT04494516
- Where
- 2 sites in Ethiopia, South Africa
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tuberculosis, Pulmonary
PCR Techniques of Dried Sputum Using a Spotcard
Molecular testing for mutations in M. tuberculosis genes associated to resistance of anti tuberculosis (TB) drugs is already part of standard laboratory TB diagnostic.
- Trial name
- NCT04055584
- Testing
- Sputum
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- University Medical Center Groningen
Serious Infections Due to Known or Suspected Gram-positive Pathogens
TD-1607 SAD Study in Healthy Subjects
TD-1607, administered intravenously as single doses, will be investigated in healthy subjects to assess its tolerability, safety, and pharmacokinetics.
- Trial name
- NCT01791049
- Testing
- TD-1607
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
BCG Vaccination Reaction, Tuberculosis
A Study of GC3107(BCG Vaccine) in Healthy Infants
The purpose of this study is to investigate the efficacy and safety of GC3107 in healthy infants
- Trial name
- NCT03947138
- Testing
- GC3107, Intradermal BCG SSI inj.
- Where
- 2 sites in South Korea
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Green Cross Corporation
HIV Infections, Tuberculosis
Prevalence of HIV and Tuberculosis in Masiphumelele Township, Cape Town, South Africa
The purpose of this study is to estimate the amount of HIV and tuberculosis (TB) infection in individuals 15 years and older in the Masiphumelele township of Cape Town, South Africa.
- Trial name
- NCT00096681
- Volunteers
- 762 people, healthy volunteers welcome
- Sponsor
- CIPRA SA
Human Papilloma Virus, Tdap - Tetanus, Diphtheria and Acellular Pertussis Vaccination
High and Low Resource Interventions to Promote HPV Vaccines
Human Papillomavirus (HPV) is a significant public health issue affecting nearly 14 million people in the United States. HPV can lead to cervical, oropharyngeal, anal, and penile cancers as well as genital warts.The purpose of…
- Conditions
- Human Papilloma Virus, Tdap - Tetanus, Diphtheria and Acellular Pertussis Vaccination, Meningitis, Meningococcal, Communication
- Trial name
- NCT03824093
- Testing
- AFIX Only, AFIX+ Provider Communication Training
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Tuberculosis, Pulmonary
Tuberculosis Cohort Avicenne Hospital
Tuberculosis represents the second highest death rate from an infectious disease in the world, just after COVID-19. The most affected department of France is Seine-Saint-Denis.
- Trial name
- COTB-AVC (NCT05539014)
- Testing
- Data collection
- Where
- 2 sites in France
- Volunteers
- 250 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tuberculosis Infection, Tuberculosis
BCG Revaccination in Children and Adolescents
Bacille Calmette Guerin (BCG) vaccine is one of the most used vaccines of the world, to reduce the risks of natural tuberculous infection.
- Trial name
- BRiC (NCT05330884)
- Testing
- BCG vaccine, Oral Chemoprophylaxis
- Where
- India
- Volunteers
- 9,200 people, healthy volunteers welcome
- Sponsor
- Tuberculosis Research Centre, India
Staphylococcus Aureus, Bacteremia
Efficacy, Immunogenicity, and Safety of a Single Dose of V710 in Adult Patients Scheduled for Cardiothoracic Surgery (V710-003 AM2)
This study will assess the efficacy of a single dose of V710 vaccine to prevent serious Staphylococcus aureus infections following elective cardiothoracic surgery.
- Conditions
- Staphylococcus Aureus, Bacteremia, Mediastinitis
- Trial name
- NCT00518687
- Testing
- V710
- Volunteers
- 8,031 people
- Sponsor
- Merck Sharp & Dohme LLC
Listeriosis, Pregnancy Complications
National Study on Listeriosis and Listeria
Listeriosis is a foodborne infection responsible for severe disease. Three main forms are described: septicaemia, central nervous system infections and maternal-fetal infections.
- Conditions
- Listeriosis, Pregnancy Complications, Infectious, Central Nervous System Infections
- Trial name
- MONALISA (NCT01520597)
- Where
- France
- Volunteers
- 2,132 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neovascularization, Tuberculosis
Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization
One complication of uveitis which is driven by an increase in VEGF is the formation of inflammatory ocular neovascularization (ION).
