Clinical trials: Groin Node
Lymph Node Dissection, Lymphoedema
A Study for Lymphocele and Lymphorrhea Control Following Inguinal and Axillary Radical Lymph Node Dissection
Patients undergoing groin or axillary Radical lymph node dissection (RLND) or completion lymph node dissection (CLND, after positive sentinel lymph node biopsy (SLNB) for melanoma or breast cancer were randomized in a controlled…
- Conditions
- Lymph Node Dissection, Lymphoedema, Lymphocoele
- Trial name
- NCT02476357
- Testing
- Harmonic scalpel
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Lausanne Hospitals
Vulvar Neoplasms, Skin Neoplasms
Prospective and Randomized Study to Evaluate Interest of Ultracision Use in Inguinal Lymph Nodes Curage
The purpose of this study is to evaluate the decrease of post-operative morbidity in inguinal lymphadenectomies realised for vulvar tumors and inferior limb skin tumors by use of Ultracision with regard to classical operative…
- Trial name
- NCT00224744
- Testing
- ultracision, classical lymphadenectomy
- Where
- 2 sites in France
- Volunteers
- 73 people
- Sponsor
- Institut Claudius Regaud
Vulvar Cancer Stage Ib, Vulvar Cancer Stage II
NODE (groiN ultrasOunD cancEr)
This study is an open label, prospective, experimental, randomised clinical trial. The primary aim of this study is to determine whether it is feasible to randomise vulvar cancer patients into one of two treatment arms:1)…
- Conditions
- Vulvar Cancer Stage Ib, Vulvar Cancer Stage II, Lymph Node Metastasis, Groin Node
- Trial name
- NODE (NCT06264167)
- Testing
- High-resolution bilateral groin ultrasound surveillance
- Where
- 5 sites in Australia
- Volunteers
- 30 people
- Sponsor
- Queensland Centre for Gynaecological Cancer
Vulvar Cancer
A Non-Randomized Study to Evaluate Leg Lymphatic Drainage Associated With Surgical Intervention for Vulvar Cancer
This will be a non-blinded, non-randomized study to further our knowledge of and experience with lymph node surgery. The investigators are interested in documenting and reporting the variations in leg lymphatic drainage sentinel…
- Trial name
- NCT01321697
- Testing
- Routine Leg edema and groin dissection
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Arkansas
Malignant Melanoma, Carcinoma, Squamous Cell
Post-Operative Drainage Following Lymph Node Dissection
The purpose of this study is to determine whether the use of fibrin sealant reduces post-operative drainage following groin and axillary lymph node dissection.
- Trial name
- NCT00324272
- Testing
- Fibrin Sealant (Tisseel) used in the Experimental Arm.
- Volunteers
- 74 people
- Sponsor
- Oxford University Hospitals NHS Trust
Malignant Neoplasm
Ultrasound-Guided Photoacoustic Imaging for the Detection of Metastases in Inguinal Lymph Nodes
This early phase I trial studies how well ultrasound-guided photoacoustic imaging works in telling the difference between healthy and cancerous inguinal (groin) lymph nodes and how well it can detect certain features of lymph…
- Trial name
- NCT04185337
- Testing
- Fine-Needle Aspiration, Lymph Node Biopsy, Photoacoustic Imaging
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- M.D. Anderson Cancer Center
HIV Infections, HIV Seronegativity
Safety and Effectiveness of Administering an HIV Vaccine in the Groin Versus the Arm
The purpose of this study is to determine the safety of and immune system response to the ALVAC-HIV (vCP205) vaccine when it is injected either into the groin area or into the arm.
- Trial name
- NCT00076817
- Testing
- ALVAC-HIV (vCP205)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Penile Cancer
Assessment of Patient Experience and Needs for Patients Undergoing Invasive Inguinal Lymph Node Procedures for Penile Cancer
To learn more about the patient experience undergoing inguinal (in the groin) lymph node procedures for penile cancer during and after surgery.
- Trial name
- NCT05842031
- Testing
- Quality of Life Questionnaires, Patient Educational Needs, Symptom Management
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Metastatic Melanoma to the Groin Lymph Nodes
Evaluation of Groin Lymphadenectomy Extent For Metastatic Melanoma
BACKGROUND: Spread of metastatic melanoma to the groin lymph nodes (LN) is a common event affecting about 350 people a year in Australia.
- Trial name
- EAGLE FM (NCT02166788)
- Testing
- Inguinal Lymphadenectomy, Ilio-inguinal Lymphadenectomy
- Where
- 17 sites in Australia, Brazil and 4 more
- Volunteers
- 634 people
- Sponsor
- Melanoma and Skin Cancer Trials Limited
Malignant Lymphoma of Lymph Nodes of Inguinal Region, Malignant Lymphoma of Lymph Nodes of Axillary
Optical Detection of Peripheral Nerve Bundles During Surgery
Investigation of application possibilities of optical spectroscopy within the field of surgical resection procedures to spare nerve tissue.
- Conditions
- Malignant Lymphoma of Lymph Nodes of Inguinal Region, Malignant Lymphoma of Lymph Nodes of Axillary, Malignant Lymphoma of Lymph Nodes of the Cervix, Carcinoma of Parotid Gland
- Trial name
- NerveSpect (NCT01731379)
- Testing
- Surgical resection
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Philips Healthcare
Vulvar Cancer
Ultrasound Morphometric and Cyto/Histological Combined Pre-operative Assessment of Inguinal Lymph Node Status in Women With Invasive Vulvar Carcinoma
Vulvar cancer is a rare and very aggressive cancer, mainly spreading through lymphatics, in which the preoperative evaluation is critical to address surgery between sentinel node biopsy or radical groin lymphadenectomy.
- Trial name
- Morpho-Node (NCT02988765)
- Testing
- Groin ultrasound +/- fine needle aspiration
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Catholic University of the Sacred Heart
Lymph Nodes
Inguinal and Axillary LN Size Distribution
Recently, intralymphatic allergen-specific immunotherapy (ILIT) showed promising treatment outcomes for allergic rhinoconjunctivitis.
- Trial name
- NCT06559202
- Testing
- chest and abdominoplevic CT
- Where
- South Korea
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Gachon University Gil Medical Center
Melanoma
Minimally Invasive Groin Dissection for Melanoma
The purpose of this this study is to determine if a structured educational training program is successful in teaching surgeons a new operative technique. It will then be determined if this new operative technique is safe.
- Trial name
- SAFE-MILND (NCT01500304)
- Testing
- Minimally invasive inguinal lymph node dissection
- Where
- 11 sites in United States
- Volunteers
- 88 people
- Sponsor
- Mayo Clinic
Latent Autoimmune Diabetes in Adults
Injections of Glutamic Acid Decarboxylase (GAD) for LADA Type of Diabetes
This study will evaluate the effects of 3 intra-nodal injections of GAD-alum (Diamyd), together with oral vitamin D supplementation.
- Trial name
- GADinLADA (NCT04262479)
- Testing
- recombinant human glutamic acid dehydrogenase (rhGAD65), formulated in aluminium hydrogel, Vitamin D
- Where
- 2 sites in Norway, Sweden
- Volunteers
- 14 people
- Sponsor
- Norwegian University of Science and Technology
Lymphedema, Perioperative/Postoperative Complications
Fibrin Sealant in Decreasing Lymphedema Following Surgery to Remove Lymph Nodes in Patients With Cancer of the Vulva
RATIONALE: Fibrin sealant may decrease lymphedema following surgery to remove lymph nodes in the groin by helping to seal the lymphatic vessels.
- Conditions
- Lymphedema, Perioperative/Postoperative Complications, Vulvar Cancer
- Trial name
- NCT00028951
- Testing
- fibrin sealant, surgical wound closure
- Where
- 49 sites in United States
- Sponsor
- Gynecologic Oncology Group
Penile Cancer, Squamous Carcinoma
Evaluation of Lymphadenectomy and Chemotherapy TIP on Inguinal Lymph Nodes in Squamous Cell Carcinoma of the Penis
Squamous cell carcinoma of the penis is a rare tumor in Europe, whose prognosis and survival are influenced by metastatic lymph node involvement. Its frequency in France is estimated at less than 1% of human cancers.
- Trial name
- MEGACEP (NCT02817958)
- Testing
- Chemotherapy TIP
- Where
- 17 sites in France
- Volunteers
- 37 people
- Sponsor
- UNICANCER
Vulvar Cancer
Groin Sentinel Node Biopsy and 18FDG-PET/CT in cN0 Vulvar Cancer Patients Candidate to Standard Lymphadenectomy
The study aim is to verify the accuracy of SNB combined with 18F-FDG PET/CT in cN0 invasive vulvar cancer (IVC) patients currently not candidate to SNB according to standard guidelines.
- Trial name
- GroSNaPET (NCT02969278)
- Testing
- 18FDG-PET/TC, Sentinel node biopsy
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Catholic University of the Sacred Heart
Lymph Node Disease
LYMPHA: Eliminating the Burden of Lymphedema in Patients Requiring Nodal Dissection
Lymphedema is the build-up of lymph fluid in the body's tissue causing chronic, debilitating swelling. This commonly occurs as a result of a disruption of the lymphatic system during lymph node dissection surgeries.
- Trial name
- NCT03073096
- Testing
- LVA at time of nodal dissection
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Ottawa Hospital Research Institute
Melanoma, Skin Cancer
The Aim of This Study is to Demonstrat That Vacuum-assisted Closure Versus Conventional Wound Closure Enables to Diminish Local Complications After Lymph Node Dissection in Patients With Metastatic Skin Tumors
In this study, we compared a negative pressure wound therapy, versus a conventional dressing in order to evaluate the most efficient wound therapy closure after axillary and inguinal lymph nodes dissections in the management of…
- Conditions
- Melanoma, Skin Cancer, Epidermoid Carcinoma, Neuroendocrine Carcinoma
- Trial name
- NCT04583605
- Testing
- PREVENA
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Central Hospital, Nancy, France
Penile Cancer, Lymph Node Metastasis
Inguinal Lymphadenectomy for Penile Cancer
The aim of the present study is to prospectively compare oncological and functional results of penile radical inguinal lymphadenectomy performed with an open versus videolaparoscopic technique.
- Conditions
- Penile Cancer, Lymph Node Metastasis, Sentinel Lymph Node, Surgical Complication
- Trial name
- NCT05887921
- Testing
- Inguinal Lymphadenectomy
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- A.O.U. Città della Salute e della Scienza