- Conditions
- Neovascularization, Tuberculosis, Multifocal Serpiginous Choroiditis, Harada Toxoplasmosis
- Trial name
- AVA-ION (NCT00645697)
- Where
- Lebanon
- Volunteers
- 100 people
- Sponsor
- Rafic Hariri University Hospital
Tuberculosis
A Study of Daily Rifapentine Combined With Isoniazid (1HP) for Tuberculosis Prevention in Children Less Than 13 Years of Age With and Without HIV
This study aims to find the proposed dose of Rifapentine (RPT) taken once daily with Isoniazid (INH) for 28 days to prevent tuberculosis (TB).
- Trial name
- NCT07124559
- Testing
- Rifapentine, Isoniazid, Dolutegravir
- Where
- 11 sites in Botswana, Haiti and 4 more
- Volunteers
- 144 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pulmonary Infection, Pulmonary Nodule
Remimazolam for Bronchoscopy in High-Risk Patients
Bronchoscopy is currently widely used for the diagnosis and treatment of various respiratory diseases. However, the operation of bronchoscopy is irritating, causes a strong stress response, and shares the airway with the patient…
- Conditions
- Pulmonary Infection, Pulmonary Nodule, Phthisis, Endotracheal Tumour
- Trial name
- NCT07395596
- Testing
- propofol and alfentanil, remimazolam combined with propofol and alfentanil
- Where
- 2 sites in China
- Volunteers
- 360 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Pulmonary Tuberculosis
A Randomised Trial to Evaluate Toxicity and Efficacy of 1200mg and 1800mg Rifampicin for Pulmonary Tuberculosis
In this trial, the investigators are assessing whether giving an increased dose of rifampicin to patients receiving the standard treatment for tuberculosis is safe and, when given for 4 months only, will also result in greater…
- Trial name
- RIFASHORT (NCT02581527)
- Testing
- Rifampicin, Isoniazid, Ethambutol
- Where
- 6 sites in Botswana, Guinea and 4 more
- Volunteers
- 672 people
- Sponsor
- St George's, University of London
Tuberculosis, Sarcoidosis
TB and Sarcoidosis Granuloma
Tuberculosis (TB) and sarcoidosis are both granulomatous diseases. Here we compared the immunological micro-environments of granulomas from TB and sarcoidosis patients using in situ sequencing (ISS) transcriptomic analysis and…
- Trial name
- NCT06396910
- Testing
- Spatial transcriptomics
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Staphylococcus Aureus Pneumonias
Panton Valentine Leucocidin
Staphylococcus aureus expresses a variety of virulence factors, including Panton Valentine leukocidin (PVL), a cytotoxin. PVL is specifically associated with primary skin and soft-tissue infections and severe necrotizing…
- Trial name
- PVL (NCT02798497)
- Testing
- Serum and Blood samples
- Where
- France
- Volunteers
- 234 people
- Sponsor
- Hospices Civils de Lyon
Cystic Fibrosis, Nontuberculous Mycobacterium Infection
Healthcare-associated Links in Transmission of Nontuberculous Mycobacteria in Cystic Fibrosis
Sources of NTM infection and modes of transmission among CF patients are poorly understood. Healthcare-associated transmission of NTM among CF patients has been suspected and is of growing concern for CF Centers.
- Trial name
- HALTNTM (NCT04024423)
- Testing
- Epidemiologic investigation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Jewish Health
Hansen's Disease
Epidemiology of Leprosy in French Guiana
The main objective of the present study is the genotyping of M. leprae strains found in leprosy patients in French Guiana. The secondary objectives are to investigate the presence of M.
- Trial name
- EPI-LEPR (NCT05031091)
- Testing
- standardised exposure questionnaire
- Where
- French Guiana
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Cayenne
Tuberculosis, Multidrug-Resistant
A Study of an Oral Short-course Regimen Including Bedaquiline for the Treatment of Participants With Multidrug-resistant Tuberculosis in China
The purpose of this study is to evaluate efficacy and safety of an oral bedaquiline-containing multidrug-resistant tuberculosis (MDR-TB) short-course regimen (SCR) compared to an oral SCR not including bedaquiline at the end of…
- Trial name
- PROSPECT (NCT05306223)
- Testing
- Bedaquiline, Levofloxacin, Linezolid
- Where
- 17 sites in China
- Volunteers
- 212 people
- Sponsor
- Beijing Chest Hospital
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